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Items: 1 to 50 of 141


Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1).

Gatta E, Grayson DR, Auta J, Saudagar V, Dong E, Chen Y, Krishnan HR, Drnevich J, Pandey SC, Guidotti A.

Mol Psychiatry. 2019 Jun 25. doi: 10.1038/s41380-019-0449-6. [Epub ahead of print]


Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking.

Sakharkar AJ, Kyzar EJ, Gavin DP, Zhang H, Chen Y, Krishnan HR, Grayson DR, Pandey SC.

Neuropharmacology. 2019 Oct;157:107679. doi: 10.1016/j.neuropharm.2019.107679. Epub 2019 Jun 20.


N-Phthalyl-l-Tryptophan (RG108), like Clozapine (CLO), Induces Chromatin Remodeling in Brains of Prenatally Stressed Mice.

Dong E, Locci V, Gatta E, Grayson DR, Guidotti A.

Mol Pharmacol. 2019 Jan;95(1):62-69. doi: 10.1124/mol.118.113415. Epub 2018 Nov 5.


DNA Methylation in Animal Models of Psychosis.

Grayson DR, Guidotti A.

Prog Mol Biol Transl Sci. 2018;157:105-132. doi: 10.1016/bs.pmbts.2017.12.012. Epub 2018 Mar 30. Review.


Some implications of an epigenetic-based omnigenic model of psychiatric disorders.

Peedicayil J, Grayson DR.

J Theor Biol. 2018 Sep 7;452:81-84. doi: 10.1016/j.jtbi.2018.05.014. Epub 2018 May 22. No abstract available.


An epigenetic basis for an omnigenic model of psychiatric disorders.

Peedicayil J, Grayson DR.

J Theor Biol. 2018 Apr 14;443:52-55. doi: 10.1016/j.jtbi.2018.01.027. Epub 2018 Jan 31. Review. No abstract available.


Low doses of prenatal ethanol exposure and maternal separation alter HPA axis function and ethanol consumption in adult male rats.

Biggio F, Talani G, Locci V, Pisu MG, Boero G, Ciarlo B, Grayson DR, Serra M.

Neuropharmacology. 2018 Mar 15;131:271-281. doi: 10.1016/j.neuropharm.2017.12.005. Epub 2017 Dec 6.


Vladimir Voevodsky (1966-2017).

Grayson DR.

Nature. 2017 Nov 9;551(7679):169. doi: 10.1038/d41586-017-05477-9. No abstract available.


Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD).

Gatta E, Auta J, Gavin DP, Bhaumik DK, Grayson DR, Pandey SC, Guidotti A.

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):1013-1026. doi: 10.1093/ijnp/pyx075.


Special Issue Introduction: Role of Epigenetic Gene Regulation in Brain Function.

Grayson DR.

Genes (Basel). 2017 Jul 13;8(7). pii: E181. doi: 10.3390/genes8070181.


Chromatin Switches during Neural Cell Differentiation and Their Dysregulation by Prenatal Alcohol Exposure.

Gavin DP, Grayson DR, Varghese SP, Guizzetti M.

Genes (Basel). 2017 May 11;8(5). pii: E137. doi: 10.3390/genes8050137. Review.


Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder (ASD) subjects.

Zhubi A, Chen Y, Guidotti A, Grayson DR.

Int J Dev Neurosci. 2017 Nov;62:63-72. doi: 10.1016/j.ijdevneu.2017.02.003. Epub 2017 Feb 14.


Epigenetic Basis of Clozapine Action.

Alessandro G, Erbo D, Grayson DR.

J Drug Des Res. 2017;4(6). pii: 1055. Epub 2017 Jun 29. No abstract available.


Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders.

Guidotti A, Grayson DR, Caruncho HJ.

Front Cell Neurosci. 2016 Apr 5;10:89. doi: 10.3389/fncel.2016.00089. eCollection 2016. Review.


Altering the course of schizophrenia: progress and perspectives.

Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, Gallinat J, Giedd J, Grayson DR, Heinrichs M, Kahn R, Krebs MO, Leboyer M, Lewis D, Marin O, Marin P, Meyer-Lindenberg A, McGorry P, McGuire P, Owen MJ, Patterson P, Sawa A, Spedding M, Uhlhaas P, Vaccarino F, Wahlestedt C, Weinberger D.

Nat Rev Drug Discov. 2016 Jul;15(7):485-515. doi: 10.1038/nrd.2016.28. Epub 2016 Mar 4. Review.


