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Items: 49

1.

Origin of metastable oligomers and their effects on amyloid fibril self-assembly.

Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CSR, Matthews G, Meisl G, Knowles TPJ, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W, Muschol M.

Chem Sci. 2018 Jun 13;9(27):5937-5948. doi: 10.1039/c8sc01479e. eCollection 2018 Jul 21.

2.

Relevance of N-terminal residues for amyloid-β binding to platelet integrin αIIbβ3, integrin outside-in signaling and amyloid-β fibril formation.

Donner L, Gremer L, Ziehm T, Gertzen CGW, Gohlke H, Willbold D, Elvers M.

Cell Signal. 2018 Oct;50:121-130. doi: 10.1016/j.cellsig.2018.06.015. Epub 2018 Jun 30.

PMID:
29964150
3.

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D.

Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1.

4.

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth.

Wördehoff MM, Shaykhalishahi H, Groß L, Gremer L, Stoldt M, Buell AK, Willbold D, Hoyer W.

J Mol Biol. 2017 Oct 13;429(20):3018-3030. doi: 10.1016/j.jmb.2017.09.005. Epub 2017 Sep 13.

5.

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.

Gremer L, Schölzel D, Schenk C, Reinartz E, Labahn J, Ravelli RBG, Tusche M, Lopez-Iglesias C, Hoyer W, Heise H, Willbold D, Schröder GF.

Science. 2017 Oct 6;358(6359):116-119. doi: 10.1126/science.aao2825. Epub 2017 Sep 7.

6.

Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs.

Elfgen A, Santiago-Schübel B, Gremer L, Kutzsche J, Willbold D.

Eur J Pharm Sci. 2017 Sep 30;107:203-207. doi: 10.1016/j.ejps.2017.07.015. Epub 2017 Jul 12.

PMID:
28711713
7.

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D.

ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900. doi: 10.1021/acschemneuro.7b00045. Epub 2017 Jun 23.

PMID:
28581708
8.

Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation.

Dammers C, Reiss K, Gremer L, Lecher J, Ziehm T, Stoldt M, Schwarten M, Willbold D.

Biophys J. 2017 Apr 25;112(8):1621-1633. doi: 10.1016/j.bpj.2017.03.007.

9.

High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs.

Thomaier M, Gremer L, Dammers C, Fabig J, Neudecker P, Willbold D.

Biochemistry. 2016 Dec 6;55(48):6662-6672. Epub 2016 Nov 18.

PMID:
27933798
10.

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR.

J Biol Chem. 2016 Dec 16;291(51):26364-26376. Epub 2016 Nov 4.

11.

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor.

Mirecka EA, Feuerstein S, Gremer L, Schröder GF, Stoldt M, Willbold D, Hoyer W.

Sci Rep. 2016 Sep 19;6:33474. doi: 10.1038/srep33474.

12.

Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core.

Weirich F, Gremer L, Mirecka EA, Schiefer S, Hoyer W, Heise H.

PLoS One. 2016 Sep 8;11(9):e0161243. doi: 10.1371/journal.pone.0161243. eCollection 2016.

13.

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity.

Rudolph S, Klein AN, Tusche M, Schlosser C, Elfgen A, Brener O, Teunissen C, Gremer L, Funke SA, Kutzsche J, Willbold D.

PLoS One. 2016 Jul 12;11(7):e0159470. doi: 10.1371/journal.pone.0159470. eCollection 2016.

14.

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D.

ACS Chem Neurosci. 2016 Aug 17;7(8):1088-96. doi: 10.1021/acschemneuro.6b00047. Epub 2016 Jun 9.

PMID:
27240424
15.

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release.

Donner L, Fälker K, Gremer L, Klinker S, Pagani G, Ljungberg LU, Lothmann K, Rizzi F, Schaller M, Gohlke H, Willbold D, Grenegard M, Elvers M.

Sci Signal. 2016 May 24;9(429):ra52. doi: 10.1126/scisignal.aaf6240.

PMID:
27221710
16.

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination.

Klein AN, Ziehm T, Tusche M, Buitenhuis J, Bartnik D, Boeddrich A, Wiglenda T, Wanker E, Funke SA, Brener O, Gremer L, Kutzsche J, Willbold D.

