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Items: 1 to 50 of 911

1.

Reactive Dopamine Leads to Triple Trouble in Nigral Neurons.

Riessland M, Kolisnyk B, Greengard P.

Biochemistry. 2017 Dec 12;56(49):6409-6410. doi: 10.1021/acs.biochem.7b01057. Epub 2017 Nov 30. No abstract available.

PMID:
29188990
2.

CK2 regulates 5-HT4 receptor signaling and modulates depressive-like behavior.

Castello J, LeFrancois B, Flajolet M, Greengard P, Friedman E, Rebholz H.

Mol Psychiatry. 2018 Apr;23(4):872-882. doi: 10.1038/mp.2017.240. Epub 2017 Nov 21.

PMID:
29158580
3.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

PMID:
29144972
4.

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.

Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, Soya H, Ni J, Brichta L, Greengard P, Neve RL, Lee FS, McEwen BS.

Neuron. 2017 Oct 11;96(2):402-413.e5. doi: 10.1016/j.neuron.2017.09.020.

PMID:
29024663
5.

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements.

Pirhaji L, Milani P, Dalin S, Wassie BT, Dunn DE, Fenster RJ, Avila-Pacheco J, Greengard P, Clish CB, Heiman M, Lo DC, Fraenkel E.

Nat Commun. 2017 Sep 20;8(1):623. doi: 10.1038/s41467-017-00353-6.

6.

Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.

Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A, Greengard P.

Neuron. 2017 Aug 2;95(3):564-576.e4. doi: 10.1016/j.neuron.2017.06.044. Epub 2017 Jul 20.

7.

Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.

Musante V, Li L, Kanyo J, Lam TT, Colangelo CM, Cheng SK, Brody AH, Greengard P, Le Novère N, Nairn AC.

Elife. 2017 Jun 14;6. pii: e24998. doi: 10.7554/eLife.24998.

8.

Bidirectional regulation of Aβ levels by Presenilin 1.

Bustos V, Pulina MV, Kelahmetoglu Y, Sinha SC, Gorelick FS, Flajolet M, Greengard P.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7142-7147. doi: 10.1073/pnas.1705235114. Epub 2017 May 22.

9.

Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.

Bustos V, Pulina MV, Bispo A, Lam A, Flajolet M, Gorelick FS, Greengard P.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7148-7153. doi: 10.1073/pnas.1705240114. Epub 2017 May 22.

10.

Elevation of p11 in lateral habenula mediates depression-like behavior.

Seo JS, Zhong P, Liu A, Yan Z, Greengard P.

Mol Psychiatry. 2018 May;23(5):1113-1119. doi: 10.1038/mp.2017.96. Epub 2017 May 16.

11.

Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia.

Devor A, Andreassen OA, Wang Y, Mäki-Marttunen T, Smeland OB, Fan CC, Schork AJ, Holland D, Thompson WK, Witoelar A, Chen CH, Desikan RS, McEvoy LK, Djurovic S, Greengard P, Svenningsson P, Einevoll GT, Dale AM.

Mol Psychiatry. 2017 Jun;22(6):792-801. doi: 10.1038/mp.2017.33. Epub 2017 Mar 28. Review.

12.

ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).

Andrade EC, Musante V, Horiuchi A, Matsuzaki H, Brody AH, Wu T, Greengard P, Taylor JR, Nairn AC.

J Neurosci. 2017 Mar 8;37(10):2709-2722. doi: 10.1523/JNEUROSCI.4559-15.2017. Epub 2017 Feb 6.

13.

Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.

Green H, Zhang X, Tiklova K, Volakakis N, Brodin L, Berg L, Greengard P, Perlmann T, Svenningsson P.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2735-2740. doi: 10.1073/pnas.1621218114. Epub 2017 Jan 30.

14.

Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage.

Netzer WJ, Bettayeb K, Sinha SC, Flajolet M, Greengard P, Bustos V.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1389-1394. doi: 10.1073/pnas.1620963114. Epub 2017 Jan 23.

15.

WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine.

Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1395-1400. doi: 10.1073/pnas.1621185114. Epub 2017 Jan 23.

16.

Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons.

Estep CM, Galtieri DJ, Zampese E, Goldberg JA, Brichta L, Greengard P, Surmeier DJ.

PLoS One. 2016 Dec 30;11(12):e0169044. doi: 10.1371/journal.pone.0169044. eCollection 2016.

17.

Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution.

Nishi A, Matamales M, Musante V, Valjent E, Kuroiwa M, Kitahara Y, Rebholz H, Greengard P, Girault JA, Nairn AC.

J Biol Chem. 2017 Jan 27;292(4):1462-1476. doi: 10.1074/jbc.M116.752402. Epub 2016 Dec 20.

18.

Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain.

Milosevic A, Liebmann T, Knudsen M, Schintu N, Svenningsson P, Greengard P.

