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Items: 38


Structural biology of glutamate receptor ion channels: towards an understanding of mechanism.

Greger IH, Mayer ML.

Curr Opin Struct Biol. 2019 Aug;57:185-195. doi: 10.1016/ Epub 2019 Jun 8. Review.


Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8.

Herguedas B, Watson JF, Ho H, Cais O, García-Nafría J, Greger IH.

Science. 2019 Apr 26;364(6438). pii: eaav9011. doi: 10.1126/science.aav9011. Epub 2019 Mar 14.


Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation.

Buonarati OR, Hammes EA, Watson JF, Greger IH, Hell JW.

Sci Signal. 2019 Jan 1;12(562). pii: eaar6889. doi: 10.1126/scisignal.aar6889. Review.


Druggability Simulations and X-Ray Crystallography Reveal a Ligand-Binding Site in the GluA3 AMPA Receptor N-Terminal Domain.

Lee JY, Krieger J, Herguedas B, García-Nafría J, Dutta A, Shaikh SA, Greger IH, Bahar I.

Structure. 2019 Feb 5;27(2):241-252.e3. doi: 10.1016/j.str.2018.10.017. Epub 2018 Dec 6.


Activation and desensitization of ionotropic glutamate receptors by selectively triggering pre-existing motions.

Krieger J, Lee JY, Greger IH, Bahar I.

Neurosci Lett. 2019 May 1;700:22-29. doi: 10.1016/j.neulet.2018.02.050. Epub 2018 Feb 23. Review.


A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.

Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A; WGS500 Consortium, Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC.

Hum Mol Genet. 2017 Oct 15;26(20):3869-3882. doi: 10.1093/hmg/ddx270.


Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins.

Greger IH, Watson JF, Cull-Candy SG.

Neuron. 2017 May 17;94(4):713-730. doi: 10.1016/j.neuron.2017.04.009. Review.


Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain.

Watson JF, Ho H, Greger IH.

Elife. 2017 Mar 14;6. pii: e23024. doi: 10.7554/eLife.23024.


Structural basis for integration of GluD receptors within synaptic organizer complexes.

Elegheert J, Kakegawa W, Clay JE, Shanks NF, Behiels E, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Yuzaki M, Aricescu AR.

Science. 2016 Jul 15;353(6296):295-9. doi: 10.1126/science.aae0104.


IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly.

García-Nafría J, Watson JF, Greger IH.

Sci Rep. 2016 Jun 6;6:27459. doi: 10.1038/srep27459.


Structure and organization of heteromeric AMPA-type glutamate receptors.

Herguedas B, García-Nafría J, Cais O, Fernández-Leiro R, Krieger J, Ho H, Greger IH.

Science. 2016 Apr 29;352(6285):aad3873. doi: 10.1126/science.aad3873. Epub 2016 Mar 10.


The dynamic AMPA receptor extracellular region: a platform for synaptic protein interactions.

García-Nafría J, Herguedas B, Watson JF, Greger IH.

J Physiol. 2016 Oct 1;594(19):5449-58. doi: 10.1113/JP271844. Epub 2016 Apr 29. Review.


Cooperative Dynamics of Intact AMPA and NMDA Glutamate Receptors: Similarities and Subfamily-Specific Differences.

Dutta A, Krieger J, Lee JY, Garcia-Nafria J, Greger IH, Bahar I.

Structure. 2015 Sep 1;23(9):1692-1704. doi: 10.1016/j.str.2015.07.002. Epub 2015 Aug 6.


Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains.

Krieger J, Bahar I, Greger IH.

Biophys J. 2015 Sep 15;109(6):1136-48. doi: 10.1016/j.bpj.2015.06.061. Epub 2015 Aug 6. Review.


Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G.

Nat Genet. 2015 Jul;47(7):717-726. doi: 10.1038/ng.3304. Epub 2015 May 18.


Mapping the interaction sites between AMPA receptors and TARPs reveals a role for the receptor N-terminal domain in channel gating.

Cais O, Herguedas B, Krol K, Cull-Candy SG, Farrant M, Greger IH.

Cell Rep. 2014 Oct 23;9(2):728-40. doi: 10.1016/j.celrep.2014.09.029. Epub 2014 Oct 16.


Receptor heteromeric assembly-how it works and why it matters: the case of ionotropic glutamate receptors.

Herguedas B, Krieger J, Greger IH.

Prog Mol Biol Transl Sci. 2013;117:361-86. doi: 10.1016/B978-0-12-386931-9.00013-1. Review.


Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system.

Penn AC, Balik A, Greger IH.

