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Treatment response in COPD: does FEV1 say it all? A post hoc analysis of the CRYSTAL study.

Kostikas K, Greulich T, Mackay AJ, Lossi NS, Aalamian-Mattheis M, Nunez X, Pagano VA, Patalano F, Clemens A, Vogelmeier CF.

ERJ Open Res. 2019 Feb 25;5(1). pii: 00243-2018. doi: 10.1183/23120541.00243-2018. eCollection 2019 Feb.


The European Alpha-1 Research Collaboration (EARCO): a new ERS Clinical Research Collaboration to promote research in alpha-1 antitrypsin deficiency.

Miravitlles M, Chorostowska-Wynimko J, Ferrarotti I, McElvaney NG, O'Hara K, Stolk J, Stockley RA, Turner A, Wilkens M, Greulich T; EARCO Clinical Research Collaboration; Members of the EARCO Clinical Research Collaboration.

Eur Respir J. 2019 Feb 14;53(2). pii: 1900138. doi: 10.1183/13993003.00138-2019. Print 2019 Feb. No abstract available.


[The stepwise approach of COPD therapy].

Watz H, Kirsten A, Greulich T.

Dtsch Med Wochenschr. 2019 Jan;144(1):15-20. doi: 10.1055/a-0570-3595. Epub 2019 Jan 2. German.


[Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology].

Buhl R, Bals R, Baur X, Berdel D, Criée CP, Gappa M, Gillissen A, Greulich T, Haidl P, Hamelmann E, Kardos P, Kenn K, Klimek L, Korn S, Lommatzsch M, Magnussen H, Nicolai T, Nowak D, Pfaar O, Rabe KF, Riedler J, Ritz T, Schultz K, Schuster A, Spindler T, Taube C, Taube K, Vogelmeier C, von Leupoldt A, Wantke F, Weise S, Wildhaber J, Worth H, Zacharasiewicz A.

Pneumologie. 2017 Dec;71(12):e3. doi: 10.1055/a-0790-0021. Epub 2018 Nov 7. German. No abstract available.


Longitudinal stability of blood eosinophil count strata in the COPD COSYCONET cohort.

Greulich T, Mager S, Lucke T, Koczulla AR, Bals R, Fähndrich S, Jörres RA, Alter P, Kirsten A, Vogelmeier CF, Watz H.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 28;13:2999-3002. doi: 10.2147/COPD.S165909. eCollection 2018. No abstract available.


Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B.

J Infect Dis. 2019 Jan 29;219(4):540-543. doi: 10.1093/infdis/jiy554.


Safety of biweekly α1-antitrypsin treatment in the RAPID programme.

Greulich T, Chlumsky J, Wencker M, Vit O, Fries M, Chung T, Shebl A, Vogelmeier C, Chapman KR, McElvaney NG; RAPID Trial Group.

Eur Respir J. 2018 Nov 29;52(5). pii: 1800897. doi: 10.1183/13993003.00897-2018. Print 2018 Nov. No abstract available.


Real world evaluation of a novel lateral flow assay (AlphaKit® QuickScreen) for the detection of alpha-1-antitrypsin deficiency.

Greulich T, Rodríguez-Frias F, Belmonte I, Klemmer A, Vogelmeier CF, Miravitlles M.

Respir Res. 2018 Aug 13;19(1):151. doi: 10.1186/s12931-018-0826-8.


An Unusual Case of Noncatamenial Recurrent Pneumothorax.

Kirschbaum A, Greulich T, Mirow N, Bartsch DK.

Thorac Cardiovasc Surg Rep. 2018 Jan;7(1):e36-e38. doi: 10.1055/s-0038-1667318. Epub 2018 Aug 9.


The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions.

Janciauskiene S, Wrenger S, Immenschuh S, Olejnicka B, Greulich T, Welte T, Chorostowska-Wynimko J.

Front Pharmacol. 2018 Apr 17;9:341. doi: 10.3389/fphar.2018.00341. eCollection 2018. Review.


Indacaterol/glycopyrronium reduces the risk of clinically important deterioration after direct switch from baseline therapies in patients with moderate COPD: a post hoc analysis of the CRYSTAL study.

Greulich T, Kostikas K, Gaga M, Aalamian-Mattheis M, Lossi NS, Patalano F, Nunez X, Pagano VA, Fogel R, Vogelmeier CF, Clemens A.

