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Items: 1 to 50 of 105


A bilobal model of Ca2+-dependent inactivation to probe the physiology of L-type Ca2+ channels.

Limpitikul WB, Greenstein JL, Yue DT, Dick IE, Winslow RL.

J Gen Physiol. 2018 Dec 3;150(12):1688-1701. doi: 10.1085/jgp.201812115. Epub 2018 Nov 23.


Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue.

Walker MA, Gurev V, Rice JJ, Greenstein JL, Winslow RL.

PLoS Comput Biol. 2017 Nov 16;13(11):e1005783. doi: 10.1371/journal.pcbi.1005783. eCollection 2017 Nov.


Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2017 May;106:29-44. doi: 10.1016/j.yjmcc.2017.01.013. Epub 2017 Mar 29.


Modeling Na+-Ca2+ exchange in the heart: Allosteric activation, spatial localization, sparks and excitation-contraction coupling.

Chu L, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2016 Oct;99:174-187. doi: 10.1016/j.yjmcc.2016.06.068. Epub 2016 Jul 2.


Models and Simulations as a Service: Exploring the Use of Galaxy for Delivering Computational Models.

Walker MA, Madduri R, Rodriguez A, Greenstein JL, Winslow RL.

Biophys J. 2016 Mar 8;110(5):1038-43. doi: 10.1016/j.bpj.2015.12.041.


Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2016 Feb;91:215-27. doi: 10.1016/j.yjmcc.2016.01.004. Epub 2016 Jan 7.


Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte.

Winslow RL, Walker MA, Greenstein JL.

Wiley Interdiscip Rev Syst Biol Med. 2016 Jan-Feb;8(1):37-67. doi: 10.1002/wsbm.1322. Epub 2015 Nov 12. Review.


On the Adjacency Matrix of RyR2 Cluster Structures.

Walker MA, Kohl T, Lehnart SE, Greenstein JL, Lederer WJ, Winslow RL.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004521. doi: 10.1371/journal.pcbi.1004521. eCollection 2015 Nov.


Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2015 Nov;88:29-38. doi: 10.1016/j.yjmcc.2015.09.011. Epub 2015 Sep 23.


Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart.

Foteinou PT, Greenstein JL, Winslow RL.

Biophys J. 2015 Aug 18;109(4):838-49. doi: 10.1016/j.bpj.2015.06.064.


Superresolution modeling of calcium release in the heart.

Walker MA, Williams GSB, Kohl T, Lehnart SE, Jafri MS, Greenstein JL, Lederer WJ, Winslow RL.

Biophys J. 2014 Dec 16;107(12):3018-3029. doi: 10.1016/j.bpj.2014.11.003.


Modeling CaMKII-mediated regulation of L-type Ca(2+) channels and ryanodine receptors in the heart.

Greenstein JL, Foteinou PT, Hashambhoy-Ramsay YL, Winslow RL.

Front Pharmacol. 2014 Apr 3;5:60. doi: 10.3389/fphar.2014.00060. eCollection 2014. Review.


An integrated mitochondrial ROS production and scavenging model: implications for heart failure.

Gauthier LD, Greenstein JL, O'Rourke B, Winslow RL.

Biophys J. 2013 Dec 17;105(12):2832-42. doi: 10.1016/j.bpj.2013.11.007.


A computational model of reactive oxygen species and redox balance in cardiac mitochondria.

Gauthier LD, Greenstein JL, Cortassa S, O'Rourke B, Winslow RL.

Biophys J. 2013 Aug 20;105(4):1045-56. doi: 10.1016/j.bpj.2013.07.006.


Extinguishing the sparks.

Winslow RL, Greenstein JL.

Biophys J. 2013 May 21;104(10):2115-7. doi: 10.1016/j.bpj.2013.04.010. No abstract available.


Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure.

Aiba T, Barth AS, Hesketh GG, Hashambhoy YL, Chakir K, Tunin RS, Greenstein JL, Winslow RL, Kass DA, Tomaselli GF.

Circ Arrhythm Electrophysiol. 2013 Jun;6(3):546-54. doi: 10.1161/CIRCEP.113.000400. Epub 2013 May 6.


Surrogate insulin-producing cells.

Wong AL, Hwa A, Hellman D, Greenstein JL.

F1000 Med Rep. 2012;4:15. doi: 10.3410/M4-15. Epub 2012 Aug 1.


Toward an integrative computational model of the Guinea pig cardiac myocyte.

Gauthier LD, Greenstein JL, Winslow RL.

Front Physiol. 2012 Jul 5;3:244. doi: 10.3389/fphys.2012.00244. eCollection 2012.


CaMKII-dependent activation of late INa contributes to cellular arrhythmia in a model of the cardiac myocyte.

Hashambhoy YL, Winslow RL, Greenstein JL.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4665-8. doi: 10.1109/IEMBS.2011.6091155.


Cardiac myocytes and local signaling in nano-domains.

Winslow RL, Greenstein JL.

Prog Biophys Mol Biol. 2011 Oct;107(1):48-59. doi: 10.1016/j.pbiomolbio.2011.06.005. Epub 2011 Jun 21. Review.


Integrative systems models of cardiac excitation-contraction coupling.

Greenstein JL, Winslow RL.

Circ Res. 2011 Jan 7;108(1):70-84. doi: 10.1161/CIRCRESAHA.110.223578. Review.


Integrative modeling of the cardiac ventricular myocyte.

Winslow RL, Cortassa S, O'Rourke B, Hashambhoy YL, Rice JJ, Greenstein JL.

Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug;3(4):392-413. doi: 10.1002/wsbm.122. Epub 2010 Sep 23. Review.


Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model.

