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Items: 49

1.

Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model.

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Gröger M, Mosig AS, Gresnigt MS, Hube B.

Dis Model Mech. 2019 Sep 12;12(9). pii: dmm039719. doi: 10.1242/dmm.039719.

2.

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies.

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS.

Biomaterials. 2019 Nov;220:119396. doi: 10.1016/j.biomaterials.2019.119396. Epub 2019 Aug 2.

PMID:
31398556
3.

A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.

Jaeger M, Matzaraki V, Aguirre-Gamboa R, Gresnigt MS, Chu X, Johnson MD, Oosting M, Smeekens SP, Withoff S, Jonkers I, Perfect JR, van de Veerdonk FL, Kullberg BJ, Joosten LAB, Li Y, Wijmenga C, Netea MG, Kumar V.

J Infect Dis. 2019 Jul 31;220(5):862-872. doi: 10.1093/infdis/jiz206.

PMID:
31241743
4.

A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis.

Jaeger M, Pinelli M, Borghi M, Constantini C, Dindo M, van Emst L, Puccetti M, Pariano M, Ricaño-Ponce I, Büll C, Gresnigt MS, Wang X, Gutierrez Achury J, Jacobs CWM, Xu N, Oosting M, Arts P, Joosten LAB, van de Veerdonk FL, Veltman JA, Ten Oever J, Kullberg BJ, Feng M, Adema GJ, Wijmenga C, Kumar V, Sobel J, Gilissen C, Romani L, Netea MG.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaar3558. doi: 10.1126/scitranslmed.aar3558.

PMID:
31189718
5.

Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst.

Grondman I, Arts RJW, Koch RM, Leijte GP, Gerretsen J, Bruse N, Kempkes RWM, Ter Horst R, Kox M, Pickkers P, Netea MG, Gresnigt MS.

J Leukoc Biol. 2019 Jul;106(1):11-25. doi: 10.1002/JLB.5HI0119-018R. Epub 2019 Jun 6.

PMID:
31169935
6.

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.

Kasper L, König A, Koenig PA, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, Hube B.

Nat Commun. 2018 Oct 15;9(1):4260. doi: 10.1038/s41467-018-06607-1.

7.

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Domínguez-Andrés J, Novakovic B, Li Y, Scicluna BP, Gresnigt MS, Arts RJW, Oosting M, Moorlag SJCFM, Groh LA, Zwaag J, Koch RM, Ter Horst R, Joosten LAB, Wijmenga C, Michelucci A, van der Poll T, Kox M, Pickkers P, Kumar V, Stunnenberg H, Netea MG.

Cell Metab. 2019 Jan 8;29(1):211-220.e5. doi: 10.1016/j.cmet.2018.09.003. Epub 2018 Oct 4.

PMID:
30293776
8.

Adjunctive interferon-γ immunotherapy in a pediatric case of Aspergillus terreus infection.

Assendorp EL, Gresnigt MS, Sprenkeler EGG, Meis JF, Dors N, van der Linden JWM, Henriet SSV.

Eur J Clin Microbiol Infect Dis. 2018 Oct;37(10):1915-1922. doi: 10.1007/s10096-018-3325-4. Epub 2018 Jul 19.

PMID:
30027379
9.

Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient.

Workum JD, de Jong SW, Gresnigt MS, Becker KL, Pickkers P, van de Veerdonk FL, Heijdra YF, Kolwijck E.

Med Mycol Case Rep. 2018 Mar 7;21:4-7. doi: 10.1016/j.mmcr.2018.03.002. eCollection 2018 Sep.

10.

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis.

Gresnigt MS, Cunha C, Jaeger M, Gonçalves SM, Malireddi RKS, Ammerdorffer A, Lubbers R, Oosting M, Rasid O, Jouvion G, Fitting C, Jong DJ, Lacerda JF, Campos A Jr, Melchers WJG, Lagrou K, Maertens J, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL.

Nat Commun. 2018 Jul 6;9(1):2636. doi: 10.1038/s41467-018-04912-3.

11.

The Multifaceted Role of T-Helper Responses in Host Defense against Aspergillus fumigatus.

Dewi IMW, van de Veerdonk FL, Gresnigt MS.

J Fungi (Basel). 2017 Oct 4;3(4). pii: E55. doi: 10.3390/jof3040055. Review.

12.

The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression.

Gresnigt MS, Jaeger M, Subbarao Malireddi RK, Rasid O, Jouvion G, Fitting C, Melchers WJG, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL.