Int J Chron Obstruct Pulmon Dis. 2018 Apr 16;13:1229-1237. doi: 10.2147/COPD.S159732. eCollection 2018.


Blood eosinophils as a marker of eosinophilic exacerbations in COPD.

Greulich T, Vogelmeier CF.

Lancet Respir Med. 2018 May;6(5):e17. doi: 10.1016/S2213-2600(18)30095-X. Epub 2018 Apr 5. No abstract available.


A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial.

Greulich T, Hohlfeld JM, Neuser P, Lueer K, Klemmer A, Schade-Brittinger C, Harnisch S, Garn H, Renz H, Homburg U, Renz J, Kirsten A, Pedersen F, Müller M, Vogelmeier CF, Watz H.

Respir Res. 2018 Apr 4;19(1):55. doi: 10.1186/s12931-018-0751-x.


[Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology].

Buhl R, Bals R, Baur X, Berdel D, Criée CP, Gappa M, Gillissen A, Greulich T, Haidl P, Hamelmann E, Kardos P, Kenn K, Klimek L, Korn S, Lommatzsch M, Magnussen H, Nicolai T, Nowak D, Pfaar O, Rabe KF, Riedler J, Ritz T, Schultz K, Schuster A, Spindler T, Taube C, Taube K, Vogelmeier C, von Leupold A, Wantke F, Weise S, Wildhaber J, Worth H, Zacharasiewicz A.

Pneumologie. 2017 Dec;71(12):e2. doi: 10.1055/s-0044-100881. Epub 2018 Jan 15. German. No abstract available.


Prevalence of comorbidities in COPD patients by disease severity in a German population.

Greulich T, Weist BJD, Koczulla AR, Janciauskiene S, Klemmer A, Lux W, Alter P, Vogelmeier CF.

Respir Med. 2017 Nov;132:132-138. doi: 10.1016/j.rmed.2017.10.007. Epub 2017 Oct 12.


[Guideline for the Diagnosis and Treatment of Asthma - Guideline of the German Respiratory Society and the German Atemwegsliga in Cooperation with the Paediatric Respiratory Society and the Austrian Society of Pneumology].

Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin e. V; Deutsche Gesellschaft für Rehabilitationswissenschaften e.V; und Deutsche Gesellschaft für Gynäkologie und Geburtshilfe e.V.;, Buhl R, Bals R, Baur X, Berdel D, Criée CP, Gappa M, Gillissen A, Greulich T, Haidl P, Hamelmann E, Kardos P, Kenn K, Klimek L, Korn S, Lommatzsch M, Magnussen H, Nicolai T, Nowak D, Pfaar O, Rabe KF, Riedler J, Ritz T, Schultz K, Schuster A, Spindler T, Taube C, Taube K, Vogelmeier C, von Leupoldt A, Wantke F, Weise S, Wildhaber J, Worth H, Zacharasiewicz A.

Pneumologie. 2017 Dec;71(12):849-919. doi: 10.1055/s-0043-119504. Epub 2017 Dec 7. German. Erratum in: Pneumologie. 2017 Dec;71(12 ):e2. Taube, R C [corrected to Taube, C]. Pneumologie. 2017 Dec;71(12):e3.


Physician perspectives on the burden and management of asthma in six countries: The Global Asthma Physician Survey (GAPS).

Chapman KR, Hinds D, Piazza P, Raherison C, Gibbs M, Greulich T, Gaalswyk K, Lin J, Adachi M, Davis KJ.

BMC Pulm Med. 2017 Nov 23;17(1):153. doi: 10.1186/s12890-017-0492-5.


Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD.

Zhumagaliyeva A, Ottaviani S, Greulich T, Gorrini M, Vogelmeier C, Karazhanova L, Nurgazina G, DeSilvestri A, Kotke V, Barzon V, Zorzetto M, Corsico A, Ferrarotti I.

Multidiscip Respir Med. 2017 Oct 25;12:23. doi: 10.1186/s40248-017-0104-5. eCollection 2017.


Obstructive sleep apnea patients can be identified by ion mobility spectrometry-derived smell prints of different biological materials.

