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The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes.

Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG.

Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E293-E304. doi: 10.1152/ajpendo.00394.2018. Epub 2018 Dec 4.


Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges.

Bernardo BC, Gregorevic P, Ritchie RH, McMullen JR.

Front Pharmacol. 2018 Sep 21;9:1090. doi: 10.3389/fphar.2018.01090. eCollection 2018.


The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance.

Garton FC, Houweling PJ, Vukcevic D, Meehan LR, Lee FXZ, Lek M, Roeszler KN, Hogarth MW, Tiong CF, Zannino D, Yang N, Leslie S, Gregorevic P, Head SI, Seto JT, North KN.

Am J Hum Genet. 2018 May 3;102(5):845-857. doi: 10.1016/j.ajhg.2018.03.009. Epub 2018 Apr 26.


Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism.

Marshall JPS, Estevez E, Kammoun HL, King EJ, Bruce CR, Drew BG, Qian H, Iliades P, Gregorevic P, Febbraio MA, Henstridge DC.

Diabetes Obes Metab. 2018 Aug;20(8):1928-1936. doi: 10.1111/dom.13319. Epub 2018 May 3.


Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling.

Bernardo BC, Weeks KL, Pongsukwechkul T, Gao X, Kiriazis H, Cemerlang N, Boey EJH, Tham YK, Johnson CJ, Qian H, Du XJ, Gregorevic P, McMullen JR.

Clin Sci (Lond). 2018 Feb 8;132(3):381-397. doi: 10.1042/CS20171269. Print 2018 Feb 14.


Molecular characterization of latent GDF8 reveals mechanisms of activation.

Walker RG, McCoy JC, Czepnik M, Mills MJ, Hagg A, Walton KL, Cotton TR, Hyvönen M, Lee RT, Gregorevic P, Harrison CA, Thompson TB.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E866-E875. doi: 10.1073/pnas.1714622115. Epub 2018 Jan 18.


The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function.

Watt KI, Goodman CA, Hornberger TA, Gregorevic P.

Exerc Sport Sci Rev. 2018 Apr;46(2):92-96. doi: 10.1249/JES.0000000000000142. Review.


Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.

Whitham M, Parker BL, Friedrichsen M, Hingst JR, Hjorth M, Hughes WE, Egan CL, Cron L, Watt KI, Kuchel RP, Jayasooriah N, Estevez E, Petzold T, Suter CM, Gregorevic P, Kiens B, Richter EA, James DE, Wojtaszewski JFP, Febbraio MA.

Cell Metab. 2018 Jan 9;27(1):237-251.e4. doi: 10.1016/j.cmet.2017.12.001.


Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway.

Watt KI, Harvey KF, Gregorevic P.

Front Physiol. 2017 Nov 24;8:942. doi: 10.3389/fphys.2017.00942. eCollection 2017. Review.


Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8372-E8381. doi: 10.1073/pnas.1707316114. Epub 2017 Sep 15.


Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin.

Nicolas N, Muir JA, Hayward S, Chen JL, Stanton PG, Gregorevic P, de Kretser DM, Loveland KL, Bhushan S, Meinhardt A, Fijak M, Hedger MP.

Reproduction. 2017 Sep;154(3):293-305. doi: 10.1530/REP-17-0010. Epub 2017 Jun 30.


Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease.

Chen JL, Walton KL, Hagg A, Colgan TD, Johnson K, Qian H, Gregorevic P, Harrison CA.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5266-E5275. doi: 10.1073/pnas.1620013114. Epub 2017 Jun 12.


Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction.

Prakoso D, De Blasio MJ, Qin C, Rosli S, Kiriazis H, Qian H, Du XJ, Weeks KL, Gregorevic P, McMullen JR, Ritchie RH.

Clin Sci (Lond). 2017 Jun 7;131(12):1345-1360. doi: 10.1042/CS20170063. Print 2017 Jun 1.


Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle.

Lee-Young RS, Hoffman NJ, Murphy KT, Henstridge DC, Samocha-Bonet D, Siebel AL, Iliades P, Zivanovic B, Hong YH, Colgan TD, Kraakman MJ, Bruce CR, Gregorevic P, McConell GK, Lynch GS, Drummond GR, Kingwell BA, Greenfield JR, Febbraio MA.