Metabotropic Glutamate 2/3 Receptors and Epigenetic Modifications in Psychotic Disorders: A Review.

Matrisciano F, Panaccione I, Grayson DR, Nicoletti F, Guidotti A.

Curr Neuropharmacol. 2016;14(1):41-7. Review.


Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs.

Dong E, Tueting P, Matrisciano F, Grayson DR, Guidotti A.

Transl Psychiatry. 2016 Jan 12;6:e711. doi: 10.1038/tp.2015.191.


Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex.

Labouesse MA, Dong E, Grayson DR, Guidotti A, Meyer U.

Epigenetics. 2015;10(12):1143-55. doi: 10.1080/15592294.2015.1114202.


Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder.

Grayson DR, Guidotti A.

Epigenomics. 2016 Jan;8(1):85-104. doi: 10.2217/epi.15.92. Epub 2015 Nov 9.


DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.

Dong E, Ruzicka WB, Grayson DR, Guidotti A.

Schizophr Res. 2015 Sep;167(1-3):35-41. doi: 10.1016/j.schres.2014.10.030. Epub 2014 Dec 2.


Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice.

Dong E, Dzitoyeva SG, Matrisciano F, Tueting P, Grayson DR, Guidotti A.

Biol Psychiatry. 2015 Mar 15;77(6):589-96. doi: 10.1016/j.biopsych.2014.08.012. Epub 2014 Aug 27.


Modeling the molecular epigenetic profile of psychosis in prenatally stressed mice.

Guidotti A, Dong E, Tueting P, Grayson DR.

Prog Mol Biol Transl Sci. 2014;128:89-101. doi: 10.1016/B978-0-12-800977-2.00004-8. Review.


DNA methylation and demethylation as targets for antipsychotic therapy.

Guidotti A, Grayson DR.

Dialogues Clin Neurosci. 2014 Sep;16(3):419-29. Review.


Epigenetic mechanisms in autism spectrum disorder.

Zhubi A, Cook EH, Guidotti A, Grayson DR.

Int Rev Neurobiol. 2014;115:203-44. doi: 10.1016/B978-0-12-801311-3.00006-8. Review.


Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats.

Sakharkar AJ, Tang L, Zhang H, Chen Y, Grayson DR, Pandey SC.

Int J Neuropsychopharmacol. 2014 Dec;17(12):2057-67. doi: 10.1017/S1461145714001047. Epub 2014 Jun 26.


Toward the identification of peripheral epigenetic biomarkers of schizophrenia.

Guidotti A, Auta J, Davis JM, Dong E, Gavin DP, Grayson DR, Sharma RP, Smith RC, Tueting P, Zhubi A.

J Neurogenet. 2014 Mar-Jun;28(1-2):41-52. doi: 10.3109/01677063.2014.892485. Epub 2014 Apr 22. Review.


Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum.

Zhubi A, Chen Y, Dong E, Cook EH, Guidotti A, Grayson DR.

Transl Psychiatry. 2014 Jan 21;4:e349. doi: 10.1038/tp.2013.123.


DNA methylation/demethylation network expression in psychotic patients with a history of alcohol abuse.

Guidotti A, Dong E, Gavin DP, Veldic M, Zhao W, Bhaumik DK, Pandey SC, Grayson DR.

Alcohol Clin Exp Res. 2013 Mar;37(3):417-24. doi: 10.1111/j.1530-0277.2012.01947.x. Epub 2012 Sep 7.


The dynamics of DNA methylation in schizophrenia and related psychiatric disorders.

Grayson DR, Guidotti A.

Neuropsychopharmacology. 2013 Jan;38(1):138-66. doi: 10.1038/npp.2012.125. Epub 2012 Sep 5. Review.


Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.

Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A.

Neuropharmacology. 2013 May;68:184-94. doi: 10.1016/j.neuropharm.2012.04.013. Epub 2012 Apr 28.


DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain.

Kadriu B, Guidotti A, Chen Y, Grayson DR.

J Comp Neurol. 2012 Jun 15;520(9):1951-64. doi: 10.1002/cne.23020.


Laboratory of molecular neurobiology (1988-1994).

Grayson DR.

Pharmacol Res. 2011 Oct;64(4):339-43. doi: 10.1016/j.phrs.2011.05.021. Epub 2011 Jun 16. Review.


A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009).

Guidotti A, Grayson DR.

