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A new mechanism for Cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models.

Perry CJ, Finch P, Müller-Taubenberger A, Leung KY, Warren EC, Damstra-Oddy J, Sharma D, Patra PH, Glyn S, Boberska J, Stewart B, Baldwin A, Piscitelli F, Harvey RJ, Harwood A, Thompson C, Claus S, Greene NDE, McNeish A, Williams CM, Whalley BJ, Williams RSB.

Br J Pharmacol. 2019 Nov 6. doi: 10.1111/bph.14892. [Epub ahead of print]


Cellular mechanisms underlying Pax3-related neural tube defects and their prevention by folic acid.

Sudiwala S, Palmer A, Massa V, Burns AJ, Dunlevy LPE, De Castro SCP, Savery D, Leung KY, Copp AJ, Greene NDE.

Dis Model Mech. 2019 Oct 21. pii: dmm.042234. doi: 10.1242/dmm.042234. [Epub ahead of print]


Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects.

Rolo A, Galea GL, Savery D, Greene NDE, Copp AJ.

Dis Model Mech. 2019 Oct 18. pii: dmm.040683. doi: 10.1242/dmm.040683. [Epub ahead of print]


Mouse whole embryo culture: Evaluating the requirement for rat serum as culture medium.

Culshaw LH, Savery D, Greene NDE, Copp AJ.

Birth Defects Res. 2019 Oct 1;111(16):1165-1177. doi: 10.1002/bdr2.1538. Epub 2019 Jun 24.


Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure.

Butler MB, Short NE, Maniou E, Alexandre P, Greene NDE, Copp AJ, Galea GL.

J Cell Sci. 2019 Jul 1;132(13). pii: jcs230300. doi: 10.1242/jcs.230300.


Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.

Nikolopoulou E, Hirst CS, Galea G, Venturini C, Moulding D, Marshall AR, Rolo A, De Castro SCP, Copp AJ, Greene NDE.

Nat Commun. 2019 Jun 6;10(1):2487. doi: 10.1038/s41467-019-10164-6.


Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons.

Lin S, Ren A, Wang L, Santos C, Huang Y, Jin L, Li Z, Greene NDE.

Clin Epigenetics. 2019 Jan 21;11(1):13. doi: 10.1186/s13148-019-0611-7.


Glycine decarboxylase deficiency-induced motor dysfunction in zebrafish is rescued by counterbalancing glycine synaptic level.

Riché R, Liao M, Pena IA, Leung KY, Lepage N, Greene NDE, Sarafoglou K, Schimmenti LA, Drapeau P, Samarut É.

JCI Insight. 2018 Nov 2;3(21). pii: 124642. doi: 10.1172/jci.insight.124642.


Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.

De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE.

Hum Mol Genet. 2018 Dec 15;27(24):4218-4230. doi: 10.1093/hmg/ddy313.


Genetically determined folate deficiency is associated with abnormal hepatic folate profiles in the spontaneously hypertensive rat.

Pravenec M, Leung KY, Zídek V, Mlejnek P, Šimáková M, Šilhavý J, Kožich V, Greene NDE.

Physiol Res. 2018 Jul 17;67(3):417-422.


Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos.

Galea GL, Nychyk O, Mole MA, Moulding D, Savery D, Nikolopoulou E, Henderson DJ, Greene NDE, Copp AJ.

Dis Model Mech. 2018 Mar 21;11(3). pii: dmm032219. doi: 10.1242/dmm.032219.


Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.

Orriss IR, Lanham S, Savery D, Greene NDE, Stanier P, Oreffo R, Copp AJ, Galea GL.

Sci Rep. 2018 Feb 20;8(1):3325. doi: 10.1038/s41598-018-21718-x.


Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.

De Castro SCP, Hirst CS, Savery D, Rolo A, Lickert H, Andersen B, Copp AJ, Greene NDE.

Dev Biol. 2018 Mar 15;435(2):130-137. doi: 10.1016/j.ydbio.2018.01.016. Epub 2018 Feb 2.


Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects.

Lin S, Ren A, Wang L, Huang Y, Wang Y, Wang C, Greene ND.

Free Radic Biol Med. 2018 Feb 20;116:149-158. doi: 10.1016/j.freeradbiomed.2018.01.004. Epub 2018 Jan 5.


Valproic acid disrupts the biomechanics of late spinal neural tube closure in mouse embryos.

Hughes A, Greene NDE, Copp AJ, Galea GL.

Mech Dev. 2018 Feb;149:20-26. doi: 10.1016/j.mod.2017.12.001. Epub 2017 Dec 7.


A targeted sequencing panel identifies rare damaging variants in multiple genes in the cranial neural tube defect, anencephaly.

Ishida M, Cullup T, Boustred C, James C, Docker J, English C; GOSgene, Lench N, Copp AJ, Moore GE, Greene NDE, Stanier P.

Clin Genet. 2018 Apr;93(4):870-879. doi: 10.1111/cge.13189. Epub 2018 Feb 11.


Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.

Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, Savery D, Ralser M, Gross SS, Copp AJ, Greene NDE.

Cell Rep. 2017 Nov 14;21(7):1795-1808. doi: 10.1016/j.celrep.2017.10.072.


The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China.

Liu J, Li Z, Greene NDE, Li H, Ren A.

Oncotarget. 2017 Aug 3;8(42):72577-72583. doi: 10.18632/oncotarget.19890. eCollection 2017 Sep 22.


Biomechanical coupling facilitates spinal neural tube closure in mouse embryos.

Galea GL, Cho YJ, Galea G, Molè MA, Rolo A, Savery D, Moulding D, Culshaw LH, Nikolopoulou E, Greene NDE, Copp AJ.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5177-E5186. doi: 10.1073/pnas.1700934114. Epub 2017 Jun 12.


Claudins are essential for cell shape changes and convergent extension movements during neural tube closure.

Baumholtz AI, Simard A, Nikolopoulou E, Oosenbrug M, Collins MM, Piontek A, Krause G, Piontek J, Greene NDE, Ryan AK.

Dev Biol. 2017 Aug 1;428(1):25-38. doi: 10.1016/j.ydbio.2017.05.013. Epub 2017 May 22.


Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans.

Scott TA, Quintaneiro LM, Norvaisas P, Lui PP, Wilson MP, Leung KY, Herrera-Dominguez L, Sudiwala S, Pessia A, Clayton PT, Bryson K, Velagapudi V, Mills PB, Typas A, Greene NDE, Cabreiro F.

Cell. 2017 Apr 20;169(3):442-456.e18. doi: 10.1016/j.cell.2017.03.040.


Neural tube closure: cellular, molecular and biomechanical mechanisms.

Nikolopoulou E, Galea GL, Rolo A, Greene ND, Copp AJ.

Development. 2017 Feb 15;144(4):552-566. doi: 10.1242/dev.145904. Review.


High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

Bahous RH, Jadavji NM, Deng L, Cosín-Tomás M, Lu J, Malysheva O, Leung KY, Ho MK, Pallàs M, Kaliman P, Greene NDE, Bedell BJ, Caudill MA, Rozen R.

Hum Mol Genet. 2017 Mar 1;26(5):888-900. doi: 10.1093/hmg/ddx004.


Use of high-frequency ultrasound to study the prenatal development of cranial neural tube defects and hydrocephalus in Gldc-deficient mice.

Autuori MC, Pai YJ, Stuckey DJ, Savery D, Marconi AM, Massa V, Lythgoe MF, Copp AJ, David AL, Greene ND.

Prenat Diagn. 2017 Mar;37(3):273-281. doi: 10.1002/pd.5004. Epub 2017 Feb 17.


Rho GTPases in mammalian spinal neural tube closure.

Rolo A, Escuin S, Greene NDE, Copp AJ.

Small GTPases. 2018 Jul 4;9(4):283-289. doi: 10.1080/21541248.2016.1235388. Epub 2016 Oct 21. Review.