J Comp Neurol. 2017 Mar 1;525(4):955-975. doi: 10.1002/cne.24113. Epub 2016 Oct 21.

19.

Cellular and molecular basis for stress-induced depression.

Seo JS, Wei J, Qin L, Kim Y, Yan Z, Greengard P.

Mol Psychiatry. 2017 Oct;22(10):1440-1447. doi: 10.1038/mp.2016.118. Epub 2016 Jul 26.

20.

Three-Dimensional Study of Alzheimer's Disease Hallmarks Using the iDISCO Clearing Method.

Liebmann T, Renier N, Bettayeb K, Greengard P, Tessier-Lavigne M, Flajolet M.

Cell Rep. 2016 Jul 26;16(4):1138-1152. doi: 10.1016/j.celrep.2016.06.060. Epub 2016 Jul 14.

21.

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.

Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ.

Neuron. 2016 Jun 1;90(5):1139. doi: 10.1016/j.neuron.2016.05.017. No abstract available.

22.

Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.

Li Z, Kelly L, Heiman M, Greengard P, Friedman JM.

Cell Metab. 2016 May 10;23(5):945. doi: 10.1016/j.cmet.2016.04.014. No abstract available.

23.

Relevance of the COPI complex for Alzheimer's disease progression in vivo.

Bettayeb K, Hooli BV, Parrado AR, Randolph L, Varotsis D, Aryal S, Gresack J, Tanzi RE, Greengard P, Flajolet M.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5418-23. doi: 10.1073/pnas.1604176113. Epub 2016 Apr 25.

24.

δ-COP modulates Aβ peptide formation via retrograde trafficking of APP.

Bettayeb K, Chang JC, Luo W, Aryal S, Varotsis D, Randolph L, Netzer WJ, Greengard P, Flajolet M.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5412-7. doi: 10.1073/pnas.1604156113. Epub 2016 Apr 25.

25.

Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice.

Thanos PK, Malave L, Delis F, Mangine P, Kane K, Grunseich A, Vitale M, Greengard P, Volkow ND.

Synapse. 2016 Jul;70(7):293-301. doi: 10.1002/syn.21904. Epub 2016 May 4.

PMID:
26990537
26.

Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.

Marongiu R, Arango-Lievano M, Francardo V, Morgenstern P, Zhang X, Cenci MA, Svenningsson P, Greengard P, Kaplitt MG.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1423-8. doi: 10.1073/pnas.1524387113. Epub 2016 Jan 19.

27.

p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism.

Schintu N, Zhang X, Alvarsson A, Marongiu R, Kaplitt MG, Greengard P, Svenningsson P.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1429-34. doi: 10.1073/pnas.1524303113. Epub 2016 Jan 19.

28.

Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum.

Virk MS, Sagi Y, Medrihan L, Leung J, Kaplitt MG, Greengard P.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):734-9. doi: 10.1073/pnas.1524183113. Epub 2016 Jan 5.

29.

Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.

Li Z, Kelly L, Heiman M, Greengard P, Friedman JM.

Cell Metab. 2015 Dec 1;22(6):1059-67. doi: 10.1016/j.cmet.2015.10.012. Epub 2015 Nov 19.

30.

DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.

Engmann O, Giralt A, Gervasi N, Marion-Poll L, Gasmi L, Filhol O, Picciotto MR, Gilligan D, Greengard P, Nairn AC, Hervé D, Girault JA.

Nat Commun. 2015 Dec 7;6:10099. doi: 10.1038/ncomms10099.

31.

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.

Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ.

Neuron. 2015 Nov 18;88(4):762-73. doi: 10.1016/j.neuron.2015.10.039.

32.

p11 regulates the surface localization of mGluR5.

Lee KW, Westin L, Kim J, Chang JC, Oh YS, Amreen B, Gresack J, Flajolet M, Kim D, Aperia A, Kim Y, Greengard P.

Mol Psychiatry. 2015 Dec;20(12):1485. doi: 10.1038/mp.2015.171. No abstract available.

PMID:
26577667
33.

Alteration by p11 of mGluR5 localization regulates depression-like behaviors.

Lee KW, Westin L, Kim J, Chang JC, Oh YS, Amreen B, Gresack J, Flajolet M, Kim D, Aperia A, Kim Y, Greengard P.

Mol Psychiatry. 2015 Dec;20(12):1546-56. doi: 10.1038/mp.2015.132. Epub 2015 Sep 15.

34.

APP intracellular domain-WAVE1 pathway reduces amyloid-β production.

Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y.

Nat Med. 2015 Sep;21(9):1054-9. doi: 10.1038/nm.3924. Epub 2015 Aug 17.

35.

Identification of neurodegenerative factors using translatome-regulatory network analysis.

Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P.

Nat Neurosci. 2015 Sep;18(9):1325-33. doi: 10.1038/nn.4070. Epub 2015 Jul 27.

