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ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins.

Al-Ismaeel Q, Neal CP, Al-Mahmoodi H, Almutairi Z, Al-Shamarti I, Straatman K, Jaunbocus N, Irvine A, Issa E, Moreman C, Dennison AR, Emre Sayan A, McDearmid J, Greaves P, Tulchinsky E, Kriajevska M.

Br J Cancer. 2019 May 24. doi: 10.1038/s41416-019-0483-9. [Epub ahead of print]


Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice.

Yamada T, Asano H, Miyata K, Rhomberg LR, Haseman JK, Greaves P, Greim H, Berry C, Cohen SM.

Regul Toxicol Pharmacol. 2019 Jul;105:1-14. doi: 10.1016/j.yrtph.2019.03.012. Epub 2019 Mar 21.


Regional differences in the mid-Victorian diet and their impact on health.

Greaves P.

JRSM Open. 2018 Mar 8;9(3):2054270417751866. doi: 10.1177/2054270417751866. eCollection 2018 Mar. Review. Erratum in: JRSM Open. 2018 Jun 08;9(6):2054270418779895.


Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).

Chernova T, Murphy FA, Galavotti S, Sun XM, Powley IR, Grosso S, Schinwald A, Zacarias-Cabeza J, Dudek KM, Dinsdale D, Le Quesne J, Bennett J, Nakas A, Greaves P, Poland CA, Donaldson K, Bushell M, Willis AE, MacFarlane M.

Curr Biol. 2017 Nov 6;27(21):3302-3314.e6. doi: 10.1016/j.cub.2017.09.007.


Full-Scale Fatigue Testing of a Wind Turbine Blade in Flapwise Direction and Examining the Effect of Crack Propagation on the Blade Performance.

Al-Khudairi O, Hadavinia H, Little C, Gillmore G, Greaves P, Dyer K.

Materials (Basel). 2017 Oct 3;10(10). pii: E1152. doi: 10.3390/ma10101152.


Successful outcome of three patients with sickle-cell disease and fat embolism syndrome treated with intensive exchange transfusion.

Greaves P, Mathew V, Peters C, Rowe S, Amos RJ, Tsitsikas DA.

Clin Case Rep. 2016 Dec 20;5(1):39-43. doi: 10.1002/ccr3.727. eCollection 2017 Jan.


Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse.

Nolte T, Brander-Weber P, Dangler C, Deschl U, Elwell MR, Greaves P, Hailey R, Leach MW, Pandiri AR, Rogers A, Shackelford CC, Spencer A, Tanaka T, Ward JM.

J Toxicol Pathol. 2016;29(1 Suppl):1S-125S. doi: 10.1293/tox.29.1S. Epub 2016 Feb 13. Review.


Scientific and Regulatory Policy Committee: Recommended ("Best") Practices for Determining, Communicating, and Using Adverse Effect Data from Nonclinical Studies.

Kerlin R, Bolon B, Burkhardt J, Francke S, Greaves P, Meador V, Popp J.

Toxicol Pathol. 2016 Feb;44(2):147-62. doi: 10.1177/0192623315623265. Epub 2015 Dec 23.


Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.

Cai H, Scott E, Kholghi A, Andreadi C, Rufini A, Karmokar A, Britton RG, Horner-Glister E, Greaves P, Jawad D, James M, Howells L, Ognibene T, Malfatti M, Goldring C, Kitteringham N, Walsh J, Viskaduraki M, West K, Miller A, Hemingway D, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2015 Jul 29;7(298):298ra117. doi: 10.1126/scitranslmed.aaa7619.


Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.

James MI, Iwuji C, Irving G, Karmokar A, Higgins JA, Griffin-Teal N, Thomas A, Greaves P, Cai H, Patel SR, Morgan B, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Howells LM, Brown K.

Cancer Lett. 2015 Aug 10;364(2):135-41. doi: 10.1016/j.canlet.2015.05.005. Epub 2015 May 12.


Sweet syndrome as terminal event in ruxolitinib-treated myelofibrosis.

Chatterjee B, Rqieh U, Greaves P, Piras D, Firth J, Saja K.