Identification of the genomic mutation in Epha4(rb-2J/rb-2J) mice.

Mohd-Zin SW, Abdullah NL, Abdullah A, Greene ND, Cheah PS, Ling KH, Yusof H, Marwan AI, Williams SM, York KT, Ahmad-Annuar A, Abdul-Aziz NM.

Genome. 2016 Jul;59(7):439-48. doi: 10.1139/gen-2015-0142.


Inositol, neural tube closure and the prevention of neural tube defects.

Greene ND, Leung KY, Copp AJ.

Birth Defects Res. 2017 Jan 30;109(2):68-80. doi: 10.1002/bdra.23533. Review.


Regulation of cell protrusions by small GTPases during fusion of the neural folds.

Rolo A, Savery D, Escuin S, de Castro SC, Armer HE, Munro PM, Molè MA, Greene ND, Copp AJ.

Elife. 2016 Apr 26;5:e13273. doi: 10.7554/eLife.13273.


Microtubules, polarity and vertebrate neural tube morphogenesis.

Cearns MD, Escuin S, Alexandre P, Greene ND, Copp AJ.

J Anat. 2016 Jul;229(1):63-74. doi: 10.1111/joa.12468. Epub 2016 Mar 29. Review.


Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects.

Sudiwala S, De Castro SC, Leung KY, Brosnan JT, Brosnan ME, Mills K, Copp AJ, Greene ND.

Biochimie. 2016 Jul;126:63-70. doi: 10.1016/j.biochi.2016.02.010. Epub 2016 Feb 23.


Inositol for prevention of neural tube defects: a pilot randomised controlled trial - CORRIGENDUM.

Greene ND, Leung KY, Gay V, Burren K, Mills K, Chitty LS, Copp AJ.

Br J Nutr. 2016 May;115(9):1697. doi: 10.1017/S0007114516000659. Epub 2016 Feb 26. No abstract available.


Inositol for the prevention of neural tube defects: a pilot randomised controlled trial.

Greene ND, Leung KY, Gay V, Burren K, Mills K, Chitty LS, Copp AJ.

Br J Nutr. 2016 Mar 28;115(6):974-83. doi: 10.1017/S0007114515005322. Epub 2016 Feb 5. Erratum in: Br J Nutr. 2016 May;115(9):1697.


Cellular basis of neuroepithelial bending during mouse spinal neural tube closure.

McShane SG, Molè MA, Savery D, Greene ND, Tam PP, Copp AJ.

Dev Biol. 2015 Aug 15;404(2):113-24. doi: 10.1016/j.ydbio.2015.06.003. Epub 2015 Jun 12.


Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

Escuin S, Vernay B, Savery D, Gurniak CB, Witke W, Greene ND, Copp AJ.

J Cell Sci. 2015 Jul 15;128(14):2468-81. doi: 10.1242/jcs.164574. Epub 2015 Jun 3.


Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice.

Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND.

Nat Commun. 2015 Mar 4;6:6388. doi: 10.1038/ncomms7388.


High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

Christensen KE, Mikael LG, Leung KY, Lévesque N, Deng L, Wu Q, Malysheva OV, Best A, Caudill MA, Greene ND, Rozen R.

Am J Clin Nutr. 2015 Mar;101(3):646-58. doi: 10.3945/ajcn.114.086603. Epub 2015 Jan 7.


Both the folate cycle and betaine-homocysteine methyltransferase contribute methyl groups for DNA methylation in mouse blastocysts.

Zhang B, Denomme MM, White CR, Leung KY, Lee MB, Greene ND, Mann MR, Trasler JM, Baltz JM.

FASEB J. 2015 Mar;29(3):1069-79. doi: 10.1096/fj.14-261131. Epub 2014 Dec 2.


Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.

Murdoch JN, Damrau C, Paudyal A, Bogani D, Wells S, Greene ND, Stanier P, Copp AJ.

Dis Model Mech. 2014 Oct;7(10):1153-63. doi: 10.1242/dmm.016758. Epub 2014 Aug 15.


Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals.

Pryor SE, Massa V, Savery D, Andre P, Yang Y, Greene ND, Copp AJ.

Development. 2014 Aug;141(16):3153-8. doi: 10.1242/dev.111427. Epub 2014 Jul 18.


Neural tube defects.

Greene ND, Copp AJ.

Annu Rev Neurosci. 2014;37:221-42. doi: 10.1146/annurev-neuro-062012-170354. Review.


Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model.

Norris FC, Siow BM, Cleary JO, Wells JA, De Castro SC, Ordidge RJ, Greene ND, Copp AJ, Scambler PJ, Alexander DC, Lythgoe MF.

Magn Reson Med. 2015 Feb;73(2):731-9. doi: 10.1002/mrm.25145. Epub 2014 Mar 13.


Novel exomphalos genetic mouse model: the importance of accurate phenotypic classification.

Carnaghan H, Roberts T, Savery D, Norris FC, McCann CJ, Copp AJ, Scambler PJ, Lythgoe MF, Greene ND, Decoppi P, Burns AJ, Pierro A, Eaton S.

J Pediatr Surg. 2013 Oct;48(10):2036-42. doi: 10.1016/j.jpedsurg.2013.04.010.


A coming of age: advanced imaging technologies for characterising the developing mouse.

Norris FC, Wong MD, Greene ND, Scambler PJ, Weaver T, Weninger WJ, Mohun TJ, Henkelman RM, Lythgoe MF.

Trends Genet. 2013 Dec;29(12):700-11. doi: 10.1016/j.tig.2013.08.004. Epub 2013 Sep 12. Review.


Neural tube defects--disorders of neurulation and related embryonic processes.

Copp AJ, Greene ND.

Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr;2(2):213-27. doi: 10.1002/wdev.71. Epub 2012 May 29. Review.


Nucleotide precursors prevent folic acid-resistant neural tube defects in the mouse.

Leung KY, De Castro SC, Savery D, Copp AJ, Greene ND.

Brain. 2013 Sep;136(Pt 9):2836-41. doi: 10.1093/brain/awt209. Epub 2013 Aug 8.


Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.

Moore DJ, Onoufriadis A, Shoemark A, Simpson MA, zur Lage PI, de Castro SC, Bartoloni L, Gallone G, Petridi S, Woollard WJ, Antony D, Schmidts M, Didonna T, Makrythanasis P, Bevillard J, Mongan NP, Djakow J, Pals G, Lucas JS, Marthin JK, Nielsen KG, Santoni F, Guipponi M, Hogg C, Antonarakis SE, Emes RD, Chung EM, Greene ND, Blouin JL, Jarman AP, Mitchison HM.

Am J Hum Genet. 2013 Aug 8;93(2):346-56. doi: 10.1016/j.ajhg.2013.07.009. Epub 2013 Jul 25.


Neural tube defects: recent advances, unsolved questions, and controversies.

Copp AJ, Stanier P, Greene ND.

Lancet Neurol. 2013 Aug;12(8):799-810. doi: 10.1016/S1474-4422(13)70110-8. Epub 2013 Jun 19. Review.


Is LMNB1 a susceptibility gene for neural tube defects in humans?

Robinson A, Partridge D, Malhas A, De Castro SC, Gustavsson P, Thompson DN, Vaux DJ, Copp AJ, Stanier P, Bassuk AG, Greene ND.

Birth Defects Res A Clin Mol Teratol. 2013 Jun;97(6):398-402. doi: 10.1002/bdra.23141. Epub 2013 Jun 3.


A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development.

Christensen KE, Deng L, Leung KY, Arning E, Bottiglieri T, Malysheva OV, Caudill MA, Krupenko NI, Greene ND, Jerome-Majewska L, MacKenzie RE, Rozen R.

Hum Mol Genet. 2013 Sep 15;22(18):3705-19. doi: 10.1093/hmg/ddt223. Epub 2013 May 23.


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