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Items: 41


Group 2 ILC Functional Assays in Allergic Airway Inflammation.

Entwistle LJ, Puttur F, Gregory LG, Lloyd CM.

Methods Mol Biol. 2020;2121:99-114. doi: 10.1007/978-1-0716-0338-3_10.


Pulmonary Group 2 Innate Lymphoid Cell Phenotype Is Context Specific: Determining the Effect of Strain, Location, and Stimuli.

Entwistle LJ, Gregory LG, Oliver RA, Branchett WJ, Puttur F, Lloyd CM.

Front Immunol. 2020 Jan 22;10:3114. doi: 10.3389/fimmu.2019.03114. eCollection 2019.


Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation.

Patel DF, Peiró T, Bruno N, Vuononvirta J, Akthar S, Puttur F, Pyle CJ, Suveizdytė K, Walker SA, Singanayagam A, Carlin LM, Gregory LG, Lloyd CM, Snelgrove RJ.

Sci Immunol. 2019 Nov 8;4(41). pii: eaax7006. doi: 10.1126/sciimmunol.aax7006.


A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma.

Branchett WJ, Stölting H, Oliver RA, Walker SA, Puttur F, Gregory LG, Gabryšová L, Wilson MS, O'Garra A, Lloyd CM.

J Allergy Clin Immunol. 2020 Feb;145(2):666-678.e9. doi: 10.1016/j.jaci.2019.08.006. Epub 2019 Aug 22.


Response to Comment on "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness".

Patel DF, Gaggar A, Blalock JE, Gregory LG, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaaw0462. doi: 10.1126/scitranslmed.aaw0462.


Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans.

Puttur F, Denney L, Gregory LG, Vuononvirta J, Oliver R, Entwistle LJ, Walker SA, Headley MB, McGhee EJ, Pease JE, Krummel MF, Carlin LM, Lloyd CM.

Sci Immunol. 2019 Jun 7;4(36). pii: eaav7638. doi: 10.1126/sciimmunol.aav7638.


Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids.

Nagakumar P, Puttur F, Gregory LG, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S.

Eur Respir J. 2019 Aug 29;54(2). pii: 1801809. doi: 10.1183/13993003.01809-2018. Print 2019 Aug.


Airway macrophages as the guardians of tissue repair in the lung.

Puttur F, Gregory LG, Lloyd CM.

Immunol Cell Biol. 2019 Mar;97(3):246-257. doi: 10.1111/imcb.12235. Epub 2019 Feb 15. Review.


Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.

Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaan4128. doi: 10.1126/sciimmunol.aan4128.


An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peiró T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.


Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection.

Peiró T, Patel DF, Akthar S, Gregory LG, Pyle CJ, Harker JA, Birrell MA, Lloyd CM, Snelgrove RJ.

Thorax. 2018 Jun;73(6):546-556. doi: 10.1136/thoraxjnl-2017-210010. Epub 2017 Oct 27.


Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection.

Denney L, Branchett W, Gregory LG, Oliver RA, Lloyd CM.

Mucosal Immunol. 2018 Mar;11(2):523-535. doi: 10.1038/mi.2017.77. Epub 2017 Oct 25.



Löser S, Lloyd CM, Gregory LG.

J Allergy Clin Immunol. 2017 Oct;140(4):1211-1212. doi: 10.1016/j.jaci.2017.01.048. Epub 2017 Jun 16. No abstract available.


Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.

Löser S, Gregory LG, Zhang Y, Schaefer K, Walker SA, Buckley J, Denney L, Dean CH, Cookson WOC, Moffatt MF, Lloyd CM.

J Allergy Clin Immunol. 2017 May;139(5):1496-1507.e3. doi: 10.1016/j.jaci.2016.07.033. Epub 2016 Sep 10.


Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

Denney L, Byrne AJ, Shea TJ, Buckley JS, Pease JE, Herledan GM, Walker SA, Gregory LG, Lloyd CM.