Greulich T, Fischer H, Lubbe D, Nell C, Ingo Baumbach J, Koehler U, Boeselt T, Vogelmeier C, Koczulla AR.

J Breath Res. 2018 Feb 6;12(2):026006. doi: 10.1088/1752-7163/aa96e2.


Cardiovascular risk in patients with alpha-1-antitrypsin deficiency.

Fähndrich S, Biertz F, Karch A, Kleibrink B, Koch A, Teschler H, Welte T, Kauczor HU, Janciauskiene S, Jörres RA, Greulich T, Vogelmeier CF, Bals R; COSYCONET investigators.

Respir Res. 2017 Sep 15;18(1):171. doi: 10.1186/s12931-017-0655-1.


Efficacy and safety of direct switch to indacaterol/glycopyrronium in patients with moderate COPD: the CRYSTAL open-label randomised trial.

Vogelmeier CF, Gaga M, Aalamian-Mattheis M, Greulich T, Marin JM, Castellani W, Ninane V, Lane S, Nunez X, Patalano F, Clemens A, Kostikas K; CRYSTAL study investigators.

Respir Res. 2017 Jul 18;18(1):140. doi: 10.1186/s12931-017-0622-x.


Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome.

Engel M, Endesfelder D, Schloter-Hai B, Kublik S, Granitsiotis MS, Boschetto P, Stendardo M, Barta I, Dome B, Deleuze JF, Boland A, Müller-Quernheim J, Prasse A, Welte T, Hohlfeld J, Subramanian D, Parr D, Gut IG, Greulich T, Koczulla AR, Nowinski A, Gorecka D, Singh D, Gupta S, Brightling CE, Hoffmann H, Frankenberger M, Hofer TP, Burggraf D, Heiss-Neumann M, Ziegler-Heitbrock L, Schloter M, Zu Castell W.

PLoS One. 2017 Jul 13;12(7):e0180859. doi: 10.1371/journal.pone.0180859. eCollection 2017.


[Alpha-2 Macroglobulin Serum Level in Patients with Alpha-1 Antitrypsin Deficiency].

Kotke V, Wiedmann S, Nell C, Vogelmeier C, Bals R, Greulich T, Klemmer A.

Pneumologie. 2017 Sep;71(9):580-586. doi: 10.1055/s-0043-103137. Epub 2017 Apr 27. German.


Costs and health-related quality of life in Alpha-1-Antitrypsin Deficient COPD patients.

Karl FM, Holle R, Bals R, Greulich T, Jörres RA, Karch A, Koch A, Karrasch S, Leidl R, Schulz H, Vogelmeier C, Wacker ME; COSYCONET Study Group.

Respir Res. 2017 Apr 17;18(1):60. doi: 10.1186/s12931-017-0543-8.


Benefits of High-Intensity Exercise Training to Patients with Chronic Obstructive Pulmonary Disease: A Controlled Study.

Boeselt T, Nell C, Lütteken L, Kehr K, Koepke J, Apelt S, Veith M, Beutel B, Spielmanns M, Greulich T, Vogelmeier CF, Kenn K, Janciauskiene S, Alter P, Koczulla AR.

Respiration. 2017;93(5):301-310. doi: 10.1159/000464139. Epub 2017 Mar 23.


Alpha-1-Antitrypsin Deficiency: Disease Management and Learning from Studies.

Greulich T.

COPD. 2017 Mar 15;14(sup1):S8-S11. doi: 10.1080/15412555.2017.1286166.


Synthesis and Physical Properties of Strained Doubly Phosphorus-Bridged Biaryls and Viologens.

Greulich TW, Yamaguchi E, Doerenkamp C, Lübbesmeyer M, Daniliuc CG, Fukazawa A, Eckert H, Yamaguchi S, Studer A.

Chemistry. 2017 May 2;23(25):6029-6033. doi: 10.1002/chem.201605272. Epub 2017 Feb 23.


Altered blood levels of vitamin D, cathelicidin and parathyroid hormone in patients with sepsis-a pilot study.

Greulich T, Regner W, Branscheidt M, Herr C, Koczulla AR, Vogelmeier CF, Bals R.

Anaesth Intensive Care. 2017 Jan;45(1):36-45.


Work of Breathing in Fixed and Pressure Relief Continuous Positive Airway Pressure (C-Flex™): A post hoc Analysis.

