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Items: 1 to 50 of 434

1.

Radioresistance of Serpinb3a-/- Mice and Derived Hematopoietic and Marrow Stromal Cell Lines.

Thermozier S, Zhang X, Hou W, Fisher R, Epperly MW, Liu B, Bahar I, Wang H, Greenberger JS.

Radiat Res. 2019 Jul 11. doi: 10.1667/RR15379.1. [Epub ahead of print]

PMID:
31295086
2.

Redox (phospho)lipidomics of signaling in inflammation and programmed cell death.

Tyurina YY, St Croix CM, Watkins SC, Watson AM, Epperly MW, Anthonymuthu TS, Kisin ER, Vlasova II, Krysko O, Krysko DV, Kapralov AA, Dar HH, Tyurin VA, Amoscato AA, Popova EN, Bolevich SB, Timashev PS, Kellum JA, Wenzel SE, Mallampalli RK, Greenberger JS, Bayir H, Shvedova AA, Kagan VE.

J Leukoc Biol. 2019 Jul;106(1):57-81. doi: 10.1002/JLB.3MIR0119-004RR. Epub 2019 May 9. Review.

PMID:
31071242
3.

Amelioration of Amyotrophic Lateral Sclerosis in SOD1G93A Mice by M2 Microglia from Transplanted Marrow.

Epperly MW, Fisher R, Rigatti L, Watkins S, Zhang X, Hou W, Shields D, Franicola D, Bayir H, Wang H, Thermozier S, Henderson A, Donnelly C, Wipf P, Greenberger JS.

In Vivo. 2019 May-Jun;33(3):675-688. doi: 10.21873/invivo.11526.

4.

Adipose-Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor-Mediated Transforming Growth Factor-β Downregulation and Recruitment of Bone Marrow Cells.

Ejaz A, Epperly MW, Hou W, Greenberger JS, Rubin JP.

Stem Cells. 2019 Jun;37(6):791-802. doi: 10.1002/stem.3000. Epub 2019 Apr 11.

PMID:
30861238
5.

Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient (Fancd2 -/-) Hematopoietic Progenitor Cells by a Single HPV16 Oncogene.

Zhang X, Fisher R, Shields D, Hou W, Franicola D, Wang H, Epperly MW, Rigatti L, Greenberger JS.

In Vivo. 2019 Mar-Apr;33(2):303-311. doi: 10.21873/invivo.11476.

6.

Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca-/-) Mice.

Sivananthan A, Shields D, Fisher R, Hou W, Zhang X, Franicola D, Epperly MW, Wipf P, Greenberger JS.

Radiat Res. 2019 Feb;191(2):139-153. doi: 10.1667/RR15199.1. Epub 2018 Nov 30.

PMID:
30499383
7.

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium.

Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE.

J Clin Invest. 2018 Oct 1;128(10):4639-4653. doi: 10.1172/JCI99490. Epub 2018 Sep 10.

8.

Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.

Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RSB.

ACS Chem Biol. 2018 Oct 19;13(10):2868-2879. doi: 10.1021/acschembio.8b00423. Epub 2018 Sep 14.

PMID:
30184433
9.

Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage.

Brand RM, Wipf P, Durham A, Epperly MW, Greenberger JS, Falo LD Jr.

Front Pharmacol. 2018 Aug 20;9:920. doi: 10.3389/fphar.2018.00920. eCollection 2018. Review.

10.

Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039).

Epperly MW, Wipf P, Fisher R, Franicola D, Beumer J, Li S, Brand RM, Falo LD Jr, Erdos G, Greenberger JS.

In Vivo. 2018 Sep-Oct;32(5):1009-1023. doi: 10.21873/invivo.11341.

11.

Development of tensile strength methodology for murine skin wound healing.

Bellare A, Epperly MW, Greenberger JS, Fisher R, Glowacki J.

MethodsX. 2018 Apr 16;5:337-344. doi: 10.1016/j.mex.2018.04.002. eCollection 2018.

12.

Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation.

