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Items: 43


Conservation of location of several specific inhibitory codon pairs in the Saccharomyces sensu stricto yeasts reveals translational selection.

Ghoneim DH, Zhang X, Brule CE, Mathews DH, Grayhack EJ.

Nucleic Acids Res. 2019 Feb 20;47(3):1164-1177. doi: 10.1093/nar/gky1262.


Multi-protein bridging factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting.

Wang J, Zhou J, Yang Q, Grayhack EJ.

Elife. 2018 Nov 22;7. pii: e39637. doi: 10.7554/eLife.39637.


The analysis of translational mechanisms that modulate gene expression.

Coller J, Grayhack EJ.

Methods. 2018 Mar 15;137:1-2. doi: 10.1016/j.ymeth.2018.03.005. No abstract available.


Synonymous Codons: Choose Wisely for Expression.

Brule CE, Grayhack EJ.

Trends Genet. 2017 Apr;33(4):283-297. doi: 10.1016/j.tig.2017.02.001. Epub 2017 Mar 12. Review.


A genome wide dosage suppressor network reveals genomic robustness.

Patra B, Kon Y, Yadav G, Sevold AW, Frumkin JP, Vallabhajosyula RR, Hintze A, Østman B, Schossau J, Bhan A, Marzolf B, Tamashiro JK, Kaur A, Baliga NS, Grayhack EJ, Adami C, Galas DJ, Raval A, Phizicky EM, Ray A.

Nucleic Acids Res. 2017 Jan 9;45(1):255-270. doi: 10.1093/nar/gkw1148. Epub 2016 Nov 29.


Adjacent Codons Act in Concert to Modulate Translation Efficiency in Yeast.

Gamble CE, Brule CE, Dean KM, Fields S, Grayhack EJ.

Cell. 2016 Jul 28;166(3):679-690. doi: 10.1016/j.cell.2016.05.070. Epub 2016 Jun 30.


RNA-ID, a Powerful Tool for Identifying and Characterizing Regulatory Sequences.

Brule CE, Dean KM, Grayhack EJ.

Methods Enzymol. 2016;572:237-53. doi: 10.1016/bs.mie.2016.02.003. Epub 2016 Mar 11.


Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants.

Quivey RG Jr, Grayhack EJ, Faustoferri RC, Hubbard CJ, Baldeck JD, Wolf AS, MacGilvray ME, Rosalen PL, Scott-Anne K, Santiago B, Gopal S, Payne J, Marquis RE.

Mol Oral Microbiol. 2015 Dec;30(6):474-95. doi: 10.1111/omi.12107. Epub 2015 Jun 19.


Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats.

Wolf AS, Grayhack EJ.

RNA. 2015 May;21(5):935-45. doi: 10.1261/rna.049080.114. Epub 2015 Mar 19.


Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis.

Guy MP, Young DL, Payea MJ, Zhang X, Kon Y, Dean KM, Grayhack EJ, Mathews DH, Fields S, Phizicky EM.

Genes Dev. 2014 Aug 1;28(15):1721-32. doi: 10.1101/gad.245936.114.


Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1.

Letzring DP, Wolf AS, Brule CE, Grayhack EJ.

RNA. 2013 Sep;19(9):1208-17. doi: 10.1261/rna.039446.113. Epub 2013 Jul 3.


The structure of yeast glutaminyl-tRNA synthetase and modeling of its interaction with tRNA.

Grant TD, Luft JR, Wolfley JR, Snell ME, Tsuruta H, Corretore S, Quartley E, Phizicky EM, Grayhack EJ, Snell EH.

J Mol Biol. 2013 Jul 24;425(14):2480-93. doi: 10.1016/j.jmb.2013.03.043. Epub 2013 Apr 10.


RNA-ID, a highly sensitive and robust method to identify cis-regulatory sequences using superfolder GFP and a fluorescence-based assay.

Dean KM, Grayhack EJ.

RNA. 2012 Dec;18(12):2335-44. doi: 10.1261/rna.035907.112. Epub 2012 Oct 24.


Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase.

Grant TD, Snell EH, Luft JR, Quartley E, Corretore S, Wolfley JR, Snell ME, Hadd A, Perona JJ, Phizicky EM, Grayhack EJ.

Nucleic Acids Res. 2012 Apr;40(8):3723-31. doi: 10.1093/nar/gkr1223. Epub 2011 Dec 17.


Control of translation efficiency in yeast by codon-anticodon interactions.

Letzring DP, Dean KM, Grayhack EJ.

RNA. 2010 Dec;16(12):2516-28. doi: 10.1261/rna.2411710. Epub 2010 Oct 22.


Heterologous expression of L. major proteins in S. cerevisiae: a test of solubility, purity, and gene recoding.

Quartley E, Alexandrov A, Mikucki M, Buckner FS, Hol WG, DeTitta GT, Phizicky EM, Grayhack EJ.

