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Items: 1 to 50 of 65

1.

Tomato Phytonutrients Balance UV Response: Results from a Double-Blind, Randomized, Placebo-Controlled Study.

Groten K, Marini A, Grether-Beck S, Jaenicke T, Ibbotson SH, Moseley H, Ferguson J, Krutmann J.

Skin Pharmacol Physiol. 2019;32(2):101-108. doi: 10.1159/000497104. Epub 2019 Mar 5.

2.

EPR Technology as Sensitive Method for Oxidative Stress Detection in Primary and Secondary Keratinocytes Induced by Two Selected Nanoparticles.

Lohan SB, Ahlberg S, Mensch A, Höppe D, Giulbudagian M, Calderón M, Grether-Beck S, Krutmann J, Lademann J, Meinke MC.

Cell Biochem Biophys. 2017 Dec;75(3-4):359-367. doi: 10.1007/s12013-017-0823-4. Epub 2017 Aug 28.

PMID:
28849322
3.

Effect of a Blueberry-Derived Antioxidant Matrix on Infrared-A Induced Gene Expression in Human Dermal Fibroblasts.

Grether-Beck S, Krutmann J, Wilkens K, D'Amato K.

J Drugs Dermatol. 2017 Aug 1;16(8):s125-s128.

PMID:
28810000
4.

Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study.

Grether-Beck S, Marini A, Jaenicke T, Stahl W, Krutmann J.

Br J Dermatol. 2017 May;176(5):1231-1240. doi: 10.1111/bjd.15080. Epub 2017 Mar 15.

PMID:
27662341
5.

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4.

Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H, Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP.

Aging (Albany NY). 2016 Mar;8(3):484-505.

6.

[Environmentally induced (extrinsic) skin aging].

Krutmann J, Schikowski T, Hüls A, Vierkötter A, Grether-Beck S.

Hautarzt. 2016 Feb;67(2):99-102. doi: 10.1007/s00105-015-3750-6. Review. German.

PMID:
26769311
7.

French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence.

Grether-Beck S, Marini A, Jaenicke T, Krutmann J.

Skin Pharmacol Physiol. 2016;29(1):13-7. doi: 10.1159/000441039. Epub 2015 Oct 23. Review.

8.

Environment-induced lentigines: formation of solar lentigines beyond ultraviolet radiation.

Nakamura M, Morita A, Seité S, Haarmann-Stemmann T, Grether-Beck S, Krutmann J.

Exp Dermatol. 2015 Jun;24(6):407-11. doi: 10.1111/exd.12690. Epub 2015 Apr 16.

PMID:
25777082
9.

Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: results from a vehicle controlled, double-blind, randomized study.

Grether-Beck S, Marini A, Jaenicke T, Krutmann J.

Photochem Photobiol. 2015 Jan-Feb;91(1):248-50. doi: 10.1111/php.12375. Epub 2014 Nov 24.

PMID:
25349107
10.

Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis.

Grether-Beck S, Felsner I, Koehler T, Farwick M, Lersch P, Rawlings AV, Krutmann J.

Exp Dermatol. 2014 Nov;23(11):853-5. doi: 10.1111/exd.12526.

PMID:
25078364
11.

Photoprotection of human skin beyond ultraviolet radiation.

Grether-Beck S, Marini A, Jaenicke T, Krutmann J.

Photodermatol Photoimmunol Photomed. 2014 Apr-Jun;30(2-3):167-74. doi: 10.1111/phpp.12111. Epub 2014 Feb 19. Review.

PMID:
24433486
12.

Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii: results from a randomized, placebo-controlled, double-blinded study.

Marini A, Jaenicke T, Grether-Beck S, Le Floc'h C, Cheniti A, Piccardi N, Krutmann J.

Photodermatol Photoimmunol Photomed. 2014 Aug;30(4):189-94. doi: 10.1111/phpp.12093. Epub 2014 Jan 2.

