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ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.

Campbell L, Hepworth MR, Whittingham-Dowd J, Thompson S, Bancroft AJ, Hayes KS, Shaw TN, Dickey BF, Flamar AL, Artis D, Schwartz DA, Evans CM, Roberts IS, Thornton DJ, Grencis RK.

J Exp Med. 2019 Oct 3. pii: jem.20180610. doi: 10.1084/jem.20180610. [Epub ahead of print]


The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function.

Bancroft AJ, Levy CW, Jowitt TA, Hayes KS, Thompson S, Mckenzie EA, Ball MD, Dubaissi E, France AP, Bellina B, Sharpe C, Mironov A, Brown SL, Cook PC, S MacDonald A, Thornton DJ, Grencis RK.

Nat Commun. 2019 May 28;10(1):2344. doi: 10.1038/s41467-019-09996-z.


TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

Steel N, Faniyi AA, Rahman S, Swietlik S, Czajkowska BI, Chan BT, Hardgrave A, Steel A, Sparwasser TD, Assas MB, Grencis RK, Travis MA, Worthington JJ.

PLoS Pathog. 2019 Apr 18;15(4):e1007657. doi: 10.1371/journal.ppat.1007657. eCollection 2019 Apr.


The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation.

Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS.

Nat Immunol. 2019 May;20(5):571-580. doi: 10.1038/s41590-019-0352-y. Epub 2019 Apr 1.


Experimental steering of electron microscopy studies using prior X-ray computed tomography.

Starborg T, O'Sullivan JDB, Carneiro CM, Behnsen J, Else KJ, Grencis RK, Withers PJ.

Ultramicroscopy. 2019 Jun;201:58-67. doi: 10.1016/j.ultramic.2019.03.002. Epub 2019 Mar 20.


Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.

Duque-Correa MA, Karp NA, McCarthy C, Forman S, Goulding D, Sankaranarayanan G, Jenkins TP, Reid AJ, Cambridge EL, Ballesteros Reviriego C; Sanger Mouse Genetics Project; 3i consortium, Müller W, Cantacessi C, Dougan G, Grencis RK, Berriman M.

PLoS Pathog. 2019 Jan 14;15(1):e1007265. doi: 10.1371/journal.ppat.1007265. eCollection 2019 Jan.


Parasite Immunology: Forty years on.

Riley EM, Grencis RK.

Parasite Immunol. 2019 Jan;41(1):e12607. doi: 10.1111/pim.12607. No abstract available.


T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function.

Garrido-Mesa N, Schroeder JH, Stolarczyk E, Gallagher AL, Lo JW, Bailey C, Campbell L, Sexl V, MacDonald TT, Howard JK, Grencis RK, Powell N, Lord GM.

Mucosal Immunol. 2019 Jan;12(1):51-63. doi: 10.1038/s41385-018-0092-6. Epub 2018 Oct 24.


Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis.

Scott NA, Andrusaite A, Andersen P, Lawson M, Alcon-Giner C, Leclaire C, Caim S, Le Gall G, Shaw T, Connolly JPR, Roe AJ, Wessel H, Bravo-Blas A, Thomson CA, Kästele V, Wang P, Peterson DA, Bancroft A, Li X, Grencis R, Mowat AM, Hall LJ, Travis MA, Milling SWF, Mann ER.

Sci Transl Med. 2018 Oct 24;10(464). pii: eaao4755. doi: 10.1126/scitranslmed.aao4755.


Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm.

Briggs N, Wei J, Versteeg L, Zhan B, Keegan B, Damania A, Pollet J, Hayes KS, Beaumier C, Seid CA, Leong J, Grencis RK, Bottazzi ME, Sastry KJ, Hotez PJ.

PLoS Pathog. 2018 Aug 28;14(8):e1007273. doi: 10.1371/journal.ppat.1007273. eCollection 2018 Aug.


Extracellular vesicles induce protective immunity against Trichuris muris.