J Struct Funct Genomics. 2009 Sep;10(3):233-47. doi: 10.1007/s10969-009-9068-9. Epub 2009 Aug 22.


Chapter 11. Identification and analysis of tRNAs that are degraded in Saccharomyces cerevisiae due to lack of modifications.

Chernyakov I, Baker MA, Grayhack EJ, Phizicky EM.

Methods Enzymol. 2008;449:221-37. doi: 10.1016/S0076-6879(08)02411-7.


The use of Saccharomyces cerevisiae proteomic libraries to identify RNA-modifying proteins.

Jackman JE, Grayhack EJ, Phizicky EM.

Methods Mol Biol. 2008;488:383-93. doi: 10.1007/978-1-60327-475-3_25.


Structural genomics of pathogenic protozoa: an overview.

Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, Earnest T, Soltis M, Zucker F, Myler PJ, Schoenfeld L, Kim D, Worthey L, Lacount D, Vignali M, Li J, Mondal S, Massey A, Carroll B, Gulde S, Luft J, Desoto L, Holl M, Caruthers J, Bosch J, Robien M, Arakaki T, Holmes M, Le Trong I, Hol WG.

Methods Mol Biol. 2008;426:497-513. doi: 10.1007/978-1-60327-058-8_33. Review.


Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.

Chernyakov I, Whipple JM, Kotelawala L, Grayhack EJ, Phizicky EM.

Genes Dev. 2008 May 15;22(10):1369-80. doi: 10.1101/gad.1654308. Epub 2008 Apr 28.


Identification and characterization of modification enzymes by biochemical analysis of the proteome.

Jackman JE, Kotelawala L, Grayhack EJ, Phizicky EM.

Methods Enzymol. 2007;425:139-52. Review.


Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing.

Malkowski MG, Quartley E, Friedman AE, Babulski J, Kon Y, Wolfley J, Said M, Luft JR, Phizicky EM, DeTitta GT, Grayhack EJ.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6678-83. Epub 2007 Apr 10.


The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4.

Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM.

RNA. 2007 Mar;13(3):404-13. Epub 2007 Jan 22.


Characteristics affecting expression and solubilization of yeast membrane proteins.

White MA, Clark KM, Grayhack EJ, Dumont ME.

J Mol Biol. 2007 Jan 19;365(3):621-36. Epub 2006 Oct 6.


Proteome-scale analysis of biochemical activity.

Phizicky EM, Grayhack EJ.

Crit Rev Biochem Mol Biol. 2006 Sep-Oct;41(5):315-27. Review.


Rapid tRNA decay can result from lack of nonessential modifications.

Alexandrov A, Chernyakov I, Gu W, Hiley SL, Hughes TR, Grayhack EJ, Phizicky EM.

Mol Cell. 2006 Jan 6;21(1):87-96.


Biochemical and genetic analysis of the yeast proteome with a movable ORF collection.

Gelperin DM, White MA, Wilkinson ML, Kon Y, Kung LA, Wise KJ, Lopez-Hoyo N, Jiang L, Piccirillo S, Yu H, Gerstein M, Dumont ME, Phizicky EM, Snyder M, Grayhack EJ.

Genes Dev. 2005 Dec 1;19(23):2816-26.


Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C.

Gu W, Hurto RL, Hopper AK, Grayhack EJ, Phizicky EM.

Mol Cell Biol. 2005 Sep;25(18):8191-201.


Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism.

Ma X, Yang C, Alexandrov A, Grayhack EJ, Behm-Ansmant I, Yu YT.

EMBO J. 2005 Jul 6;24(13):2403-13. Epub 2005 Jun 16.


A facile method for high-throughput co-expression of protein pairs.

Alexandrov A, Vignali M, LaCount DJ, Quartley E, de Vries C, De Rosa D, Babulski J, Mitchell SF, Schoenfeld LW, Fields S, Hol WG, Dumont ME, Phizicky EM, Grayhack EJ.

Mol Cell Proteomics. 2004 Sep;3(9):934-8. Epub 2004 Jul 7.


Biochemical genomics approach to map activities to genes.

Phizicky EM, Martzen MR, McCraith SM, Spinelli SL, Xing F, Shull NP, Van Slyke C, Montagne RK, Torres FM, Fields S, Grayhack EJ.

Methods Enzymol. 2002;350:546-59. No abstract available.


Genomic analysis of biochemical function.

Grayhack EJ, Phizicky EM.

Curr Opin Chem Biol. 2001 Feb;5(1):34-9. Review.


A biochemical genomics approach for identifying genes by the activity of their products.

Martzen MR, McCraith SM, Spinelli SL, Torres FM, Fields S, Grayhack EJ, Phizicky EM.

Science. 1999 Nov 5;286(5442):1153-5.


Purification of the bacteriophage lambda late gene regulator encoded by gene Q.

Grayhack EJ, Roberts JW.

J Biol Chem. 1983 Aug 10;258(15):9192-6.


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