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Items: 1 to 50 of 89

1.

Neisseria gonorrhoeae Infects the Heterogeneous Epithelia of the Human Cervix Using Distinct Mechanisms.

Yu Q, Wang LC, Di Benigno S, Gray-Owen SD, Stein DC, Song W.

PLoS Pathog. 2019 Dec 2;15(12):e1008136. doi: 10.1371/journal.ppat.1008136. [Epub ahead of print]

2.

Progress Toward a Gonococcal Vaccine: The Way Forward.

Russell MW, Jerse AE, Gray-Owen SD.

Front Immunol. 2019 Oct 15;10:2417. doi: 10.3389/fimmu.2019.02417. eCollection 2019. Review.

3.

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.

Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE.

Science. 2019 Jul 5;365(6448). pii: eaaw4144. doi: 10.1126/science.aaw4144.

PMID:
31273097
4.

Modeling Neisseria meningitidis Infection in Mice: Methods and Logistical Considerations for Nasal Colonization and Invasive Disease.

Johswich KO, Gray-Owen SD.

Methods Mol Biol. 2019;1969:149-168. doi: 10.1007/978-1-4939-9202-7_11.

PMID:
30877676
5.

Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species.

Fegan JE, Calmettes C, Islam EA, Ahn SK, Chaudhuri S, Yu RH, Gray-Owen SD, Moraes TF, Schryvers AB.

Front Immunol. 2019 Feb 19;10:247. doi: 10.3389/fimmu.2019.00247. eCollection 2019.

6.

Metagenomics-Based, Strain-Level Analysis of Escherichia coli From a Time-Series of Microbiome Samples From a Crohn's Disease Patient.

Fang X, Monk JM, Nurk S, Akseshina M, Zhu Q, Gemmell C, Gianetto-Hill C, Leung N, Szubin R, Sanders J, Beck PL, Li W, Sandborn WJ, Gray-Owen SD, Knight R, Allen-Vercoe E, Palsson BO, Smarr L.

Front Microbiol. 2018 Oct 30;9:2559. doi: 10.3389/fmicb.2018.02559. eCollection 2018.

7.

d-Glycero-β-d-Manno-Heptose 1-Phosphate and d-Glycero-β-d-Manno-Heptose 1,7-Biphosphate Are Both Innate Immune Agonists.

Adekoya IA, Guo CX, Gray-Owen SD, Cox AD, Sauvageau J.

J Immunol. 2018 Oct 15;201(8):2385-2391. doi: 10.4049/jimmunol.1801012. Epub 2018 Sep 17.

8.

Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases.

Francis IP, Islam EA, Gower AC, Shaik-Dasthagirisaheb YB, Gray-Owen SD, Wetzler LM.

BMC Genomics. 2018 Aug 22;19(1):627. doi: 10.1186/s12864-018-5000-7.

9.

High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis.

O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE.

MBio. 2018 Aug 21;9(4). pii: e01581-18. doi: 10.1128/mBio.01581-18.

10.

Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract.

Islam EA, Anipindi VC, Francis I, Shaik-Dasthagirisaheb Y, Xu S, Leung N, Sintsova A, Amin M, Kaushic C, Wetzler LM, Gray-Owen SD.

Infect Immun. 2018 Jul 23;86(8). pii: e00092-18. doi: 10.1128/IAI.00092-18. Print 2018 Aug.

11.

Shikimate Induced Transcriptional Activation of Protocatechuate Biosynthesis Genes by QuiR, a LysR-Type Transcriptional Regulator, in Listeria monocytogenes.

Prezioso SM, Xue K, Leung N, Gray-Owen SD, Christendat D.

J Mol Biol. 2018 Apr 27;430(9):1265-1283. doi: 10.1016/j.jmb.2018.03.003. Epub 2018 Mar 9.

PMID:
29530613
12.

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.