PMID:
24283388
13.

Dihydrodehydrodiisoeugenol enhances adipocyte differentiation and decreases lipolysis in murine and human cells.

Nehrenheim K, Meyer I, Brenden H, Vielhaber G, Krutmann J, Grether-Beck S.

Exp Dermatol. 2013 Oct;22(10):638-43. doi: 10.1111/exd.12218.

PMID:
24079732
14.

The new aryl hydrocarbon receptor antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one protects against UVB-induced signal transduction.

Tigges J, Haarmann-Stemmann T, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J, Fritsche E.

J Invest Dermatol. 2014 Feb;134(2):556-559. doi: 10.1038/jid.2013.362. Epub 2013 Aug 30. No abstract available.

15.

Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins.

Gerber PA, Hevezi P, Buhren BA, Martinez C, Schrumpf H, Gasis M, Grether-Beck S, Krutmann J, Homey B, Zlotnik A.

PLoS One. 2013 Jun 20;8(6):e63949. doi: 10.1371/journal.pone.0063949. Print 2013.

16.

Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors.

Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K, Jänicke RU.

PLoS One. 2013 Apr 11;8(4):e61438. doi: 10.1371/journal.pone.0061438. Print 2013.

17.

Broad-spectrum moisturizer effectively prevents molecular reactions to UVA radiation.

Seité S, Reinhold K, Jaenicke T, Brenden H, Krutmann J, Grether-Beck S.

Cutis. 2012 Dec;90(6):321-6.

PMID:
23409485
18.

Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation.

Peuschel H, Sydlik U, Grether-Beck S, Felsner I, Stöckmann D, Jakob S, Kroker M, Haendeler J, Gotić M, Bieschke C, Krutmann J, Unfried K.

Part Fibre Toxicol. 2012 Dec 10;9:48. doi: 10.1186/1743-8977-9-48.

19.

Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression.

Grether-Beck S, Felsner I, Brenden H, Kohne Z, Majora M, Marini A, Jaenicke T, Rodriguez-Martin M, Trullas C, Hupe M, Elias PM, Krutmann J.

J Invest Dermatol. 2012 Jun;132(6):1561-72. doi: 10.1038/jid.2012.42. Epub 2012 Mar 15.

20.

Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women.

Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J.

Skin Pharmacol Physiol. 2012;25(2):86-92. doi: 10.1159/000335261. Epub 2012 Jan 21.

PMID:
22270036
21.

Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects.

Marini A, Farwick M, Grether-Beck S, Brenden H, Felsner I, Jaenicke T, Weber M, Schild J, Maczkiewitz U, Köhler T, Bonfigli A, Pagani V, Krutmann J.

Exp Dermatol. 2012 Feb;21(2):140-6. doi: 10.1111/j.1600-0625.2011.01415.x. Epub 2011 Dec 6.

PMID:
22142309
22.

Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure.

Bayer M, Proksch P, Felsner I, Brenden H, Kohne Z, Walli R, Duong TN, Götz C, Krutmann J, Grether-Beck S.

Exp Dermatol. 2011 Nov;20(11):955-8. doi: 10.1111/j.1600-0625.2011.01350.x. Epub 2011 Aug 8.

PMID:
21824200
23.

Bioactive tetrapeptide GEKG boosts extracellular matrix formation: in vitro and in vivo molecular and clinical proof.

Farwick M, Grether-Beck S, Marini A, Maczkiewitz U, Lange J, Köhler T, Lersch P, Falla T, Felsner I, Brenden H, Jaenicke T, Franke S, Krutmann J.

Exp Dermatol. 2011 Jul;20(7):602-4. doi: 10.1111/j.1600-0625.2011.01307.x.

PMID:
21692860
24.

A broad-spectrum sunscreen prevents UVA radiation-induced gene expression in reconstructed skin in vitro and in human skin in vivo.

