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Items: 1 to 50 of 59

1.

Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.

Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI.

Mol Cell. 2018 Jun 21. pii: S1097-2765(18)30443-X. doi: 10.1016/j.molcel.2018.06.001. [Epub ahead of print]

PMID:
29983320
2.

An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.

Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, Gregory RI.

Cell Stem Cell. 2018 Jun 1;22(6):851-864.e5. doi: 10.1016/j.stem.2018.04.021. Epub 2018 May 24.

PMID:
29804889
3.

TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.

Ogórek B, Lam HC, Khabibullin D, Liu HJ, Nijmeh J, Triboulet R, Kwiatkowski DJ, Gregory RI, Henske EP.

Hum Mol Genet. 2018 May 1;27(9):1654-1663. doi: 10.1093/hmg/ddy073.

PMID:
29509898
4.

A small molecule screen to identify regulators of let-7 targets.

Cinkornpumin J, Roos M, Nguyen L, Liu X, Gaeta X, Lin S, Chan DN, Liu A, Gregory RI, Jung M, Chute J, Zhu H, Lowry WE.

Sci Rep. 2017 Nov 21;7(1):15973. doi: 10.1038/s41598-017-16258-9.

5.

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.

Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ.

Nat Cell Biol. 2017 Jan;19(1):60-67. doi: 10.1038/ncb3453. Epub 2016 Dec 19.

6.

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA.

J Clin Invest. 2016 Oct 3;126(10):3868-3878. doi: 10.1172/JCI87885. Epub 2016 Sep 6.

7.

Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs.

Pirouz M, Du P, Munafò M, Gregory RI.

Cell Rep. 2016 Aug 16;16(7):1861-73. doi: 10.1016/j.celrep.2016.07.025. Epub 2016 Aug 4.

8.

The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.

Lin S, Choe J, Du P, Triboulet R, Gregory RI.

Mol Cell. 2016 May 5;62(3):335-345. doi: 10.1016/j.molcel.2016.03.021. Epub 2016 Apr 21.

9.

A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression.

Triboulet R, Pirouz M, Gregory RI.

Cell Rep. 2015 Oct 13;13(2):260-6. doi: 10.1016/j.celrep.2015.08.086. Epub 2015 Oct 1.

10.

PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.

Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH.

Cell Rep. 2015 Sep 1;12(9):1456-70. doi: 10.1016/j.celrep.2015.07.053. Epub 2015 Aug 20.

11.

A Biogenesis Step Upstream of Microprocessor Controls miR-17∼92 Expression.

Du P, Wang L, Sliz P, Gregory RI.

Cell. 2015 Aug 13;162(4):885-99. doi: 10.1016/j.cell.2015.07.008. Epub 2015 Aug 6.

12.

Identification of small molecule inhibitors of Zcchc11 TUTase activity.

Lin S, Gregory RI.

RNA Biol. 2015;12(8):792-800. doi: 10.1080/15476286.2015.1058478.

13.

miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.

Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA.

Mol Ther. 2015 Sep;23(9):1465-74. doi: 10.1038/mt.2015.113. Epub 2015 Jun 17.

14.

MicroRNA biogenesis pathways in cancer.

Lin S, Gregory RI.

Nat Rev Cancer. 2015 Jun;15(6):321-33. doi: 10.1038/nrc3932. Review.

15.

Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).

Thornton JE, Du P, Jing L, Sjekloca L, Lin S, Grossi E, Sliz P, Zon LI, Gregory RI.

Nucleic Acids Res. 2014 Oct;42(18):11777-91. doi: 10.1093/nar/gku805. Epub 2014 Sep 15.

16.

Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.

Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo FD, Gregory RI.

Cell. 2014 Feb 27;156(5):893-906. doi: 10.1016/j.cell.2013.12.043.

17.

Methyltransferases modulate RNA stability in embryonic stem cells.

Lin S, Gregory RI.

Nat Cell Biol. 2014 Feb;16(2):129-31. doi: 10.1038/ncb2914.

