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Regulation of musculoskeletal tissues in ageing and health: the human perspective - Celebrating the research of Professor Mike Rennie.

Greenhaff PL.

J Physiol. 2019 Mar;597(5):1233. doi: 10.1113/JP276972. No abstract available.


Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans.

Gaffney CJ, Pollard A, Barratt TF, Constantin-Teodosiu D, Greenhaff PL, Szewczyk NJ.

Aging (Albany NY). 2018 Nov 19;10(11):3382-3396. doi: 10.18632/aging.101654.


The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points.

Crossland H, Skirrow S, Puthucheary ZA, Constantin-Teodosiu D, Greenhaff PL.

J Physiol. 2019 Mar;597(5):1259-1270. doi: 10.1113/JP275444. Epub 2018 Aug 18.


Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake.

Constantin-Teodosiu D, Cederblad G, Bergström M, Greenhaff PL.

Clin Nutr. 2019 Apr;38(2):948-953. doi: 10.1016/j.clnu.2018.02.001. Epub 2018 Feb 15.


Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance.

Handzlik MK, Constantin-Teodosiu D, Greenhaff PL, Cole MA.

J Physiol. 2018 Aug;596(15):3357-3369. doi: 10.1113/JP275357. Epub 2018 Mar 5.


Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.

Varadhan KK, Constantin-Teodosiu D, Constantin D, Greenhaff PL, Lobo DN.

Clin Nutr. 2018 Dec;37(6 Pt A):2178-2185. doi: 10.1016/j.clnu.2017.10.020. Epub 2017 Nov 2.


Response to the letter to editor by Dankel et al. 2017 "Changes in muscle size via MRI and ultrasound: Are they equivalent?"

Franchi MV, Greenhaff PL, Narici MV.

Scand J Med Sci Sports. 2018 Apr;28(4):1469. doi: 10.1111/sms.13010. Epub 2017 Nov 22. No abstract available.


Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women.

Wilkinson DJ, Bukhari SSI, Phillips BE, Limb MC, Cegielski J, Brook MS, Rankin D, Mitchell WK, Kobayashi H, Williams JP, Lund J, Greenhaff PL, Smith K, Atherton PJ.

Clin Nutr. 2018 Dec;37(6 Pt A):2011-2021. doi: 10.1016/j.clnu.2017.09.008. Epub 2017 Sep 23.


Muscle and Tendon Contributions to Reduced Rate of Torque Development in Healthy Older Males.

Quinlan JI, Maganaris CN, Franchi MV, Smith K, Atherton PJ, Szewczyk NJ, Greenhaff PL, Phillips BE, Blackwell JI, Boereboom C, Williams JP, Lund J, Narici MV.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):539-545. doi: 10.1093/gerona/glx149.


Physiological adaptations to resistance exercise as a function of age.

Phillips BE, Williams JP, Greenhaff PL, Smith K, Atherton PJ.

JCI Insight. 2017 Sep 7;2(17). pii: 95581. doi: 10.1172/jci.insight.95581. eCollection 2017 Sep 7.


A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle.

Brook MS, Wilkinson DJ, Mitchell WK, Lund JL, Phillips BE, Szewczyk NJ, Kainulainen H, Lensu S, Koch LG, Britton SL, Greenhaff PL, Smith K, Atherton PJ.

Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E681-E689. doi: 10.1152/ajpendo.00157.2017. Epub 2017 Aug 15.


Muscle thickness correlates to muscle cross-sectional area in the assessment of strength training-induced hypertrophy.

Franchi MV, Longo S, Mallinson J, Quinlan JI, Taylor T, Greenhaff PL, Narici MV.

Scand J Med Sci Sports. 2018 Mar;28(3):846-853. doi: 10.1111/sms.12961. Epub 2017 Sep 21.


Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent.

Porter C, Constantin-Teodosiu D, Constantin D, Leighton B, Poucher SM, Greenhaff PL.

J Physiol. 2017 Sep 1;595(17):5765-5780. doi: 10.1113/JP274415. Epub 2017 Jul 16.


Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats.

Crossland H, Constantin-Teodosiu D, Gardiner SM, Greenhaff PL.

Clin Sci (Lond). 2017 Jun 22;131(13):1437-1447. doi: 10.1042/CS20170958. Print 2017 Jul 1.


Increasing skeletal muscle carnitine availability does not alter the adaptations to high-intensity interval training.

Shannon CE, Ghasemi R, Greenhaff PL, Stephens FB.

Scand J Med Sci Sports. 2018 Jan;28(1):107-115. doi: 10.1111/sms.12885. Epub 2017 May 12.


Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.

Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Phillips BE, Szewczyk NJ, Greenhaff PL, Smith K, Atherton PJ.

J Physiol. 2016 Dec 15;594(24):7399-7417. doi: 10.1113/JP272857. Epub 2016 Nov 7.


Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance-A Qualitative Review.

