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Items: 1 to 50 of 97

1.

Soluble Intercellular Adhesion Molecule-1 (sICAM-1) as a Biomarker of Vascular Cognitive Impairment in Older Adults.

Gregory MA, Manuel-Apolinar L, Sánchez-Garcia S, Villa Romero AR, de Jesús Iuit Rivera J, Basurto Acevedo L, Grijalva-Otero I, Cuadros-Moreno J, Garcia-de la Torre P, Guerrero Cantera J, Garcia Dominguez JA, Martínez Gallardo S, Vega Garcia S, Mejía Alonso LA, Sánchez-Arenas R.

Dement Geriatr Cogn Disord. 2019;47(4-6):243-253. doi: 10.1159/000500068. Epub 2019 Aug 13.

PMID:
31408858
2.

Examining the Association between Life-Space Mobility and Cognitive Function in Older Adults: A Systematic Review.

De Silva NA, Gregory MA, Venkateshan SS, Verschoor CP, Kuspinar A.

J Aging Res. 2019 Jun 2;2019:3923574. doi: 10.1155/2019/3923574. eCollection 2019. Review.

3.

Monocyte chemoattractant protein-1 (MCP-1) and fibroblast growth factor-21 (FGF-21) as biomarkers of subclinical atherosclerosis in women.

Basurto L, Gregory MA, Hernández SB, Sánchez-Huerta L, Martínez AD, Manuel-Apolinar L, Avelar FJ, Alonso LAM, Sánchez-Arenas R.

Exp Gerontol. 2019 Sep;124:110624. doi: 10.1016/j.exger.2019.05.013. Epub 2019 May 29.

PMID:
31152776
4.

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.

Gregory MA, Nemkov T, Park HJ, Zaberezhnyy V, Gehrke S, Adane B, Jordan CT, Hansen KC, D'Alessandro A, DeGregori J.

Clin Cancer Res. 2019 Jul 1;25(13):4079-4090. doi: 10.1158/1078-0432.CCR-18-3223. Epub 2019 Apr 2.

PMID:
30940653
5.

The Impact of Blood Pressure Dipping Status on Cognition, Mobility, and Cardiovascular Health in Older Adults Following an Exercise Program.

Boa Sorte Silva NC, Gregory MA, Gill DP, McGowan CL, Petrella RJ.

Gerontol Geriatr Med. 2018 Apr 23;4:2333721418770333. doi: 10.1177/2333721418770333. eCollection 2018 Jan-Dec.

6.

Multiple-modality exercise and mind-motor training to improve mobility in older adults: A randomized controlled trial.

Boa Sorte Silva NC, Gill DP, Gregory MA, Bocti J, Petrella RJ.

Exp Gerontol. 2018 Mar;103:17-26. doi: 10.1016/j.exger.2017.12.011. Epub 2017 Dec 17.

PMID:
29262308
7.

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.

Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, Alt S, Heine D, Carter GT, Graziani EI, Koehn FE, McDonald L, Alanine A, Rodríguez Sarmiento RM, Chao SK, Ratni H, Steward L, Norville IH, Sarkar-Tyson M, Moss SJ, Leadlay PF, Wilkinson B, Gregory MA.

Nat Commun. 2017 Oct 31;8(1):1206. doi: 10.1038/s41467-017-01344-3.

8.

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.

Gregory MA, Nemkov T, Reisz JA, Zaberezhnyy V, Hansen KC, D'Alessandro A, DeGregori J.

Exp Hematol. 2018 Feb;58:52-58. doi: 10.1016/j.exphem.2017.09.007. Epub 2017 Sep 22.

9.

Combined Dual-Task Gait Training and Aerobic Exercise to Improve Cognition, Mobility, and Vascular Health in Community-Dwelling Older Adults at Risk for Future Cognitive Decline1.

Gregory MA, Boa Sorte Silva NC, Gill DP, McGowan CL, Liu-Ambrose T, Shoemaker JK, Hachinski V, Holmes J, Petrella RJ.

J Alzheimers Dis. 2017;57(3):747-763. doi: 10.3233/JAD-161240.

PMID:
28304305
10.

Multiple-modality exercise and mind-motor training to improve cardiovascular health and fitness in older adults at risk for cognitive impairment: A randomized controlled trial.

Boa Sorte Silva NC, Gregory MA, Gill DP, Petrella RJ.

Arch Gerontol Geriatr. 2017 Jan - Feb;68:149-160. doi: 10.1016/j.archger.2016.10.009. Epub 2016 Oct 24.

PMID:
27810663
11.

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA, Wempe MF, Jordan CT, Serkova NJ, Tan AC, Hansen KC, DeGregori J.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6669-E6678. Epub 2016 Oct 10.

12.
13.

An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35.

Netzker T, Schroeckh V, Gregory MA, Flak M, Krespach MKC, Leadlay PF, Brakhage AA.

Appl Environ Microbiol. 2016 May 31;82(12):3481-3492. doi: 10.1128/AEM.00371-16. Print 2016 Jun 15.

14.