Front Immunol. 2017 Dec 13;8:1777. doi: 10.3389/fimmu.2017.01777. eCollection 2017.

13.

Differential Kinetics of Aspergillus nidulans and Aspergillus fumigatus Phagocytosis.

Gresnigt MS, Becker KL, Leenders F, Alonso MF, Wang X, Meis JF, Bain JM, Erwig LP, van de Veerdonk FL.

J Innate Immun. 2018;10(2):145-160. doi: 10.1159/000484562. Epub 2017 Dec 16.

14.

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis.

Domínguez-Andrés J, Arts RJW, Ter Horst R, Gresnigt MS, Smeekens SP, Ratter JM, Lachmandas E, Boutens L, van de Veerdonk FL, Joosten LAB, Notebaart RA, Ardavín C, Netea MG.

PLoS Pathog. 2017 Sep 18;13(9):e1006632. doi: 10.1371/journal.ppat.1006632. eCollection 2017 Sep.

15.

Aspergillus fumigatus morphology and dynamic host interactions.

van de Veerdonk FL, Gresnigt MS, Romani L, Netea MG, Latgé JP.

Nat Rev Microbiol. 2017 Nov;15(11):661-674. doi: 10.1038/nrmicro.2017.90. Epub 2017 Sep 18. Review.

PMID:
28919635
16.

Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics.

Raijmakers RPH, Sprenkeler EGG, Aleva FE, Jacobs CWM, Kanneganti TD, Joosten LAB, van de Veerdonk FL, Gresnigt MS.

Sci Rep. 2017 Sep 13;7(1):11500. doi: 10.1038/s41598-017-11738-4.

17.

Immunotherapeutic approaches to treatment of fungal diseases.

Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt MS, van de Veerdonk FL, Levitz SM.

Lancet Infect Dis. 2017 Dec;17(12):e393-e402. doi: 10.1016/S1473-3099(17)30442-5. Epub 2017 Jul 31. Review.

18.

An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility.

Matzaraki V, Gresnigt MS, Jaeger M, Ricaño-Ponce I, Johnson MD, Oosting M, Franke L, Withoff S, Perfect JR, Joosten LAB, Kullberg BJ, van de Veerdonk FL, Jonkers I, Li Y, Wijmenga C, Netea MG, Kumar V.

PLoS One. 2017 Jul 20;12(7):e0180824. doi: 10.1371/journal.pone.0180824. eCollection 2017.

19.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

20.

Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses.

Leentjens J, Gresnigt MS, van de Veerdonk FL, Kox M, Kullberg BJ, Pickkers P, Brouwer AE, Netea MG.

Int J Infect Dis. 2017 Jun;59:25-28. doi: 10.1016/j.ijid.2017.03.013. Epub 2017 Mar 22.

21.

Personalized medicine in influenza: a bridge too far or the near future?

van de Veerdonk FL, Gresnigt MS, Verweij PE, Netea MG.

Curr Opin Pulm Med. 2017 May;23(3):237-240. doi: 10.1097/MCP.0000000000000378. Review.

PMID:
28257314
22.

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.

Lachmandas E, Beigier-Bompadre M, Cheng SC, Kumar V, van Laarhoven A, Wang X, Ammerdorffer A, Boutens L, de Jong D, Kanneganti TD, Gresnigt MS, Ottenhoff TH, Joosten LA, Stienstra R, Wijmenga C, Kaufmann SH, van Crevel R, Netea MG.

Eur J Immunol. 2016 Nov;46(11):2574-2586. doi: 10.1002/eji.201546259. Epub 2016 Sep 27.

23.

Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression.

Lasonder E, Rijpma SR, van Schaijk BC, Hoeijmakers WA, Kensche PR, Gresnigt MS, Italiaander A, Vos MW, Woestenenk R, Bousema T, Mair GR, Khan SM, Janse CJ, Bártfai R, Sauerwein RW.

Nucleic Acids Res. 2016 Jul 27;44(13):6087-101. doi: 10.1093/nar/gkw536. Epub 2016 Jun 13.

24.

Cellular metabolism of myeloid cells in sepsis.

Arts RJ, Gresnigt MS, Joosten LA, Netea MG.

J Leukoc Biol. 2017 Jan;101(1):151-164. doi: 10.1189/jlb.4MR0216-066R. Epub 2016 Jun 6. Review.

PMID:
27272310
25.

Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway.

Becker KL, Aimanianda V, Wang X, Gresnigt MS, Ammerdorffer A, Jacobs CW, Gazendam RP, Joosten LA, Netea MG, Latgé JP, van de Veerdonk FL.

