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Adrenal Cortical Carcinoma Associated With Lynch Syndrome: A Case Report and Review of Literature.

Kaur RJ, Pichurin PN, Hines JM, Singh RJ, Grebe SK, Bancos I.

J Endocr Soc. 2019 Mar 5;3(4):784-790. doi: 10.1210/js.2019-00050. eCollection 2019 Apr 1.


Compound heterozygosity for a whole gene deletion and p.R124C mutation in CYP21A2 causing nonclassic congenital adrenal hyperplasia.

Nasir H, Ali SI, Haque N, Grebe SK, Kirmani S.

Ann Pediatr Endocrinol Metab. 2018 Sep;23(3):158-161. doi: 10.6065/apem.2018.23.3.158. Epub 2018 Sep 28.


Applying Standard Clinical Chemistry Assay Validation to Droplet Digital PCR Quantitative Liquid Biopsy Testing.

Milosevic D, Mills JR, Campion MB, Vidal-Folch N, Voss JS, Halling KC, Highsmith WE, Liu MC, Kipp BR, Grebe SKG.

Clin Chem. 2018 Dec;64(12):1732-1742. doi: 10.1373/clinchem.2018.291278. Epub 2018 Sep 20.


In Reply.

Hines J, Bancos I, Grebe SKG, Singh RJ.

Clin Chem. 2018 Aug;64(8):1258-1259. doi: 10.1373/clinchem.2018.290205. Epub 2018 May 30. No abstract available.


Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts.

Marlow LA, Rohl SD, Miller JL, Knauf JA, Fagin JA, Ryder M, Milosevic D, Netzel BC, Grebe SK, Reddi HV, Smallridge RC, Copland JA.

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3169-3182. doi: 10.1210/jc.2017-01845.


Genotype-Phenotype Correlation of Hereditary Erythrocytosis Mutations, a single center experience.

Oliveira JL, Coon LM, Frederick LA, Hein M, Swanson KC, Savedra ME, Porter TR, Patnaik MM, Tefferi A, Pardanani A, Grebe SK, Viswanatha DS, Hoyer JD.

Am J Hematol. 2018 May 23. doi: 10.1002/ajh.25150. [Epub ahead of print]


High-Resolution, Accurate-Mass (HRAM) Mass Spectrometry Urine Steroid Profiling in the Diagnosis of Adrenal Disorders.

Hines JM, Bancos I, Bancos C, Singh RD, Avula AV, Young WF, Grebe SK, Singh RJ.

Clin Chem. 2017 Dec;63(12):1824-1835. doi: 10.1373/clinchem.2017.271106. Epub 2017 Aug 16.


Analytical and clinical performance of thyroglobulin autoantibody assays in thyroid cancer follow-up.

Katrangi W, Grebe SKG, Algeciras-Schimnich A.

Clin Chem Lab Med. 2017 Oct 26;55(12):1987-1994. doi: 10.1515/cclm-2017-0034.


Primary Renal Paragangliomas and Renal Neoplasia Associated with Pheochromocytoma/Paraganglioma: Analysis of von Hippel-Lindau (VHL), Succinate Dehydrogenase (SDHX) and Transmembrane Protein 127 (TMEM127).

Gupta S, Zhang J, Milosevic D, Mills JR, Grebe SK, Smith SC, Erickson LA.

Endocr Pathol. 2017 Sep;28(3):253-268. doi: 10.1007/s12022-017-9489-0.


First Steps toward Harmonization of LC-MS/MS Thyroglobulin Assays.

Netzel BC, Grant RP, Hoofnagle AN, Rockwood AL, Shuford CM, Grebe SK.

Clin Chem. 2016 Jan;62(1):297-9. doi: 10.1373/clinchem.2015.245266. Epub 2015 Oct 1. No abstract available.


Altered Calcium and Vitamin D Homeostasis in First-Time Calcium Kidney Stone-Formers.

Ketha H, Singh RJ, Grebe SK, Bergstralh EJ, Rule AD, Lieske JC, Kumar R.

PLoS One. 2015 Sep 2;10(9):e0137350. doi: 10.1371/journal.pone.0137350. eCollection 2015.


Monocyte HLA-DR expression and neutrophil CD64 expression as biomarkers of infection in critically ill neonates and infants.

