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Items: 37


Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.

Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF.

EMBO J. 2019 Feb 8. pii: e100492. doi: 10.15252/embj.2018100492. [Epub ahead of print]


Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations.

Su T, Grady JP, Afshar S, McDonald SA, Taylor RW, Turnbull DM, Greaves LC.

J Pathol. 2018 Dec;246(4):427-432. doi: 10.1002/path.5156. Epub 2018 Nov 5.


Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

Stamp C, Zupanic A, Sachdeva A, Stoll EA, Shanley DP, Mathers JC, Kirkwood TBL, Heer R, Simons BD, Turnbull DM, Greaves LC.

EBioMedicine. 2018 May;31:166-173. doi: 10.1016/j.ebiom.2018.04.017. Epub 2018 Apr 25.


A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

Simard ML, Mourier A, Greaves LC, Taylor RW, Stewart JB.

J Pathol. 2018 Jul;245(3):311-323. doi: 10.1002/path.5084. Epub 2018 May 14.


Roles of Mitochondrial DNA Mutations in Stem Cell Ageing.

Su T, Turnbull DM, Greaves LC.

Genes (Basel). 2018 Mar 27;9(4). pii: E182. doi: 10.3390/genes9040182. Review.


Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition.

Houghton D, Stewart CJ, Stamp C, Nelson A, Aj Ami NJ, Petrosino JF, Wipat A, Trenell MI, Turnbull DM, Greaves LC.

J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):571-578. doi: 10.1093/gerona/glx197.


A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB.

Cell Rep. 2016 Sep 13;16(11):2980-2990. doi: 10.1016/j.celrep.2016.08.037.


Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(-/-) mice.

Dobson PF, Rocha MC, Grady JP, Chrysostomou A, Hipps D, Watson S, Greaves LC, Deehan DJ, Turnbull DM.

Sci Rep. 2016 Aug 24;6:31907. doi: 10.1038/srep31907.


The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease.

Elson JL, Smith PM, Greaves LC, Lightowlers RN, Chrzanowska-Lightowlers ZM, Taylor RW, Vila-Sanjurjo A.

Mitochondrion. 2015 Nov;25:17-27. doi: 10.1016/j.mito.2015.08.004. Epub 2015 Sep 5.


Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression.

Gorman GS, Blakely EL, Hornig-Do HT, Tuppen HA, Greaves LC, He L, Baker A, Falkous G, Newman J, Trenell MI, Lecky B, Petty RK, Turnbull DM, McFarland R, Taylor RW.

Clin Sci (Lond). 2015 Jun;128(12):895-904. doi: 10.1042/CS20140705.


SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.

Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S.

Cell Stem Cell. 2015 Jan 8;16(1):33-8. doi: 10.1016/j.stem.2014.11.003. Epub 2014 Nov 20.


Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy.

Di Foggia V, Zhang X, Licastro D, Gerli MF, Phadke R, Muntoni F, Mourikis P, Tajbakhsh S, Ellis M, Greaves LC, Taylor RW, Cossu G, Robson LG, Marino S.

J Exp Med. 2014 Dec 15;211(13):2617-33. doi: 10.1084/jem.20140317. Epub 2014 Dec 1.


Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

Greaves LC, Nooteboom M, Elson JL, Tuppen HA, Taylor GA, Commane DM, Arasaradnam RP, Khrapko K, Taylor RW, Kirkwood TB, Mathers JC, Turnbull DM.

PLoS Genet. 2014 Sep 18;10(9):e1004620. doi: 10.1371/journal.pgen.1004620. eCollection 2014 Sep.


Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans.

Baines HL, Stewart JB, Stamp C, Zupanic A, Kirkwood TB, Larsson NG, Turnbull DM, Greaves LC.

Mech Ageing Dev. 2014 Jul;139:22-30. doi: 10.1016/j.mad.2014.06.003. Epub 2014 Jun 7.


Human stem cell aging: do mitochondrial DNA mutations have a causal role?

Baines HL, Turnbull DM, Greaves LC.

Aging Cell. 2014 Apr;13(2):201-5. doi: 10.1111/acel.12199. Epub 2014 Jan 28. Review.


The role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential.

Smith PM, Elson JL, Greaves LC, Wortmann SB, Rodenburg RJ, Lightowlers RN, Chrzanowska-Lightowlers ZM, Taylor RW, Vila-Sanjurjo A.

Hum Mol Genet. 2014 Feb 15;23(4):949-67. doi: 10.1093/hmg/ddt490. Epub 2013 Oct 2.


Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.

Greaves LC, Elson JL, Nooteboom M, Grady JP, Taylor GA, Taylor RW, Mathers JC, Kirkwood TB, Turnbull DM.

PLoS Genet. 2012;8(11):e1003082. doi: 10.1371/journal.pgen.1003082. Epub 2012 Nov 15.


Differences in the accumulation of mitochondrial defects with age in mice and humans.

Greaves LC, Barron MJ, Campbell-Shiel G, Kirkwood TB, Turnbull DM.

Mech Ageing Dev. 2011 Nov-Dec;132(11-12):588-91. doi: 10.1016/j.mad.2011.10.004. Epub 2011 Oct 12.