Shears RK, Bancroft AJ, Hughes GW, Grencis RK, Thornton DJ.

Parasite Immunol. 2018 Jul;40(7):e12536. doi: 10.1111/pim.12536. Epub 2018 May 23.


Manipulation of host and parasite microbiotas: Survival strategies during chronic nematode infection.

White EC, Houlden A, Bancroft AJ, Hayes KS, Goldrick M, Grencis RK, Roberts IS.

Sci Adv. 2018 Mar 14;4(3):eaap7399. doi: 10.1126/sciadv.aap7399. eCollection 2018 Mar.


Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material.

Shears RK, Bancroft AJ, Sharpe C, Grencis RK, Thornton DJ.

Sci Rep. 2018 Mar 14;8(1):4508. doi: 10.1038/s41598-018-22783-y.


Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity.

Rošić S, Amouroux R, Requena CE, Gomes A, Emperle M, Beltran T, Rane JK, Linnett S, Selkirk ME, Schiffer PH, Bancroft AJ, Grencis RK, Jeltsch A, Hajkova P, Sarkies P.

Nat Genet. 2018 Mar;50(3):452-459. doi: 10.1038/s41588-018-0061-8. Epub 2018 Feb 19.


A sticky end for gastrointestinal helminths; the role of the mucus barrier.

Sharpe C, Thornton DJ, Grencis RK.

Parasite Immunol. 2018 Apr;40(4):e12517. doi: 10.1111/pim.12517. Epub 2018 Mar 4. Review.


Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface.

Dubaissi E, Rousseau K, Hughes GW, Ridley C, Grencis RK, Roberts IS, Thornton DJ.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):726-731. doi: 10.1073/pnas.1713539115. Epub 2018 Jan 8.


Immunity to gastrointestinal nematode infections.

Sorobetea D, Svensson-Frej M, Grencis R.

Mucosal Immunol. 2018 Mar;11(2):304-315. doi: 10.1038/mi.2017.113. Epub 2018 Jan 3. Review.


Chronic Trichuris muris infection causes neoplastic change in the intestine and exacerbates tumour formation in APC min/+ mice.

Hayes KS, Cliffe LJ, Bancroft AJ, Forman SP, Thompson S, Booth C, Grencis RK.

PLoS Negl Trop Dis. 2017 Jun 26;11(6):e0005708. doi: 10.1371/journal.pntd.0005708. eCollection 2017 Jun.


Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion.

Hasnain SZ, Dawson PA, Lourie R, Hutson P, Tong H, Grencis RK, McGuckin MA, Thornton DJ.

PLoS Pathog. 2017 Feb 13;13(2):e1006218. doi: 10.1371/journal.ppat.1006218. eCollection 2017 Feb.


Tuft Cells: A New Flavor in Innate Epithelial Immunity.

Grencis RK, Worthington JJ.

Trends Parasitol. 2016 Aug;32(8):583-585. doi: 10.1016/ Epub 2016 May 5.


The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation.

Kabat AM, Harrison OJ, Riffelmacher T, Moghaddam AE, Pearson CF, Laing A, Abeler-Dörner L, Forman SP, Grencis RK, Sattentau Q, Simon AK, Pott J, Maloy KJ.

Elife. 2016 Feb 24;5:e12444. doi: 10.7554/eLife.12444.


New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection.

Wang H, Kim JJ, Denou E, Gallagher A, Thornton DJ, Shajib MS, Xia L, Schertzer JD, Grencis RK, Philpott DJ, Khan WI.

Infect Immun. 2015 Nov 2;84(1):275-85. doi: 10.1128/IAI.01187-15. Print 2016 Jan.


Differential alterations in the small intestine epithelial cell turnover during acute and chronic infection with Echinostoma caproni (Trematoda).

Cortés A, Muñoz-Antoli C, Martín-Grau C, Esteban JG, Grencis RK, Toledo R.

