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Items: 14

1.

Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.

Gillooly KM, Pattoli MA, Taylor TL, Chen L, Cheng L, Gregor KR, Whitney GS, Susulic V, Watterson SH, Kempson J, Pitts WJ, Booth-Lute H, Yang G, Davies P, Kukral DW, Strnad J, McIntyre KW, Darienzo CJ, Salter-Cid L, Yang Z, Wang-Iverson DB, Burke JR.

J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018. Epub 2009 Aug 3.

PMID:
19652024
2.

Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors.

Beaulieu F, Ouellet C, Ruediger EH, Belema M, Qiu Y, Yang X, Banville J, Burke JR, Gregor KR, MacMaster JF, Martel A, McIntyre KW, Pattoli MA, Zusi FC, Vyas D.

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1233-7. Epub 2006 Dec 9.

PMID:
17197177
3.
4.

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice.

Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW, Yang X, Iotzova VS, Clarke W, Strnad J, Qiu Y, Zusi FC.

J Biol Chem. 2003 Jan 17;278(3):1450-6. Epub 2002 Oct 25.

5.

BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models.

Burke JR, Davern LB, Stanley PL, Gregor KR, Banville J, Remillard R, Russell JW, Brassil PJ, Witmer MR, Johnson G, Tredup JA, Tramposch KM.

J Pharmacol Exp Ther. 2001 Jul;298(1):376-85.

PMID:
11408565
6.

Biaryl diacid inhibitors of human s-PLA2 with anti-inflammatory activity.

Springer DM, Luh BY, Bronson JJ, McElhone KE, Mansuri MM, Gregor KR, Nettleton DO, Stanley PL, Tramposch KM.

Bioorg Med Chem. 2000 May;8(5):1087-109.

PMID:
10882020
7.

Competitive, reversible inhibition of cytosolic phospholipase A2 at the lipid-water interface by choline derivatives that partially partition into the phospholipid bilayer.

Burke JR, Witmer MR, Zusi FC, Gregor KR, Davern LB, Padmanabha R, Swann RT, Smith D, Tredup JA, Micanovic R, Manly SP, Villafranca JJ, Tramposch KM.

J Biol Chem. 1999 Jul 2;274(27):18864-71.

8.

Differentiation of U937 cells enables a phospholipase D-dependent pathway of cytosolic phospholipase A2 activation.

Burke JR, Davern LB, Gregor KR, Owczarczak LM.

Biochem Biophys Res Commun. 1999 Jun 24;260(1):232-9.

PMID:
10381372
9.

A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface.

Burke JR, Gregor KR, Padmanabha R, Banville J, Witmer MR, Davern LB, Manly SP, Tramposch KM.

J Enzyme Inhib. 1998 Jun;13(3):195-206.

PMID:
9629537
10.

Leukotriene B4 stimulates the release of arachidonate in human neutrophils via the action of cytosolic phospholipase A2.

Burke JR, Davern LB, Gregor KR, Tramposch KM.

Biochim Biophys Acta. 1997 Oct 30;1359(1):80-8.

11.

Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: requirement for a Gi alpha-type G-protein.

Burke JR, Davern LB, Gregor KR, Todderud G, Alford JG, Tramposch KM.

Biochim Biophys Acta. 1997 Sep 5;1341(2):223-37.

PMID:
9357962
12.

Cooperativity and binding in the mechanism of cytosolic phospholipase A2.

Burke JR, Witmer MR, Tredup J, Micanovic R, Gregor KR, Lahiri J, Tramposch KM, Villafranca JJ.

Biochemistry. 1995 Nov 21;34(46):15165-74. Erratum in: Biochemistry 1997 Jun 3;36(22):6854.

PMID:
7578131
13.
14.

Schistosomiasis: role of endogenous opioids in suppression of gonadal steroid secretion.

Isseroff H, Sylvester PW, Bessette CL, Jones PL, Fisher WG, Rynkowski TA, Gregor KR.

Comp Biochem Physiol A Comp Physiol. 1989;94(1):41-5.

PMID:
2571452

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