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Items: 20


Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility.

Radder JE, Gregory AD, Leme AS, Cho MH, Chu Y, Kelly NJ, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Beaty TH, Crapo JD, Silverman EK, Zhang Y, Berndt A, Shapiro SD.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):367-375. doi: 10.1165/rcmb.2016-0220OC.


Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain.

Dandachi N, Kelly NJ, Wood JP, Burton CL, Radder JE, Leme AS, Gregory AD, Shapiro SD.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):353-363. doi: 10.1164/rccm.201606-1150OC.


Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction.

Radder JE, Zhang Y, Gregory AD, Yu S, Kelly NJ, Leader JK, Kaminski N, Sciurba FC, Shapiro SD.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):159-171. doi: 10.1164/rccm.201606-1147OC.


Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor.

Kelly NJ, Radder JE, Baust JJ, Burton CL, Lai YC, Potoka KC, Agostini BA, Wood JP, Bachman TN, Vanderpool RR, Dandachi N, Leme AS, Gregory AD, Morris A, Mora AL, Gladwin MT, Shapiro SD.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):488-496. doi: 10.1165/rcmb.2016-0176OC.


Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination.

Han S, Jerome JA, Gregory AD, Mallampalli RK.

Respir Res. 2017 Jan 5;18(1):2. doi: 10.1186/s12931-016-0485-6.


Automated Measurement of Blood Vessels in Tissues from Microscopy Images.

Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD.

Curr Protoc Cytom. 2016 Oct 10;78:12.44.1-12.44.13. doi: 10.1002/cpcy.10.


Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster.

Kaynar AM, Bakalov V, Laverde SM, Cambriel AI, Lee BH, Towheed A, Gregory AD, Webb SA, Palladino MJ, Bozza FA, Shapiro SD, Angus DC.

Intensive Care Med Exp. 2016 Dec;4(1):4. doi: 10.1186/s40635-016-0075-4. Epub 2016 Jan 21.


Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis.

Gregory AD, Kliment CR, Metz HE, Kim KH, Kargl J, Agostini BA, Crum LT, Oczypok EA, Oury TA, Houghton AM.

J Leukoc Biol. 2015 Aug;98(2):143-52. doi: 10.1189/jlb.3HI1014-493R. Epub 2015 Mar 5.


Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.

Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS.

Mucosal Immunol. 2015 Jul;8(4):896-905. doi: 10.1038/mi.2014.120. Epub 2014 Dec 10.


Effects of intra-abdominal sepsis on atherosclerosis in mice.

Kaynar AM, Yende S, Zhu L, Frederick DR, Chambers R, Burton CL, Carter M, Stolz DB, Agostini B, Gregory AD, Nagarajan S, Shapiro SD, Angus DC.

Crit Care. 2014 Sep 3;18(5):469. doi: 10.1186/s13054-014-0469-1.


Authors' response.

Kaynar AM, Gregory AD, Shapiro SD, Angus DC.

Crit Care. 2014;18(6):645. No abstract available.


Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.

Gregory AD, Hale P, Perlmutter DH, Houghton AM.

J Biol Chem. 2012 Oct 12;287(42):35341-50. doi: 10.1074/jbc.M112.385617. Epub 2012 Aug 22.


Tumor-associated neutrophils: new targets for cancer therapy.

Gregory AD, Houghton AM.

Cancer Res. 2011 Apr 1;71(7):2411-6. doi: 10.1158/0008-5472.CAN-10-2583. Epub 2011 Mar 22. Review.


Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes.

Gregory AD, Capoccia BJ, Woloszynek JR, Link DC.

J Leukoc Biol. 2010 Jul;88(1):123-31. doi: 10.1189/jlb.0709499. Epub 2010 Mar 30.


Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.

Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD.

Nat Med. 2010 Feb;16(2):219-23. doi: 10.1038/nm.2084. Epub 2010 Jan 17.


Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion.

Capoccia BJ, Gregory AD, Link DC.

J Leukoc Biol. 2008 Sep;84(3):760-8. doi: 10.1189/jlb.1107756. Epub 2008 Jun 11.


Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential.

Rawls AS, Gregory AD, Woloszynek JR, Liu F, Link DC.

Blood. 2007 Oct 1;110(7):2414-22. Epub 2007 Jul 17.


Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.

Gregory AD, Hogue LA, Ferkol TW, Link DC.

Blood. 2007 Apr 15;109(8):3235-43. Epub 2006 Dec 21.


G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood.

Semerad CL, Liu F, Gregory AD, Stumpf K, Link DC.

Immunity. 2002 Oct;17(4):413-23.


Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats.

Jones TA, Chu CJ, Grande LA, Gregory AD.

J Neurosci. 1999 Nov 15;19(22):10153-63.

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