Front Neurosci. 2013 Apr 18;7:61. doi: 10.3389/fnins.2013.00061. eCollection 2013.


Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing.

Penn AC, Balik A, Greger IH.

Nucleic Acids Res. 2013 Jan;41(2):1113-23. doi: 10.1093/nar/gks1044. Epub 2012 Nov 20.


Activity-regulated RNA editing in select neuronal subfields in hippocampus.

Balik A, Penn AC, Nemoda Z, Greger IH.

Nucleic Acids Res. 2013 Jan;41(2):1124-34. doi: 10.1093/nar/gks1045. Epub 2012 Nov 20.


Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain.

Penn AC, Balik A, Wozny C, Cais O, Greger IH.

Neuron. 2012 Nov 8;76(3):503-10. doi: 10.1016/j.neuron.2012.08.010.


Comparative dynamics of NMDA- and AMPA-glutamate receptor N-terminal domains.

Dutta A, Shrivastava IH, Sukumaran M, Greger IH, Bahar I.

Structure. 2012 Nov 7;20(11):1838-49. doi: 10.1016/j.str.2012.08.012. Epub 2012 Sep 6.


Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L.

Shanks NF, Savas JN, Maruo T, Cais O, Hirao A, Oe S, Ghosh A, Noda Y, Greger IH, Yates JR 3rd, Nakagawa T.

Cell Rep. 2012 Jun 28;1(6):590-8. doi: 10.1016/j.celrep.2012.05.004. Epub 2012 May 23.


AMPA receptor assembly: atomic determinants and built-in modulators.

Sukumaran M, Penn AC, Greger IH.

Adv Exp Med Biol. 2012;970:241-64. doi: 10.1007/978-3-7091-0932-8_11. Review.


Intrinsic motions in the N-terminal domain of an ionotropic glutamate receptor detected by fluorescence correlation spectroscopy.

Jensen MH, Sukumaran M, Johnson CM, Greger IH, Neuweiler H.

J Mol Biol. 2011 Nov 18;414(1):96-105. doi: 10.1016/j.jmb.2011.09.037. Epub 2011 Oct 6.


Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.

Rossmann M, Sukumaran M, Penn AC, Veprintsev DB, Babu MM, Greger IH.

EMBO J. 2011 Mar 2;30(5):959-71. doi: 10.1038/emboj.2011.16. Epub 2011 Feb 11.


Dynamics and allosteric potential of the AMPA receptor N-terminal domain.

Sukumaran M, Rossmann M, Shrivastava I, Dutta A, Bahar I, Greger IH.

EMBO J. 2011 Mar 2;30(5):972-82. doi: 10.1038/emboj.2011.17. Epub 2011 Feb 11.


Sculpting AMPA receptor formation and function by alternative RNA processing.

Penn AC, Greger IH.

RNA Biol. 2009 Nov-Dec;6(5):517-21. Epub 2009 Nov 18. Review.


Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum.

Penn AC, Williams SR, Greger IH.

EMBO J. 2008 Nov 19;27(22):3056-68. doi: 10.1038/emboj.2008.222. Epub 2008 Oct 16.


Molecular determinants of AMPA receptor subunit assembly.

Greger IH, Ziff EB, Penn AC.

Trends Neurosci. 2007 Aug;30(8):407-16. Epub 2007 Jul 16. Review.


AMPA receptor biogenesis and trafficking.

Greger IH, Esteban JA.

Curr Opin Neurobiol. 2007 Jun;17(3):289-97. Epub 2007 May 1. Review.


Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis.

Greger IH, Akamine P, Khatri L, Ziff EB.

Neuron. 2006 Jul 6;51(1):85-97. Erratum in: Neuron. 2007 May 3;54(3):491.


AMPA receptor tetramerization is mediated by Q/R editing.

Greger IH, Khatri L, Kong X, Ziff EB.

Neuron. 2003 Nov 13;40(4):763-74.


RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum.

Greger IH, Khatri L, Ziff EB.

Neuron. 2002 May 30;34(5):759-72.


Balancing transcriptional interference and initiation on the GAL7 promoter of Saccharomyces cerevisiae.

Greger IH, Aranda A, Proudfoot N.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8415-20.


In vivo footprinting studies suggest a role for chromatin in transcription of the human 7SK gene.

Boyd DC, Greger IH, Murphy S.

Gene. 2000 Apr 18;247(1-2):33-44.


Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.

Greger IH, Demarchi F, Giacca M, Proudfoot NJ.

Nucleic Acids Res. 1998 Mar 1;26(5):1294-301.

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