Marionnet C, Grether-Beck S, Seité S, Marini A, Jaenicke T, Lejeune F, Bastien P, Rougier A, Bernerd F, Krutmann J.

Exp Dermatol. 2011 Jun;20(6):477-82. doi: 10.1111/j.1600-0625.2011.01265.x. Epub 2011 Mar 16.

PMID:
21410776
25.

[Adipose tissue. Cellular and molecular principles].

Grether-Beck S, Krutmann J.

Hautarzt. 2010 Oct;61(10):838-46. doi: 10.1007/s00105-010-1983-y. Review. German.

PMID:
20871971
26.

Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT.

Fernau NS, Fugmann D, Leyendecker M, Reimann K, Grether-Beck S, Galban S, Ale-Agha N, Krutmann J, Klotz LO.

J Biol Chem. 2010 Feb 5;285(6):3896-904. doi: 10.1074/jbc.M109.081430. Epub 2009 Nov 16.

27.

Functional consequences of mitochondrial DNA deletions in human skin fibroblasts: increased contractile strength in collagen lattices is due to oxidative stress-induced lysyl oxidase activity.

Majora M, Wittkampf T, Schuermann B, Schneider M, Franke S, Grether-Beck S, Wilichowski E, Bernerd F, Schroeder P, Krutmann J.

Am J Pathol. 2009 Sep;175(3):1019-29. doi: 10.2353/ajpath.2009.080832. Epub 2009 Aug 6.

28.

[Urea plus ceramides and vitamins: improving the efficacy of a topical urea preparation by addition of ceramides and vitamins].

Grether-Beck S, Mühlberg K, Brenden H, Krutmann J.

Hautarzt. 2008 Sep;59(9):717-8, 720-3. doi: 10.1007/s00105-008-1594-z. German.

PMID:
18679637
29.

Ultraviolet A induces transport of compatible organic osmolytes in human dermal fibroblasts.

Warskulat U, Brookmann S, Felsner I, Brenden H, Grether-Beck S, Häussinger D.

Exp Dermatol. 2008 Dec;17(12):1031-6. doi: 10.1111/j.1600-0625.2008.00746.x. Epub 2008 Jun 14.

PMID:
18557924
30.
31.

UV-induced DNA damage initiates release of MMP-1 in human skin.

Dong KK, Damaghi N, Picart SD, Markova NG, Obayashi K, Okano Y, Masaki H, Grether-Beck S, Krutmann J, Smiles KA, Yarosh DB.

Exp Dermatol. 2008 Dec;17(12):1037-44. doi: 10.1111/j.1600-0625.2008.00747.x. Epub 2008 May 3.

PMID:
18459971
32.

Ceramide and raft signaling are linked with each other in UVA radiation-induced gene expression.

Grether-Beck S, Salahshour-Fard M, Timmer A, Brenden H, Felsner I, Walli R, Füllekrug J, Krutmann J.

Oncogene. 2008 Aug 14;27(35):4768-78. doi: 10.1038/onc.2008.116. Epub 2008 Apr 28.

PMID:
18438433
33.

Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing.

Grether-Beck S, Mühlberg K, Brenden H, Felsner I, Brynjólfsdóttir A, Einarsson S, Krutmann J.

Exp Dermatol. 2008 Sep;17(9):771-9. doi: 10.1111/j.1600-0625.2007.00693.x. Epub 2008 Feb 28.

PMID:
18312388
34.

Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes.

Reinehr R, Sommerfeld A, Keitel V, Grether-Beck S, Haüssinger D.

J Biol Chem. 2008 Jan 25;283(4):2211-22. Epub 2007 Nov 28.

35.

Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases.

Dai G, Freudenberger T, Zipper P, Melchior A, Grether-Beck S, Rabausch B, de Groot J, Twarock S, Hanenberg H, Homey B, Krutmann J, Reifenberger J, Fischer JW.

Am J Pathol. 2007 Nov;171(5):1451-61.