Immunity. 2015 Nov 17;43(5):945-58. doi: 10.1016/j.immuni.2015.10.012.


Pulmonary macrophages: key players in the innate defence of the airways.

Byrne AJ, Mathie SA, Gregory LG, Lloyd CM.

Thorax. 2015 Dec;70(12):1189-96. doi: 10.1136/thoraxjnl-2015-207020. Epub 2015 Aug 18. Review.


Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.

Lee DC, Walker SA, Byrne AJ, Gregory LG, Buckley J, Bush A, Shaheen SO, Saglani S, Lloyd CM.

Thorax. 2015 Jun;70(6):528-36. doi: 10.1136/thoraxjnl-2014-205280. Epub 2015 Apr 3.


Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge.

Mathie SA, Dixon KL, Walker SA, Tyrrell V, Mondhe M, O'Donnell VB, Gregory LG, Lloyd CM.

Allergy. 2015 Jan;70(1):80-9. doi: 10.1111/all.12536. Epub 2014 Nov 28.


γδT cells regulate chronic airway inflammation and development of airway remodelling.

Murdoch JR, Gregory LG, Lloyd CM.

Clin Exp Allergy. 2014 Nov;44(11):1386-98. doi: 10.1111/cea.12395.


Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations.

Snelgrove RJ, Gregory LG, Peiró T, Akthar S, Campbell GA, Walker SA, Lloyd CM.

J Allergy Clin Immunol. 2014 Sep;134(3):583-592.e6. doi: 10.1016/j.jaci.2014.02.002. Epub 2014 Mar 15.


Endothelin-1 directs airway remodeling and hyper-reactivity in a murine asthma model.

Gregory LG, Jones CP, Mathie SA, Pegorier S, Lloyd CM.

Allergy. 2013 Dec;68(12):1579-88. doi: 10.1111/all.12271. Epub 2013 Oct 14.


IL-25 drives remodelling in allergic airways disease induced by house dust mite.

Gregory LG, Jones CP, Walker SA, Sawant D, Gowers KH, Campbell GA, McKenzie AN, Lloyd CM.

Thorax. 2013 Jan;68(1):82-90. doi: 10.1136/thoraxjnl-2012-202003. Epub 2012 Oct 23.


Activin A and TGF-β promote T(H)9 cell-mediated pulmonary allergic pathology.

Jones CP, Gregory LG, Causton B, Campbell GA, Lloyd CM.

J Allergy Clin Immunol. 2012 Apr;129(4):1000-10.e3. doi: 10.1016/j.jaci.2011.12.965. Epub 2012 Jan 24.


Orchestrating house dust mite-associated allergy in the lung.

Gregory LG, Lloyd CM.

Trends Immunol. 2011 Sep;32(9):402-11. doi: 10.1016/ Epub 2011 Jul 23. Review.


Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25.

Gregory LG, Mathie SA, Walker SA, Pegorier S, Jones CP, Lloyd CM.

Am J Respir Crit Care Med. 2010 Jul 15;182(2):143-54. doi: 10.1164/rccm.200905-0725OC. Epub 2010 Mar 25.


Inhaled house dust mite induces pulmonary T helper 2 cytokine production.

Gregory LG, Causton B, Murdoch JR, Mathie SA, O'Donnell V, Thomas CP, Priest FM, Quint DJ, Lloyd CM.

Clin Exp Allergy. 2009 Oct;39(10):1597-610. doi: 10.1111/j.1365-2222.2009.03302.x. Epub 2009 Jun 22.


Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice.

Saglani S, Mathie SA, Gregory LG, Bell MJ, Bush A, Lloyd CM.

Am J Respir Cell Mol Biol. 2009 Sep;41(3):281-9. doi: 10.1165/rcmb.2008-0396OC. Epub 2009 Jan 16.


Corrigendum to "Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice".

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Themis M, Holder MV, Buckley SM, Dighe N, Ruthe AT, Mistry A, Bigger B, Rahim A, Nguyen TH, Trono D, Thrasher AJ, Coutelle C.