PMID:
24481042
18.

The imprinted H19 lncRNA antagonizes let-7 microRNAs.

Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, Min W, Bennett AM, Gregory RI, Ding Y, Huang Y.

Mol Cell. 2013 Oct 10;52(1):101-12. doi: 10.1016/j.molcel.2013.08.027. Epub 2013 Sep 19.

19.

The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly.

Martinez NJ, Chang HM, Borrajo Jde R, Gregory RI.

RNA. 2013 Nov;19(11):1583-93. doi: 10.1261/rna.040790.113. Epub 2013 Sep 18.

20.

Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.

Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ.

Stem Cells. 2013 Aug;31(8):1563-73. doi: 10.1002/stem.1423.

21.

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway.

Chang HM, Triboulet R, Thornton JE, Gregory RI.

Nature. 2013 May 9;497(7448):244-8. doi: 10.1038/nature12119. Epub 2013 Apr 17.

22.

Argonaute2 expression is post-transcriptionally coupled to microRNA abundance.

Martinez NJ, Gregory RI.

RNA. 2013 May;19(5):605-12. doi: 10.1261/rna.036434.112. Epub 2013 Mar 13.

23.

Lin28a regulates germ cell pool size and fertility.

Shinoda G, De Soysa TY, Seligson MT, Yabuuchi A, Fujiwara Y, Huang PY, Hagan JP, Gregory RI, Moss EG, Daley GQ.

Stem Cells. 2013 May;31(5):1001-9. doi: 10.1002/stem.1343.

24.

EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.

Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, Wu X, Stack EC, Loda M, Liu T, Xu H, Cato L, Thornton JE, Gregory RI, Morrissey C, Vessella RL, Montironi R, Magi-Galluzzi C, Kantoff PW, Balk SP, Liu XS, Brown M.

Science. 2012 Dec 14;338(6113):1465-9. doi: 10.1126/science.1227604.

25.

Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty.

Silveira-Neto AP, Leal LF, Emerman AB, Henderson KD, Piskounova E, Henderson BE, Gregory RI, Silveira LF, Hirschhorn JN, Nguyen TT, Beneduzzi D, Tusset C, Reis AC, Brito VN, Mendonca BB, Palmert MR, Antonini SR, Latronico AC.

Horm Res Paediatr. 2012;78(3):144-50. doi: 10.1159/000342212. Epub 2012 Sep 6.

26.

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).

Thornton JE, Chang HM, Piskounova E, Gregory RI.

RNA. 2012 Oct;18(10):1875-85. doi: 10.1261/rna.034538.112. Epub 2012 Aug 16.

27.

How does Lin28 let-7 control development and disease?

Thornton JE, Gregory RI.

Trends Cell Biol. 2012 Sep;22(9):474-82. doi: 10.1016/j.tcb.2012.06.001. Epub 2012 Jul 9. Review.

28.

Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation.

Chang HM, Martinez NJ, Thornton JE, Hagan JP, Nguyen KD, Gregory RI.

Nat Commun. 2012 Jun 26;3:923. doi: 10.1038/ncomms1909.

29.

Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI.

Cell. 2011 Nov 23;147(5):1066-79. doi: 10.1016/j.cell.2011.10.039.

30.

Molecular basis for interaction of let-7 microRNAs with Lin28.

Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P.

Cell. 2011 Nov 23;147(5):1080-91. doi: 10.1016/j.cell.2011.10.020. Epub 2011 Nov 10.

31.

The Lin28/let-7 axis regulates glucose metabolism.

Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ.

Cell. 2011 Sep 30;147(1):81-94. doi: 10.1016/j.cell.2011.08.033.

32.

Autoregulatory mechanisms controlling the microprocessor.

Triboulet R, Gregory RI.

Adv Exp Med Biol. 2011;700:56-66.

PMID:
21755473
33.

MicroRNAs and reprogramming.

Chang HM, Gregory RI.

Nat Biotechnol. 2011 Jun 7;29(6):499-500. doi: 10.1038/nbt.1889. No abstract available.