Juskewitch JE, Abraham RS, League SC, Jenkins SM, Smith CY, Enders FT, Grebe SK, Carey WA, Huskins WC.

Pediatr Res. 2015 Dec;78(6):683-90. doi: 10.1038/pr.2015.164. Epub 2015 Aug 31.


Thyroglobulin (Tg) Testing Revisited: Tg Assays, TgAb Assays, and Correlation of Results With Clinical Outcomes.

Netzel BC, Grebe SK, Carranza Leon BG, Castro MR, Clark PM, Hoofnagle AN, Spencer CA, Turcu AF, Algeciras-Schimnich A.

J Clin Endocrinol Metab. 2015 Aug;100(8):E1074-83. doi: 10.1210/jc.2015-1967. Epub 2015 Jun 16.


Detection of IGF-1 protein variants by use of LC-MS with high-resolution accurate mass in routine clinical analysis.

Hines J, Milosevic D, Ketha H, Taylor R, Algeciras-Schimnich A, Grebe SK, Singh RJ.

Clin Chem. 2015 Jul;61(7):990-1. doi: 10.1373/clinchem.2014.234799. Epub 2015 Apr 28. No abstract available.


Clinical validation of a haplotyping method with next-generation sequencing.

Cradic KW, Murphy SJ, Sikkink RA, Neuhauser C, Vasmatzis G, Grebe SK.

Clin Chem. 2015 Feb;61(2):430-1. doi: 10.1373/clinchem.2014.228627. Epub 2014 Nov 11. No abstract available.


Thyroglobulin measurement by highly sensitive assays: focus on laboratory challenges.

Giovanella L, Feldt-Rasmussen U, Verburg FA, Grebe SK, Plebani M, Clark PM.

Clin Chem Lab Med. 2015 Aug;53(9):1301-14. doi: 10.1515/cclm-2014-0813. Review.


Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome.

Liu DM, Torchen LC, Sung Y, Paparodis R, Legro RS, Grebe SK, Singh RJ, Taylor RL, Dunaif A.

Hum Reprod. 2014 Dec;29(12):2764-72. doi: 10.1093/humrep/deu282. Epub 2014 Oct 21.


Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4.

von Roemeling CA, Radisky DC, Marlow LA, Cooper SJ, Grebe SK, Anastasiadis PZ, Tun HW, Copland JA.

Cancer Res. 2014 Sep 1;74(17):4796-810. doi: 10.1158/0008-5472.CAN-14-0210. Epub 2014 Jun 24.


Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.

Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society.

J Clin Endocrinol Metab. 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498.



Grebe SK.

Clin Chem. 2014 Jun;60(6):822. doi: 10.1373/clinchem.2013.214296. No abstract available.


Usefulness of a thyroglobulin liquid chromatography-tandem mass spectrometry assay for evaluation of suspected heterophile interference.

Netzel BC, Grebe SK, Algeciras-Schimnich A.

Clin Chem. 2014 Jul;60(7):1016-8. doi: 10.1373/clinchem.2014.224816. Epub 2014 May 8. No abstract available.


Clinical applications of LC-MS sex steroid assays: evolution of methodologies in the 21st century.

Ketha H, Kaur S, Grebe SK, Singh RJ.

Curr Opin Endocrinol Diabetes Obes. 2014 Jun;21(3):217-26. doi: 10.1097/MED.0000000000000068. Review.


Development and characterization of a differentiated thyroid cancer cell line resistant to VEGFR-targeted kinase inhibitors.

Isham CR, Netzel BC, Bossou AR, Milosevic D, Cradic KW, Grebe SK, Bible KC.

J Clin Endocrinol Metab. 2014 Jun;99(6):E936-43. doi: 10.1210/jc.2013-2658. Epub 2014 Mar 14.


A simple method for gene phasing using mate pair sequencing.

Cradic KW, Murphy SJ, Drucker TM, Sikkink RA, Eberhardt NL, Neuhauser C, Vasmatzis G, Grebe SK.

BMC Med Genet. 2014 Feb 6;15:19. doi: 10.1186/1471-2350-15-19.


Evaluation of Variables Influencing the Measurement of Insulin-like Growth Factor-1.

Bancos I, Algeciras-Schimnich A, Grebe SK, Donato LJ, Nippoldt TB, Erickson D.

Endocr Pract. 2014 May;20(5):421-6. doi: 10.4158/EP13359.OR.


RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma.