Mol Metab. 2016 Sep 9;5(11):1083-1091. doi: 10.1016/j.molmet.2016.09.002. eCollection 2016 Nov.


Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology.

Swiderski K, Martins KJ, Chee A, Trieu J, Naim T, Gehrig SM, Baum DM, Brenmoehl J, Chau L, Koopman R, Gregorevic P, Metzger F, Hoeflich A, Lynch GS.

Growth Horm IGF Res. 2016 Oct - Dec;30-31:1-10. doi: 10.1016/j.ghir.2016.07.002. Epub 2016 Jul 29.


Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

Gaur V, Connor T, Sanigorski A, Martin SD, Bruce CR, Henstridge DC, Bond ST, McEwen KA, Kerr-Bayles L, Ashton TD, Fleming C, Wu M, Pike Winer LS, Chen D, Hudson GM, Schwabe JWR, Baar K, Febbraio MA, Gregorevic P, Pfeffer FM, Walder KR, Hargreaves M, McGee SL.

Cell Rep. 2016 Sep 13;16(11):2802-2810. doi: 10.1016/j.celrep.2016.08.005.


Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.

Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen JR, Rodgers BD, Harrison CA, Lynch GS, Gregorevic P.

Sci Transl Med. 2016 Jul 20;8(348):348ra98. doi: 10.1126/scitranslmed.aac4976.


Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia.

Chen JL, Walton KL, Qian H, Colgan TD, Hagg A, Watt MJ, Harrison CA, Gregorevic P.

Cancer Res. 2016 Sep 15;76(18):5372-82. doi: 10.1158/0008-5472.CAN-15-3152. Epub 2016 Jun 21.


Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass.

Davey JR, Watt KI, Parker BL, Chaudhuri R, Ryall JG, Cunningham L, Qian H, Sartorelli V, Sandri M, Chamberlain J, James DE, Gregorevic P.

JCI Insight. 2016 Apr 21;1(5). pii: e85477.


The TGF-β Signalling Network in Muscle Development, Adaptation and Disease.

Chen JL, Colgan TD, Walton KL, Gregorevic P, Harrison CA.

Adv Exp Med Biol. 2016;900:97-131. doi: 10.1007/978-3-319-27511-6_5. Review.


Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size.

Hagg A, Colgan TD, Thomson RE, Qian H, Lynch GS, Gregorevic P.

Sci Rep. 2016 Mar 14;6:23042. doi: 10.1038/srep23042.


Modulating myosin restores muscle function in a mouse model of nemaline myopathy.

Lindqvist J, Levy Y, Pati-Alam A, Hardeman EC, Gregorevic P, Ochala J.

Ann Neurol. 2016 May;79(5):717-725. doi: 10.1002/ana.24619. Epub 2016 Mar 22.


Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis.

Coughlan MT, Higgins GC, Nguyen TV, Penfold SA, Thallas-Bonke V, Tan SM, Ramm G, Van Bergen NJ, Henstridge DC, Sourris KC, Harcourt BE, Trounce IA, Robb PM, Laskowski A, McGee SL, Genders AJ, Walder K, Drew BG, Gregorevic P, Qian H, Thomas MC, Jerums G, Macisaac RJ, Skene A, Power DA, Ekinci EI, Wijeyeratne XW, Gallo LA, Herman-Edelstein M, Ryan MT, Cooper ME, Thorburn DR, Forbes JM.

Diabetes. 2016 Apr;65(4):1085-98. doi: 10.2337/db15-0864. Epub 2016 Jan 28.


Forced expression of muscle specific kinase slows postsynaptic acetylcholine receptor loss in a mouse model of MuSK myasthenia gravis.

Ghazanfari N, Linsao EL, Trajanovska S, Morsch M, Gregorevic P, Liang SX, Reddel SW, Phillips WD.

Physiol Rep. 2015 Dec;3(12). pii: e12658. doi: 10.14814/phy2.12658. Epub 2015 Dec 22.


Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy.