36.

Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice.

Wang H, Warner-Schmidt J, Varela S, Enikolopov G, Greengard P, Flajolet M.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9745-50. doi: 10.1073/pnas.1510291112. Epub 2015 Jul 20.

37.

The role of ventral striatal cAMP signaling in stress-induced behaviors.

Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD, Bibb JA.

Nat Neurosci. 2015 Aug;18(8):1094-100. doi: 10.1038/nn.4066. Epub 2015 Jul 20.

38.

Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol-Mediated Induction of ΔFosB in the Mouse Forebrain.

Lazenka MF, Tomarchio AJ, Lichtman AH, Greengard P, Flajolet M, Selley DE, Sim-Selley LJ.

J Pharmacol Exp Ther. 2015 Sep;354(3):316-27. doi: 10.1124/jpet.115.224428. Epub 2015 Jun 22.

39.

Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function.

Uematsu K, Heiman M, Zelenina M, Padovan J, Chait BT, Aperia A, Nishi A, Greengard P.

J Neurochem. 2015 Mar;132(6):677-86. doi: 10.1111/jnc.13038. Epub 2015 Mar 4.

40.

Molecular determinants of selective dopaminergic vulnerability in Parkinson's disease: an update.

Brichta L, Greengard P.

Front Neuroanat. 2014 Dec 15;8:152. doi: 10.3389/fnana.2014.00152. eCollection 2014. Review.

41.

Nitric oxide regulates synaptic transmission between spiny projection neurons.

Sagi Y, Heiman M, Peterson JD, Musatov S, Scarduzio M, Logan SM, Kaplitt MG, Surmeier DJ, Heintz N, Greengard P.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17636-41. doi: 10.1073/pnas.1420162111. Epub 2014 Nov 20. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1811.

42.

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia.

Fieblinger T, Graves SM, Sebel LE, Alcacer C, Plotkin JL, Gertler TS, Chan CS, Heiman M, Greengard P, Cenci MA, Surmeier DJ.

Nat Commun. 2014 Oct 31;5:5316. doi: 10.1038/ncomms6316.

43.

Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.

Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ.

PLoS Biol. 2014 Aug 5;12(8):e1001923. doi: 10.1371/journal.pbio.1001923. eCollection 2014 Aug.

44.

Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease.

Plotkin JL, Day M, Peterson JD, Xie Z, Kress GJ, Rafalovich I, Kondapalli J, Gertler TS, Flajolet M, Greengard P, Stavarache M, Kaplitt MG, Rosinski J, Chan CS, Surmeier DJ.

Neuron. 2014 Jul 2;83(1):178-88. doi: 10.1016/j.neuron.2014.05.032.

45.

Ischemic stroke injury is mediated by aberrant Cdk5.

Meyer DA, Torres-Altoro MI, Tan Z, Tozzi A, Di Filippo M, DiNapoli V, Plattner F, Kansy JW, Benkovic SA, Huber JD, Miller DB, Greengard P, Calabresi P, Rosen CL, Bibb JA.

J Neurosci. 2014 Jun 11;34(24):8259-67. doi: 10.1523/JNEUROSCI.4368-13.2014.

46.

Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP).

Heiman M, Kulicke R, Fenster RJ, Greengard P, Heintz N.

Nat Protoc. 2014;9(6):1282-91. doi: 10.1038/nprot.2014.085. Epub 2014 May 8.

47.

Cell-type specific expression of p11 controls cocaine reward.

Arango-Lievano M, Schwarz JT, Vernov M, Wilkinson MB, Bradbury K, Feliz A, Marongiu R, Gelfand Y, Warner-Schmidt J, Nestler EJ, Greengard P, Russo SJ, Kaplitt MG.

Biol Psychiatry. 2014 Nov 15;76(10):794-801. doi: 10.1016/j.biopsych.2014.02.012. Epub 2014 Feb 26.

48.

Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram.

Svenningsson P, Berg L, Matthews D, Ionescu DF, Richards EM, Niciu MJ, Malinger A, Toups M, Manji H, Trivedi MH, Zarate CA Jr, Greengard P.

Mol Psychiatry. 2014 Sep;19(9):962-4. doi: 10.1038/mp.2014.13. Epub 2014 Mar 11. No abstract available.

49.

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia.

Heiman M, Heilbut A, Francardo V, Kulicke R, Fenster RJ, Kolaczyk ED, Mesirov JP, Surmeier DJ, Cenci MA, Greengard P.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4578-83. doi: 10.1073/pnas.1401819111. Epub 2014 Mar 5.

50.

The convergence of endosomal and autophagosomal pathways: implications for APP-CTF degradation.

Tian Y, Chang JC, Greengard P, Flajolet M.

Autophagy. 2014 Apr;10(4):694-6. doi: 10.4161/auto.27802. Epub 2014 Jan 16.

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