PLoS One. 2016 Apr 22;11(4):e0153035. doi: 10.1371/journal.pone.0153035. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0158960.

17.

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity.

Rudolph S, Klein AN, Tusche M, Schlosser C, Elfgen A, Brener O, Teunissen C, Gremer L, Funke SA, Kutzsche J, Willbold D.

PLoS One. 2016 Feb 3;11(2):e0147470. doi: 10.1371/journal.pone.0147470. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0159470.

18.

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol.

Dammers C, Gremer L, Reiß K, Klein AN, Neudecker P, Hartmann R, Sun N, Demuth HU, Schwarten M, Willbold D.

PLoS One. 2015 Nov 23;10(11):e0143647. doi: 10.1371/journal.pone.0143647. eCollection 2015.

19.

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy.

Dammers C, Gremer L, Neudecker P, Demuth HU, Schwarten M, Willbold D.

PLoS One. 2015 Oct 5;10(10):e0139710. doi: 10.1371/journal.pone.0139710. eCollection 2015.

20.

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.

Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D.

Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222.

21.

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease.

Jiang N, Leithold LH, Post J, Ziehm T, Mauler J, Gremer L, Cremer M, Schartmann E, Shah NJ, Kutzsche J, Langen KJ, Breitkreutz J, Willbold D, Willuweit A.

PLoS One. 2015 Jun 5;10(6):e0128553. doi: 10.1371/journal.pone.0128553. eCollection 2015.

22.

Impact of subunit linkages in an engineered homodimeric binding protein to α-synuclein.

Gauhar A, Shaykhalishahi H, Gremer L, Mirecka EA, Hoyer W.

Protein Eng Des Sel. 2014 Dec;27(12):473-9. doi: 10.1093/protein/gzu047. Epub 2014 Oct 20.

PMID:
25332193
23.

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E, Nürnberg B, Ahmadian MR.

PLoS One. 2014 Jul 11;9(7):e102425. doi: 10.1371/journal.pone.0102425. eCollection 2014.

24.

Engineered aggregation inhibitor fusion for production of highly amyloidogenic human islet amyloid polypeptide.

Mirecka EA, Gremer L, Schiefer S, Oesterhelt F, Stoldt M, Willbold D, Hoyer W.

J Biotechnol. 2014 Dec 10;191:221-7. doi: 10.1016/j.jbiotec.2014.06.006. Epub 2014 Jun 11.

PMID:
24928165
25.

The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.

Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.

J Biol Chem. 2014 Jan 3;289(1):74-88. doi: 10.1074/jbc.M113.532333. Epub 2013 Nov 22.

26.

Rho-kinase: regulation, (dys)function, and inhibition.

Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR.

Biol Chem. 2013 Nov;394(11):1399-410. doi: 10.1515/hsz-2013-0181. Review.

27.

Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.

Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Fansa EK, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.

Biol Chem. 2013 Nov;394(11):1411-23. doi: 10.1515/hsz-2013-0184. Review.

PMID:
23787465
28.

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes.

Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR.

Hum Mol Genet. 2013 Jan 15;22(2):262-70. doi: 10.1093/hmg/dds426. Epub 2012 Oct 11.

PMID:
23059812
29.

Structural analysis of the pyroglutamate-modified isoform of the Alzheimer's disease-related amyloid-β using NMR spectroscopy.

Sun N, Hartmann R, Lecher J, Stoldt M, Funke SA, Gremer L, Ludwig HH, Demuth HU, Kleinschmidt M, Willbold D.

J Pept Sci. 2012 Nov;18(11):691-5. doi: 10.1002/psc.2456. Epub 2012 Sep 24.

PMID:
23001756
30.

Biochemical assays to characterize Rho GTPases.

Jaiswal M, Dubey BN, Koessmeier KT, Gremer L, Ahmadian MR.

Methods Mol Biol. 2012;827:37-58. doi: 10.1007/978-1-61779-442-1_3.

PMID:
22144266
31.

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

Ismail SA, Chen YX, Rusinova A, Chandra A, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens PI, Wittinghofer A.