MBio. 2016 May 31;7(3). pii: e01823-15. doi: 10.1128/mBio.01823-15.

26.

Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor.

Gresnigt MS, Rekiki A, Rasid O, Savers A, Jouvion G, Dannaoui E, Parlato M, Fitting C, Brock M, Cavaillon JM, van de Veerdonk FL, Ibrahim-Granet O.

Sci Rep. 2016 May 24;6:26490. doi: 10.1038/srep26490.

27.

LC3-associated phagocytosis: a crucial mechanism for antifungal host defence against Aspergillus fumigatus.

Sprenkeler EG, Gresnigt MS, van de Veerdonk FL.

Cell Microbiol. 2016 Sep;18(9):1208-16. doi: 10.1111/cmi.12616. Epub 2016 Jul 6. Review.

PMID:
27185357
28.

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis.

Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG.

Nat Immunol. 2016 Apr;17(4):406-13. doi: 10.1038/ni.3398. Epub 2016 Mar 7.

PMID:
26950237
29.

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity.

Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, Boumpas D, Muszkieta L, Prevost MC, Kontoyiannis DP, Chavakis T, Netea MG, van de Veerdonk FL, Brakhage AA, El-Benna J, Beauvais A, Latge JP, Chamilos G.

Cell Host Microbe. 2016 Jan 13;19(1):79-90. doi: 10.1016/j.chom.2015.12.002. Epub 2015 Dec 31.

30.

Interferon-gamma Immunotherapy in a Patient With Refractory Disseminated Candidiasis.

Buddingh EP, Leentjens J, van der Lugt J, Dik WA, Gresnigt MS, Netea MG, Pickkers P, Driessen GJ.

Pediatr Infect Dis J. 2015 Dec;34(12):1391-4. doi: 10.1097/INF.0000000000000909.

PMID:
26379166
31.

Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37.

van de Veerdonk FL, Gresnigt MS, Oosting M, van der Meer JW, Joosten LA, Netea MG, Dinarello CA.

Front Microbiol. 2015 Jan 7;5:762. doi: 10.3389/fmicb.2014.00762. eCollection 2014.

32.

An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism.

Smeekens SP, Gresnigt MS, Becker KL, Cheng SC, Netea SA, Jacobs L, Jansen T, van de Veerdonk FL, Williams DL, Joosten LA, Dinarello CA, Netea MG.

Cytokine. 2015 Feb;71(2):215-22. doi: 10.1016/j.cyto.2014.10.013. Epub 2014 Nov 20.

33.

IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation.

Wójtowicz A, Gresnigt MS, Lecompte T, Bibert S, Manuel O, Joosten LA, Rüeger S, Berger C, Boggian K, Cusini A, Garzoni C, Hirsch HH, Weisser M, Mueller NJ, Meylan PR, Steiger J, Kutalik Z, Pascual M, van Delden C, van de Veerdonk FL, Bochud PY; Swiss Transplant Cohort Study (STCS); Swiss Transplant Cohort Study STCS.

J Infect Dis. 2015 May 15;211(10):1646-57. doi: 10.1093/infdis/jiu636. Epub 2014 Nov 14.

34.

Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.

Ammerdorffer A, Schoffelen T, Gresnigt MS, Oosting M, den Brok MH, Abdollahi-Roodsaz S, Kanneganti TD, de Jong DJ, van Deuren M, Roest HJ, Rebel JM, Netea MG, Joosten LA, Sprong T.

J Infect Dis. 2015 Mar 15;211(6):978-87. doi: 10.1093/infdis/jiu526. Epub 2014 Sep 22.

PMID:
25246533
35.

The role of interleukin-1 family members in the host defence against Aspergillus fumigatus.

Gresnigt MS, van de Veerdonk FL.

Mycopathologia. 2014 Dec;178(5-6):395-401. doi: 10.1007/s11046-014-9776-y. Epub 2014 Jul 22. Review.

PMID:
25048411
36.

Pattern recognition pathways leading to a Th2 cytokine bias in allergic bronchopulmonary aspergillosis patients.

Becker KL, Gresnigt MS, Smeekens SP, Jacobs CW, Magis-Escurra C, Jaeger M, Wang X, Lubbers R, Oosting M, Joosten LA, Netea MG, Reijers MH, van de Veerdonk FL.

Clin Exp Allergy. 2015 Feb;45(2):423-37. doi: 10.1111/cea.12354.

PMID:
24912986
37.

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series.

