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Items: 1 to 50 of 171

1.

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle.

Xia Y, Pfeifer CR, Zhu K, Irianto J, Liu D, Pannell K, Chen EJ, Dooling LJ, Tobin MP, Wang M, Ivanovska IL, Smith LR, Greenberg RA, Discher DE.

J Cell Biol. 2019 Jun 25. pii: jcb.201811100. doi: 10.1083/jcb.201811100. [Epub ahead of print]

PMID:
31239284
2.

Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.

Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel J, George R, Ault JR, El Oualid F, Pawłowski K, Salvino JM, Eyers PA, Ranson NA, Del Galdo F, Greenberg RA, Zeqiraj E.

Nature. 2019 Jun;570(7760):194-199. doi: 10.1038/s41586-019-1232-1. Epub 2019 May 29.

PMID:
31142841
3.

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.

Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE.

Dev Cell. 2019 Jun 17;49(6):920-935.e5. doi: 10.1016/j.devcel.2019.04.020. Epub 2019 May 16.

PMID:
31105008
4.

Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models.

Makvandi M, Lee H, Puentes LN, Reilly SW, Rathi KS, Weng CC, Chan HS, Hou C, Raman P, Martinez D, Xu K, Carlin SD, Greenberg RA, Pawel BR, Mach RH, Maris JM, Pryma DA.

Mol Cancer Ther. 2019 Jul;18(7):1195-1204. doi: 10.1158/1535-7163.MCT-18-0837. Epub 2019 May 9.

PMID:
31072830
5.

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.

Bast RC Jr, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ Jr, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L.

Cancer. 2019 Jun 15;125(12):1963-1972. doi: 10.1002/cncr.32004. Epub 2019 Mar 5.

PMID:
30835824
6.

The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.

Donaghy R, Han X, Rozenova K, Lv K, Jiang Q, Doepner M, Greenberg RA, Tong W.

Blood. 2019 Apr 4;133(14):1560-1571. doi: 10.1182/blood-2018-10-877563. Epub 2019 Feb 12.

PMID:
30755420
7.

RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening.

Verma P, Dilley RL, Zhang T, Gyparaki MT, Li Y, Greenberg RA.

Genes Dev. 2019 Feb 1;33(3-4):221-235. doi: 10.1101/gad.319723.118. Epub 2019 Jan 28.

PMID:
30692206
8.

Phosphorylation of TIP60 Suppresses 53BP1 Localization at DNA Damage Sites.

Li ML, Jiang Q, Bhanu NV, Wu J, Li W, Garcia BA, Greenberg RA.

Mol Cell Biol. 2018 Dec 11;39(1). pii: e00209-18. doi: 10.1128/MCB.00209-18. Print 2019 Jan 1.

9.

Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.

Balcerek J, Jiang J, Li Y, Jiang Q, Holdreith N, Singh B, Chandra V, Lv K, Ren JG, Rozenova K, Li W, Greenberg RA, Tong W.

Nat Commun. 2018 Sep 25;9(1):3915. doi: 10.1038/s41467-018-06380-1.

10.

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors.

Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE.

J Cell Biol. 2018 Nov 5;217(11):3796-3808. doi: 10.1083/jcb.201711161. Epub 2018 Aug 31.

11.

Assembling a protective shield.

Greenberg RA.

Nat Cell Biol. 2018 Aug;20(8):862-863. doi: 10.1038/s41556-018-0152-x. No abstract available.

12.

Parental Moral Distress and Moral Schism in the Neonatal ICU.

Foe G, Hellmann J, Greenberg RA.

J Bioeth Inq. 2018 Sep;15(3):319-325. doi: 10.1007/s11673-018-9858-5. Epub 2018 May 25.

PMID:
29802588
13.

Constricted migration increases DNA damage and independently represses cell cycle.

Pfeifer CR, Xia Y, Zhu K, Liu D, Irianto J, García VMM, Millán LMS, Niese B, Harding S, Deviri D, Greenberg RA, Discher DE.

Mol Biol Cell. 2018 Aug 8;29(16):1948-1962. doi: 10.1091/mbc.E18-02-0079. Epub 2018 May 9.

14.

A PET imaging agent for evaluating PARP-1 expression in ovarian cancer.

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL.

J Clin Invest. 2018 May 1;128(5):2116-2126. doi: 10.1172/JCI97992. Epub 2018 Apr 16.

15.

Direct Quantitative Monitoring of Homology-Directed DNA Repair of Damaged Telomeres.

Verma P, Dilley RL, Gyparaki MT, Greenberg RA.

Methods Enzymol. 2018;600:107-134. doi: 10.1016/bs.mie.2017.11.010. Epub 2018 Feb 1.

16.

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer.

Weigelt B, Comino-Méndez I, de Bruijn I, Tian L, Meisel JL, García-Murillas I, Fribbens C, Cutts R, Martelotto LG, Ng CKY, Lim RS, Selenica P, Piscuoglio S, Aghajanian C, Norton L, Murali R, Hyman DM, Borsu L, Arcila ME, Konner J, Reis-Filho JS, Greenberg RA, Robson ME, Turner NC.