Nat Chem Biol. 2011 Oct 16;7(12):942-9. doi: 10.1038/nchembio.686.

PMID:
22002721
32.

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.

Stark Z, Gillessen-Kaesbach G, Ryan MM, Cirstea IC, Gremer L, Ahmadian MR, Savarirayan R, Zenker M.

Clin Genet. 2012 Jun;81(6):590-4. doi: 10.1111/j.1399-0004.2011.01754.x. Epub 2011 Aug 18.

PMID:
21797849
33.

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR.

J Biol Chem. 2011 May 20;286(20):18202-12. doi: 10.1074/jbc.M111.226431. Epub 2011 Mar 28.

34.

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

Gremer L, Merbitz-Zahradnik T, Dvorsky R, Cirstea IC, Kratz CP, Zenker M, Wittinghofer A, Ahmadian MR.

Hum Mutat. 2011 Jan;32(1):33-43. doi: 10.1002/humu.21377. Epub 2010 Dec 9.

35.

Synthesis of the Rheb and K-Ras4B GTPases.

Chen YX, Koch S, Uhlenbrock K, Weise K, Das D, Gremer L, Brunsveld L, Wittinghofer A, Winter R, Triola G, Waldmann H.

Angew Chem Int Ed Engl. 2010 Aug 16;49(35):6090-5. doi: 10.1002/anie.201001884. No abstract available.

PMID:
20652921
36.

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes.

Rosnizeck IC, Graf T, Spoerner M, Tränkle J, Filchtinski D, Herrmann C, Gremer L, Vetter IR, Wittinghofer A, König B, Kalbitzer HR.

Angew Chem Int Ed Engl. 2010 May 17;49(22):3830-3. doi: 10.1002/anie.200907002. No abstract available.

PMID:
20401883
37.

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation.

Gremer L, De Luca A, Merbitz-Zahradnik T, Dallapiccola B, Morlot S, Tartaglia M, Kutsche K, Ahmadian MR, Rosenberger G.

Hum Mol Genet. 2010 Mar 1;19(5):790-802. doi: 10.1093/hmg/ddp548. Epub 2009 Dec 8.

PMID:
19995790
38.

A restricted spectrum of NRAS mutations causes Noonan syndrome.

Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M.

Nat Genet. 2010 Jan;42(1):27-9. doi: 10.1038/ng.497. Epub 2009 Dec 6.

39.

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family.

Eberth A, Lundmark R, Gremer L, Dvorsky R, Koessmeier KT, McMahon HT, Ahmadian MR.

Biochem J. 2009 Jan 1;417(1):371-7. doi: 10.1042/BJ20081535.

PMID:
18954304
40.

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.

Gremer L, Gilsbach B, Ahmadian MR, Wittinghofer A.

Biol Chem. 2008 Sep;389(9):1163-71. doi: 10.1515/BC.2008.132.

PMID:
18713003
41.

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.

Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K.

EMBO Rep. 2008 Apr;9(4):350-5. doi: 10.1038/embor.2008.20. Epub 2008 Mar 7.

42.

A novel binuclear [CuSMo] cluster at the active site of carbon monoxide dehydrogenase: characterization by X-ray absorption spectroscopy.

Gnida M, Ferner R, Gremer L, Meyer O, Meyer-Klaucke W.

Biochemistry. 2003 Jan 14;42(1):222-30.

PMID:
12515558
43.

Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution.

Dobbek H, Gremer L, Kiefersauer R, Huber R, Meyer O.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15971-6.

44.

Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster.

Dobbek H, Svetlitchnyi V, Gremer L, Huber R, Meyer O.

Science. 2001 Aug 17;293(5533):1281-5.

45.

The role of Se, Mo and Fe in the structure and function of carbon monoxide dehydrogenase.

Meyer O, Gremer L, Ferner R, Ferner M, Dobbek H, Gnida M, Meyer-Klaucke W, Huber R.

Biol Chem. 2000 Sep-Oct;381(9-10):865-76. Review.

PMID:
11076018
48.

Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine.

Dobbek H, Gremer L, Meyer O, Huber R.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8884-9.

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