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Items: 31


Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell.

Ayyaz A, Kumar S, Sangiorgi B, Ghoshal B, Gosio J, Ouladan S, Fink M, Barutcu S, Trcka D, Shen J, Chan K, Wrana JL, Gregorieff A.

Nature. 2019 May;569(7754):121-125. doi: 10.1038/s41586-019-1154-y. Epub 2019 Apr 24.


Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc".

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, Moreno de Alboran I, Clevers H, Clarke AR.

Mol Cell Biol. 2018 Nov 28;38(24). pii: e00482-18. doi: 10.1128/MCB.00482-18. Print 2018 Dec 15. No abstract available.


A feed forward loop enforces YAP/TAZ signaling during tumorigenesis.

Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L.

Nat Commun. 2018 Aug 29;9(1):3510. doi: 10.1038/s41467-018-05939-2.


Use of Organoids to Characterize Signaling Pathways in Cancer Initiation.

Oatway C, Hirsch CL, Gregorieff A.

Methods Mol Biol. 2018;1765:315-331. doi: 10.1007/978-1-4939-7765-9_21.


Hippo signalling in intestinal regeneration and cancer.

Gregorieff A, Wrana JL.

Curr Opin Cell Biol. 2017 Oct;48:17-25. doi: 10.1016/ Epub 2017 May 18. Review.


A critical role for NF2 and the Hippo pathway in branching morphogenesis.

Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H.

Nat Commun. 2016 Aug 2;7:12309. doi: 10.1038/ncomms12309.


Multiple roles for the hippo effector yap in gut regeneration and cancer initiation.

Gregorieff A, Wrana JL.

Mol Cell Oncol. 2016 Mar 16;3(3):e1143992. doi: 10.1080/23723556.2016.1143992. eCollection 2016 May.


YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.

Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, Wrana JL, Asmani M, Zhao R, Sim FJ, Wrabetz L, Svaren J, Feltri ML.

Nat Neurosci. 2016 Jul;19(7):879-87. doi: 10.1038/nn.4316. Epub 2016 Jun 6.


Seeing is believing: Wnt3 localization in the gut epithelium.

Gregorieff A, Wrana JL.

Cell Res. 2016 May;26(5):515-6. doi: 10.1038/cr.2016.41. Epub 2016 Mar 25.


YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.

Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL, Taylor MD, Angers S, Kenney AM.

Oncogene. 2016 Aug 11;35(32):4256-68. doi: 10.1038/onc.2015.491. Epub 2016 Jan 4.


Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.

Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y, Wrana JL.

Nature. 2015 Oct 29;526(7575):715-8. doi: 10.1038/nature15382. Epub 2015 Oct 21.


In Situ Hybridization to Identify Gut Stem Cells.

Gregorieff A, Clevers H.

Curr Protoc Stem Cell Biol. 2015 Aug 3;34:2F.1.1-11. doi: 10.1002/9780470151808.sc02f01s34.


Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.

Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H.

PLoS Genet. 2013 Mar;9(3):e1003380. doi: 10.1371/journal.pgen.1003380. Epub 2013 Mar 21.


Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.

van Es JH, Sato T, van de Wetering M, Lyubimova A, Yee Nee AN, Gregorieff A, Sasaki N, Zeinstra L, van den Born M, Korving J, Martens ACM, Barker N, van Oudenaarden A, Clevers H.

Nat Cell Biol. 2012 Oct;14(10):1099-1104. doi: 10.1038/ncb2581. Epub 2012 Sep 23.


The Hippo pathway regulates Wnt/beta-catenin signaling.

Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L.

Dev Cell. 2010 Apr 20;18(4):579-91. doi: 10.1016/j.devcel.2010.03.007.


In situ hybridization to identify gut stem cells.

Gregorieff A, Clevers H.

Curr Protoc Stem Cell Biol. 2010 Jan;Chapter 2:Unit 2F.1. doi: 10.1002/9780470151808.sc02f01s12.


SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA.

J Clin Invest. 2009 Oct;119(10):2914-24. doi: 10.1172/JCI39731. Epub 2009 Sep 14.


The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium.

Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H.

Gastroenterology. 2009 Oct;137(4):1333-45.e1-3. doi: 10.1053/j.gastro.2009.06.044. Epub 2009 Jun 21.


The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.

Wehkamp J, Wang G, Kübler I, Nuding S, Gregorieff A, Schnabel A, Kays RJ, Fellermann K, Burk O, Schwab M, Clevers H, Bevins CL, Stange EF.

J Immunol. 2007 Sep 1;179(5):3109-18.


Wnt signaling mediates regional specification in the vertebrate face.

Brugmann SA, Goodnough LH, Gregorieff A, Leucht P, ten Berge D, Fuerer C, Clevers H, Nusse R, Helms JA.

Development. 2007 Sep;134(18):3283-95. Epub 2007 Aug 15.


Giving APCmin tumours a SPARC.

Gregorieff A, Clevers H.

Gut. 2007 Oct;56(10):1341-3. Epub 2007 Apr 19. No abstract available.


Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, de Alboran IM, Clevers H, Clarke AR.

Mol Cell Biol. 2006 Nov;26(22):8418-26. Epub 2006 Sep 5. Erratum in: Mol Cell Biol. 2018 Nov 28;38(24):.


Expression pattern of Wnt signaling components in the adult intestine.

Gregorieff A, Pinto D, Begthel H, Destrée O, Kielman M, Clevers H.

Gastroenterology. 2005 Aug;129(2):626-38.


EphB receptor activity suppresses colorectal cancer progression.

Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H.

Nature. 2005 Jun 23;435(7045):1126-30. Erratum in: Nature. 2005 Aug 11;436(7052):881. Jonkeer, Suzanne [corrected to Jonkheer, Suzanne].


Wnt signaling in the intestinal epithelium: from endoderm to cancer.

Gregorieff A, Clevers H.

Genes Dev. 2005 Apr 15;19(8):877-90. Review.


Wnt signalling induces maturation of Paneth cells in intestinal crypts.

van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, van den Born M, Begthel H, Brabletz T, Taketo MM, Clevers H.

Nat Cell Biol. 2005 Apr;7(4):381-6. Epub 2005 Mar 20.


Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos.

Gregorieff A, Grosschedl R, Clevers H.

EMBO J. 2004 Apr 21;23(8):1825-33. Epub 2004 Apr 1.


Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.

Pinto D, Gregorieff A, Begthel H, Clevers H.

Genes Dev. 2003 Jul 15;17(14):1709-13.


Regulation of SOCS-1 expression by translational repression.

Gregorieff A, Pyronnet S, Sonenberg N, Veillette A.

J Biol Chem. 2000 Jul 14;275(28):21596-604.


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