Jerrentrup L, Canisius S, Wilhelm S, Kesper K, Ploch T, Vogelmeier C, Greulich T, Becker HF.

Respiration. 2017;93(1):23-31. Epub 2016 Nov 22.


The prevalence of diagnosed α1-antitrypsin deficiency and its comorbidities: results from a large population-based database.

Greulich T, Nell C, Hohmann D, Grebe M, Janciauskiene S, Koczulla AR, Vogelmeier CF.

Eur Respir J. 2017 Jan 4;49(1). pii: 1600154. doi: 10.1183/13993003.00154-2016. Print 2017 Jan.


Validity and Usability of Physical Activity Monitoring in Patients with Chronic Obstructive Pulmonary Disease (COPD).

Boeselt T, Spielmanns M, Nell C, Storre JH, Windisch W, Magerhans L, Beutel B, Kenn K, Greulich T, Alter P, Vogelmeier C, Koczulla AR.

PLoS One. 2016 Jun 15;11(6):e0157229. doi: 10.1371/journal.pone.0157229. eCollection 2016.


Results from a large targeted screening program for alpha-1-antitrypsin deficiency: 2003 - 2015.

Greulich T, Nell C, Herr C, Vogelmeier C, Kotke V, Wiedmann S, Wencker M, Bals R, Koczulla AR.

Orphanet J Rare Dis. 2016 Jun 10;11(1):75. doi: 10.1186/s13023-016-0453-8.


Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography.

Subramanian DR, Gupta S, Burggraf D, Vom Silberberg SJ, Heimbeck I, Heiss-Neumann MS, Haeussinger K, Newby C, Hargadon B, Raj V, Singh D, Kolsum U, Hofer TP, Al-Shair K, Luetzen N, Prasse A, Müller-Quernheim J, Benea G, Leprotti S, Boschetto P, Gorecka D, Nowinski A, Oniszh K, Castell WZ, Hagen M, Barta I, Döme B, Strausz J, Greulich T, Vogelmeier C, Koczulla AR, Gut I, Hohlfeld J, Welte T, Lavae-Mokhtari M, Ziegler-Heitbrock L, Brightling C, Parr DG.

Eur Respir J. 2016 Jul;48(1):92-103. doi: 10.1183/13993003.01878-2015. Epub 2016 May 26.


Correction: Comparison of Two Devices and Two Breathing Patterns for Exhaled Breath Condensate Sampling.

Hüttmann EM, Greulich T, Koepke J, Nell C, Hattesohl A, Schmid S, Noeske S, Herr C, John G, Jörres RA, Müller B, Vogelmeier C, Koczulla AR.

PLoS One. 2016 Mar 28;11(3):e0152620. doi: 10.1371/journal.pone.0152620. eCollection 2016. No abstract available.


Whole-body vibration therapy in intensive care patients: A feasibility and safety study.

Boeselt T, Nell C, Kehr K, Holland A, Dresel M, Greulich T, Tackenberg B, Kenn K, Boeder J, Klapdor B, Kirschbaum A, Vogelmeier C, Alter P, Koczulla AR.

J Rehabil Med. 2016 Mar;48(3):316-21. doi: 10.2340/16501977-2052.


A biphenyl containing two electron-donating and two electron-accepting moieties: a rigid and small donor-acceptor-donor ladder system.

Greulich TW, Suzuki N, Daniliuc CG, Fukazawa A, Yamaguchi E, Studer A, Yamaguchi S.

Chem Commun (Camb). 2016 Feb 7;52(11):2374-7. doi: 10.1039/c5cc03063c.


Alpha-1-antitrypsin deficiency: increasing awareness and improving diagnosis.

Greulich T, Vogelmeier CF.

Ther Adv Respir Dis. 2016 Feb;10(1):72-84. doi: 10.1177/1753465815602162. Epub 2015 Sep 4. Review.


Effect of a Three-Week Inpatient Rehabilitation Program on 544 Consecutive Patients with Very Severe COPD: A Retrospective Analysis.

Greulich T, Koczulla AR, Nell C, Kehr K, Vogelmeier CF, Stojanovic D, Wittmann M, Schultz K.

Respiration. 2015;90(4):287-92. doi: 10.1159/000436979. Epub 2015 Sep 5.


