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Items: 27

1.

Thioamide-based fluorescent protease sensors.

Goldberg JM, Chen X, Meinhardt N, Greenbaum DC, Petersson EJ.

J Am Chem Soc. 2014 Feb 5;136(5):2086-93. doi: 10.1021/ja412297x. Epub 2014 Jan 28.

2.

A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites.

Millholland MG, Mishra S, Dupont CD, Love MS, Patel B, Shilling D, Kazanietz MG, Foskett JK, Hunter CA, Sinnis P, Greenbaum DC.

Cell Host Microbe. 2013 Jan 16;13(1):15-28. doi: 10.1016/j.chom.2012.12.001. Epub 2013 Jan 16.

3.

Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.

Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC.

Cell Host Microbe. 2012 Dec 13;12(6):815-23. doi: 10.1016/j.chom.2012.10.017.

4.

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.

Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21486-91. doi: 10.1073/pnas.1216016110. Epub 2012 Dec 11.

5.

Development of α-helical calpain probes by mimicking a natural protein-protein interaction.

Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC.

J Am Chem Soc. 2012 Oct 24;134(42):17704-13. doi: 10.1021/ja307599z. Epub 2012 Oct 11.

6.

OspC is potent plasminogen receptor on surface of Borrelia burgdorferi.

Önder Ö, Humphrey PT, McOmber B, Korobova F, Francella N, Greenbaum DC, Brisson D.

J Biol Chem. 2012 May 11;287(20):16860-8. doi: 10.1074/jbc.M111.290775. Epub 2012 Mar 20.

7.

The Trypanosoma cruzi protease cruzain mediates immune evasion.

Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC.

PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1.

8.

The malaria parasite progressively dismantles the host erythrocyte cytoskeleton for efficient egress.

Millholland MG, Chandramohanadas R, Pizzarro A, Wehr A, Shi H, Darling C, Lim CT, Greenbaum DC.

Mol Cell Proteomics. 2011 Dec;10(12):M111.010678. doi: 10.1074/mcp.M111.010678. Epub 2011 Sep 8.

9.

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.

Harbut MB, Velmourougane G, Dalal S, Reiss G, Whisstock JC, Onder O, Brisson D, McGowan S, Klemba M, Greenbaum DC.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E526-34. doi: 10.1073/pnas.1105601108. Epub 2011 Aug 15.

10.

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

Kalińska M, Kantyka T, Greenbaum DC, Larsen KS, Władyka B, Jabaiah A, Bogyo M, Daugherty PS, Wysocka M, Jaros M, Lesner A, Rolka K, Schaschke N, Stennicke H, Dubin A, Potempa J, Dubin G.

Biochimie. 2012 Feb;94(2):318-27. doi: 10.1016/j.biochi.2011.07.020. Epub 2011 Jul 23.

PMID:
21802486
11.

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Velmourougane G, Harbut MB, Dalal S, McGowan S, Oellig CA, Meinhardt N, Whisstock JC, Klemba M, Greenbaum DC.

J Med Chem. 2011 Mar 24;54(6):1655-66. doi: 10.1021/jm101227t. Epub 2011 Mar 2.

12.

Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Lucumi E, Darling C, Jo H, Napper AD, Chandramohanadas R, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL, Greenbaum DC.

Antimicrob Agents Chemother. 2010 Sep;54(9):3597-604. doi: 10.1128/AAC.00431-10. Epub 2010 Jun 14.

13.

A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.

Shah PP, Wang T, Kaletsky RL, Myers MC, Purvis JE, Jing H, Huryn DM, Greenbaum DC, Smith AB 3rd, Bates P, Diamond SL.

Mol Pharmacol. 2010 Aug;78(2):319-24. doi: 10.1124/mol.110.064261. Epub 2010 May 13.

14.

Platelets, pyrexia, and plasmodia.

Greenbaum DC, FitzGerald GA.

N Engl J Med. 2009 Jul 30;361(5):526-8. doi: 10.1056/NEJMcibr0903050. No abstract available.

PMID:
19641212
15.

Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.

Golde TE, Wolfe MS, Greenbaum DC.

Semin Cell Dev Biol. 2009 Apr;20(2):225-30. doi: 10.1016/j.semcdb.2009.02.003. Epub 2009 Feb 13. Review.

16.

Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.

Chandramohanadas R, Davis PH, Beiting DP, Harbut MB, Darling C, Velmourougane G, Lee MY, Greer PA, Roos DS, Greenbaum DC.

Science. 2009 May 8;324(5928):794-7. doi: 10.1126/science.1171085. Epub 2009 Apr 2.

17.

Development of bestatin-based activity-based probes for metallo-aminopeptidases.

Harbut MB, Velmourougane G, Reiss G, Chandramohanadas R, Greenbaum DC.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5932-6. doi: 10.1016/j.bmcl.2008.09.021. Epub 2008 Sep 10.

18.

Is chemical genetics the new frontier for malaria biology?

Greenbaum DC.

Trends Pharmacol Sci. 2008 Feb;29(2):51-6. doi: 10.1016/j.tips.2007.11.008. Epub 2008 Jan 15.

PMID:
18199489
19.

Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts.

Sanders PR, Cantin GT, Greenbaum DC, Gilson PR, Nebl T, Moritz RL, Yates JR 3rd, Hodder AN, Crabb BS.

Mol Biochem Parasitol. 2007 Aug;154(2):148-57. Epub 2007 Apr 27.

PMID:
17553576
20.

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.

Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS.

J Biol Chem. 2006 May 5;281(18):12824-32. Epub 2006 Mar 6.

21.

Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum.

Sanders PR, Gilson PR, Cantin GT, Greenbaum DC, Nebl T, Carucci DJ, McConville MJ, Schofield L, Hodder AN, Yates JR 3rd, Crabb BS.

J Biol Chem. 2005 Dec 2;280(48):40169-76. Epub 2005 Oct 3.

22.

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.

Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH.

J Biol Chem. 2004 Nov 12;279(46):48426-33. Epub 2004 Aug 23.

23.

Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth.

Eksi S, Czesny B, Greenbaum DC, Bogyo M, Williamson KC.

Mol Microbiol. 2004 Jul;53(1):243-50.

24.

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K.

J Med Chem. 2004 Jun 3;47(12):3212-9.

PMID:
15163200
25.

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.

Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai FY, Greenbaum DC, Hager JH, Bogyo M, Hanahan D.

Cancer Cell. 2004 May;5(5):443-53.

26.

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite.

Greenbaum DC, Baruch A, Grainger M, Bozdech Z, Medzihradszky KF, Engel J, DeRisi J, Holder AA, Bogyo M.

Science. 2002 Dec 6;298(5600):2002-6.

27.

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.

Greenbaum DC, Arnold WD, Lu F, Hayrapetian L, Baruch A, Krumrine J, Toba S, Chehade K, Brömme D, Kuntz ID, Bogyo M.

Chem Biol. 2002 Oct;9(10):1085-94.

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