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Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives.

Green KD, Fosso MY, Mayhoub AS, Garneau-Tsodikova S.

Bioorg Med Chem Lett. 2019 May 1;29(9):1127-1132. doi: 10.1016/j.bmcl.2019.02.025. Epub 2019 Feb 21.


N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents.

Thamban Chandrika N, Dennis EK, Shrestha SK, Ngo HX, Green KD, Kwiatkowski S, Deaciuc AG, Dwoskin LP, Watt DS, Garneau-Tsodikova S.

Eur J Med Chem. 2019 Feb 15;164:273-281. doi: 10.1016/j.ejmech.2018.12.042. Epub 2018 Dec 18.


Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors.

Green KD, Fosso MY, Garneau-Tsodikova S.

Molecules. 2018 Dec 8;23(12). pii: E3252. doi: 10.3390/molecules23123252.


Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates.

Story S, Skriba MJ, Maiti K, Nihar Ranjan, Degtyareva NN, Green KD, Khodaverdian V, Oyelere AK, Garneau-Tsodikova S, Arya DP.

Eur J Med Chem. 2019 Feb 1;163:381-393. doi: 10.1016/j.ejmech.2018.11.022. Epub 2018 Nov 14.


Interfering With DNA Decondensation as a Strategy Against Mycobacteria.

Scutigliani EM, Scholl ER, Grootemaat AE, Khanal S, Kochan JA, Krawczyk PM, Reits EA, Garzan A, Ngo HX, Green KD, Garneau-Tsodikova S, Ruijter JM, van Veen HA, van der Wel NN.

Front Microbiol. 2018 Sep 5;9:2034. doi: 10.3389/fmicb.2018.02034. eCollection 2018.


Using MbtH-Like Proteins to Alter the Substrate Profile of a Nonribosomal Peptide Adenylation Enzyme.

Mori S, Green KD, Choi R, Buchko GW, Fried MG, Garneau-Tsodikova S.

Chembiochem. 2018 Oct 18;19(20):2186-2194. doi: 10.1002/cbic.201800240. Epub 2018 Oct 4.


Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall.

Louzoun Zada S, Green KD, Shrestha SK, Herzog IM, Garneau-Tsodikova S, Fridman M.

ACS Infect Dis. 2018 Jul 13;4(7):1121-1129. doi: 10.1021/acsinfecdis.8b00078. Epub 2018 May 1.


Differential Effects of Linkers on the Activity of Amphiphilic Tobramycin Antifungals.

Fosso MY, Shrestha SK, Thamban Chandrika N, Dennis EK, Green KD, Garneau-Tsodikova S.

Molecules. 2018 Apr 13;23(4). pii: E899. doi: 10.3390/molecules23040899.


Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.

Ngo HX, Green KD, Gajadeera CS, Willby MJ, Holbrook SYL, Hou C, Garzan A, Mayhoub AS, Posey JE, Tsodikov OV, Garneau-Tsodikova S.

ACS Infect Dis. 2018 Jun 8;4(6):1030-1040. doi: 10.1021/acsinfecdis.8b00074. Epub 2018 Mar 30.


Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.

Green KD, Biswas T, Pang AH, Willby MJ, Reed MS, Stuchlik O, Pohl J, Posey JE, Tsodikov OV, Garneau-Tsodikova S.

Biochemistry. 2018 Feb 6;57(5):781-790. doi: 10.1021/acs.biochem.7b01089. Epub 2018 Jan 18.


Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors.

Garzan A, Willby MJ, Ngo HX, Gajadeera CS, Green KD, Holbrook SY, Hou C, Posey JE, Tsodikov OV, Garneau-Tsodikova S.

ACS Infect Dis. 2017 Apr 14;3(4):302-309. doi: 10.1021/acsinfecdis.6b00193. Epub 2017 Feb 17.


Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone-Neomycin Conjugates.

Degtyareva NN, Gong C, Story S, Levinson NS, Oyelere AK, Green KD, Garneau-Tsodikova S, Arya DP.

ACS Infect Dis. 2017 Mar 10;3(3):206-215. doi: 10.1021/acsinfecdis.6b00176. Epub 2017 Feb 17.


Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis.

Garzan A, Willby MJ, Green KD, Tsodikov OV, Posey JE, Garneau-Tsodikova S.

ACS Med Chem Lett. 2016 Sep 15;7(12):1219-1221. eCollection 2016 Dec 8.


Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.

Garzan A, Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S.

J Med Chem. 2016 Dec 8;59(23):10619-10628. Epub 2016 Nov 22.


Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.

Shrestha SK, Kril LM, Green KD, Kwiatkowski S, Sviripa VM, Nickell JR, Dwoskin LP, Watt DS, Garneau-Tsodikova S.

Bioorg Med Chem. 2017 Jan 1;25(1):58-66. doi: 10.1016/j.bmc.2016.10.009. Epub 2016 Oct 10.


A complex game of hide and seek: the search for new antifungals.

Ngo HX, Garneau-Tsodikova S, Green KD.

Medchemcomm. 2016 Jul 1;7(7):1285-1306. Epub 2016 May 17.


Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus.

Ngo HX, Shrestha SK, Green KD, Garneau-Tsodikova S.

Bioorg Med Chem. 2016 Dec 15;24(24):6298-6306. doi: 10.1016/j.bmc.2016.03.060. Epub 2016 Mar 31.


A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW.

Liu X, Jin Y, Cai W, Green KD, Goswami A, Garneau-Tsodikova S, Nonaka K, Baba S, Funabashi M, Yang Z, Van Lanen SG.

Org Biomol Chem. 2016 Apr 28;14(16):3956-62. doi: 10.1039/c6ob00381h. Epub 2016 Apr 6.


Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.

Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S.

ACS Chem Biol. 2016 Jun 17;11(6):1639-46. doi: 10.1021/acschembio.6b00110. Epub 2016 Apr 7.


Arginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity.

Jin Y, Watkins D, Degtyareva NN, Green KD, Spano MN, Garneau-Tsodikova S, Arya DP.

Medchemcomm. 2016 Jan 1;7(1):164-169. Epub 2015 Oct 3.


Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides.

Thamban Chandrika N, Green KD, Houghton JL, Garneau-Tsodikova S.

ACS Med Chem Lett. 2015 Sep 30;6(11):1134-9. doi: 10.1021/acsmedchemlett.5b00255. eCollection 2015 Nov 12.


Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.

Fosso MY, Shrestha SK, Green KD, Garneau-Tsodikova S.

J Med Chem. 2015 Dec 10;58(23):9124-32. doi: 10.1021/acs.jmedchem.5b01375. Epub 2015 Dec 1.


Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones.

Fosso MY, LeVine H 3rd, Green KD, Tsodikov OV, Garneau-Tsodikova S.

Org Biomol Chem. 2015 Sep 28;13(36):9418-26. doi: 10.1039/c5ob01478f. Epub 2015 Aug 6.


Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.

Wasserman MR, Pulk A, Zhou Z, Altman RB, Zinder JC, Green KD, Garneau-Tsodikova S, Cate JH, Blanchard SC.

Nat Commun. 2015 Jul 30;6:7896. doi: 10.1038/ncomms8896.


Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria.

Green KD, Pricer RE, Stewart MN, Garneau-Tsodikova S.

ACS Infect Dis. 2015 Jun 12;1(6):272-83. doi: 10.1021/acsinfecdis.5b00036. Epub 2015 May 4.


Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents.

Shrestha SK, Fosso MY, Green KD, Garneau-Tsodikova S.

Antimicrob Agents Chemother. 2015 Aug;59(8):4861-9. doi: 10.1128/AAC.00229-15. Epub 2015 Jun 1.


Tobramycin Variants with Enhanced Ribosome-Targeting Activity.

Fosso MY, Zhu H, Green KD, Garneau-Tsodikova S, Fredrick K.

Chembiochem. 2015 Jul 27;16(11):1565-70. doi: 10.1002/cbic.201500256. Epub 2015 Jun 17.


Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts.

Li Y, Green KD, Johnson BR, Garneau-Tsodikova S.

Antimicrob Agents Chemother. 2015 Jul;59(7):4148-56. doi: 10.1128/AAC.00885-15. Epub 2015 May 4.


Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis.

Green KD, Biswas T, Chang C, Wu R, Chen W, Janes BK, Chalupska D, Gornicki P, Hanna PC, Tsodikov OV, Joachimiak A, Garneau-Tsodikova S.

Biochemistry. 2015 May 26;54(20):3197-206. doi: 10.1021/acs.biochem.5b00244. Epub 2015 May 12.


Influence of linker length and composition on enzymatic activity and ribosomal binding of neomycin dimers.

Watkins D, Kumar S, Green KD, Arya DP, Garneau-Tsodikova S.

Antimicrob Agents Chemother. 2015 Jul;59(7):3899-905. doi: 10.1128/AAC.00861-15. Epub 2015 Apr 20.



Cai W, Goswami A, Yang Z, Liu X, Green KD, Barnard-Britson S, Baba S, Funabashi M, Nonaka K, Sunkara M, Morris AJ, Spork AP, Ducho C, Garneau-Tsodikova S, Thorson JS, Van Lanen SG.

J Biol Chem. 2015 May 29;290(22):13710-24. doi: 10.1074/jbc.M115.646414. Epub 2015 Apr 8.


Rapid synthesis, RNA binding, and antibacterial screening of a peptidic-aminosugar (PA) library.

Jiang L, Watkins D, Jin Y, Gong C, King A, Washington AZ, Green KD, Garneau-Tsodikova S, Oyelere AK, Arya DP.

ACS Chem Biol. 2015 May 15;10(5):1278-89. doi: 10.1021/cb5010367. Epub 2015 Feb 23.


Percutaneous management of RetroFlex 3 balloon rupture and separation of the Edwards Sapien delivery system.

Green KD, Waked A, Majeed U, Fudim M, Robbins MA, Crenshaw M, Zhao D.

Tex Heart Inst J. 2014 Dec 1;41(6):641-4. doi: 10.14503/THIJ-13-3447. eCollection 2014 Dec.


Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG.

Gajadeera C, Willby MJ, Green KD, Shaul P, Fridman M, Garneau-Tsodikova S, Posey JE, Tsodikov OV.

J Antibiot (Tokyo). 2015 Mar;68(3):153-7. doi: 10.1038/ja.2014.131. Epub 2014 Sep 24.


Shear effects on aluminum phosphate adjuvant particle properties in vaccine drug products.

Kolade OO, Jin W, Tengroth C, Green KD, Bracewell DG.

J Pharm Sci. 2015 Feb;104(2):378-87. doi: 10.1002/jps.24127. Epub 2014 Aug 29.


Inhibition of glioma progression by a newly discovered CD38 inhibitor.

Blacher E, Ben Baruch B, Levy A, Geva N, Green KD, Garneau-Tsodikova S, Fridman M, Stein R.

Int J Cancer. 2015 Mar 15;136(6):1422-33. doi: 10.1002/ijc.29095. Epub 2014 Aug 7.


Racial differences in the prevalence of severe aortic stenosis.

Patel DK, Green KD, Fudim M, Harrell FE, Wang TJ, Robbins MA.

J Am Heart Assoc. 2014 May 28;3(3):e000879. doi: 10.1161/JAHA.114.000879.


A random sequential mechanism of aminoglycoside acetylation by Mycobacterium tuberculosis Eis protein.

Tsodikov OV, Green KD, Garneau-Tsodikova S.

PLoS One. 2014 Apr 3;9(4):e92370. doi: 10.1371/journal.pone.0092370. eCollection 2014.


Discovery of inhibitors of Bacillus anthracis primase DnaG.

Biswas T, Green KD, Garneau-Tsodikova S, Tsodikov OV.

Biochemistry. 2013 Oct 1;52(39):6905-10. doi: 10.1021/bi4011286. Epub 2013 Sep 19.


Resistance in tuberculosis: what do we know and where can we go?

Green KD, Garneau-Tsodikova S.

Front Microbiol. 2013 Jul 23;4:208. doi: 10.3389/fmicb.2013.00208. eCollection 2013.


Redesign of substrate specificity and identification of the aminoglycoside binding residues of Eis from Mycobacterium tuberculosis.

Jennings BC, Labby KJ, Green KD, Garneau-Tsodikova S.

Biochemistry. 2013 Jul 30;52(30):5125-32. doi: 10.1021/bi4002985. Epub 2013 Jul 16.


Peripheral vascular complications during transcatheter aortic valve replacement: management and potential role of chronic steroid use.

Fudim M, Green KD, Fredi JL, Robbins MA, Zhao D.

Perspect Vasc Surg Endovasc Ther. 2012 Dec;24(4):206-9. doi: 10.1177/1531003513491985. Epub 2013 Jun 21.


Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance.

Berkov-Zrihen Y, Green KD, Labby KJ, Feldman M, Garneau-Tsodikova S, Fridman M.

J Med Chem. 2013 Jul 11;56(13):5613-25. doi: 10.1021/jm400707f. Epub 2013 Jul 1.


Investigation of the role of linker moieties in bifunctional tacrine hybrids.

Eckroat TJ, Green KD, Reed RA, Bornstein JJ, Garneau-Tsodikova S.

Bioorg Med Chem. 2013 Jun 15;21(12):3614-23. doi: 10.1016/j.bmc.2013.02.047. Epub 2013 Mar 14.


Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6')-IId from Serratia marcescens.

Green KD, Garneau-Tsodikova S.

Biochimie. 2013 Jun;95(6):1319-25. doi: 10.1016/j.biochi.2013.02.011. Epub 2013 Feb 26.


Combining PCI and CABG: the role of hybrid revascularization.

Green KD, Lynch DR Jr, Chen TP, Zhao D.

Curr Cardiol Rep. 2013 Apr;15(4):351. doi: 10.1007/s11886-013-0351-9. Review.


Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.

Houghton JL, Green KD, Pricer RE, Mayhoub AS, Garneau-Tsodikova S.

J Antimicrob Chemother. 2013 Apr;68(4):800-5. doi: 10.1093/jac/dks497. Epub 2012 Dec 11.


Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis.

Pricer RE, Houghton JL, Green KD, Mayhoub AS, Garneau-Tsodikova S.

Mol Biosyst. 2012 Oct 30;8(12):3305-13. doi: 10.1039/c2mb25341k.


Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis.

Chen W, Green KD, Garneau-Tsodikova S.

Antimicrob Agents Chemother. 2012 Nov;56(11):5831-8. doi: 10.1128/AAC.00932-12. Epub 2012 Sep 4.


Reverse remodeling and recovery from cachexia in rats with aldosteronism.

Cheema Y, Zhao W, Zhao T, Khan MU, Green KD, Ahokas RA, Gerling IC, Bhattacharya SK, Weber KT.

Am J Physiol Heart Circ Physiol. 2012 Aug 15;303(4):H486-95. doi: 10.1152/ajpheart.00192.2012. Epub 2012 Jun 22.

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