Parasit Vectors. 2015 Jun 18;8:334. doi: 10.1186/s13071-015-0948-5.


Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance.

Houlden A, Hayes KS, Bancroft AJ, Worthington JJ, Wang P, Grencis RK, Roberts IS.

PLoS One. 2015 May 4;10(5):e0125945. doi: 10.1371/journal.pone.0125945. eCollection 2015.


Immunity to helminths: resistance, regulation, and susceptibility to gastrointestinal nematodes.

Grencis RK.

Annu Rev Immunol. 2015;33:201-25. doi: 10.1146/annurev-immunol-032713-120218. Epub 2014 Dec 17. Review.


Neutrophils worm their way into macrophage long-term memory.

Grainger JR, Grencis RK.

Nat Immunol. 2014 Oct;15(10):902-4. doi: 10.1038/ni.2990. No abstract available.


Immunity to gastrointestinal nematodes: mechanisms and myths.

Grencis RK, Humphreys NE, Bancroft AJ.

Immunol Rev. 2014 Jul;260(1):183-205. doi: 10.1111/imr.12188. Review.


Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction.

Foth BJ, Tsai IJ, Reid AJ, Bancroft AJ, Nichol S, Tracey A, Holroyd N, Cotton JA, Stanley EJ, Zarowiecki M, Liu JZ, Huckvale T, Cooper PJ, Grencis RK, Berriman M.

Nat Genet. 2014 Jul;46(7):693-700. doi: 10.1038/ng.3010. Epub 2014 Jun 15.


Sex-dependent genetic effects on immune responses to a parasitic nematode.

Hayes KS, Hager R, Grencis RK.

BMC Genomics. 2014 Mar 14;15:193. doi: 10.1186/1471-2164-15-193.


There and back again: 35 years of Parasite Immunology.

Grencis R, Riley E.

Parasite Immunol. 2014 Mar;36(3):113-4. doi: 10.1111/pim.12089. No abstract available.


A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103+ dendritic cells to the colon in response to Trichuris muris infection.

Bowcutt R, Bramhall M, Logunova L, Wilson J, Booth C, Carding SR, Grencis R, Cruickshank S.

Mucosal Immunol. 2014 Sep;7(5):1094-105. doi: 10.1038/mi.2013.125. Epub 2014 Jan 22.


Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

Worthington JJ, Klementowicz JE, Rahman S, Czajkowska BI, Smedley C, Waldmann H, Sparwasser T, Grencis RK, Travis MA.

PLoS Pathog. 2013;9(10):e1003675. doi: 10.1371/journal.ppat.1003675. Epub 2013 Oct 3.


Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection.

Dhungana H, Malm T, Denes A, Valonen P, Wojciechowski S, Magga J, Savchenko E, Humphreys N, Grencis R, Rothwell N, Koistinaho J.

Aging Cell. 2013 Oct;12(5):842-50. doi: 10.1111/acel.12106. Epub 2013 Jul 7.


Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation.

Levison SE, Fisher P, Hankinson J, Zeef L, Eyre S, Ollier WE, McLaughlin JT, Brass A, Grencis RK, Pennock JL.

BMC Genomics. 2013 Feb 26;14:127. doi: 10.1186/1471-2164-14-127.


Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion.

Worthington JJ, Samuelson LC, Grencis RK, McLaughlin JT.

PLoS Pathog. 2013 Jan;9(1):e1003122. doi: 10.1371/journal.ppat.1003122. Epub 2013 Jan 17.


A new role for mucins in immunity: insights from gastrointestinal nematode infection.

Hasnain SZ, Gallagher AL, Grencis RK, Thornton DJ.

Int J Biochem Cell Biol. 2013 Feb;45(2):364-74. doi: 10.1016/j.biocel.2012.10.011. Epub 2012 Oct 27. Review.


Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier.

Hasnain SZ, McGuckin MA, Grencis RK, Thornton DJ.