Hashambhoy YL, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2010 Oct;49(4):617-24. doi: 10.1016/j.yjmcc.2010.07.011. Epub 2010 Jul 23.


Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450. 1989.

Porcelli S, Brenner MB, Greenstein JL, Terhorst C, Balk SP, Bleicher PA.

J Immunol. 2010 Apr 1;184(7):3306-9. No abstract available.


Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization.

Maleckar MM, Greenstein JL, Giles WR, Trayanova NA.

Biophys J. 2009 Oct 21;97(8):2179-90. doi: 10.1016/j.bpj.2009.07.054.


K+ current changes account for the rate dependence of the action potential in the human atrial myocyte.

Maleckar MM, Greenstein JL, Giles WR, Trayanova NA.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1398-410. doi: 10.1152/ajpheart.00411.2009. Epub 2009 Jul 24.


CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study.

Hashambhoy YL, Winslow RL, Greenstein JL.

Biophys J. 2009 Mar 4;96(5):1770-85. doi: 10.1016/j.bpj.2008.11.055.


Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium.

Maleckar MM, Greenstein JL, Trayanova NA, Giles WR.

Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):161-70. doi: 10.1016/j.pbiomolbio.2009.01.010. Epub 2009 Jan 30.


From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales.

Plank G, Zhou L, Greenstein JL, Cortassa S, Winslow RL, O'Rourke B, Trayanova NA.

Philos Trans A Math Phys Eng Sci. 2008 Sep 28;366(1879):3381-409. doi: 10.1098/rsta.2008.0112. Review.


Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release.

Tanskanen AJ, Greenstein JL, Chen A, Sun SX, Winslow RL.

Biophys J. 2007 May 15;92(10):3379-96. Epub 2007 Feb 26.


Multiscale modeling of calcium signaling in the cardiac dyad.

Winslow RL, Tanskanen A, Chen M, Greenstein JL.

Ann N Y Acad Sci. 2006 Oct;1080:362-75.


Multi-scale models of local control of calcium induced calcium release.

Hinch R, Greenstein JL, Winslow RL.

Prog Biophys Mol Biol. 2006 Jan-Apr;90(1-3):136-50. Review.


Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte.

Greenstein JL, Hinch R, Winslow RL.

Biophys J. 2006 Jan 1;90(1):77-91. Epub 2005 Oct 7.


Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.

Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Houser SL, Sanderson TM, Lancos CJ, Prabharasuth DD, Cheng J, Moran K, Hisashi Y, Mueller N, Yamada K, Greenstein JL, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Schuurman HJ, Sachs DH, Cooper DK.

Nat Med. 2005 Jan;11(1):29-31. Epub 2004 Dec 26.


Using models of the myocyte for functional interpretation of cardiac proteomic data.

Winslow RL, Cortassa S, Greenstein JL.

J Physiol. 2005 Feb 15;563(Pt 1):73-81. Epub 2004 Dec 20. Review.


The ongoing journey to understand heart function through integrative modeling.

Winslow RL, Greenstein JL.

Circ Res. 2004 Dec 10;95(12):1135-6. No abstract available.


The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations.

Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL.

Biophys J. 2005 Jan;88(1):85-95. Epub 2004 Oct 22.


A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes.

Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL.

Biophys J. 2004 Dec;87(6):3723-36. Epub 2004 Oct 1.


Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes.

Greenstein JL, Tanskanen AJ, Winslow RL.

Ann N Y Acad Sci. 2004 May;1015:16-27.


Porcine endogenous retrovirus transmission characteristics of galactose alpha1-3 galactose-deficient pig cells.

Quinn G, Wood JC, Ryan DJ, Suling KM, Moran KM, Kolber-Simonds DL, Greenstein JL, Schuurman HJ, Hawley RJ, Patience C.

J Virol. 2004 Jun;78(11):5805-11.


Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations.

Kolber-Simonds D, Lai L, Watt SR, Denaro M, Arn S, Augenstein ML, Betthauser J, Carter DB, Greenstein JL, Hao Y, Im GS, Liu Z, Mell GD, Murphy CN, Park KW, Rieke A, Ryan DJ, Sachs DH, Forsberg EJ, Prather RS, Hawley RJ.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7335-40. Epub 2004 May 3.


Transgenic swine for biomedicine and agriculture.

Prather RS, Hawley RJ, Carter DB, Lai L, Greenstein JL.

Theriogenology. 2003 Jan 1;59(1):115-23. Review.


Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine.

Oldmixon BA, Wood JC, Ericsson TA, Wilson CA, White-Scharf ME, Andersson G, Greenstein JL, Schuurman HJ, Patience C.

J Virol. 2002 Mar;76(6):3045-8.


Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

Lai L, Kolber-Simonds D, Park KW, Cheong HT, Greenstein JL, Im GS, Samuel M, Bonk A, Rieke A, Day BN, Murphy CN, Carter DB, Hawley RJ, Prather RS.

Science. 2002 Feb 8;295(5557):1089-92. Epub 2002 Jan 3.


Xenotransplantation: a review of current issues.

Greenstein JL, White-Scharf M.

J Biolaw Bus. 1998 Autumn;2(1):46-50. No abstract available.


Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis.

Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB.

Circ Res. 2001 Jul 6;89(1):33-8.


Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration.

Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL.

Circ Res. 2000 Nov 24;87(11):1026-33.


Production of transgenic porcine blastocysts by nuclear transfer.

Kühholzer B, Tao T, Machaty Z, Hawley RJ, Greenstein JL, Day BN, Prather RS.

Mol Reprod Dev. 2000 Jun;56(2):145-8.


Current and future prospects for xenotransplantation.

French AJ, Greenstein JL, Loveland BE, Mountford PS.

Reprod Fertil Dev. 1998;10(7-8):683-96. Review.


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