Lou W, Ting HC, Reynolds CA, Tyurina YY, Tyurin VA, Li Y, Ji J, Yu W, Liang Z, Stoyanovsky DA, Anthonymuthu TS, Frasso MA, Wipf P, Greenberger JS, Bayır H, Kagan VE, Greenberg ML.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1354-1368. doi: 10.1016/j.bbalip.2018.06.016. Epub 2018 Jun 20.

PMID:
29935382
13.

Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039).

Willis J, Epperly MW, Fisher R, Zhang X, Shields D, Hou W, Wang H, Li S, Wipf P, Parmar K, Guinan E, Steinman J, Greenberger JS.

Radiat Res. 2018 Jun;189(6):560-578. doi: 10.1667/RR14878.1. Epub 2018 Mar 27.

14.

The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice.

Wei L, Leibowitz BJ, Epperly M, Bi C, Li A, Steinman J, Wipf P, Li S, Zhang L, Greenberger J, Yu J.

Sci Rep. 2018 Feb 1;8(1):2072. doi: 10.1038/s41598-018-20370-9.

15.

Challenges in the Analysis of Outcomes for Surgical Compared to Radiotherapy Treatment of Prostate Cancer.

Glaser SM, Kalash R, Bongiorni DR, Roberts MS, Balasubramani GK, Jacobs BL, Beriwal S, Heron DE, Greenberger JS.

In Vivo. 2018 Jan-Feb;32(1):113-120.

16.

Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma.

Christner S, Guo J, Parise RA, Ringeval M, Hoye AT, Wipf P, Epperly MW, Greenberger JS, Beumer JH, Eiseman JL.

J Pharm Biomed Anal. 2018 Feb 20;150:169-175. doi: 10.1016/j.jpba.2017.12.023. Epub 2017 Dec 12.

17.

Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways.

Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS.

Radiat Res. 2018 Jan;189(1):68-83. doi: 10.1667/RR14787.1. Epub 2017 Nov 15.

18.

"Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions.

Tyurina YY, Shrivastava I, Tyurin VA, Mao G, Dar HH, Watkins S, Epperly M, Bahar I, Shvedova AA, Pitt B, Wenzel SE, Mallampalli RK, Sadovsky Y, Gabrilovich D, Greenberger JS, Bayır H, Kagan VE.

Antioxid Redox Signal. 2018 Nov 1;29(13):1333-1358. doi: 10.1089/ars.2017.7124. Epub 2017 Oct 16.

PMID:
28835115
19.

Effect of the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation Therapy for Patients With Esophageal Cancer: The NRG Oncology RTOG 0436 Phase 3 Randomized Clinical Trial.

Suntharalingam M, Winter K, Ilson D, Dicker AP, Kachnic L, Konski A, Chakravarthy AB, Anker CJ, Thakrar H, Horiba N, Dubey A, Greenberger JS, Raben A, Giguere J, Roof K, Videtic G, Pollock J, Safran H, Crane CH.

JAMA Oncol. 2017 Nov 1;3(11):1520-1528. doi: 10.1001/jamaoncol.2017.1598. Erratum in: JAMA Oncol. 2017 Nov 1;3(11):1589.

20.

Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice.

Epperly MW, Zhang X, Fisher R, Hou W, Franicola D, Shields D, Quickel M, Hankey-Giblin P, Wang H, Greenberger JS.

In Vivo. 2017 May-Jun;31(3):313-320.

21.

Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350.

Epperly MW, Rhieu BH, Franicola D, Dixon T, Cao S, Zhang X, Shields D, Wang H, Wipf P, Greenberger JS.

In Vivo. 2017 Mar-Apr;31(2):159-168.

22.

Results of a Single Institution Experience with Dose-Escalated Chemoradiation for Locally Advanced Unresectable Non-Small Cell Lung Cancer.

Bernard ME, Glaser SM, Gill BS, Beriwal S, Heron DE, Luketich JD, Friedland DM, Socinski MA, Greenberger JS.