Group-based exercise combined with dual-task training improves gait but not vascular health in active older adults without dementia.

Gregory MA, Gill DP, Zou G, Liu-Ambrose T, Shigematsu R, Fitzgerald C, Hachinski V, Shoemaker K, Petrella RJ.

Arch Gerontol Geriatr. 2016 Mar-Apr;63:18-27. doi: 10.1016/j.archger.2015.11.008. Epub 2015 Dec 2.

PMID:
26791167
15.

Group-based exercise and cognitive-physical training in older adults with self-reported cognitive complaints: The Multiple-Modality, Mind-Motor (M4) study protocol.

Gregory MA, Gill DP, Shellington EM, Liu-Ambrose T, Shigematsu R, Zou G, Shoemaker K, Owen AM, Hachinski V, Stuckey M, Petrella RJ.

BMC Geriatr. 2016 Jan 16;16:17. doi: 10.1186/s12877-016-0190-9.

16.

Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis.

Fayed B, Ashford DA, Hashem AM, Amin MA, El Gazayerly ON, Gregory MA, Smith MC.

Appl Environ Microbiol. 2015 Dec;81(24):8402-13. doi: 10.1128/AEM.02403-15. Epub 2015 Oct 2.

17.

The Healthy Mind, Healthy Mobility Trial: A Novel Exercise Program for Older Adults.

Gill DP, Gregory MA, Zou G, Liu-Ambrose T, Shigematsu R, Hachinski V, Fitzgerald C, Petrella RJ.

Med Sci Sports Exerc. 2016 Feb;48(2):297-306. doi: 10.1249/MSS.0000000000000758.

PMID:
26285025
18.

Distributed efficient similarity search mechanism in wireless sensor networks.

Ahmed K, Gregory MA.

Sensors (Basel). 2015 Mar 5;15(3):5474-503. doi: 10.3390/s150305474.

19.

A model for determining baseline morphometrics of skeletal myofibres.

Mars M, Gregory MA.

J S Afr Vet Assoc. 2014 Nov 14;85(1):1125. doi: 10.4102/jsava.v85i1.1125.

PMID:
25685981
20.

Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection.

Hansson MJ, Moss SJ, Bobardt M, Chatterji U, Coates N, Garcia-Rivera JA, Elmér E, Kendrew S, Leyssen P, Neyts J, Nur-E-Alam M, Warneck T, Wilkinson B, Gallay P, Gregory MA.

Chem Biol. 2015 Feb 19;22(2):285-92. doi: 10.1016/j.chembiol.2014.10.023. Epub 2015 Jan 22.

21.

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.

Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J.

Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29.

22.

Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia.

Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC.

Am J Hematol. 2014 Sep;89(9):896-903. doi: 10.1002/ajh.23776. Epub 2014 Jun 19.

23.

Brain health and exercise in older adults.

Gregory MA, Gill DP, Petrella RJ.

Curr Sports Med Rep. 2013 Jul-Aug;12(4):256-71. doi: 10.1249/JSR.0b013e31829a74fd. Review.

PMID:
23851414
24.

Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer.

Spreafico A, Tentler JJ, Pitts TM, Tan AC, Gregory MA, Arcaroli JJ, Klauck PJ, McManus MC, Hansen RJ, Kim J, Micel LN, Selby HM, Newton TP, McPhillips KL, Gustafson DL, Degregori JV, Messersmith WA, Winn RA, Eckhardt SG.

Clin Cancer Res. 2013 Aug 1;19(15):4149-62. doi: 10.1158/1078-0432.CCR-12-3140. Epub 2013 Jun 11.

25.

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity.

Zhang Q, Spears E, Boone DN, Li Z, Gregory MA, Hann SR.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):978-83. doi: 10.1073/pnas.1208334110. Epub 2012 Dec 31.

26.

Development of a flow cytometry live cell assay for the screening of inhibitors of hepatitis C virus (HCV) replication.

Garcia-Rivera JA, Lin K, Hopkins S, Gregory MA, Wilkinson B, Gallay PA.

Open Virol J. 2012;6:97-102. doi: 10.2174/1874357901206010097. Epub 2012 Nov 26.

27.

Recombinant strains for the enhanced production of bioengineered rapalogs.

Kendrew SG, Petkovic H, Gaisser S, Ready SJ, Gregory MA, Coates NJ, Nur-E-Alam M, Warneck T, Suthar D, Foster TA, McDonald L, Schlingman G, Koehn FE, Skotnicki JS, Carter GT, Moss SJ, Zhang MQ, Martin CJ, Sheridan RM, Wilkinson B.

Metab Eng. 2013 Jan;15:167-73. doi: 10.1016/j.ymben.2012.11.001. Epub 2012 Nov 17.

PMID:
23164580
28.

Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer.

Nifoussi SK, Vrana JA, Domina AM, De Biasio A, Gui J, Gregory MA, Hann SR, Craig RW.

PLoS One. 2012;7(10):e47060. doi: 10.1371/journal.pone.0047060. Epub 2012 Oct 9.

29.

Using functional genomics to overcome therapeutic resistance in hematological malignancies.