Pharmacol Res. 2011 Oct;64(4):344-9. doi: 10.1016/j.phrs.2011.05.026. Epub 2011 Jun 15. Review.


Krüppel-like factor 2 regulated gene expression in mouse embryonic yolk sac erythroid cells.

Redmond LC, Dumur CI, Archer KJ, Grayson DR, Haar JL, Lloyd JA.

Blood Cells Mol Dis. 2011 Jun 15;47(1):1-11. doi: 10.1016/j.bcmd.2011.03.002. Epub 2011 Apr 29.


Epigenetic GABAergic targets in schizophrenia and bipolar disorder.

Guidotti A, Auta J, Chen Y, Davis JM, Dong E, Gavin DP, Grayson DR, Matrisciano F, Pinna G, Satta R, Sharma RP, Tremolizzo L, Tueting P.

Neuropharmacology. 2011 Jun;60(7-8):1007-16. doi: 10.1016/j.neuropharm.2010.10.021. Epub 2010 Nov 11. Review.


Analysis of the GAD1 promoter: trans-acting factors and DNA methylation converge on the 5' untranslated region.

Chen Y, Dong E, Grayson DR.

Neuropharmacology. 2011 Jun;60(7-8):1075-87. doi: 10.1016/j.neuropharm.2010.09.017. Epub 2010 Sep 28.


Valproate induces DNA demethylation in nuclear extracts from adult mouse brain.

Dong E, Chen Y, Gavin DP, Grayson DR, Guidotti A.

Epigenetics. 2010 Nov-Dec;5(8):730-5. doi: 10.4161/epi.5.8.13053. Epub 2010 Nov 1.


CpG methylation in neurons: message, memory, or mask?

Sharma RP, Gavin DP, Grayson DR.

Neuropsychopharmacology. 2010 Sep;35(10):2009-20. doi: 10.1038/npp.2010.85. Epub 2010 Jul 14. Review.


Schizophrenia and the epigenetic hypothesis.

Grayson DR.

Epigenomics. 2010 Jun;2(3):341-4. doi: 10.2217/epi.10.22. No abstract available.


Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?

Grayson DR, Kundakovic M, Sharma RP.

Mol Pharmacol. 2010 Feb;77(2):126-35. doi: 10.1124/mol.109.061333. Epub 2009 Nov 16. Review.


Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation.

Dong E, Grayson DR, Guidotti A, Costa E.

Epigenomics. 2009 Oct;1(1):201-11. doi: 10.2217/epi.09.2.


From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia.

Grayson DR, Chen Y, Dong E, Kundakovic M, Guidotti A.

Epigenetics. 2009 Apr 1;4(3):144-9. Epub 2009 Apr 25. Review.


Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling.

Guidotti A, Dong E, Kundakovic M, Satta R, Grayson DR, Costa E.

Trends Pharmacol Sci. 2009 Feb;30(2):55-60. doi: 10.1016/ Epub 2008 Dec 26.


GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability.

Costa E, Chen Y, Dong E, Grayson DR, Kundakovic M, Maloku E, Ruzicka W, Satta R, Veldic M, Zhubi A, Guidotti A.

Expert Rev Neurother. 2009 Jan;9(1):87-98. doi: 10.1586/14737175.9.1.87. Review.


The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes.

Kundakovic M, Chen Y, Guidotti A, Grayson DR.

Mol Pharmacol. 2009 Feb;75(2):342-54. doi: 10.1124/mol.108.051763. Epub 2008 Nov 24.


Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation.

Dong E, Nelson M, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13614-9. doi: 10.1073/pnas.0805493105. Epub 2008 Aug 29.


Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects.

Gavin DP, Kartan S, Chase K, Grayson DR, Sharma RP.

Schizophr Res. 2008 Aug;103(1-3):330-2. doi: 10.1016/j.schres.2008.04.026. Epub 2008 Jun 9. No abstract available.


Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical cultures.

Sharma RP, Tun N, Grayson DR.

Epigenetics. 2008 Mar-Apr;3(2):74-80. Epub 2008 Mar 12.


Expression of GABA A receptor alpha1 subunit mRNA and protein in rat neocortex following photothrombotic infarction.

Kharlamov EA, Downey KL, Jukkola PI, Grayson DR, Kelly KM.

Brain Res. 2008 May 19;1210:29-38. doi: 10.1016/j.brainres.2008.02.070. Epub 2008 Mar 5.

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