Mitochondrial DNA and disease.

Greaves LC, Reeve AK, Taylor RW, Turnbull DM.

J Pathol. 2012 Jan;226(2):274-86. doi: 10.1002/path.3028. Epub 2011 Nov 21. Review.


In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells.

Blackwood JK, Williamson SC, Greaves LC, Wilson L, Rigas AC, Sandher R, Pickard RS, Robson CN, Turnbull DM, Taylor RW, Heer R.

J Pathol. 2011 Oct;225(2):181-8. doi: 10.1002/path.2965.


Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO.

Greaves LC, Yu-Wai-Man P, Blakely EL, Krishnan KJ, Beadle NE, Kerin J, Barron MJ, Griffiths PG, Dickinson AJ, Turnbull DM, Taylor RW.

Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3340-6. doi: 10.1167/iovs.09-4659. Epub 2010 Feb 17.


Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.

Yu-Wai-Man P, Lai-Cheong J, Borthwick GM, He L, Taylor GA, Greaves LC, Taylor RW, Griffiths PG, Turnbull DM.

Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3347-53. doi: 10.1167/iovs.09-4660. Epub 2010 Feb 17.


Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts.

Greaves LC, Barron MJ, Plusa S, Kirkwood TB, Mathers JC, Taylor RW, Turnbull DM.

Exp Gerontol. 2010 Aug;45(7-8):573-9. doi: 10.1016/j.exger.2010.01.013. Epub 2010 Jan 22.


Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts.

Nooteboom M, Johnson R, Taylor RW, Wright NA, Lightowlers RN, Kirkwood TB, Mathers JC, Turnbull DM, Greaves LC.

Aging Cell. 2010 Feb;9(1):96-9. doi: 10.1111/j.1474-9726.2009.00531.x. Epub 2009 Oct 30.


Quantification of mitochondrial DNA mutation load.

Greaves LC, Beadle NE, Taylor GA, Commane D, Mathers JC, Khrapko K, Turnbull DM.

Aging Cell. 2009 Sep;8(5):566-72. doi: 10.1111/j.1474-9726.2009.00505.x. Epub 2009 Jul 18.


A methodological approach to tracing cell lineage in human epithelial tissues.

Fellous TG, McDonald SA, Burkert J, Humphries A, Islam S, De-Alwis NM, Gutierrez-Gonzalez L, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, El-Bahrawy M, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Day CP, Wright NA, Alison MR.

Stem Cells. 2009 Jun;27(6):1410-20. doi: 10.1002/stem.67.


Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: link to colon cancer?

Greaves LC, Mathers JC, Taylor RW, Turnbull DM.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):E57. doi: 10.1073/pnas.0903000106. Epub 2009 May 15. No abstract available.


Mitochondrial DNA mutations and ageing.

Greaves LC, Turnbull DM.

Biochim Biophys Acta. 2009 Oct;1790(10):1015-20. doi: 10.1016/j.bbagen.2009.04.018. Epub 2009 May 4. Review.


Locating the stem cell niche and tracing hepatocyte lineages in human liver.

Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Taylor G, McDonald SA, Wright NA, Alison MR.

Hepatology. 2009 May;49(5):1655-63. doi: 10.1002/hep.22791.


Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells.

McDonald SA, Greaves LC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY, Preston SL, Lovell M, Hunt T, Elia G, Oukrif D, Harrison R, Novelli MR, Mitchell I, Stoker DL, Turnbull DM, Jankowski JA, Wright NA.

Gastroenterology. 2008 Feb;134(2):500-10. doi: 10.1053/j.gastro.2007.11.035. Epub 2007 Nov 28.


The ageing mitochondrial genome.

Krishnan KJ, Greaves LC, Reeve AK, Turnbull D.

Nucleic Acids Res. 2007;35(22):7399-405. Epub 2007 Oct 2. Review.


Mitochondrial DNA mutations and aging.

Krishnan KJ, Greaves LC, Reeve AK, Turnbull DM.

Ann N Y Acad Sci. 2007 Apr;1100:227-40. Review.


Mitochondrial DNA mutations in human disease.

Greaves LC, Taylor RW.

IUBMB Life. 2006 Mar;58(3):143-51. Review.


Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.

McDonald SA, Preston SL, Greaves LC, Leedham SJ, Lovell MA, Jankowski JA, Turnbull DM, Wright NA.

Cell Cycle. 2006 Apr;5(8):808-11. Epub 2006 Apr 17. Review.


Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies.

Wilkinson SC, Maas WJ, Nielsen JB, Greaves LC, van de Sandt JJ, Williams FM.

Int Arch Occup Environ Health. 2006 May;79(5):405-13. Epub 2006 Jan 25.


Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.

Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M, Sasieni P, Novelli MR, Jankowski JA, Turnbull DM, Wright NA, McDonald SA.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):714-9. Epub 2006 Jan 6.


Mitochondrial DNA mutations in human colonic crypt stem cells.

Taylor RW, Barron MJ, Borthwick GM, Gospel A, Chinnery PF, Samuels DC, Taylor GA, Plusa SM, Needham SJ, Greaves LC, Kirkwood TB, Turnbull DM.

J Clin Invest. 2003 Nov;112(9):1351-60.

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