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Items: 40


Diagnostic Utility of Exome Sequencing for Kidney Disease.

Bleyer AJ, Kmoch S, Greka A.

N Engl J Med. 2019 May 23;380(21):2080. doi: 10.1056/NEJMc1903250. No abstract available.


Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903.

Sharma SH, Pablo JL, Montesinos MS, Greka A, Hopkins CR.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):155-159. doi: 10.1016/j.bmcl.2018.12.007. Epub 2018 Dec 4.


Structures and gating mechanism of human TRPM2.

Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H.

Science. 2018 Dec 21;362(6421). pii: eaav4809. doi: 10.1126/science.aav4809. Epub 2018 Nov 22.


Noninvasive Immunohistochemical Diagnosis and Novel MUC1 Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease.

Živná M, Kidd K, Přistoupilová A, Barešová V, DeFelice M, Blumenstiel B, Harden M, Conlon P, Lavin P, Connaughton DM, Hartmannová H, Hodaňová K, Stránecký V, Vrbacká A, Vyleťal P, Živný J, Votruba M, Sovová J, Hůlková H, Robins V, Perry R, Wenzel A, Beck BB, Seeman T, Viklický O, Rajnochová-Bloudíčková S, Papagregoriou G, Deltas CC, Alper SL, Greka A, Bleyer AJ, Kmoch S.

J Am Soc Nephrol. 2018 Sep;29(9):2418-2431. doi: 10.1681/ASN.2018020180. Epub 2018 Jul 2.


Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.

Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A.

JCI Insight. 2018 Feb 22;3(4). pii: 95091. doi: 10.1172/jci.insight.95091. eCollection 2018 Feb 22.


Randomized Clinical Trial Design to Assess Abatacept in Resistant Nephrotic Syndrome.

Trachtman H, Gipson DS, Somers M, Spino C, Adler S, Holzman L, Kopp JB, Sedor J, Overfield S, Elegbe A, Maldonado M, Greka A.

Kidney Int Rep. 2017 Aug 31;3(1):115-121. doi: 10.1016/j.ekir.2017.08.013. eCollection 2018 Jan.


GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death.

Sieber J, Wieder N, Clark A, Reitberger M, Matan S, Schoenfelder J, Zhang J, Mandinova A, Bittker JA, Gutierrez J, Aygün O, Udeshi N, Carr S, Mundel P, Jehle AW, Greka A.

Cell Chem Biol. 2018 Feb 15;25(2):175-184.e4. doi: 10.1016/j.chembiol.2017.11.006. Epub 2017 Dec 14.


A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A.

Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178.


Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.

Sieber J, Wieder N, Ostrosky-Frid M, Dvela-Levitt M, Aygün O, Udeshi ND, Carr SA, Greka A.

J Biol Chem. 2017 Nov 17;292(46):18878-18885. doi: 10.1074/jbc.M117.797084. Epub 2017 Sep 14.


The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.

Xiao L, Xu X, Zhang F, Wang M, Xu Y, Tang D, Wang J, Qin Y, Liu Y, Tang C, He L, Greka A, Zhou Z, Liu F, Dong Z, Sun L.

Redox Biol. 2017 Apr;11:297-311. doi: 10.1016/j.redox.2016.12.022. Epub 2016 Dec 21.


Personalized Comments on Challenges and Opportunities in Kidney Disease Therapeutics: The Glom-NExT Symposium.

Greka A, Gibson D, Mundel P, Demetri G, Hildebrandt F, Pollak M, Florez J.

Semin Nephrol. 2016 Nov;36(6):448. doi: 10.1016/j.semnephrol.2016.09.005.


An Introduction to the Glom-NExT Inaugural Symposium: Toward Precision Medicine in Nephrology.

Greka A.

Semin Nephrol. 2016 Nov;36(6):448-452. doi: 10.1016/j.semnephrol.2016.09.006. No abstract available.


Introduction: Toward Precision Medicines for Kidney Disease.

Greka A.

Semin Nephrol. 2016 Nov;36(6):435. doi: 10.1016/j.semnephrol.2016.09.001. No abstract available.


Immune Complex-Mediated Proliferative Glomerulonephritis Induced by Paclitaxel Treatment.

Siddiqui B, Greka A, Popovtzer M, Rennke HG, Jeselsohn R.

J Oncol Pract. 2016 Dec;12(12):1272-1274. Epub 2016 Nov 15. No abstract available.


Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes.

Buvall L, Wallentin H, Sieber J, Andreeva S, Choi HY, Mundel P, Greka A.

J Am Soc Nephrol. 2017 Mar;28(3):837-851. doi: 10.1681/ASN.2016040414. Epub 2016 Sep 14.


Differential associations between systemic markers of disease and white matter tissue health in middle-aged and older adults.

Ryu CW, Coutu JP, Greka A, Rosas HD, Jahng GH, Rosen BR, Salat DH.

J Cereb Blood Flow Metab. 2017 Nov;37(11):3568-3579. doi: 10.1177/0271678X16653613. Epub 2016 Jul 21.


Calcium-permeable ion channels in the kidney.

Zhou Y, Greka A.

Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1157-67. doi: 10.1152/ajprenal.00117.2016. Epub 2016 Mar 30. Review.


Human genetics of nephrotic syndrome and the quest for precision medicine.

Greka A.

Curr Opin Nephrol Hypertens. 2016 Mar;25(2):138-43. doi: 10.1097/MNH.0000000000000204. Review.


Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies.

Wieder N, Greka A.

Pediatr Nephrol. 2016 Jul;31(7):1047-54. doi: 10.1007/s00467-015-3224-1. Epub 2015 Oct 21. Review.


Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.

Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW.

Science. 2015 Jul 31;349(6247):1261669. doi: 10.1126/science.1261669.