Mol Ther. 2006 Apr;13(4):830. doi: 10.1016/j.ymthe.2005.10.003. Epub 2005 Nov 3. No abstract available.


Nuclear-targeted minicircle to enhance gene transfer with non-viral vectors in vitro and in vivo.

Vaysse L, Gregory LG, Harbottle RP, Perouzel E, Tolmachov O, Coutelle C.

J Gene Med. 2006 Jun;8(6):754-63.


Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy.

Weisz B, David AL, Gregory LG, Perocheau D, Ruthe A, Waddington SN, Themis M, Cook T, Coutelle C, Rodeck CH, Peebles DM.

Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):1105-9.


Gene therapy progress and prospects: fetal gene therapy--first proofs of concept--some adverse effects.

Coutelle C, Themis M, Waddington SN, Buckley SM, Gregory LG, Nivsarkar MS, David AL, Peebles D, Weisz B, Rodeck C.

Gene Ther. 2005 Nov;12(22):1601-7. Review.


Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.

Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Themis M, Holder MV, Buckley SM, Dighe N, Ruthe AT, Mistry A, Bigger B, Rahim A, Nguyen TH, Trono D, Thrasher AJ, Coutelle C.

Mol Ther. 2005 Oct;12(4):763-71. Erratum in: Mol Ther. 2006 Apr;13(4):830.


Fetal and neonatal gene therapy: benefits and pitfalls.

Waddington SN, Kennea NL, Buckley SM, Gregory LG, Themis M, Coutelle C.

Gene Ther. 2004 Oct;11 Suppl 1:S92-7. Review.


Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.

Waddington SN, Nivsarkar MS, Mistry AR, Buckley SM, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder MV, Brittan M, Georgiadis A, Al-Allaf F, Bigger BW, Gregory LG, Cook HT, Ali RR, Thrasher A, Tuddenham EG, Themis M, Coutelle C.

Blood. 2004 Nov 1;104(9):2714-21. Epub 2004 Jul 1. Erratum in: Blood. 2006 Mar 1;107(5):1750.


Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy.

Gregory LG, Waddington SN, Holder MV, Mitrophanous KA, Buckley SM, Mosley KL, Bigger BW, Ellard FM, Walmsley LE, Lawrence L, Al-Allaf F, Kingsman S, Coutelle C, Themis M.

Gene Ther. 2004 Jul;11(14):1117-25.


Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero.

Peebles D, Gregory LG, David A, Themis M, Waddington SN, Knapton HJ, Miah M, Cook T, Lawrence L, Nivsarkar M, Rodeck C, Coutelle C.

Gene Ther. 2004 Jan;11(1):70-8.


Characterization of a nitrate-respiring bacterial community using the nitrate reductase gene (narG) as a functional marker.

Gregory LG, Bond PL, Richardson DJ, Spiro S.

Microbiology. 2003 Jan;149(Pt 1):229-37.


Enhancement of adenovirus-mediated gene transfer to the airways by DEAE dextran and sodium caprate in vivo.

Gregory LG, Harbottle RP, Lawrence L, Knapton HJ, Themis M, Coutelle C.

Mol Ther. 2003 Jan;7(1):19-26.


Detection of genes for membrane-bound nitrate reductase in nitrate-respiring bacteria and in community DNA.

Gregory LG, Karakas-Sen A, Richardson DJ, Spiro S.

FEMS Microbiol Lett. 2000 Feb 15;183(2):275-9.


An unusual Ca(2+) entry pathway activated by protein kinase C in dog splenic artery.

Khoyi MA, Gregory LG, Smith AD, Keef KD, Westfall DP.

J Pharmacol Exp Ther. 1999 Nov;291(2):823-8.


Detection of genes for periplasmic nitrate reductase in nitrate respiring bacteria and in community DNA.

Flanagan DA, Gregory LG, Carter JP, Karakas-Sen A, Richardson DJ, Spiro S.

FEMS Microbiol Lett. 1999 Aug 15;177(2):263-70.

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