Br J Haematol. 2015 May;169(3):307. doi: 10.1111/bjh.13334. Epub 2015 Feb 23. No abstract available.


Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note.

James MI, Howells LM, Karmokar A, Higgins JA, Greaves P, Cai H, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Brown K.

PLoS One. 2015 Feb 6;10(2):e0117776. doi: 10.1371/journal.pone.0117776. eCollection 2015.


Revisiting the immune microenvironment of diffuse large B-cell lymphoma using a tissue microarray and immunohistochemistry: robust semi-automated analysis reveals CD3 and FoxP3 as potential predictors of response to R-CHOP.

Coutinho R, Clear AJ, Mazzola E, Owen A, Greaves P, Wilson A, Matthews J, Lee A, Alvarez R, da Silva MG, Cabeçadas J, Neuberg D, Calaminici M, Gribben JG.

Haematologica. 2015 Mar;100(3):363-9. doi: 10.3324/haematol.2014.110189. Epub 2014 Nov 25.


Parenthood in long-term survivors after CHOP with or without etoposide treatment for aggressive lymphoma - response to Meissner et al.

Greaves P, Lister TA, Gribben JG.

Br J Haematol. 2014 Aug;166(4):615-6. doi: 10.1111/bjh.12874. Epub 2014 Apr 2. No abstract available.


Bone marrow necrosis and fat embolism syndrome in sickle cell disease: increased susceptibility of patients with non-SS genotypes and a possible association with human parvovirus B19 infection.

Tsitsikas DA, Gallinella G, Patel S, Seligman H, Greaves P, Amos RJ.

Blood Rev. 2014 Jan;28(1):23-30. doi: 10.1016/j.blre.2013.12.002. Epub 2014 Jan 11. Review.


Psychosocial factors associated with impact of cancer in longterm haematological cancer survivors.

Korszun A, Sarker SJ, Chowdhury K, Clark C, Greaves P, Johnson R, Kingston J, Levitt G, Matthews J, White P, Lister A, Gribben J.

Br J Haematol. 2014 Mar;164(6):790-803. doi: 10.1111/bjh.12698. Epub 2013 Dec 23.


Fertility and sexual function in long-term survivors of haematological malignancy: using patient-reported outcome measures to assess a neglected area of need in the late effects clinic.

Greaves P, Sarker SJ, Chowdhury K, Johnson R, Matthews J, Matthews R, Smith M, Korszun A, Gribben JG, Lister TA.

Br J Haematol. 2014 Feb;164(4):526-35. doi: 10.1111/bjh.12651. Epub 2013 Nov 15.


Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells.

Greaves P, Clear A, Owen A, Iqbal S, Lee A, Matthews J, Wilson A, Calaminici M, Gribben JG.

Blood. 2013 Oct 17;122(16):2856-63. doi: 10.1182/blood-2013-06-508044. Epub 2013 Sep 4.


The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies.

Liapis K, Clear A, Owen A, Coutinho R, Greaves P, Lee AM, Montoto S, Calaminici M, Gribben JG.

Blood. 2013 Jul 18;122(3):424-33. doi: 10.1182/blood-2013-03-488171. Epub 2013 May 7.


A shot in the arm for radiotherapy.

Greaves P, Gribben JG.

Blood. 2013 Jan 10;121(2):246-8. doi: 10.1182/blood-2012-11-465526.


Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle and mesothelium.

Greaves P, Chouinard L, Ernst H, Mecklenburg L, Pruimboom-Brees IM, Rinke M, Rittinghausen S, Thibault S, Von Erichsen J, Yoshida T.

J Toxicol Pathol. 2013;26(3 Suppl):1S-26S. doi: 10.1293/tox.26.1S. Review.


The role of B7 family molecules in hematologic malignancy.

Greaves P, Gribben JG.

Blood. 2013 Jan 31;121(5):734-44. doi: 10.1182/blood-2012-10-385591. Epub 2012 Dec 6. Review.


Lymphoid neoplasia. Laser-capturing the essence of Hodgkin lymphoma.