Clin Cancer Res. 2017 Nov 1;23(21):6708-6720. doi: 10.1158/1078-0432.CCR-17-0544. Epub 2017 Aug 1.

17.

Mitotic progression following DNA damage enables pattern recognition within micronuclei.

Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA.

Nature. 2017 Aug 24;548(7668):466-470. doi: 10.1038/nature23470. Epub 2017 Jul 31.

18.

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.

Sivanand S, Rhoades S, Jiang Q, Lee JV, Benci J, Zhang J, Yuan S, Viney I, Zhao S, Carrer A, Bennett MJ, Minn AJ, Weljie AM, Greenberg RA, Wellen KE.

Mol Cell. 2017 Jul 20;67(2):252-265.e6. doi: 10.1016/j.molcel.2017.06.008. Epub 2017 Jul 6.

19.
20.

Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.

Mantere T, Tervasmäki A, Nurmi A, Rapakko K, Kauppila S, Tang J, Schleutker J, Kallioniemi A, Hartikainen JM, Mannermaa A, Nieminen P, Hanhisalo R, Lehto S, Suvanto M, Grip M, Jukkola-Vuorinen A, Tengström M, Auvinen P, Kvist A, Borg Å, Blomqvist C, Aittomäki K, Greenberg RA, Winqvist R, Nevanlinna H, Pylkäs K.

Sci Rep. 2017 Apr 6;7(1):681. doi: 10.1038/s41598-017-00766-9.

21.

As a Nucleus Enters a Small Pore, Chromatin Stretches and Maintains Integrity, Even with DNA Breaks.

Irianto J, Xia Y, Pfeifer CR, Greenberg RA, Discher DE.

Biophys J. 2017 Feb 7;112(3):446-449. doi: 10.1016/j.bpj.2016.09.047. Epub 2016 Oct 27.

22.

Putting PHDs to work: PHF11 clears the way for EXO1 in double-strand break repair.

Zahn KE, Greenberg RA.

Genes Dev. 2017 Jan 1;31(1):3-5. doi: 10.1101/gad.295923.117.

23.

DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration.

Irianto J, Xia Y, Pfeifer CR, Athirasala A, Ji J, Alvey C, Tewari M, Bennett RR, Harding SM, Liu AJ, Greenberg RA, Discher DE.

Curr Biol. 2017 Jan 23;27(2):210-223. doi: 10.1016/j.cub.2016.11.049. Epub 2016 Dec 15.

24.

Break-induced telomere synthesis underlies alternative telomere maintenance.

Dilley RL, Verma P, Cho NW, Winters HD, Wondisford AR, Greenberg RA.

Nature. 2016 Nov 3;539(7627):54-58. doi: 10.1038/nature20099. Epub 2016 Oct 19.

25.

Nuclear constriction segregates mobile nuclear proteins away from chromatin.

Irianto J, Pfeifer CR, Bennett RR, Xia Y, Ivanovska IL, Liu AJ, Greenberg RA, Discher DE.

Mol Biol Cell. 2016 Dec 15;27(25):4011-4020. Epub 2016 Oct 26.

26.

In vivo imaging of DNA double-strand break induced telomere mobility during alternative lengthening of telomeres.

Cho NW, Lampson MA, Greenberg RA.

Methods. 2017 Feb 1;114:54-59. doi: 10.1016/j.ymeth.2016.07.010. Epub 2016 Aug 1.

27.

Developing a bioethics curriculum for medical students from divergent geo-political regions.

Greenberg RA, Kim C, Stolte H, Hellmann J, Shaul RZ, Valani R, Scolnik D.

BMC Med Educ. 2016 Jul 27;16:193. doi: 10.1186/s12909-016-0711-4.

28.

Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture.

Harding SM, Greenberg RA.

Front Genet. 2016 Jun 7;7:103. doi: 10.3389/fgene.2016.00103. eCollection 2016. Review.

29.

A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy.

Makvandi M, Xu K, Lieberman BP, Anderson RC, Effron SS, Winters HD, Zeng C, McDonald ES, Pryma DA, Greenberg RA, Mach RH.

Cancer Res. 2016 Aug 1;76(15):4516-24. doi: 10.1158/0008-5472.CAN-16-0416. Epub 2016 Jun 3.

30.

Noncanonical views of homology-directed DNA repair.

Verma P, Greenberg RA.

Genes Dev. 2016 May 15;30(10):1138-54. doi: 10.1101/gad.280545.116. Review.

31.

[(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer.

Edmonds CE, Makvandi M, Lieberman BP, Xu K, Zeng C, Li S, Hou C, Lee H, Greenberg RA, Mankoff DA, Mach RH.

Am J Nucl Med Mol Imaging. 2016 Jan 28;6(1):94-101. eCollection 2016.

32.

ALTernative Telomere Maintenance and Cancer.

Dilley RL, Greenberg RA.

Trends Cancer. 2015 Oct 1;1(2):145-156.

33.

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition.

Harding SM, Boiarsky JA, Greenberg RA.

Cell Rep. 2015 Oct 13;13(2):251-9. doi: 10.1016/j.celrep.2015.08.085. Epub 2015 Oct 1.