Smallridge RC, Chindris AM, Asmann YW, Casler JD, Serie DJ, Reddi HV, Cradic KW, Rivera M, Grebe SK, Necela BM, Eberhardt NL, Carr JM, McIver B, Copland JA, Thompson EA.

J Clin Endocrinol Metab. 2014 Feb;99(2):E338-47. doi: 10.1210/jc.2013-2792. Epub 2013 Dec 2.


Companion-diagnostic testing limited to KRAS codons 12 and 13 misses 17% of potentially relevant RAS mutations in colorectal cancer.

Netzel BC, Grebe SK.

Clin Chim Acta. 2013 Oct 21;425:1-2. doi: 10.1016/j.cca.2013.06.025. Epub 2013 Jul 4.


Individualized correction of neuron-specific enolase (NSE) measurement in hemolyzed serum samples.

Tolan NV, Vidal-Folch N, Algeciras-Schimnich A, Singh RJ, Grebe SK.

Clin Chim Acta. 2013 Sep 23;424:216-21. doi: 10.1016/j.cca.2013.06.009. Epub 2013 Jun 15.


Failure of current laboratory protocols to detect lot-to-lot reagent differences: findings and possible solutions.

Algeciras-Schimnich A, Bruns DE, Boyd JC, Bryant SC, La Fortune KA, Grebe SK.

Clin Chem. 2013 Aug;59(8):1187-94. doi: 10.1373/clinchem.2013.205070. Epub 2013 Apr 16.


Laboratory testing in hyperthyroidism.

Grebe SK, Kahaly GJ.

Am J Med. 2012 Sep;125(9):S2. doi: 10.1016/j.amjmed.2012.05.013.


Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas.

Vasmatzis G, Johnson SH, Knudson RA, Ketterling RP, Braggio E, Fonseca R, Viswanatha DS, Law ME, Kip NS, Ozsan N, Grebe SK, Frederick LA, Eckloff BW, Thompson EA, Kadin ME, Milosevic D, Porcher JC, Asmann YW, Smith DI, Kovtun IV, Ansell SM, Dogan A, Feldman AL.

Blood. 2012 Sep 13;120(11):2280-9. doi: 10.1182/blood-2012-03-419937. Epub 2012 Aug 1.


Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers.

Cooper SJ, von Roemeling CA, Kang KH, Marlow LA, Grebe SK, Menefee ME, Tun HW, Colon-Otero G, Perez EA, Copland JA.

Mol Cancer Ther. 2012 Oct;11(10):2105-15. doi: 10.1158/1535-7163.MCT-11-0873. Epub 2012 Jul 23.


Ionic cross talk can lead to overestimation of 3-methoxytyramine during quantification of metanephrines by mass spectrometry.

Twentyman JM, Cradic KW, Singh RJ, Grebe SK.

Clin Chem. 2012 Jul;58(7):1156-8. doi: 10.1373/clinchem.2012.186601. Epub 2012 May 4. No abstract available.


The Putative PAX8/PPARγ Fusion Oncoprotein Exhibits Partial Tumor Suppressor Activity through Up-Regulation of Micro-RNA-122 and Dominant-Negative PPARγ Activity.

Reddi HV, Madde P, Milosevic D, Hackbarth JS, Algeciras-Schimnich A, McIver B, Grebe SK, Eberhardt NL.

Genes Cancer. 2011 Jan;2(1):46-55. doi: 10.1177/1947601911405045.


Graves' disease: diagnostic and therapeutic challenges (multimedia activity).

Kahaly GJ, Grebe SK, Lupo MA, McDonald N, Sipos JA.

Am J Med. 2011 Jun;124(6):S2-3. doi: 10.1016/j.amjmed.2011.03.001.


Molecular testing in congenital adrenal hyperplasia due to 21α-hydroxylase deficiency in the era of newborn screening.

Sarafoglou K, Lorentz CP, Otten N, Oetting WS, Grebe SK.

Clin Genet. 2012 Jul;82(1):64-70. doi: 10.1111/j.1399-0004.2011.01694.x. Epub 2011 Jun 3.


Analysis of circulating microRNA: preanalytical and analytical challenges.

McDonald JS, Milosevic D, Reddi HV, Grebe SK, Algeciras-Schimnich A.

Clin Chem. 2011 Jun;57(6):833-40. doi: 10.1373/clinchem.2010.157198. Epub 2011 Apr 12.