Greaves P, Gribben JG.

Blood. 2012 Nov 29;120(23):4451-2. doi: 10.1182/blood-2012-09-455873.


Myeloablative chemotherapy for chemo-sensitive recurrent follicular lymphoma: potential benefit in second relapse.

Montoto S, Matthews J, Greaves P, Lillington D, Anderson D, Gribben JG, Lister TA.

Haematologica. 2013 Apr;98(4):620-5. doi: 10.3324/haematol.2012.069583. Epub 2012 Nov 9.


Expression of FOXP3, CD68, and CD20 at diagnosis in the microenvironment of classical Hodgkin lymphoma is predictive of outcome.

Greaves P, Clear A, Coutinho R, Wilson A, Matthews J, Owen A, Shanyinde M, Lister TA, Calaminici M, Gribben JG.

J Clin Oncol. 2013 Jan 10;31(2):256-62. doi: 10.1200/JCO.2011.39.9881. Epub 2012 Oct 8. Erratum in: J Clin Oncol. 2017 Apr 1;35(10):1140.


Early relapse and refractory disease remain risk factors in the anthracycline and autologous transplant era for patients with relapsed/refractory classical Hodgkin lymphoma: a single centre intention-to-treat analysis.

Greaves P, Wilson A, Matthews J, Brown DL, Auer R, Montoto S, Lister TA, Gribben JG.

Br J Haematol. 2012 Apr;157(2):201-4. doi: 10.1111/j.1365-2141.2011.08993.x. Epub 2012 Jan 9.


Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL.

Sayan AE, Stanford R, Vickery R, Grigorenko E, Diesch J, Kulbicki K, Edwards R, Pal R, Greaves P, Jariel-Encontre I, Piechaczyk M, Kriajevska M, Mellon JK, Dhillon AS, Tulchinsky E.

Oncogene. 2012 Mar 22;31(12):1493-503. doi: 10.1038/onc.2011.336. Epub 2011 Aug 8.


A GC-MS metabolic profiling study of plasma samples from mice on low- and high-fat diets.

Spagou K, Theodoridis G, Wilson I, Raikos N, Greaves P, Edwards R, Nolan B, Klapa MI.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 15;879(17-18):1467-75. doi: 10.1016/j.jchromb.2011.01.028. Epub 2011 Feb 4.


Demonstration of durable graft versus lymphoma effects in Hodgkin's lymphoma.

Greaves PJ, Gribben JG.

J Clin Oncol. 2011 Mar 10;29(8):952-3. doi: 10.1200/JCO.2010.33.2437. Epub 2011 Jan 31. No abstract available.


Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.

Howells LM, Britton RG, Mazzoletti M, Greaves P, Broggini M, Brown K, Steward WP, Gescher AJ, Sale S.

Cancer Prev Res (Phila). 2010 Aug;3(8):929-39. doi: 10.1158/1940-6207.CAPR-09-0236. Epub 2010 Jul 13.


Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer.

Teichert F, Verschoyle RD, Greaves P, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gescher AJ, Keun HC.

Mol Biosyst. 2010 Oct;6(10):1911-6. doi: 10.1039/c004702c. Epub 2010 Jun 25.


Histopathologic changes in the kidneys of male F344 rats from a 2-year inhalation carcinogenicity study of tetrahydrofuran: a pathology working group review and re-evaluation.

Bruner RH, Greaves P, Hard GC, Regan KS, Ward JM, David RM.

Regul Toxicol Pharmacol. 2010 Oct;58(1):100-5. doi: 10.1016/j.yrtph.2010.04.009. Epub 2010 May 4.


Determination of 8-oxo-2'-deoxyguanosine and creatinine in murine and human urine by liquid chromatography/tandem mass spectrometry: application to chemoprevention studies.

Teichert F, Verschoyle RD, Greaves P, Thorpe JF, Mellon JK, Steward WP, Farmer PB, Gescher AJ, Singh R.

Rapid Commun Mass Spectrom. 2009 Jan;23(2):258-66. doi: 10.1002/rcm.3873. Erratum in: Rapid Commun Mass Spectrom. 2010 Jul;24(14):2175.


Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.

Teichert F, Verschoyle RD, Greaves P, Edwards RE, Teahan O, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gant TW, Gescher AJ, Keun HC.

Prostate. 2008 Jul 1;68(10):1035-47. doi: 10.1002/pros.20761.


Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.

Verschoyle RD, Greaves P, Patel K, Marsden DA, Brown K, Steward WP, Gescher AJ.

Eur J Cancer. 2008 Apr;44(6):898-906. doi: 10.1016/j.ejca.2008.02.020. Epub 2008 Mar 17.


Safe and efficacious use of recombinant human erythropoietin in malignancy.

Greaves P, Agrawal S.

Clin Med (Lond). 2007 Dec;7(6):617-20. Review. No abstract available.


Essential role of the AH receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Davies R, Clothier B, Robinson SW, Edwards RE, Greaves P, Luo J, Gant TW, Chernova T, Smith AG.

Chem Res Toxicol. 2008 Feb;21(2):330-40. doi: 10.1021/tx700176r. Epub 2007 Dec 29.


Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists.

Hardisty JF, Elwell MR, Ernst H, Greaves P, Kolenda-Roberts H, Malarkey DE, Mann PC, Tellier PA.

Toxicol Pathol. 2007 Dec;35(7):928-41.


Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo.

Pathak S, Singh R, Verschoyle RD, Greaves P, Farmer PB, Steward WP, Mellon JK, Gescher AJ, Sharma RA.

Cancer Lett. 2008 Mar 8;261(1):74-83. Epub 2007 Dec 21.


Absence of uterine tumours in CD-1 mice treated neonatally with subcutaneous tamoxifen or 4-hydroxyoestradiol.

Razvi N, Greaves P, Styles J, Edwards R, White IN.

Exp Toxicol Pathol. 2007 Nov;59(3-4):177-85. Epub 2007 Sep 6.


Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts.

Kaur S, Greaves P, Cooke DN, Edwards R, Steward WP, Gescher AJ, Marczylo TH.

J Agric Food Chem. 2007 May 2;55(9):3378-85. Epub 2007 Apr 4.


Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis.

Verschoyle RD, Greaves P, Cai H, Edwards RE, Steward WP, Gescher AJ.

Br J Cancer. 2007 Jan 29;96(2):248-54. Epub 2007 Jan 9.


Posterior reversible encephalopathy syndrome following anti-lymphocyte globulin treatment for severe aplastic anaemia.

Greaves P, Oakervee H, Kon SS, Jones R, Farah N.

Br J Haematol. 2006 Aug;134(3):251. No abstract available.


Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin.

Ridd K, Zhang SD, Edwards RE, Davies R, Greaves P, Wolfreys A, Smith AG, Gant TW.

Carcinogenesis. 2006 Aug;27(8):1556-66. Epub 2006 Mar 14.


Experimental adenomyosis.

Greaves P, White IN.

Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20(4):503-10. Epub 2006 Feb 23. Review.


The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice.

Cai H, Al-Fayez M, Tunstall RG, Platton S, Greaves P, Steward WP, Gescher AJ.

Mol Cancer Ther. 2005 Sep;4(9):1287-92.


Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone.

Verschoyle RD, Greaves P, Cai H, Borkhardt A, Broggini M, D'Incalci M, Riccio E, Doppalapudi R, Kapetanovic IM, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2006 Jan;57(1):1-6. Epub 2005 Nov 5.


Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.

Greaves P, Clothier B, Davies R, Higginson FM, Edwards RE, Dalton TP, Nebert DW, Smith AG.

Biochem Biophys Res Commun. 2005 May 27;331(1):147-52.


Neonatal tamoxifen treatment of mice leads to adenomyosis but not uterine cancer.

Green AR, Styles JA, Parrott EL, Gray D, Edwards RE, Smith AG, Gant TW, Greaves P, Al-Azzawi F, White IN.

Exp Toxicol Pathol. 2005 Mar;56(4-5):255-63.


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