34.

Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.

Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F.

Mol Cell. 2015 Sep 17;59(6):970-83. doi: 10.1016/j.molcel.2015.07.028. Epub 2015 Sep 3.

35.

MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.

Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, Seidman MM, Greenberg RA.

Genes Dev. 2015 Sep 15;29(18):1955-68. doi: 10.1101/gad.264192.115. Epub 2015 Sep 3.

36.

Deciphering the BRCA1 Tumor Suppressor Network.

Jiang Q, Greenberg RA.

J Biol Chem. 2015 Jul 17;290(29):17724-32. doi: 10.1074/jbc.R115.667931. Epub 2015 Jun 5. Review.

37.

DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.

Yu Q, Katlinskaya YV, Carbone CJ, Zhao B, Katlinski KV, Zheng H, Guha M, Li N, Chen Q, Yang T, Lengner CJ, Greenberg RA, Johnson FB, Fuchs SY.

Cell Rep. 2015 May 5;11(5):785-797. doi: 10.1016/j.celrep.2015.03.069. Epub 2015 Apr 23.

38.

When health care professionals say "more" and parents say "enough".

Greenberg RA, Weingarten K.

Paediatr Child Health. 2015 Apr;20(3):131-4. No abstract available. Erratum in: Paediatr Child Health. 2015 Nov-Dec;20(8):466-7.

39.

Type I interferon controls propagation of long interspersed element-1.

Yu Q, Carbone CJ, Katlinskaya YV, Zheng H, Zheng K, Luo M, Wang PJ, Greenberg RA, Fuchs SY.

J Biol Chem. 2015 Apr 17;290(16):10191-9. doi: 10.1074/jbc.M114.612374. Epub 2015 Feb 25.

40.

DNA repair: Familiar ends with alternative endings.

Cho NW, Greenberg RA.

Nature. 2015 Feb 12;518(7538):174-6. doi: 10.1038/nature14200. Epub 2015 Feb 4. No abstract available.

PMID:
25642961
41.

MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling.

Rozenova K, Jiang J, Donaghy R, Aressy B, Greenberg RA, Tong W.

Blood. 2015 Mar 12;125(11):1730-8. doi: 10.1182/blood-2014-07-588145. Epub 2015 Jan 30.

42.

Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas.

Fishbein L, Khare S, Wubbenhorst B, DeSloover D, D'Andrea K, Merrill S, Cho NW, Greenberg RA, Else T, Montone K, LiVolsi V, Fraker D, Daber R, Cohen DL, Nathanson KL.

Nat Commun. 2015 Jan 21;6:6140. doi: 10.1038/ncomms7140.

43.

Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype.

Sawyer SL, Tian L, Kähkönen M, Schwartzentruber J, Kircher M; University of Washington Centre for Mendelian Genomics; FORGE Canada Consortium, Majewski J, Dyment DA, Innes AM, Boycott KM, Moreau LA, Moilanen JS, Greenberg RA.

Cancer Discov. 2015 Feb;5(2):135-42. doi: 10.1158/2159-8290.CD-14-1156. Epub 2014 Dec 3.

44.

Chromatin yo-yo: expansion and condensation during DNA repair.

Li ML, Yuan G, Greenberg RA.

Trends Cell Biol. 2014 Nov;24(11):616-618. doi: 10.1016/j.tcb.2014.09.004. Epub 2014 Oct 7.

45.

Interchromosomal homology searches drive directional ALT telomere movement and synapsis.

Cho NW, Dilley RL, Lampson MA, Greenberg RA.

Cell. 2014 Sep 25;159(1):108-121. doi: 10.1016/j.cell.2014.08.030.

46.

Identifying prioritization criteria to supplement critical care triage protocols for the allocation of ventilators during a pandemic influenza.

Winsor S, Bensimon CM, Sibbald R, Anstey K, Chidwick P, Coughlin K, Cox P, Fowler R, Godkin D, Greenberg RA, Shaul RZ.

Healthc Q. 2014;17(2):44-51.

PMID:
25191808
47.

Bioethics consultation practices and procedures: a survey of a large Canadian community of practice.

Greenberg RA, Anstey KW, Macri R, Heesters A, Bean S, Zlotnik Shaul R.

HEC Forum. 2014 Jun;26(2):135-46. doi: 10.1007/s10730-013-9230-4.

PMID:
24306818
48.

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Katlinski K, Wu J, Varghese B, Carbone CJ, Aressy B, Fuchs SY, Greenberg RA.

Cell Rep. 2013 Oct 17;5(1):180-93. doi: 10.1016/j.celrep.2013.08.025. Epub 2013 Sep 26.

49.

Conversations between chromatin modifications and DNA double strand break repair: a commentary.

Hendzel MJ, Greenberg RA.

Mutat Res. 2013 Oct;750(1-2):1-4. doi: 10.1016/j.mrfmmm.2013.08.003. Epub 2013 Aug 27. No abstract available.

50.

The dynamics of DNA damage repair and transcription.

Shanbhag NM, Greenberg RA.

Methods Mol Biol. 2013;1042:227-35. doi: 10.1007/978-1-62703-526-2_16.

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