36.

The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression.

Rockel N, Esser C, Grether-Beck S, Warskulat U, Flögel U, Schwarz A, Schwarz T, Yarosh D, Häussinger D, Krutmann J.

J Immunol. 2007 Sep 15;179(6):3604-12.

37.

Recommendation: daily sun protection in the prevention of chronic UV-induced skin damage.

Elsner P, Hölzle E, Diepgen T, Grether-Beck S, Hönigsmann H, Krutmann J, Scharffetter-Kochanek K, Schwarz T, Luger T.

J Dtsch Dermatol Ges. 2007 Feb;5(2):166-73. English, German. No abstract available.

PMID:
17274786
38.

Hydrophobic bile salts trigger ceramide formation through endosomal acidification.

Becker S, Reinehr R, Grether-Beck S, Eberle A, Häussinger D.

Biol Chem. 2007 Feb;388(2):185-96.

PMID:
17261082
39.

Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.

Reinehr R, Becker S, Braun J, Eberle A, Grether-Beck S, Haüssinger D.

J Biol Chem. 2006 Aug 11;281(32):23150-66. Epub 2006 Jun 13.

40.
41.

Bile salt-induced apoptosis involves NADPH oxidase isoform activation.

Reinehr R, Becker S, Keitel V, Eberle A, Grether-Beck S, Häussinger D.

Gastroenterology. 2005 Dec;129(6):2009-31.

PMID:
16344068
42.

Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis.

Grether-Beck S, Timmer A, Felsner I, Brenden H, Brammertz D, Krutmann J.

J Invest Dermatol. 2005 Sep;125(3):545-53.

43.

[Photodamage and photoaging--prevention and treatment].

Grether-Beck S, Wlaschek M, Krutmann J, Scharffetter-Kochanek K.

J Dtsch Dermatol Ges. 2005 Sep;3 Suppl 2:S19-25. Review. German.

PMID:
16117739
44.

Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis.

Reinehr R, Becker S, Eberle A, Grether-Beck S, Häussinger D.

J Biol Chem. 2005 Jul 22;280(29):27179-94. Epub 2005 May 25.

45.

Molecular crosstalk of the ultraviolet a and ultraviolet B signaling responses at the level of mitogen-activated protein kinases.

Schieke SM, Ruwiedel K, Gers-Barlag H, Grether-Beck S, Krutmann J.

J Invest Dermatol. 2005 Apr;124(4):857-9. No abstract available.

46.

Singlet oxygen-induced attenuation of growth factor signaling: possible role of ceramides.

Schieke SM, von Montfort C, Buchczyk DP, Timmer A, Grether-Beck S, Krutmann J, Holbrook NJ, Klotz LO.

Free Radic Res. 2004 Jul;38(7):729-37.

PMID:
15453638
47.

The osmolyte strategy of normal human keratinocytes in maintaining cell homeostasis.

Warskulat U, Reinen A, Grether-Beck S, Krutmann J, Häussinger D.

J Invest Dermatol. 2004 Sep;123(3):516-21.

48.

Different susceptibility of malignant versus nonmalignant human T cells toward ultraviolet A-1 radiation-induced apoptosis.

Yamauchi R, Morita A, Yasuda Y, Grether-Beck S, Klotz LO, Tsuji T, Krutmann J.

J Invest Dermatol. 2004 Feb;122(2):477-83.

49.

Mitochondrial cytochrome c release mediates ceramide-induced activator protein 2 activation and gene expression in keratinocytes.

Grether-Beck S, Felsner I, Brenden H, Krutmann J.

J Biol Chem. 2003 Nov 28;278(48):47498-507. Epub 2003 Sep 2.

50.

Analysis of cytokine profiles in human skin.

Krutmann J, Mang R, Grether-Beck S.

Methods Mol Biol. 2003;215:23-7. No abstract available.

PMID:
12512288

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