Front Oncol. 2017 Jan 23;7:1. doi: 10.3389/fonc.2017.00001. eCollection 2017.

23.

Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators.

Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS.

In Vivo. 2017 Jan 2;31(1):39-43.

24.

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H.

Nat Chem Biol. 2017 Jan;13(1):81-90. doi: 10.1038/nchembio.2238. Epub 2016 Nov 14.

25.

Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice.

Wei L, Leibowitz BJ, Wang X, Epperly M, Greenberger J, Zhang L, Yu J.

J Clin Invest. 2016 Nov 1;126(11):4076-4087. doi: 10.1172/JCI88410. Epub 2016 Oct 4.

26.

A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage.

Brand RM, Epperly MW, Stottlemyer JM, Skoda EM, Gao X, Li S, Huq S, Wipf P, Kagan VE, Greenberger JS, Falo LD Jr.

J Invest Dermatol. 2017 Mar;137(3):576-586. doi: 10.1016/j.jid.2016.09.033. Epub 2016 Oct 26.

27.

FANCD2 protects against bone marrow injury from ferroptosis.

Song X, Xie Y, Kang R, Hou W, Sun X, Epperly MW, Greenberger JS, Tang D.

Biochem Biophys Res Commun. 2016 Nov 18;480(3):443-449. doi: 10.1016/j.bbrc.2016.10.068. Epub 2016 Oct 20.

28.

Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures.

Zhang X, Hou W, Epperly MW, Rigatti L, Wang H, Franicola D, Sivanathan A, Greenberger JS.

Oncotarget. 2016 Oct 18;7(42):68449-68472. doi: 10.18632/oncotarget.12036.

29.

Correction to "Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator".

Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bayır H.

ACS Med Chem Lett. 2016 Jun 1;7(6):653-4. doi: 10.1021/acsmedchemlett.6b00212. eCollection 2016 Jun 9.

30.

TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.

Zhang H, Kozono DE, O'Connor KW, Vidal-Cardenas S, Rousseau A, Hamilton A, Moreau L, Gaudiano EF, Greenberger J, Bagby G, Soulier J, Grompe M, Parmar K, D'Andrea AD.

Cell Stem Cell. 2016 May 5;18(5):668-81. doi: 10.1016/j.stem.2016.03.002. Epub 2016 Mar 24.

31.

A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis.

Sharlow ER, Leimgruber S, Lira A, McConnell MJ, Norambuena A, Bloom GS, Epperly MW, Greenberger JS, Lazo JS.

ACS Chem Biol. 2016 May 20;11(5):1428-37. doi: 10.1021/acschembio.5b00909. Epub 2016 Mar 14.

32.

Necrostatin-1 rescues mice from lethal irradiation.

Huang Z, Epperly M, Watkins SC, Greenberger JS, Kagan VE, Bayır H.

Biochim Biophys Acta. 2016 Apr;1862(4):850-856. doi: 10.1016/j.bbadis.2016.01.014. Epub 2016 Jan 20.

33.

Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice.

Shinde A, Berhane H, Rhieu BH, Kalash R, Xu K, Goff J, Epperly MW, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Parmar K, Guinan E, Kagan V, Tyurin V, Ferris RL, Zhang X, Li S, Greenberger JS.

Radiat Res. 2016 Feb;185(2):134-50. doi: 10.1667/RR14035.1. Epub 2016 Jan 20.

34.

Antioxidant Approaches to Management of Ionizing Irradiation Injury.

Greenberger J, Kagan V, Bayir H, Wipf P, Epperly M.

Antioxidants (Basel). 2015 Jan 23;4(1):82-101. doi: 10.3390/antiox4010082.

35.

Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition.

Gomez-Casal R, Epperly MW, Wang H, Proia DA, Greenberger JS, Levina V.

Oncotarget. 2015 Dec 29;6(42):44306-22. doi: 10.18632/oncotarget.6248.

36.

A Mobile Alert System for Preparing the Delivery of Radiation Mitigators.