LC-MS/MS in the Clinical Laboratory - Where to From Here?

Grebe SK, Singh RJ.

Clin Biochem Rev. 2011 Feb;32(1):5-31.


Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma.

Eisenhofer G, Lenders JW, Timmers H, Mannelli M, Grebe SK, Hofbauer LC, Bornstein SR, Tiebel O, Adams K, Bratslavsky G, Linehan WM, Pacak K.

Clin Chem. 2011 Mar;57(3):411-20. doi: 10.1373/clinchem.2010.153320. Epub 2011 Jan 24.


Increasing liquid chromatography-tandem mass spectrometry throughput by mass tagging: a sample-multiplexed high-throughput assay for 25-hydroxyvitamin D2 and D3.

Netzel BC, Cradic KW, Bro ET, Girtman AB, Cyr RC, Singh RJ, Grebe SK.

Clin Chem. 2011 Mar;57(3):431-40. doi: 10.1373/clinchem.2010.157115. Epub 2011 Jan 18.


Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma.

Eisenhofer G, Pacak K, Huynh TT, Qin N, Bratslavsky G, Linehan WM, Mannelli M, Friberg P, Grebe SK, Timmers HJ, Bornstein SR, Lenders JW.

Endocr Relat Cancer. 2010 Dec 21;18(1):97-111. doi: 10.1677/ERC-10-0211. Print 2011 Feb.


Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma.

Jovanovic L, Delahunt B, McIver B, Eberhardt NL, Bhattacharya A, Lea R, Grebe SK.

Pathology. 2010;42(6):524-33. doi: 10.3109/00313025.2010.508780.


Expression of the PAX8/PPARγ Fusion Protein Is Associated with Decreased Neovascularization In Vivo: Impact on Tumorigenesis and Disease Prognosis.

Reddi HV, Madde P, Marlow LA, Copland JA, McIver B, Grebe SK, Eberhardt NL.

Genes Cancer. 2010 May;1(5):480-492.


Accuracy of calculated free testosterone differs between equations and depends on gender and SHBG concentration.

Hackbarth JS, Hoyne JB, Grebe SK, Singh RJ.

Steroids. 2011 Jan;76(1-2):48-55. doi: 10.1016/j.steroids.2010.08.008.


Detailed molecular fingerprinting of four new anaplastic thyroid carcinoma cell lines and their use for verification of RhoB as a molecular therapeutic target.

Marlow LA, D'Innocenzi J, Zhang Y, Rohl SD, Cooper SJ, Sebo T, Grant C, McIver B, Kasperbauer JL, Wadsworth JT, Casler JD, Kennedy PW, Highsmith WE, Clark O, Milosevic D, Netzel B, Cradic K, Arora S, Beaudry C, Grebe SK, Silverberg ML, Azorsa DO, Smallridge RC, Copland JA.

J Clin Endocrinol Metab. 2010 Dec;95(12):5338-47. doi: 10.1210/jc.2010-1421. Epub 2010 Sep 1. Erratum in: J Clin Endocrinol Metab. 2013 Oct;98(10):4213. J Clin Endocrinol Metab. 2013 Nov;98(11):4546.


Thyroglobulin autoantibodies, thyroid nodules, and new insights into some old questions.

Grebe SK.

Thyroid. 2010 Aug;20(8):841-2. doi: 10.1089/thy.2010.1651. No abstract available.


Screening for kidney cancer: is there a role for aquaporin-1 and adipophilin?

Grebe SK, Erickson LA.

Mayo Clin Proc. 2010 May;85(5):410-2. doi: 10.4065/mcp.2010.0165. No abstract available.


Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and estradiol levels.

Anderson H, Fogel N, Grebe SK, Singh RJ, Taylor RL, Dunaif A.

J Clin Endocrinol Metab. 2010 May;95(5):2180-6. doi: 10.1210/jc.2009-2651. Epub 2010 Mar 12.


Development and validation of a comprehensive mutation and deletion detection assay for SDHB, SDHC, and SDHD.

Milosevic D, Lundquist P, Cradic K, Vidal-Folch N, Huynh T, Pacak K, Grebe SK.

Clin Biochem. 2010 May;43(7-8):700-4. doi: 10.1016/j.clinbiochem.2010.01.016. Epub 2010 Feb 12.

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