Sepulveda PV, Lamon S, Hagg A, Thomson RE, Winbanks CE, Qian H, Bruce CR, Russell AP, Gregorevic P.

Sci Rep. 2015 Dec 11;5:17535. doi: 10.1038/srep17535.


miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7.

McClelland AD, Herman-Edelstein M, Komers R, Jha JC, Winbanks CE, Hagiwara S, Gregorevic P, Kantharidis P, Cooper ME.

Clin Sci (Lond). 2015 Dec;129(12):1237-49. doi: 10.1042/CS20150427. Epub 2015 Sep 28.


Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

Johnston AJ, Murphy KT, Jenkinson L, Laine D, Emmrich K, Faou P, Weston R, Jayatilleke KM, Schloegel J, Talbo G, Casey JL, Levina V, Wong WW, Dillon H, Sahay T, Hoogenraad J, Anderton H, Hall C, Schneider P, Tanzer M, Foley M, Scott AM, Gregorevic P, Liu SY, Burkly LC, Lynch GS, Silke J, Hoogenraad NJ.

Cell. 2015 Sep 10;162(6):1365-78. doi: 10.1016/j.cell.2015.08.031.


The atypical 'b' splice variant of phospholipase Cβ1 promotes cardiac contractile dysfunction.

Grubb DR, Crook B, Ma Y, Luo J, Qian HW, Gao XM, Kiriazis H, Du XJ, Gregorevic P, Woodcock EA.

J Mol Cell Cardiol. 2015 Jul;84:95-103. doi: 10.1016/j.yjmcc.2015.04.016. Epub 2015 Apr 25.


The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size.

Watt KI, Turner BJ, Hagg A, Zhang X, Davey JR, Qian H, Beyer C, Winbanks CE, Harvey KF, Gregorevic P.

Nat Commun. 2015 Jan 12;6:6048. doi: 10.1038/ncomms7048.


Development of novel activin-targeted therapeutics.

Chen JL, Walton KL, Al-Musawi SL, Kelly EK, Qian H, La M, Lu L, Lovrecz G, Ziemann M, Lazarus R, El-Osta A, Gregorevic P, Harrison CA.

Mol Ther. 2015 Mar;23(3):434-44. doi: 10.1038/mt.2014.221. Epub 2014 Nov 17.


Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy.

Bernardo BC, Nguyen SS, Winbanks CE, Gao XM, Boey EJ, Tham YK, Kiriazis H, Ooi JY, Porrello ER, Igoor S, Thomas CJ, Gregorevic P, Lin RC, Du XJ, McMullen JR.

FASEB J. 2014 Dec;28(12):5097-110. doi: 10.1096/fj.14-253856. Epub 2014 Aug 21.


Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury.

Williams D, Venardos KM, Byrne M, Joshi M, Horlock D, Lam NT, Gregorevic P, McGee SL, Kaye DM.

PLoS One. 2014 Aug 11;9(8):e104643. doi: 10.1371/journal.pone.0104643. eCollection 2014.


Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting.

Swiderski K, Shaffer SA, Gallis B, Odom GL, Arnett AL, Scott Edgar J, Baum DM, Chee A, Naim T, Gregorevic P, Murphy KT, Moody J, Goodlett DR, Lynch GS, Chamberlain JS.

Hum Mol Genet. 2014 Dec 20;23(25):6697-711. doi: 10.1093/hmg/ddu388. Epub 2014 Jul 31.


TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease.

Sartori R, Gregorevic P, Sandri M.

Trends Endocrinol Metab. 2014 Sep;25(9):464-71. doi: 10.1016/j.tem.2014.06.002. Epub 2014 Jul 16. Review.


Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation.

Church JE, Trieu J, Sheorey R, Chee AY, Naim T, Baum DM, Ryall JG, Gregorevic P, Lynch GS.

PLoS One. 2014 Jul 7;9(7):e101379. doi: 10.1371/journal.pone.0101379. eCollection 2014.


Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Bernardo BC, Gao XM, Tham YK, Kiriazis H, Winbanks CE, Ooi JY, Boey EJ, Obad S, Kauppinen S, Gregorevic P, Du XJ, Lin RC, McMullen JR.

