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Science. 2013 Aug 2;341(6145):565-9. doi: 10.1126/science.1237947.

Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny.

Author information

1
Dipartimento di Scienze della Natura e del Territorio, UniversitĂ  di Sassari, Sassari, Italy. pfrancalacci@uniss.it

Abstract

Genetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA-based estimates.

PMID:
23908240
PMCID:
PMC5500864
DOI:
10.1126/science.1237947
[Indexed for MEDLINE]
Free PMC Article

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