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Items: 20


Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats.

Cardoso T, Adler AF, Mattsson B, Hoban DB, Nolbrant S, Wahlestedt JN, Kirkeby A, Grealish S, Björklund A, Parmar M.

J Comp Neurol. 2018 Jul 14. doi: 10.1002/cne.24500. [Epub ahead of print]


IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells.

Lehnen D, Barral S, Cardoso T, Grealish S, Heuer A, Smiyakin A, Kirkeby A, Kollet J, Cremer H, Parmar M, Bosio A, Knöbel S.

Stem Cell Reports. 2017 Oct 10;9(4):1207-1220. doi: 10.1016/j.stemcr.2017.08.016. Epub 2017 Sep 21.


Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli.

Tornero D, Tsupykov O, Granmo M, Rodriguez C, Grønning-Hansen M, Thelin J, Smozhanik E, Laterza C, Wattananit S, Ge R, Tatarishvili J, Grealish S, Brüstle O, Skibo G, Parmar M, Schouenborg J, Lindvall O, Kokaia Z.

Brain. 2017 Mar 1;140(3):692-706. doi: 10.1093/brain/aww347.


Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.

Kirkeby A, Nolbrant S, Tiklova K, Heuer A, Kee N, Cardoso T, Ottosson DR, Lelos MJ, Rifes P, Dunnett SB, Grealish S, Perlmann T, Parmar M.

Cell Stem Cell. 2017 Jan 5;20(1):135-148. doi: 10.1016/j.stem.2016.09.004. Epub 2016 Oct 27.


Plug and Play Brain: Understanding Integration of Transplanted Neurons for Brain Repair.

Grealish S, Parmar M.

Cell Stem Cell. 2016 Dec 1;19(6):679-680. doi: 10.1016/j.stem.2016.11.008.


Brain repair and reprogramming: the route to clinical translation.

Grealish S, Drouin-Ouellet J, Parmar M.

J Intern Med. 2016 Sep;280(3):265-75. doi: 10.1111/joim.12475. Review.


In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry.

Torper O, Ottosson DR, Pereira M, Lau S, Cardoso T, Grealish S, Parmar M.

Cell Rep. 2015 Jul 21;12(3):474-81. doi: 10.1016/j.celrep.2015.06.040. Epub 2015 Jul 9.


Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons.

Grealish S, Heuer A, Cardoso T, Kirkeby A, Jönsson M, Johansson J, Björklund A, Jakobsson J, Parmar M.

Stem Cell Reports. 2015 Jun 9;4(6):975-83. doi: 10.1016/j.stemcr.2015.04.011. Epub 2015 May 21.


GDNF is not required for catecholaminergic neuron survival in vivo.

Kopra J, Vilenius C, Grealish S, Härma MA, Varendi K, Lindholm J, Castrén E, Võikar V, Björklund A, Piepponen TP, Saarma M, Andressoo JO.

Nat Neurosci. 2015 Mar;18(3):319-22. doi: 10.1038/nn.3941. No abstract available.


Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease.

Grealish S, Diguet E, Kirkeby A, Mattsson B, Heuer A, Bramoulle Y, Van Camp N, Perrier AL, Hantraye P, Björklund A, Parmar M.

Cell Stem Cell. 2014 Nov 6;15(5):653-65. doi: 10.1016/j.stem.2014.09.017. Epub 2014 Nov 6.


Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.

Pereira M, Pfisterer U, Rylander D, Torper O, Lau S, Lundblad M, Grealish S, Parmar M.

Sci Rep. 2014 Sep 11;4:6330. doi: 10.1038/srep06330.


Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases.

Nelander J, Grealish S, Parmar M.

Neuroreport. 2013 Dec 18;24(18):1025-30. doi: 10.1097/WNR.0000000000000058. Review.


Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism.

Rylander D, Bagetta V, Pendolino V, Zianni E, Grealish S, Gardoni F, Di Luca M, Calabresi P, Cenci MA, Picconi B.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4375-84. doi: 10.1073/pnas.1311187110. Epub 2013 Oct 29.


Generation of induced neurons via direct conversion in vivo.

Torper O, Pfisterer U, Wolf DA, Pereira M, Lau S, Jakobsson J, Björklund A, Grealish S, Parmar M.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7038-43. doi: 10.1073/pnas.1303829110. Epub 2013 Mar 25.


Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.

Kirkeby A, Grealish S, Wolf DA, Nelander J, Wood J, Lundblad M, Lindvall O, Parmar M.

Cell Rep. 2012 Jun 28;1(6):703-14. doi: 10.1016/j.celrep.2012.04.009. Epub 2012 May 26.


Lineage reprogramming: a shortcut to generating functional neurons from fibroblasts.

Grealish S, Jakobsson J, Parmar M.

Cell Cycle. 2011 Oct 15;10(20):3421-2. doi: 10.4161/cc.10.20.17691. No abstract available.


Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.

Grealish S, Mattsson B, Draxler P, Björklund A.

Eur J Neurosci. 2010 Jun;31(12):2266-78. doi: 10.1111/j.1460-9568.2010.07265.x. Epub 2010 Jun 1.


The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease.

Grealish S, Jönsson ME, Li M, Kirik D, Björklund A, Thompson LH.

Brain. 2010 Feb;133(Pt 2):482-95. doi: 10.1093/brain/awp328. Epub 2010 Jan 31.


Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain.

Thompson LH, Grealish S, Kirik D, Björklund A.

Eur J Neurosci. 2009 Aug;30(4):625-38. doi: 10.1111/j.1460-9568.2009.06878.x. Epub 2009 Aug 10.


Unilateral axonal or terminal injection of 6-hydroxydopamine causes rapid-onset nigrostriatal degeneration and contralateral motor impairments in the rat.

Grealish S, Xie L, Kelly M, Dowd E.

Brain Res Bull. 2008 Nov 25;77(5):312-9. doi: 10.1016/j.brainresbull.2008.08.018. Epub 2008 Sep 24.


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