Herrmann JB, Muenstermann M, Strobel L, Schubert-Unkmeir A, Woodruff TM, Gray-Owen SD, Klos A, Johswich KO.

MBio. 2018 Jan 23;9(1). pii: e01755-17. doi: 10.1128/mBio.01755-17.

13.

Neisseria gonorrhoeae co-infection exacerbates vaginal HIV shedding without affecting systemic viral loads in human CD34+ engrafted mice.

Xu SX, Leontyev D, Kaul R, Gray-Owen SD.

PLoS One. 2018 Jan 23;13(1):e0191672. doi: 10.1371/journal.pone.0191672. eCollection 2018.

14.

Bcl10 synergistically links CEACAM3 and TLR-dependent inflammatory signalling.

Sintsova A, Guo CX, Sarantis H, Mak TW, Glogauer M, Gray-Owen SD.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12788. Epub 2017 Oct 9.

PMID:
28886618
15.

Alternate synthesis to d-glycero-β-d-manno-heptose 1,7-biphosphate.

Sauvageau J, Bhasin M, Guo CX, Adekoya IA, Gray-Owen SD, Oscarson S, Guazzelli L, Cox A.

Carbohydr Res. 2017 Oct 10;450:38-43. doi: 10.1016/j.carres.2017.08.011. Epub 2017 Aug 24.

PMID:
28866079
16.

CEACAM1 as a multi-purpose target for cancer immunotherapy.

Dankner M, Gray-Owen SD, Huang YH, Blumberg RS, Beauchemin N.

Oncoimmunology. 2017 May 16;6(7):e1328336. doi: 10.1080/2162402X.2017.1328336. eCollection 2017. Review.

17.

TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection.

Gall A, Gaudet RG, Gray-Owen SD, Salama NR.

MBio. 2017 Aug 15;8(4). pii: e01168-17. doi: 10.1128/mBio.01168-17.

18.

Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway.

Gaudet RG, Guo CX, Molinaro R, Kottwitz H, Rohde JR, Dangeard AS, Arrieumerlou C, Girardin SE, Gray-Owen SD.

Cell Rep. 2017 May 16;19(7):1418-1430. doi: 10.1016/j.celrep.2017.04.063.

19.

Discordant Effects of Licensed Meningococcal Serogroup B Vaccination on Invasive Disease and Nasal Colonization in a Humanized Mouse Model.

Buckwalter CM, Currie EG, Tsang RSW, Gray-Owen SD.

J Infect Dis. 2017 May 15;215(10):1590-1598. doi: 10.1093/infdis/jix162.

20.

A comparative, cross-species investigation of the properties and roles of transferrin- and lactoferrin-binding protein B from pathogenic bacteria.

Ostan N, Morgenthau A, Yu RH, Gray-Owen SD, Schryvers AB.

Biochem Cell Biol. 2017 Feb;95(1):5-11. doi: 10.1139/bcb-2016-0055. Epub 2016 Aug 19.

PMID:
28129513
21.

High Density or Urban Sprawl: What Works Best in Biology?

Oreopoulos J, Gray-Owen SD, Yip CM.

ACS Nano. 2017 Feb 28;11(2):1131-1135. doi: 10.1021/acsnano.7b00061. Epub 2017 Jan 23.

PMID:
28112892
22.

Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity.

Gaudet RG, Gray-Owen SD.

PLoS Pathog. 2016 Sep 22;12(9):e1005807. doi: 10.1371/journal.ppat.1005807. eCollection 2016 Sep. No abstract available.

23.

Slam is an outer membrane protein that is required for the surface display of lipidated virulence factors in Neisseria.

Hooda Y, Lai CC, Judd A, Buckwalter CM, Shin HE, Gray-Owen SD, Moraes TF.

Nat Microbiol. 2016 Feb 29;1:16009. doi: 10.1038/nmicrobiol.2016.9.

PMID:
27572441
24.

Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward".