Airflow limitation in COPD is associated with increased left ventricular wall stress in coincident heart failure.

Alter P, van de Sand K, Nell C, Figiel JH, Greulich T, Vogelmeier CF, Koczulla AR.

Respir Med. 2015 Sep;109(9):1131-7. doi: 10.1016/j.rmed.2015.07.012. Epub 2015 Jul 17.


Sex differences in alpha-1-antitrypsin deficiency lung disease-analysis from the German registry.

Fähndrich S, Herr C, Greulich T, Seibert M, Lepper PM, Bernhard N, Lützow C, Vogelmeier C, Bals R.

COPD. 2015 May;12 Suppl 1:58-62. doi: 10.3109/15412555.2015.1023785.


European screening for alpha1 -antitrypsin deficiency in subjects with lung disease.

Greulich T, Averyanov A, Borsa L, Rozborilová E, Vaicius D, Major T, Chopyak V, Tudorache V, Konstantinova T, Camprubí S.

Clin Respir J. 2017 Jan;11(1):90-97. doi: 10.1111/crj.12310. Epub 2015 Jun 11.


Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO.

Koepke J, Dresel M, Schmid S, Greulich T, Beutel B, Schmeck B, Vogelmeier CF, Janciauskiene S, Koczulla AR.

PLoS One. 2015 Jan 30;10(1):e0117497. doi: 10.1371/journal.pone.0117497. eCollection 2015.


N-aminopyridinium salts as precursors for N-centered radicals--direct amidation of arenes and heteroarenes.

Greulich TW, Daniliuc CG, Studer A.

Org Lett. 2015 Jan 16;17(2):254-7. doi: 10.1021/ol503338b. Epub 2014 Dec 26.


[Expert statement for augmentation therapy in patients with alpha-1 antitrypsin deficiency].

Köhnlein T, Schmidt-Scherzer K, Greulich T, Bals R.

Pneumologie. 2014 Jul;68(7):492-5. doi: 10.1055/s-0034-1365802. Epub 2014 Jul 9. German.


Exercise training leads to physiological left ventricular hypertrophy in COPD.

Alter P, Luetteken L, Nell C, Haid D, Kehr K, Greulich T, Apelt S, Langenhan K, Hohmann C, Vogelmeier CF, Koczulla AR.

Int J Cardiol. 2014 Jun 1;174(1):156-7. doi: 10.1016/j.ijcard.2014.03.160. Epub 2014 Mar 28. No abstract available.


Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial.

Greulich T, Nell C, Koepke J, Fechtel J, Franke M, Schmeck B, Haid D, Apelt S, Filipovic S, Kenn K, Janciauskiene S, Vogelmeier C, Koczulla AR.

BMC Pulm Med. 2014 Apr 11;14:60. doi: 10.1186/1471-2466-14-60.


A randomized clinical trial to assess the influence of a three months training program (gym-based individualized vs. calisthenics-based non-invidualized) in COPD-patients.

Greulich T, Kehr K, Nell C, Koepke J, Haid D, Koehler U, Koehler K, Filipovic S, Kenn K, Vogelmeier C, Koczulla AR.

Respir Res. 2014 Mar 25;15:36. doi: 10.1186/1465-9921-15-36.


[Chronic obstructive pulmonary disease (COPD). Current concepts and new therapeutic options].

Klemmer A, Greulich T, Koczulla AR, Vogelmeier CF.

Internist (Berl). 2014 Apr;55(4):401-14. doi: 10.1007/s00108-013-3406-5. Review. German.


Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing.

Zakharkina T, Heinzel E, Koczulla RA, Greulich T, Rentz K, Pauling JK, Baumbach J, Herrmann M, Grünewald C, Dienemann H, von Müller L, Bals R.

PLoS One. 2013 Jul 9;8(7):e68302. doi: 10.1371/journal.pone.0068302. Print 2013.


Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms?

Vanfleteren LE, Kocks JW, Stone IS, Breyer-Kohansal R, Greulich T, Lacedonia D, Buhl R, Fabbri LM, Pavord ID, Barnes N, Wouters EF, Agusti A.

Thorax. 2014 Jan;69(1):72-9. doi: 10.1136/thoraxjnl-2013-203602. Epub 2013 Jun 22. Review.


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