Rudrappa SS, Wilkinson DJ, Greenhaff PL, Smith K, Idris I, Atherton PJ.

Front Physiol. 2016 Aug 25;7:361. doi: 10.3389/fphys.2016.00361. eCollection 2016. Review.


Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle.

Gaffney CJ, Shephard F, Chu J, Baillie DL, Rose A, Constantin-Teodosiu D, Greenhaff PL, Szewczyk NJ.

J Cachexia Sarcopenia Muscle. 2016 May;7(2):181-92. doi: 10.1002/jcsm.12040. Epub 2015 Jun 4.


Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence.

Atherton PJ, Greenhaff PL, Phillips SM, Bodine SC, Adams CM, Lang CH.

Am J Physiol Endocrinol Metab. 2016 Sep 1;311(3):E594-604. doi: 10.1152/ajpendo.00257.2016. Epub 2016 Jul 5. Review.


Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24 h of recovery following prolonged exhaustive exercise in humans.

Roberts PA, Fox J, Peirce N, Jones SW, Casey A, Greenhaff PL.

Amino Acids. 2016 Aug;48(8):1831-42. doi: 10.1007/s00726-016-2252-x. Epub 2016 May 19.


The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle.

Vigelsø A, Gram M, Dybboe R, Kuhlman AB, Prats C, Greenhaff PL, Constantin-Teodosiu D, Birk JB, Wojtaszewski JF, Dela F, Helge JW.

J Physiol. 2016 Apr 15;594(8):2339-58. doi: 10.1113/JP271712. Epub 2016 Mar 4.


Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals.

Chee C, Shannon CE, Burns A, Selby AL, Wilkinson D, Smith K, Greenhaff PL, Stephens FB.

Diabetes. 2016 Apr;65(4):840-50. doi: 10.2337/db15-1383. Epub 2016 Jan 6.


Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men.

Shannon CE, Nixon AV, Greenhaff PL, Stephens FB.

Am J Clin Nutr. 2016 Jan;103(1):276-82. doi: 10.3945/ajcn.115.119826. Epub 2015 Dec 16.


Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling.

Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Szewczyk NJ, Greenhaff PL, Smith K, Atherton PJ.

FASEB J. 2015 Nov;29(11):4485-96. doi: 10.1096/fj.15-273755. Epub 2015 Jul 13.


Obesity Appears to Be Associated With Altered Muscle Protein Synthetic and Breakdown Responses to Increased Nutrient Delivery in Older Men, but Not Reduced Muscle Mass or Contractile Function.

Murton AJ, Marimuthu K, Mallinson JE, Selby AL, Smith K, Rennie MJ, Greenhaff PL.

Diabetes. 2015 Sep;64(9):3160-71. doi: 10.2337/db15-0021. Epub 2015 May 26.


Application of deuterium oxide (D2O) to metabolic research: just D2O it? Depends just how you D2O it!

Wilkinson DJ, Atherton PJ, Phillips BE, Greenhaff PL, Smith K.

Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E847. doi: 10.1152/ajpendo.00581.2014. No abstract available.


Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise.

Bukhari SS, Phillips BE, Wilkinson DJ, Limb MC, Rankin D, Mitchell WK, Kobayashi H, Greenhaff PL, Smith K, Atherton PJ.

Am J Physiol Endocrinol Metab. 2015 Jun 15;308(12):E1056-65. doi: 10.1152/ajpendo.00481.2014. Epub 2015 Mar 31.


Age is just a number! Or is it?

Atherton PJ, Greenhaff PL.

J Physiol. 2015 Feb 1;593(3):491-2. No abstract available.


Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.

Mallinson JE, Marimuthu K, Murton A, Selby A, Smith K, Constantin-Teodosiu D, Rennie MJ, Greenhaff PL.

J Physiol. 2015 Mar 1;593(5):1239-57. doi: 10.1113/jphysiol.2014.285577. Epub 2015 Jan 26.


Perpetual muscle PDH activation in PDH kinase knockout mice protects against high-fat feeding-induced muscle insulin resistance.

Constantin-Teodosiu D, Stephens FB, Greenhaff PL.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E824. doi: 10.1073/pnas.1422929112. Epub 2015 Jan 23. No abstract available.


The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans.

Etheridge T, Rahman M, Gaffney CJ, Shaw D, Shephard F, Magudia J, Solomon DE, Milne T, Blawzdziewicz J, Constantin-Teodosiu D, Greenhaff PL, Vanapalli SA, Szewczyk NJ.

FASEB J. 2015 Apr;29(4):1235-46. doi: 10.1096/fj.14-259119. Epub 2014 Dec 9.


Pre-Operative nutrition In Neck of femur Trial (POINT)--carbohydrate loading in patients with fragility hip fracture: study protocol for a randomised controlled trial.

Moppett IK, Greenhaff PL, Ollivere BJ, Joachim T, Lobo DN, Rowlands M.