Delsing CE, Gresnigt MS, Leentjens J, Preijers F, Frager FA, Kox M, Monneret G, Venet F, Bleeker-Rovers CP, van de Veerdonk FL, Pickkers P, Pachot A, Kullberg BJ, Netea MG.

BMC Infect Dis. 2014 Mar 26;14:166. doi: 10.1186/1471-2334-14-166.

38.

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist.

Gresnigt MS, Bozza S, Becker KL, Joosten LA, Abdollahi-Roodsaz S, van der Berg WB, Dinarello CA, Netea MG, Fontaine T, De Luca A, Moretti S, Romani L, Latge JP, van de Veerdonk FL.

PLoS Pathog. 2014 Mar 6;10(3):e1003936. doi: 10.1371/journal.ppat.1003936. eCollection 2014 Mar.

39.

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.

de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LA, van der Meer JW, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3526-31. doi: 10.1073/pnas.1322831111. Epub 2014 Feb 18.

40.

The dipeptidyl peptidase-4 inhibitor vildagliptin does not affect ex vivo cytokine response and lymphocyte function in patients with type 2 diabetes mellitus.

van Poppel PC, Gresnigt MS, Smits P, Netea MG, Tack CJ.

Diabetes Res Clin Pract. 2014 Mar;103(3):395-401. doi: 10.1016/j.diabres.2013.12.039. Epub 2014 Jan 3.

PMID:
24485397
41.

Biology of IL-36 cytokines and their role in disease.

Gresnigt MS, van de Veerdonk FL.

Semin Immunol. 2013 Dec 15;25(6):458-65. doi: 10.1016/j.smim.2013.11.003. Epub 2013 Dec 17. Review.

PMID:
24355486
42.

Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling.

Kyrmizi I, Gresnigt MS, Akoumianaki T, Samonis G, Sidiropoulos P, Boumpas D, Netea MG, van de Veerdonk FL, Kontoyiannis DP, Chamilos G.

J Immunol. 2013 Aug 1;191(3):1287-99. doi: 10.4049/jimmunol.1300132. Epub 2013 Jul 1.

43.

Aspergillus fumigatus-induced IL-22 is not restricted to a specific Th cell subset and is dependent on complement receptor 3.

Gresnigt MS, Becker KL, Smeekens SP, Jacobs CW, Joosten LA, van der Meer JW, Netea MG, van de Veerdonk FL.

J Immunol. 2013 Jun 1;190(11):5629-39. doi: 10.4049/jimmunol.1202601. Epub 2013 May 3.

44.

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.

Smeekens SP, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, van Sommeren S, Oosting M, Cheng SC, Joosten LA, Hoischen A, Kullberg BJ, Scott WK, Perfect JR, van der Meer JW, Wijmenga C, Netea MG, Xavier RJ.

Nat Commun. 2013;4:1342. doi: 10.1038/ncomms2343.

45.

Pattern recognition receptors and their role in invasive aspergillosis.

Gresnigt MS, Netea MG, van de Veerdonk FL.

Ann N Y Acad Sci. 2012 Dec;1273:60-7. doi: 10.1111/j.1749-6632.2012.06759.x.

PMID:
23230838
46.

The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses.

Gresnigt MS, Rösler B, Jacobs CW, Becker KL, Joosten LA, van der Meer JW, Netea MG, Dinarello CA, van de Veerdonk FL.

Eur J Immunol. 2013 Feb;43(2):416-26. doi: 10.1002/eji.201242711. Epub 2012 Dec 18.

47.

Neutrophil-mediated inhibition of proinflammatory cytokine responses.

Gresnigt MS, Joosten LA, Verschueren I, van der Meer JW, Netea MG, Dinarello CA, van de Veerdonk FL.

J Immunol. 2012 Nov 15;189(10):4806-15. doi: 10.4049/jimmunol.1103551. Epub 2012 Oct 10.

48.

Low interleukin-17A production in response to fungal pathogens in patients with chronic granulomatous disease.

Smeekens SP, Henriet SS, Gresnigt MS, Joosten LA, Hermans PW, Netea MG, Warris A, van de Veerdonk FL.

J Interferon Cytokine Res. 2012 Apr;32(4):159-68. doi: 10.1089/jir.2011.0046. Epub 2011 Dec 22.

PMID:
22191467
49.

Th17 responses and host defense against microorganisms: an overview.

van de Veerdonk FL, Gresnigt MS, Kullberg BJ, van der Meer JW, Joosten LA, Netea MG.

BMB Rep. 2009 Dec 31;42(12):776-87. Review.

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