Dickson R, Kim JO, Huq MS, Bednarz G, Suyama J, Yealy DM, Wang H, Greenberger JS.

In Vivo. 2015 Sep-Oct;29(5):505-13.

PMID:
26359406
37.

Are We Ready for a Radiological Terrorist Attack Yet? Report From the Centers for Medical Countermeasures Against Radiation Network.

Brenner DJ, Chao NJ, Greenberger JS, Guha C, McBride WH, Swartz HM, Williams JP.

Int J Radiat Oncol Biol Phys. 2015 Jul 1;92(3):504-5. doi: 10.1016/j.ijrobp.2015.02.042. No abstract available.

38.

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells.

Gomez-Casal R, Bhattacharya C, Epperly MW, Basse PH, Wang H, Wang X, Proia DA, Greenberger JS, Socinski MA, Levina V.

Cancers (Basel). 2015 May 22;7(2):876-907. doi: 10.3390/cancers7020814.

39.

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation.

Wang X, Wei L, Cramer JM, Leibowitz BJ, Judge C, Epperly M, Greenberger J, Wang F, Li L, Stelzner MG, Dunn JCY, Martin MG, Lagasse E, Zhang L, Yu J.

Sci Rep. 2015 Apr 10;5:8566. doi: 10.1038/srep08566.

40.

Quantitative evaluation of radiation oncologists' adaptability to lower reimbursing treatment programs.

Gill BS, Beriwal S, Rajagopalan MS, Wang H, Hodges K, Greenberger JS.

Pract Radiat Oncol. 2015 Jul-Aug;5(4):267-73. doi: 10.1016/j.prro.2014.10.014. Epub 2014 Nov 5.

PMID:
25544552
41.

Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator.

Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bayır H.

ACS Med Chem Lett. 2014 Nov 18;5(12):1304-1307. eCollection 2014 Dec 11.

42.

Organ-specific responses of total body irradiated doxycycline-inducible manganese superoxide dismutase Tet/Tet mice.

Rhieu BH, Shinde A, Epperly MW, Dixon T, Wang H, Chaillet R, Greenberger JS.

In Vivo. 2014 Nov-Dec;28(6):1033-43.

43.

Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines.

Shinde A, Epperly MW, Cao S, Holt D, Goff J, Shields D, Franicola D, Wipf P, Wang H, Greenberger JS.

In Vivo. 2014 Sep-Oct;28(5):699-708.

44.

Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies.

Liu B, Bhatt D, Oltvai ZN, Greenberger JS, Bahar I.

Sci Rep. 2014 Sep 1;4:6245. doi: 10.1038/srep06245.

45.

Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines.

Shinde A, Epperly MW, Cao S, Franicola D, Shields D, Wang H, Wipf P, Sprachman MM, Greenberger JS.

In Vivo. 2014 Jul-Aug;28(4):457-65.

46.
47.
48.

Esophageal radioprotection by swallowed JP4-039/F15 in thoracic-irradiated mice with transgenic lung tumors.

Epperly MW, Goff JP, Franicola D, Wang H, Wipf P, Li S, Greenberger JS.

In Vivo. 2014 Jul-Aug;28(4):435-40.

49.

Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039.

Berhane H, Shinde A, Kalash R, Xu K, Epperly MW, Goff J, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Li S, Gao X, Greenberger JS.

Radiat Res. 2014 Jul;182(1):35-49. doi: 10.1667/RR13633.1. Epub 2014 Jun 16.

50.

A mitochondrial pathway for biosynthesis of lipid mediators.

Tyurina YY, Poloyac SM, Tyurin VA, Kapralov AA, Jiang J, Anthonymuthu TS, Kapralova VI, Vikulina AS, Jung MY, Epperly MW, Mohammadyani D, Klein-Seetharaman J, Jackson TC, Kochanek PM, Pitt BR, Greenberger JS, Vladimirov YA, Bayır H, Kagan VE.

Nat Chem. 2014 Jun;6(6):542-52. doi: 10.1038/nchem.1924. Epub 2014 Apr 20.

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