PMID:
21654668
34.

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW.

Cell. 2011 Feb 4;144(3):353-63. doi: 10.1016/j.cell.2011.01.001. Epub 2011 Jan 20.

35.

Reconstitution of human RNA interference in budding yeast.

Suk K, Choi J, Suzuki Y, Ozturk SB, Mellor JC, Wong KH, MacKay JL, Gregory RI, Roth FP.

Nucleic Acids Res. 2011 Apr;39(7):e43. doi: 10.1093/nar/gkq1321. Epub 2011 Jan 19.

36.

Pumilio turns on microRNA function.

Triboulet R, Gregory RI.

Nat Cell Biol. 2010 Oct;12(10):928-9. doi: 10.1038/ncb1010-928.

PMID:
20885420
37.

MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity.

Martinez NJ, Gregory RI.

Cell Stem Cell. 2010 Jul 2;7(1):31-5. doi: 10.1016/j.stem.2010.06.011. Review.

38.

Autoregulatory mechanisms controlling the Microprocessor.

Triboulet R, Gregory RI.

Adv Exp Med Biol. 2010;700:56-66. Review.

PMID:
21627030
39.

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.

Hagan JP, Piskounova E, Gregory RI.

Nat Struct Mol Biol. 2009 Oct;16(10):1021-5. doi: 10.1038/nsmb.1676. Epub 2009 Aug 27.

40.

Post-transcriptional control of DGCR8 expression by the Microprocessor.

Triboulet R, Chang HM, Lapierre RJ, Gregory RI.

RNA. 2009 Jun;15(6):1005-11. doi: 10.1261/rna.1591709. Epub 2009 Apr 21.

41.

Many roads to maturity: microRNA biogenesis pathways and their regulation.

Winter J, Jung S, Keller S, Gregory RI, Diederichs S.

Nat Cell Biol. 2009 Mar;11(3):228-34. doi: 10.1038/ncb0309-228. Review.

PMID:
19255566
42.

Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury.

Ho J, Ng KH, Rosen S, Dostal A, Gregory RI, Kreidberg JA.

J Am Soc Nephrol. 2008 Nov;19(11):2069-75. doi: 10.1681/ASN.2008020162. Epub 2008 Oct 2.

43.

Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, Sliz P, Gregory RI.

J Biol Chem. 2008 Aug 1;283(31):21310-4. doi: 10.1074/jbc.C800108200. Epub 2008 Jun 12.

44.

Linking miRNA regulation to BCR-ABL expression: the next dimension.

Faber J, Gregory RI, Armstrong SA.

Cancer Cell. 2008 Jun;13(6):467-9. doi: 10.1016/j.ccr.2008.05.013.

45.

MicroRNA regulation of stem cell fate.

Li Q, Gregory RI.

Cell Stem Cell. 2008 Mar 6;2(3):195-6. doi: 10.1016/j.stem.2008.02.008.

46.

Selective blockade of microRNA processing by Lin28.

Viswanathan SR, Daley GQ, Gregory RI.

Science. 2008 Apr 4;320(5872):97-100. doi: 10.1126/science.1154040. Epub 2008 Feb 21.

47.

MicroRNA silencing through RISC recruitment of eIF6.

Chendrimada TP, Finn KJ, Ji X, Baillat D, Gregory RI, Liebhaber SA, Pasquinelli AE, Shiekhattar R.

Nature. 2007 Jun 14;447(7146):823-8. Epub 2007 May 16.

PMID:
17507929
48.

MicroRNA biogenesis: isolation and characterization of the microprocessor complex.

Gregory RI, Chendrimada TP, Shiekhattar R.

Methods Mol Biol. 2006;342:33-47. Review.

PMID:
16957365
49.

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.

Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R.

Cell. 2005 Nov 18;123(4):631-40. Epub 2005 Nov 3.

50.

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.

Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, Shiekhattar R.

Nature. 2005 Aug 4;436(7051):740-4. Epub 2005 Jun 22.

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