PLoS Negl Trop Dis. 2012;6(10):e1856. doi: 10.1371/journal.pntd.0001856. Epub 2012 Oct 11.


Trichuris muris: a model of gastrointestinal parasite infection.

Klementowicz JE, Travis MA, Grencis RK.

Semin Immunopathol. 2012 Nov;34(6):815-28. doi: 10.1007/s00281-012-0348-2. Epub 2012 Oct 11. Review.


Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection.

Giacomin PR, Siracusa MC, Walsh KP, Grencis RK, Kubo M, Comeau MR, Artis D.

J Immunol. 2012 Nov 1;189(9):4371-8. doi: 10.4049/jimmunol.1200691. Epub 2012 Sep 28.


Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction.

Perona-Wright G, Lundie RJ, Jenkins SJ, Webb LM, Grencis RK, MacDonald AS.

J Immunol. 2012 Mar 1;188(5):2350-8. doi: 10.4049/jimmunol.1101642. Epub 2012 Jan 27.


Life on the edge: the balance between macrofauna, microflora and host immunity.

Bancroft AJ, Hayes KS, Grencis RK.

Trends Parasitol. 2012 Mar;28(3):93-8. doi: 10.1016/ Epub 2012 Jan 16.


Wild immunology: converging on the real world.

Babayan SA, Allen JE, Bradley JE, Geuking MB, Graham AL, Grencis RK, Kaufman J, McCoy KD, Paterson S, Smith KG, Turnbaugh PJ, Viney ME, Maizels RM, Pedersen AB.

Ann N Y Acad Sci. 2011 Oct;1236:17-29. doi: 10.1111/j.1749-6632.2011.06251.x.


Trichinella spiralis antigens prime mixed Th1/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro.

Ilic N, Worthington JJ, Gruden-Movsesijan A, Travis MA, Sofronic-Milosavljevic L, Grencis RK.

Parasite Immunol. 2011 Oct;33(10):572-82. doi: 10.1111/j.1365-3024.2011.01322.x.


Muc5ac: a critical component mediating the rejection of enteric nematodes.

Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ.

J Exp Med. 2011 May 9;208(5):893-900. doi: 10.1084/jem.20102057. Epub 2011 Apr 18.


Changes in the mucosal barrier during acute and chronic Trichuris muris infection.

Hasnain SZ, Thornton DJ, Grencis RK.

Parasite Immunol. 2011 Jan;33(1):45-55. doi: 10.1111/j.1365-3024.2010.01258.x.


Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses.

Denes A, McColl BW, Leow-Dyke SF, Chapman KZ, Humphreys NE, Grencis RK, Allan SM, Rothwell NJ.

J Cereb Blood Flow Metab. 2011 Apr;31(4):1036-50. doi: 10.1038/jcbfm.2010.198. Epub 2010 Nov 3.


Mechanisms underlying gut dysfunction in a murine model of chronic parasitic infection.

Motomura Y, Khan WI, El-Sharkawy RT, Verma-Gandhu M, Grencis RK, Collins SM.

Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1354-60. doi: 10.1152/ajpgi.00324.2010. Epub 2010 Sep 23.


Colonic transcriptional profiling in resistance and susceptibility to trichuriasis: phenotyping a chronic colitis and lessons for iatrogenic helminthosis.

Levison SE, McLaughlin JT, Zeef LA, Fisher P, Grencis RK, Pennock JL.

Inflamm Bowel Dis. 2010 Dec;16(12):2065-79. doi: 10.1002/ibd.21326.


Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice.

Dénes A, Humphreys N, Lane TE, Grencis R, Rothwell N.

J Neurosci. 2010 Jul 28;30(30):10086-95. doi: 10.1523/JNEUROSCI.1227-10.2010.


Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris.

Hayes KS, Bancroft AJ, Goldrick M, Portsmouth C, Roberts IS, Grencis RK.

Science. 2010 Jun 11;328(5984):1391-4. doi: 10.1126/science.1187703.

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