PLoS One. 2014 Feb 27;9(2):e90337. doi: 10.1371/journal.pone.0090337. eCollection 2014.


Elevated expression of activins promotes muscle wasting and cachexia.

Chen JL, Walton KL, Winbanks CE, Murphy KT, Thomson RE, Makanji Y, Qian H, Lynch GS, Harrison CA, Gregorevic P.

FASEB J. 2014 Apr;28(4):1711-23. doi: 10.1096/fj.13-245894. Epub 2013 Dec 30.


The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.

Winbanks CE, Chen JL, Qian H, Liu Y, Bernardo BC, Beyer C, Watt KI, Thomson RE, Connor T, Turner BJ, McMullen JR, Larsson L, McGee SL, Harrison CA, Gregorevic P.

J Cell Biol. 2013 Oct 28;203(2):345-57. doi: 10.1083/jcb.201211134. Epub 2013 Oct 21.


ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling.

Seto JT, Quinlan KG, Lek M, Zheng XF, Garton F, MacArthur DG, Hogarth MW, Houweling PJ, Gregorevic P, Turner N, Cooney GJ, Yang N, North KN.

J Clin Invest. 2013 Oct;123(10):4255-63. doi: 10.1172/JCI67691. Epub 2013 Sep 16.


miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4.

Winbanks CE, Beyer C, Hagg A, Qian H, Sepulveda PV, Gregorevic P.

PLoS One. 2013 Sep 2;8(9):e73589. doi: 10.1371/journal.pone.0073589. eCollection 2013.


Transduction of skeletal muscles with common reporter genes can promote muscle fiber degeneration and inflammation.

Winbanks CE, Beyer C, Qian H, Gregorevic P.

PLoS One. 2012;7(12):e51627. doi: 10.1371/journal.pone.0051627. Epub 2012 Dec 12.


Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.

Nicholls PK, Stanton PG, Rainczuk KE, Qian H, Gregorevic P, Harrison CA.

Spermatogenesis. 2012 Oct 1;2(4):279-284.


Activin signaling regulates Sertoli cell differentiation and function.

Nicholls PK, Stanton PG, Chen JL, Olcorn JS, Haverfield JT, Qian H, Walton KL, Gregorevic P, Harrison CA.

Endocrinology. 2012 Dec;153(12):6065-77. doi: 10.1210/en.2012-1821. Epub 2012 Nov 1.


Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.

Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9.


Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.

Winbanks CE, Weeks KL, Thomson RE, Sepulveda PV, Beyer C, Qian H, Chen JL, Allen JM, Lancaster GI, Febbraio MA, Harrison CA, McMullen JR, Chamberlain JS, Gregorevic P.

J Cell Biol. 2012 Jun 25;197(7):997-1008. doi: 10.1083/jcb.201109091. Epub 2012 Jun 18.


Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.

Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR.

Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15.


Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis.

Wang B, Komers R, Carew R, Winbanks CE, Xu B, Herman-Edelstein M, Koh P, Thomas M, Jandeleit-Dahm K, Gregorevic P, Cooper ME, Kantharidis P.

J Am Soc Nephrol. 2012 Feb;23(2):252-65. doi: 10.1681/ASN.2011010055. Epub 2011 Nov 17.


Generation of a specific activin antagonist by modification of the activin A propeptide.

Makanji Y, Walton KL, Chan KL, Gregorevic P, Robertson DM, Harrison CA.

Endocrinology. 2011 Oct;152(10):3758-68. doi: 10.1210/en.2011-1052. Epub 2011 Jul 12.


TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4.

Winbanks CE, Wang B, Beyer C, Koh P, White L, Kantharidis P, Gregorevic P.

J Biol Chem. 2011 Apr 22;286(16):13805-14. doi: 10.1074/jbc.M110.192625. Epub 2011 Feb 15.


Gene therapy of mdx mice with large truncated dystrophins generated by recombination using rAAV6.

Odom GL, Gregorevic P, Allen JM, Chamberlain JS.

Mol Ther. 2011 Jan;19(1):36-45. doi: 10.1038/mt.2010.205. Epub 2010 Sep 21.

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