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Items: 1 to 50 of 101

1.

Diagnostic utility of telomere length testing in a hospital-based setting.

Alder JK, Hanumanthu VS, Strong MA, DeZern AE, Stanley SE, Takemoto CM, Danilova L, Applegate CD, Bolton SG, Mohr DW, Brodsky RA, Casella JF, Greider CW, Jackson JB, Armanios M.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2358-E2365. doi: 10.1073/pnas.1720427115. Epub 2018 Feb 20. Erratum in: Proc Natl Acad Sci U S A. 2018 Apr 23;:.

2.

BRD4 inhibitors block telomere elongation.

Wang S, Pike AM, Lee SS, Strong MA, Connelly CJ, Greider CW.

Nucleic Acids Res. 2017 Aug 21;45(14):8403-8410. doi: 10.1093/nar/gkx561.

3.

Regulating telomere length from the inside out: the replication fork model.

Greider CW.

Genes Dev. 2016 Jul 1;30(13):1483-91. doi: 10.1101/gad.280578.116.

4.

SCIENTIFIC COMMUNITY. Preprints for the life sciences.

Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale RD, VijayRaghavan K, Wolberger C.

Science. 2016 May 20;352(6288):899-901. doi: 10.1126/science.aaf9133. No abstract available.

PMID:
27199406
5.

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells.

Lee SS, Bohrson C, Pike AM, Wheelan SJ, Greider CW.

Cell Rep. 2015 Nov 24;13(8):1623-32. doi: 10.1016/j.celrep.2015.10.035. Epub 2015 Nov 12.

6.

Treating Myeloproliferation--On Target or Off?

Armanios M, Greider CW.

N Engl J Med. 2015 Sep 3;373(10):965-6. doi: 10.1056/NEJMe1508740. No abstract available.

PMID:
26332552
7.

Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae.

Kaizer H, Connelly CJ, Bettridge K, Viggiani C, Greider CW.

Genetics. 2015 Oct;201(2):573-86. doi: 10.1534/genetics.115.177899. Epub 2015 Aug 20.

8.

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.

Bender HS, Murchison EP, Pickett HA, Deakin JE, Strong MA, Conlan C, McMillan DA, Neumann AA, Greider CW, Hannon GJ, Reddel RR, Graves JA.

PLoS One. 2012;7(9):e46195. doi: 10.1371/journal.pone.0046195. Epub 2012 Sep 25.

9.

Molecular biology. Wnt regulates TERT--putting the horse before the cart.

Greider CW.

Science. 2012 Jun 22;336(6088):1519-20. doi: 10.1126/science.1223785. No abstract available.

PMID:
22723405
10.

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.

Strong MA, Vidal-Cardenas SL, Karim B, Yu H, Guo N, Greider CW.

Mol Cell Biol. 2011 Jun;31(12):2369-79. doi: 10.1128/MCB.05312-11. Epub 2011 Apr 4.

11.

A sequence-dependent exonuclease activity from Tetrahymena thermophila.

Tom HI, Greider CW.

BMC Biochem. 2010 Nov 16;11:45. doi: 10.1186/1471-2091-11-45.

12.

Telomerase discovery: the excitement of putting together pieces of the puzzle (Nobel lecture).

Greider CW.

Angew Chem Int Ed Engl. 2010 Oct 4;49(41):7422-39. doi: 10.1002/anie.201002408. Review. No abstract available.

PMID:
20872384
13.

Short telomeres are sufficient to cause the degenerative defects associated with aging.

Armanios M, Alder JK, Parry EM, Karim B, Strong MA, Greider CW.

Am J Hum Genet. 2009 Dec;85(6):823-32. doi: 10.1016/j.ajhg.2009.10.028.

14.
15.

Kinase-independent functions of TEL1 in telomere maintenance.

Ma Y, Greider CW.

Mol Cell Biol. 2009 Sep;29(18):5193-202. doi: 10.1128/MCB.01896-08. Epub 2009 Jul 13.

16.

Short telomeres initiate telomere recombination in primary and tumor cells.

Morrish TA, Greider CW.

PLoS Genet. 2009 Jan;5(1):e1000357. doi: 10.1371/journal.pgen.1000357. Epub 2009 Jan 30.

17.

Short telomeres limit tumor progression in vivo by inducing senescence.

Feldser DM, Greider CW.

Cancer Cell. 2007 May;11(5):461-9. Epub 2007 Apr 12.

18.

Telomerase mutations in families with idiopathic pulmonary fibrosis.

Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, Lawson WE, Xie M, Vulto I, Phillips JA 3rd, Lansdorp PM, Greider CW, Loyd JE.

N Engl J Med. 2007 Mar 29;356(13):1317-26.

19.

Telomerase RNA levels limit the telomere length equilibrium.

Greider CW.

Cold Spring Harb Symp Quant Biol. 2006;71:225-9. Review.

PMID:
17381301
20.

Regulation of telomere elongation by the cyclin-dependent kinase CDK1.

Frank CJ, Hyde M, Greider CW.

Mol Cell. 2006 Nov 3;24(3):423-32.

21.

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging.

