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Items: 1 to 50 of 87

1.

Modulating inflammation for cancer therapy.

Ritter B, Greten FR.

J Exp Med. 2019 Jun 3;216(6):1234-1243. doi: 10.1084/jem.20181739. Epub 2019 Apr 25. Review.

PMID:
31023715
2.

Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis.

De Oliveira T, Ramakrishnan M, Diamanti MA, Ziegler PK, Brombacher F, Greten FR.

Oncogene. 2019 Mar;38(11):1787-1801. doi: 10.1038/s41388-018-0551-2. Epub 2018 Oct 23.

PMID:
30353167
3.

Fungi Enter the Stage of Colon Carcinogenesis.

Conche C, Greten FR.

Immunity. 2018 Sep 18;49(3):384-386. doi: 10.1016/j.immuni.2018.09.002.

PMID:
30231977
4.

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.

Schulz-Heddergott R, Stark N, Edmunds SJ, Li J, Conradi LC, Bohnenberger H, Ceteci F, Greten FR, Dobbelstein M, Moll UM.

Cancer Cell. 2018 Aug 13;34(2):298-314.e7. doi: 10.1016/j.ccell.2018.07.004.

5.

Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells.

Ruder B, Murtadak V, Stürzl M, Wirtz S, Distler U, Tenzer S, Mahapatro M, Greten FR, Hu Y, Neurath MF, Cesarman E, Ballon G, Günther C, Becker C.

Mucosal Immunol. 2018 Nov;11(6):1621-1629. doi: 10.1038/s41385-018-0068-6. Epub 2018 Aug 13.

PMID:
30104627
6.

Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis.

Finkelmeier F, Canli Ö, Peiffer KH, Walter D, Tal A, Koch C, Pession U, Vermehren J, Trojan J, Zeuzem S, Piiper A, Greten FR, Grammatikos G, Waidmann O.

PLoS One. 2018 Jul 16;13(7):e0200855. doi: 10.1371/journal.pone.0200855. eCollection 2018.

7.

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR.

Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14.

PMID:
29909986
8.

NoxO1 Controls Proliferation of Colon Epithelial Cells.

Moll F, Walter M, Rezende F, Helfinger V, Vasconez E, De Oliveira T, Greten FR, Olesch C, Weigert A, Radeke HH, Schröder K.

Front Immunol. 2018 May 8;9:973. doi: 10.3389/fimmu.2018.00973. eCollection 2018.

9.

Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model.

Neumann T, Canli Ö, Greten FR.

Oncotarget. 2018 Mar 30;9(24):16775-16791. doi: 10.18632/oncotarget.24697. eCollection 2018 Mar 30.

10.

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells.

Schwab A, Siddiqui A, Vazakidou ME, Napoli F, Böttcher M, Menchicchi B, Raza U, Saatci Ö, Krebs AM, Ferrazzi F, Rapa I, Dettmer-Wilde K, Waldner MJ, Ekici AB, Rasheed SAK, Mougiakakos D, Oefner PJ, Sahin O, Volante M, Greten FR, Brabletz T, Ceppi P.

Cancer Res. 2018 Apr 1;78(7):1604-1618. doi: 10.1158/0008-5472.CAN-17-2834. Epub 2018 Jan 17.

11.

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.

Canli Ö, Nicolas AM, Gupta J, Finkelmeier F, Goncharova O, Pesic M, Neumann T, Horst D, Löwer M, Sahin U, Greten FR.

Cancer Cell. 2017 Dec 11;32(6):869-883.e5. doi: 10.1016/j.ccell.2017.11.004.

12.

Cell plasticity in epithelial homeostasis and tumorigenesis.

Varga J, Greten FR.

Nat Cell Biol. 2017 Oct;19(10):1133-1141. doi: 10.1038/ncb3611. Epub 2017 Sep 25. Review.

PMID:
28945230
13.

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.

Cammareri P, Vincent DF, Hodder MC, Ridgway RA, Murgia C, Nobis M, Campbell AD, Varga J, Huels DJ, Subramani C, Prescott KLH, Nixon C, Hedley A, Barry ST, Greten FR, Inman GJ, Sansom OJ.

Cell Death Differ. 2017 Oct;24(10):1681-1693. doi: 10.1038/cdd.2017.92. Epub 2017 Jun 16.

14.

Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer.

Bergmann H, Roth S, Pechloff K, Kiss EA, Kuhn S, Heikenwälder M, Diefenbach A, Greten FR, Ruland J.

Eur J Immunol. 2017 Aug;47(8):1342-1353. doi: 10.1002/eji.201646765. Epub 2017 Jul 4.

15.

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I.

Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66.

PMID:
28481361
16.

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients.

Srivatsa S, Paul MC, Cardone C, Holcmann M, Amberg N, Pathria P, Diamanti MA, Linder M, Timelthaler G, Dienes HP, Kenner L, Wrba F, Prager GW, Rose-John S, Eferl R, Liguori G, Botti G, Martinelli E, Greten FR, Ciardiello F, Sibilia M.