Alvarez-Calderon F, Gregory MA, DeGregori J.

Immunol Res. 2013 Mar;55(1-3):100-15. doi: 10.1007/s12026-012-8353-z. Review.

30.

Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir.

Garcia-Rivera JA, Bobardt M, Chatterji U, Hopkins S, Gregory MA, Wilkinson B, Lin K, Gallay PA.

Antimicrob Agents Chemother. 2012 Oct;56(10):5113-21. doi: 10.1128/AAC.00919-12. Epub 2012 Jul 16.

31.

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4776-81. doi: 10.1073/pnas.1015773108. Epub 2011 Mar 7. Erratum in: Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8080.

32.

Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family.

Gregory MA, Bobardt M, Obeid S, Chatterji U, Coates NJ, Foster T, Gallay P, Leyssen P, Moss SJ, Neyts J, Nur-e-Alam M, Paeshuyse J, Piraee M, Suthar D, Warneck T, Zhang MQ, Wilkinson B.

Antimicrob Agents Chemother. 2011 May;55(5):1975-81. doi: 10.1128/AAC.01627-10. Epub 2011 Mar 7.

33.

Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.

Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, Bates DO, Wilkinson B.

Chem Sci. 2011 Feb 1;2011(2):273-278.

34.

Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.

Gregory MA, Phang TL, Neviani P, Alvarez-Calderon F, Eide CA, O'Hare T, Zaberezhnyy V, Williams RT, Druker BJ, Perrotti D, Degregori J.

Cancer Cell. 2010 Jul 13;18(1):74-87. doi: 10.1016/j.ccr.2010.04.025.

35.

Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.

Zhang MQ, Gaisser S, Nur-E-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L, Boyd SM, Wilkinson B, Martin CJ.

J Med Chem. 2008 Sep 25;51(18):5494-7. doi: 10.1021/jm8006068.

PMID:
18800759
36.

Compressed air massage hastens healing of the diabetic foot.

Mars M, Desai Y, Gregory MA.

Diabetes Technol Ther. 2008 Feb;10(1):39-45. doi: 10.1089/dia.2007.0240.

PMID:
18275361
37.

A model for determining baseline morphometrics of the capillary bed in skeletal muscle.

Gregory MA, Mars M.

Cardiovasc J S Afr. 2006 Jul-Aug;17(4):172-7.

38.

Rapamycin biosynthesis: Elucidation of gene product function.

Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, Wilkinson B, Sheridan RM.

Org Biomol Chem. 2006 Oct 7;4(19):3565-8. Epub 2006 Aug 22.

PMID:
16990929
39.

Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.

Wilkinson B, Gregory MA, Moss SJ, Carletti I, Sheridan RM, Kaja A, Ward M, Olano C, Mendez C, Salas JA, Leadlay PF, vanGinckel R, Zhang MQ.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5814-7. Epub 2006 Sep 8.

PMID:
16962775
40.

Understanding Guillain-Barré syndrome and central nervous system involvement.

Gregory MA, Gregory RJ, Podd JV.

Rehabil Nurs. 2005 Sep-Oct;30(5):207-12. Review.

PMID:
16175926
41.

Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis.

Gregory MA, Petkovic H, Lill RE, Moss SJ, Wilkinson B, Gaisser S, Leadlay PF, Sheridan RM.

Angew Chem Int Ed Engl. 2005 Jul 25;44(30):4757-60. No abstract available.

PMID:
15977283
42.

The ARF tumor suppressor: keeping Myc on a leash.

Gregory MA, Qi Y, Hann SR.

Cell Cycle. 2005 Feb;4(2):249-52. Epub 2005 Feb 21.

PMID:
15655352
43.

p19ARF directly and differentially controls the functions of c-Myc independently of p53.

Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR.

Nature. 2004 Oct 7;431(7009):712-7. Epub 2004 Sep 8.

PMID:
15361884
44.
45.

Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.

Gregory MA, Gaisser S, Lill RE, Hong H, Sheridan RM, Wilkinson B, Petkovic H, Weston AJ, Carletti I, Lee HL, Staunton J, Leadlay PF.

Angew Chem Int Ed Engl. 2004 May 3;43(19):2551-3. No abstract available.

PMID:
15127450
46.

Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization.

Gregory MA, Qi Y, Hann SR.

J Biol Chem. 2003 Dec 19;278(51):51606-12. Epub 2003 Oct 16.

47.
48.

Correlations between metal uptake in the soft tissue of Perna perna and gill filament pathology after exposure to mercury.

Gregory MA, Marshall DJ, George RC, Anandraj A, McClurg TP.

Mar Pollut Bull. 2002;45(1-12):114-25.

PMID:
12398375
49.
50.

Metal accumulation, filtration and O(2) uptake rates in the mussel Perna perna (Mollusca: Bivalvia) exposed to Hg(2+), Cu(2+) and Zn(2+).

Anandraj A, Marshall DJ, Gregory MA, McClurg TP.

Comp Biochem Physiol C Toxicol Pharmacol. 2002 Jul;132(3):355-63.

PMID:
12161169

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