Blackburn EH, Greider CW, Szostak JW.

Nat Med. 2006 Oct;12(10):1133-8. No abstract available.

PMID:
17024208
22.

Telomerase and cancer stem cells.

Armanios M, Greider CW.

Cold Spring Harb Symp Quant Biol. 2005;70:205-8. Review.

PMID:
16869755
23.

Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres.

Feldser D, Strong MA, Greider CW.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2249-51. Epub 2006 Feb 7.

24.

Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.

Hao LY, Armanios M, Strong MA, Karim B, Feldser DM, Huso D, Greider CW.

Cell. 2005 Dec 16;123(6):1121-31.

25.

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita.

Armanios M, Chen JL, Chang YP, Brodsky RA, Hawkins A, Griffin CA, Eshleman JR, Cohen AR, Chakravarti A, Hamosh A, Greider CW.

Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15960-4. Epub 2005 Oct 24.

26.

Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation.

Qi L, Strong MA, Karim BO, Huso DL, Greider CW.

Nat Cell Biol. 2005 Jul;7(7):706-11. Epub 2005 Jun 19.

27.

Functional analysis of the pseudoknot structure in human telomerase RNA.

Chen JL, Greider CW.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8080-5; discussion 8077-9. Epub 2005 Apr 22.

28.

An emerging consensus for telomerase RNA structure.

Chen JL, Greider CW.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14683-4. Epub 2004 Oct 4. No abstract available. Erratum in: Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16391.

29.

Phosphorylation of H2AX at short telomeres in T cells and fibroblasts.

Hao LY, Strong MA, Greider CW.

J Biol Chem. 2004 Oct 22;279(43):45148-54. Epub 2004 Aug 17.

PMID:
15322096
30.

Genomic instability in both wild-type and telomerase null MEFs.

Hao LY, Greider CW.

Chromosoma. 2004 Sep;113(2):62-8. Epub 2004 Jul 16.

PMID:
15258806
31.

Telomerase RNA structure and function: implications for dyskeratosis congenita.

Chen JL, Greider CW.

Trends Biochem Sci. 2004 Apr;29(4):183-92. Review. No abstract available.

PMID:
15082312
32.

Tracking telomerase.

Greider CW, Blackburn EH.

Cell. 2004 Jan 23;116(2 Suppl):S83-6, 1 p following S86. No abstract available.

33.

Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.

Qi L, Strong MA, Karim BO, Armanios M, Huso DL, Greider CW.

Cancer Res. 2003 Dec 1;63(23):8188-96.

34.

Template boundary definition in mammalian telomerase.

Chen JL, Greider CW.

Genes Dev. 2003 Nov 15;17(22):2747-52.

35.

End resection initiates genomic instability in the absence of telomerase.

Hackett JA, Greider CW.

Mol Cell Biol. 2003 Dec;23(23):8450-61.

36.

Stem-loop IV of tetrahymena telomerase RNA stimulates processivity in trans.

Mason DX, Goneska E, Greider CW.

Mol Cell Biol. 2003 Aug;23(16):5606-13.

37.

Telomere dysfunction and the initiation of genome instability.

Feldser DM, Hackett JA, Greider CW.

Nat Rev Cancer. 2003 Aug;3(8):623-7. doi: 10.1038/nrc1142.

PMID:
12894250
38.

Telomere length, telomere-binding proteins, and DNA damage signaling.

Hemann MT, Hackett J, IJpma A, Greider CW.

Cold Spring Harb Symp Quant Biol. 2000;65:275-9. Review. No abstract available.

PMID:
12760041
39.

Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.

IJpma AS, Greider CW.

Mol Biol Cell. 2003 Mar;14(3):987-1001.

41.

Cellular responses to telomere shortening: cellular senescence as a tumor suppressor mechanism.

Greider CW.

Harvey Lect. 2000-2001;96:33-50. Review. No abstract available.

PMID:
12200870
42.

Haploinsufficiency of mTR results in defects in telomere elongation.

Hathcock KS, Hemann MT, Opperman KK, Strong MA, Greider CW, Hodes RJ.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3591-6.

43.

Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis.

Hackett JA, Greider CW.

Oncogene. 2002 Jan 21;21(4):619-26. Review.

44.

A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.

Chen JL, Opperman KK, Greider CW.

Nucleic Acids Res. 2002 Jan 15;30(2):592-7.

45.
46.

Tetrahymena proteins p80 and p95 are not core telomerase components.

Mason DX, Autexier C, Greider CW.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12368-73. Epub 2001 Oct 9.

47.

Telomere dysfunction increases mutation rate and genomic instability.

Hackett JA, Feldser DM, Greider CW.

Cell. 2001 Aug 10;106(3):275-86.

48.

Telomere dysfunction triggers developmentally regulated germ cell apoptosis.

Hemann MT, Rudolph KL, Strong MA, DePinho RA, Chin L, Greider CW.

Mol Biol Cell. 2001 Jul;12(7):2023-30.

49.
50.

Wild-derived inbred mouse strains have short telomeres.

Hemann MT, Greider CW.

Nucleic Acids Res. 2000 Nov 15;28(22):4474-8.

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