Wetzler LM, Feavers IM, Gray-Owen SD, Jerse AE, Rice PA, Deal CD.

Clin Vaccine Immunol. 2016 Aug 5;23(8):656-63. doi: 10.1128/CVI.00230-16. Print 2016 Aug. Review.

25.

The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps.

Gottlieb SL, Deal CD, Giersing B, Rees H, Bolan G, Johnston C, Timms P, Gray-Owen SD, Jerse AE, Cameron CE, Moorthy VS, Kiarie J, Broutet N.

Vaccine. 2016 Jun 3;34(26):2939-2947. doi: 10.1016/j.vaccine.2016.03.111. Epub 2016 Apr 19. Review.

26.

Induction of antigen-specific TH 9 immunity accompanied by mast cell activation blocks tumor cell engraftment.

Abdul-Wahid A, Cydzik M, Prodeus A, Alwash M, Stanojcic M, Thompson M, Huang EH, Shively JE, Gray-Owen SD, Gariépy J.

Int J Cancer. 2016 Aug 15;139(4):841-53. doi: 10.1002/ijc.30121. Epub 2016 Apr 15.

27.

Whole-Genome Sequencing Reveals the Origin and Rapid Evolution of an Emerging Outbreak Strain of Streptococcus pneumoniae 12F.

Deng X, Peirano G, Schillberg E, Mazzulli T, Gray-Owen SD, Wylie JL, Robinson DA, Mahmud SM, Pillai DR.

Clin Infect Dis. 2016 May 1;62(9):1126-1132. doi: 10.1093/cid/ciw050. Epub 2016 Feb 7.

PMID:
26908785
28.

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.

Goodreid JD, Janetzko J, Santa Maria JP Jr, Wong KS, Leung E, Eger BT, Bryson S, Pai EF, Gray-Owen SD, Walker S, Houry WA, Batey RA.

J Med Chem. 2016 Jan 28;59(2):624-46. doi: 10.1021/acs.jmedchem.5b01451. Epub 2016 Jan 12.

PMID:
26818454
29.

The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.

Islam EA, Shaik-Dasthagirisaheb Y, Kaushic C, Wetzler LM, Gray-Owen SD.

Mucosal Immunol. 2016 Jul;9(4):1051-64. doi: 10.1038/mi.2015.122. Epub 2015 Dec 23.

30.

Genome-based Definition of an Inflammatory Bowel Disease-associated Adherent-Invasive Escherichia coli Pathovar.

Desilets M, Deng X, Rao C, Ensminger AW, Krause DO, Sherman PM, Gray-Owen SD.

Inflamm Bowel Dis. 2016 Jan;22(1):1-12. doi: 10.1097/MIB.0000000000000574. Erratum in: Inflamm Bowel Dis. 2016 Feb;22(2):E10. Deng, Xiangding [corrected to Deng, Xianding].

PMID:
26444104
31.

The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD.

Calmettes C, Ing C, Buckwalter CM, El Bakkouri M, Chieh-Lin Lai C, Pogoutse A, Gray-Owen SD, Pomès R, Moraes TF.

Nat Commun. 2015 Aug 18;6:7996. doi: 10.1038/ncomms8996.

32.

INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.

Gaudet RG, Sintsova A, Buckwalter CM, Leung N, Cochrane A, Li J, Cox AD, Moffat J, Gray-Owen SD.

Science. 2015 Jun 12;348(6240):1251-5. doi: 10.1126/science.aaa4921.

33.

A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice.

Pajon R, Buckwalter CM, Johswich KO, Gray-Owen SD, Granoff DM.

Vaccine. 2015 Mar 10;33(11):1317-1323. doi: 10.1016/j.vaccine.2015.01.057. Epub 2015 Feb 4.

34.

Selection for a CEACAM receptor-specific binding phenotype during Neisseria gonorrhoeae infection of the human genital tract.

Sintsova A, Wong H, MacDonald KS, Kaul R, Virji M, Gray-Owen SD.