Trials. 2014 Dec 4;15:475. doi: 10.1186/1745-6215-15-475.


A validation of the application of D(2)O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.

Wilkinson DJ, Franchi MV, Brook MS, Narici MV, Williams JP, Mitchell WK, Szewczyk NJ, Greenhaff PL, Atherton PJ, Smith K.

Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E571-9. doi: 10.1152/ajpendo.00650.2013. Epub 2013 Dec 31.


Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training.

Murton AJ, Billeter R, Stephens FB, Des Etages SG, Graber F, Hill RJ, Marimuthu K, Greenhaff PL.

J Appl Physiol (1985). 2014 Jan 1;116(1):113-25. doi: 10.1152/japplphysiol.00426.2013. Epub 2013 Nov 21.


Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans.

Stephens FB, Wall BT, Marimuthu K, Shannon CE, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL.

J Physiol. 2013 Sep 15;591(18):4655-66. doi: 10.1113/jphysiol.2013.255364. Epub 2013 Jul 1.


Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks.

Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG, Goodyear LJ.

Diabetes. 2013 Aug;62(8):2717-27. doi: 10.2337/db13-0062. Epub 2013 Apr 22.


Impaired muscle mitochondrial density and/or function: a COPD-specific mitochondropathy or simply deconditioning?

Lazaar AL, Greenhaff PL.

Eur Respir J. 2012 Nov;40(5):1070-1. doi: 10.1183/09031936.00051012. No abstract available.


Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.

Mallinson JE, Constantin-Teodosiu D, Glaves PD, Martin EA, Davies WJ, Westwood FR, Sidaway JE, Greenhaff PL.

J Physiol. 2012 Dec 15;590(24):6389-402. doi: 10.1113/jphysiol.2012.238022. Epub 2012 Oct 8.


Dietary supplements for athletes: emerging trends and recurring themes.

Maughan RJ, Greenhaff PL, Hespel P.

J Sports Sci. 2011;29 Suppl 1:S57-66. doi: 10.1080/02640414.2011.587446.


Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humans.

Wall BT, Stephens FB, Marimuthu K, Constantin-Teodosiu D, Macdonald IA, Greenhaff PL.

J Appl Physiol (1985). 2012 Jan;112(2):272-8. doi: 10.1152/japplphysiol.00807.2011. Epub 2011 Nov 3.


Vegetarians have a reduced skeletal muscle carnitine transport capacity.

Stephens FB, Marimuthu K, Cheng Y, Patel N, Constantin D, Simpson EJ, Greenhaff PL.

Am J Clin Nutr. 2011 Sep;94(3):938-44. doi: 10.3945/ajcn.111.012047. Epub 2011 Jul 13.


Novel events in the molecular regulation of muscle mass in critically ill patients.

Constantin D, McCullough J, Mahajan RP, Greenhaff PL.

J Physiol. 2011 Aug 1;589(Pt 15):3883-95. doi: 10.1113/jphysiol.2011.206193. Epub 2011 Jun 13.


Applications of multi-nuclear magnetic resonance spectroscopy at 7T.

Stephenson MC, Gunner F, Napolitano A, Greenhaff PL, Macdonald IA, Saeed N, Vennart W, Francis ST, Morris PG.

World J Radiol. 2011 Apr 28;3(4):105-13. doi: 10.4329/wjr.v3.i4.105.


Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans.

Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL.

J Physiol. 2011 Feb 15;589(Pt 4):963-73. doi: 10.1113/jphysiol.2010.201343. Epub 2011 Jan 4.


'Systems biology' in human exercise physiology: is it something different from integrative physiology?

Greenhaff PL, Hargreaves M.

J Physiol. 2011 Mar 1;589(Pt 5):1031-6. doi: 10.1113/jphysiol.2010.201525. Epub 2011 Jan 10. Review.


Mechanisms regulating muscle mass during disuse atrophy and rehabilitation in humans.

Marimuthu K, Murton AJ, Greenhaff PL.

J Appl Physiol (1985). 2011 Feb;110(2):555-60. doi: 10.1152/japplphysiol.00962.2010. Epub 2010 Oct 28. Review.


Regulation of human metabolism by hypoxia-inducible factor.

Formenti F, Constantin-Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington KL, Edwards LM, Humphreys SM, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Ratcliffe PJ, Smith TG, Treacy M, Frayn KN, Greenhaff PL, Karpe F, Clarke K, Robbins PA.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12722-7. doi: 10.1073/pnas.1002339107. Epub 2010 Jun 28.


Low-dose dexamethasone prevents endotoxaemia-induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle.

Crossland H, Constantin-Teodosiu D, Greenhaff PL, Gardiner SM.

J Physiol. 2010 Apr 15;588(Pt 8):1333-47. doi: 10.1113/jphysiol.2009.183699. Epub 2010 Feb 22.

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