Gastroenterology. 2017 Jul;153(1):178-190.e10. doi: 10.1053/j.gastro.2017.03.053. Epub 2017 Apr 9.

17.

Cancer: Tumour stem-cell surprises.

Greten FR.

Nature. 2017 Mar 29;543(7647):626-627. doi: 10.1038/543626a. No abstract available.

PMID:
28358084
18.

Mesenchymal Cells in Colon Cancer.

Koliaraki V, Pallangyo CK, Greten FR, Kollias G.

Gastroenterology. 2017 Apr;152(5):964-979. doi: 10.1053/j.gastro.2016.11.049. Epub 2017 Jan 20. Review.

PMID:
28111227
19.

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.

Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR.

J Exp Med. 2017 Feb;214(2):423-437. doi: 10.1084/jem.20161867. Epub 2017 Jan 12.

20.

Inflammation and cancer: tissue regeneration gone awry.

Pesic M, Greten FR.

Curr Opin Cell Biol. 2016 Dec;43:55-61. doi: 10.1016/j.ceb.2016.07.010. Epub 2016 Aug 10. Review.

PMID:
27521599
21.

The Irony of Tumor-Induced Inflammation.

Greten FR.

Cell Metab. 2016 Sep 13;24(3):368-369. doi: 10.1016/j.cmet.2016.08.025.

22.

Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool.

Bocklitz TW, Salah FS, Vogler N, Heuke S, Chernavskaia O, Schmidt C, Waldner MJ, Greten FR, Bräuer R, Schmitt M, Stallmach A, Petersen I, Popp J.

BMC Cancer. 2016 Jul 26;16:534. doi: 10.1186/s12885-016-2520-x.

23.

High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis.

Finkelmeier F, Canli Ö, Tal A, Pleli T, Trojan J, Schmidt M, Kronenberger B, Zeuzem S, Piiper A, Greten FR, Waidmann O.

Eur J Cancer. 2016 May;59:152-159. doi: 10.1016/j.ejca.2016.03.002. Epub 2016 Mar 31.

PMID:
27039170
24.

The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.

Göktuna SI, Shostak K, Chau TL, Heukamp LC, Hennuy B, Duong HQ, Ladang A, Close P, Klevernic I, Olivier F, Florin A, Ehx G, Baron F, Vandereyken M, Rahmouni S, Vereecke L, van Loo G, Büttner R, Greten FR, Chariot A.

Cancer Res. 2016 May 1;76(9):2587-99. doi: 10.1158/0008-5472.CAN-15-1473. Epub 2016 Mar 15.

25.

Bcl-2 is a critical mediator of intestinal transformation.

van der Heijden M, Zimberlin CD, Nicholson AM, Colak S, Kemp R, Meijer SL, Medema JP, Greten FR, Jansen M, Winton DJ, Vermeulen L.

Nat Commun. 2016 Mar 9;7:10916. doi: 10.1038/ncomms10916.

26.

Lifting the Mist on Gastric Stem Cells.

Varga J, Greten FR.

Cell Stem Cell. 2016 Jan 7;18(1):7-9. doi: 10.1016/j.stem.2015.12.008.

27.

Systematic evaluation of the biological variance within the Raman based colorectal tissue diagnostics.

Vogler N, Bocklitz T, Subhi Salah F, Schmidt C, Bräuer R, Cui T, Mireskandari M, Greten FR, Schmitt M, Stallmach A, Petersen I, Popp J.

J Biophotonics. 2016 May;9(5):533-41. doi: 10.1002/jbio.201500237. Epub 2015 Dec 20.

PMID:
26687775
28.

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.

Pallangyo CK, Ziegler PK, Greten FR.

J Exp Med. 2015 Dec 14;212(13):2253-66. doi: 10.1084/jem.20150576. Epub 2015 Nov 30.

29.

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.

Canli Ö, Alankuş YB, Grootjans S, Vegi N, Hültner L, Hoppe PS, Schroeder T, Vandenabeele P, Bornkamm GW, Greten FR.

Blood. 2016 Jan 7;127(1):139-48. doi: 10.1182/blood-2015-06-654194. Epub 2015 Oct 13.

30.

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

Drube S, Weber F, Göpfert C, Loschinski R, Rothe M, Boelke F, Diamanti MA, Löhn T, Ruth J, Schütz D, Häfner N, Greten FR, Stumm R, Hartmann K, Krämer OH, Dudeck A, Kamradt T.

Oncotarget. 2015 Oct 6;6(30):28833-50. doi: 10.18632/oncotarget.5008.

31.

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T.

Oncotarget. 2015 Mar 10;6(7):5354-68.

32.

Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

Rokavec M, Öner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, Slotta-Huspenina J, Bader FG, Greten FR, Hermeking H.