Developing therapeutic 'arrows' with the precision of William Tell: the time has come for targeted therapies in kidney disease.

Mundel P, Greka A.

Curr Opin Nephrol Hypertens. 2015 Jul;24(4):388-92. doi: 10.1097/MNH.0000000000000137. Review.


Abatacept in B7-1-positive proteinuric kidney disease.

Greka A, Weins A, Mundel P.

N Engl J Med. 2014 Mar 27;370(13):1263-6. doi: 10.1056/NEJMc1400502. No abstract available.


An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts.

Hoeppner MP, Lundquist A, Pirun M, Meadows JR, Zamani N, Johnson J, Sundström G, Cook A, FitzGerald MG, Swofford R, Mauceli E, Moghadam BT, Greka A, Alföldi J, Abouelleil A, Aftuck L, Bessette D, Berlin A, Brown A, Gearin G, Lui A, Macdonald JP, Priest M, Shea T, Turner-Maier J, Zimmer A, Lander ES, di Palma F, Lindblad-Toh K, Grabherr MG.

PLoS One. 2014 Mar 13;9(3):e91172. doi: 10.1371/journal.pone.0091172. eCollection 2014.


Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.

Buvall L, Rashmi P, Lopez-Rivera E, Andreeva S, Weins A, Wallentin H, Greka A, Mundel P.

Nat Commun. 2013;4:2863. doi: 10.1038/ncomms3863.


Inhibition of the TRPC5 ion channel protects the kidney filter.

Schaldecker T, Kim S, Tarabanis C, Tian D, Hakroush S, Castonguay P, Ahn W, Wallentin H, Heid H, Hopkins CR, Lindsley CW, Riccio A, Buvall L, Weins A, Greka A.

J Clin Invest. 2013 Dec;123(12):5298-309. doi: 10.1172/JCI71165. Epub 2013 Nov 15.


Abatacept in B7-1-positive proteinuric kidney disease.

Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW 3rd, Mundel P.

N Engl J Med. 2013 Dec 19;369(25):2416-23. doi: 10.1056/NEJMoa1304572. Epub 2013 Nov 8.


Case 4-2013: A man with acute flank pain.

Greka A, Dekker JP, Calderwood SB.

N Engl J Med. 2013 Jun 6;368(23):2237. doi: 10.1056/NEJMc1302635. No abstract available.


Case records of the Massachusetts General Hospital. Case 4-2013. A 50-year-old man with acute flank pain.

Greka A, Bhatia RS, Sabir SH, Dekker JP.

N Engl J Med. 2013 Jan 31;368(5):466-72. doi: 10.1056/NEJMcpc1201414. Epub 2013 Jan 23. No abstract available.


SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity.

Carrasquillo R, Tian D, Krishna S, Pollak MR, Greka A, Schlöndorff J.

BMC Cell Biol. 2012 Nov 21;13:33. doi: 10.1186/1471-2121-13-33.


Calcium regulates podocyte actin dynamics.

Greka A, Mundel P.

Semin Nephrol. 2012 Jul;32(4):319-26. doi: 10.1016/j.semnephrol.2012.06.003. Review.


Cell biology and pathology of podocytes.

Greka A, Mundel P.

Annu Rev Physiol. 2012;74:299-323. doi: 10.1146/annurev-physiol-020911-153238. Epub 2011 Nov 4. Review.


Balancing calcium signals through TRPC5 and TRPC6 in podocytes.

Greka A, Mundel P.

J Am Soc Nephrol. 2011 Nov;22(11):1969-80. doi: 10.1681/ASN.2011040370. Epub 2011 Oct 6. Review.


Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels.

Tian D, Jacobo SM, Billing D, Rozkalne A, Gage SD, Anagnostou T, Pavenstädt H, Hsu HH, Schlondorff J, Ramos A, Greka A.

Sci Signal. 2010 Oct 26;3(145):ra77. doi: 10.1126/scisignal.2001200. Erratum in: Sci Signal. 2010;3(147):er11. Pavenstaedt, Hermann [corrected to Pavenstädt, Hermann].


Metabolite profiling identifies markers of uremia.

Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, Thadhani R, Clish CB, Greka A, Gerszten RE.

J Am Soc Nephrol. 2010 Jun;21(6):1041-1051. doi: 10.1681/ASN.2009111132. Epub 2010 Apr 8.


Induction of TRPC6 channel in acquired forms of proteinuric kidney disease.

Möller CC, Wei C, Altintas MM, Li J, Greka A, Ohse T, Pippin JW, Rastaldi MP, Wawersik S, Schiavi S, Henger A, Kretzler M, Shankland SJ, Reiser J.

J Am Soc Nephrol. 2007 Jan;18(1):29-36. Epub 2006 Dec 13.


Rapid vesicular translocation and insertion of TRP channels.

Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE.

Nat Cell Biol. 2004 Aug;6(8):709-20. Epub 2004 Jul 18.


TRPC5 is a regulator of hippocampal neurite length and growth cone morphology.

Greka A, Navarro B, Oancea E, Duggan A, Clapham DE.

Nat Neurosci. 2003 Aug;6(8):837-45.


Mechanism of persistent protein kinase D1 translocation and activation.

Oancea E, Bezzerides VJ, Greka A, Clapham DE.

Dev Cell. 2003 Apr;4(4):561-74.


Expression of GABA(C) receptor rho1 and rho2 subunits during development of the mouse retina.

Greka A, Lipton SA, Zhang D.

Eur J Neurosci. 2000 Oct;12(10):3575-82.


Cloning and characterization of mouse GABA(C) receptor subunits.

Greka A, Koolen JA, Lipton SA, Zhang D.

Neuroreport. 1998 Jan 26;9(2):229-32.


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