J Clin Invest. 2015 Mar 2;125(3):1362. doi: 10.1172/JCI81340. Epub 2015 Mar 2. No abstract available.

33.

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.

Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, Jaeger E, Lewis A, Freeman-Mills L, Giner FC, Rodenas-Cuadrado P, Mallappa S, Clark S, Thomas H, Jeffery R, Poulsom R, Rodriguez-Justo M, Novelli M, Chetty R, Silver A, Sansom OJ, Greten FR, Wang LM, East JE, Tomlinson I, Leedham SJ.

Nat Med. 2015 Jan;21(1):62-70. doi: 10.1038/nm.3750. Epub 2014 Dec 1.

34.

Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe.

Stangl S, Varga J, Freysoldt B, Trajkovic-Arsic M, Siveke JT, Greten FR, Ntziachristos V, Multhoff G.

Cancer Res. 2014 Dec 1;74(23):6903-12. doi: 10.1158/0008-5472.CAN-14-0413. Epub 2014 Oct 9.

35.

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.

Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, Aydin B, Ziegler PK, Varga J, Reindl W, Pommerenke C, Salinas-Riester G, Böck A, Alpert C, Blaut M, Polson SC, Brandl L, Kirchner T, Greten FR, Polson SW, Arkan MC.

Nature. 2014 Oct 23;514(7523):508-12. doi: 10.1038/nature13398. Epub 2014 Aug 31.

36.

YAP1 takes over when oncogenic K-Ras slumbers.

Greten FR.

Cell. 2014 Jul 3;158(1):11-2. doi: 10.1016/j.cell.2014.06.021.

37.

The architect who never sleeps: tumor-induced plasticity.

Varga J, De Oliveira T, Greten FR.

FEBS Lett. 2014 Aug 1;588(15):2422-7. doi: 10.1016/j.febslet.2014.06.019. Epub 2014 Jun 12. Review.

38.

IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.

Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR.

Cell Rep. 2014 Jun 26;7(6):1914-25. doi: 10.1016/j.celrep.2014.05.006. Epub 2014 May 29.

39.

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

Rokavec M, Öner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, Slotta-Huspenina J, Bader FG, Greten FR, Hermeking H.

J Clin Invest. 2014 Apr;124(4):1853-67. doi: 10.1172/JCI73531. Epub 2014 Mar 18. Erratum in: J Clin Invest. 2015 Mar 2;125(3):1362.

40.

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.

Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M.

Cancer Cell. 2013 Aug 12;24(2):257-71. doi: 10.1016/j.ccr.2013.06.017.

41.

Concurrent video-rate color and near-infrared fluorescence laparoscopy.

Glatz J, Varga J, Garcia-Allende PB, Koch M, Greten FR, Ntziachristos V.

J Biomed Opt. 2013 Oct;18(10):101302. doi: 10.1117/1.JBO.18.10.101302.

PMID:
23797876
42.

Trp53 deficiency protects against acute intestinal inflammation.

Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.

J Immunol. 2013 Jul 15;191(2):837-47. doi: 10.4049/jimmunol.1201716. Epub 2013 Jun 14.

43.

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.

Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ.

Cell Stem Cell. 2013 Jun 6;12(6):761-73. doi: 10.1016/j.stem.2013.04.006. Epub 2013 May 9.

44.

The gastrointestinal tumor microenvironment.

Quante M, Varga J, Wang TC, Greten FR.

Gastroenterology. 2013 Jul;145(1):63-78. doi: 10.1053/j.gastro.2013.03.052. Epub 2013 Apr 10. Review.

45.

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK.

Neufert C, Becker C, Türeci Ö, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten FR, Threadgill DW, Sahin U, Neurath MF.

J Clin Invest. 2013 Apr;123(4):1428-43. doi: 10.1172/JCI63748. Epub 2013 Mar 15.

46.

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.

Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR.

Cell. 2013 Jan 17;152(1-2):25-38. doi: 10.1016/j.cell.2012.12.012. Epub 2012 Dec 27.

47.

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.

Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR.

Cancer Cell. 2013 Jan 14;23(1):93-106. doi: 10.1016/j.ccr.2012.11.014. Epub 2012 Dec 27.

48.

Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors.

Mankan AK, Greten FR.

Expert Opin Investig Drugs. 2011 Sep;20(9):1263-75. doi: 10.1517/13543784.2011.601739. Epub 2011 Jul 14. Review.

PMID:
21751940
49.

TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma.

Greten FR.

J Hepatol. 2011 Sep;55(3):721-723. doi: 10.1016/j.jhep.2011.02.037. Epub 2011 May 10.

50.

TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis.

Mankan AK, Canli O, Schwitalla S, Ziegler P, Tschopp J, Korn T, Greten FR.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6567-72. doi: 10.1073/pnas.1018331108. Epub 2011 Apr 4.

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