Infect Immun. 2015 Apr;83(4):1372-83. doi: 10.1128/IAI.03123-14. Epub 2015 Jan 20.

35.

Sterilizing immunity elicited by Neisseria meningitidis carriage shows broader protection than predicted by serum antibody cross-reactivity in CEACAM1-humanized mice.

Johswich KO, McCaw SE, Strobel L, Frosch M, Gray-Owen SD.

Infect Immun. 2015 Jan;83(1):354-63. doi: 10.1128/IAI.02495-14. Epub 2014 Nov 3.

36.

Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.

Goodreid JD, Wong K, Leung E, McCaw SE, Gray-Owen SD, Lough A, Houry WA, Batey RA.

J Nat Prod. 2014 Oct 24;77(10):2170-81. doi: 10.1021/np500158q. Epub 2014 Sep 25.

PMID:
25255326
37.

Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program.

Sintsova A, Sarantis H, Islam EA, Sun CX, Amin M, Chan CH, Stanners CP, Glogauer M, Gray-Owen SD.

PLoS Pathog. 2014 Sep 4;10(9):e1004341. doi: 10.1371/journal.ppat.1004341. eCollection 2014 Sep.

38.

Inside-out signaling promotes dynamic changes in the carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) oligomeric state to control its cell adhesion properties.

Patel PC, Lee HS, Ming AY, Rath A, Deber CM, Yip CM, Rocheleau JV, Gray-Owen SD.

J Biol Chem. 2013 Oct 11;288(41):29654-69. doi: 10.1074/jbc.M113.504639. Epub 2013 Sep 4.

39.

In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa.

Johswich KO, McCaw SE, Islam E, Sintsova A, Gu A, Shively JE, Gray-Owen SD.

PLoS Pathog. 2013;9(7):e1003509. doi: 10.1371/journal.ppat.1003509. Epub 2013 Jul 25.

40.

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression.

Malott RJ, Keller BO, Gaudet RG, McCaw SE, Lai CC, Dobson-Belaire WN, Hobbs JL, St Michael F, Cox AD, Moraes TF, Gray-Owen SD.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10234-9. doi: 10.1073/pnas.1303738110. Epub 2013 Jun 3.

41.

Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.

Yu Q, Chow EM, McCaw SE, Hu N, Byrd D, Amet T, Hu S, Ostrowski MA, Gray-Owen SD.

PLoS One. 2013;8(2):e56705. doi: 10.1371/journal.pone.0056705. Epub 2013 Feb 12.

42.

Impact of the Listeria monocytogenes protein InlC on infection in mice.

Leung N, Gianfelice A, Gray-Owen SD, Ireton K.

Infect Immun. 2013 Apr;81(4):1334-40. doi: 10.1128/IAI.01377-12. Epub 2013 Feb 12.

43.

Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells.

Ossa JC, Ho NK, Wine E, Leung N, Gray-Owen SD, Sherman PM.

Cell Microbiol. 2013 Mar;15(3):446-57. doi: 10.1111/cmi.12048. Epub 2012 Nov 7.

PMID:
23072252
44.

Invasive potential of nonencapsulated disease isolates of Neisseria meningitidis.

Johswich KO, Zhou J, Law DK, St Michael F, McCaw SE, Jamieson FB, Cox AD, Tsang RS, Gray-Owen SD.

Infect Immun. 2012 Jul;80(7):2346-53. doi: 10.1128/IAI.00293-12. Epub 2012 Apr 16.

45.

Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae.

So NS, Ostrowski MA, Gray-Owen SD.

J Immunol. 2012 Apr 15;188(8):4008-22. doi: 10.4049/jimmunol.1100718. Epub 2012 Mar 16.

46.

Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms.

Liu Y, Islam EA, Jarvis GA, Gray-Owen SD, Russell MW.

Mucosal Immunol. 2012 May;5(3):320-31. doi: 10.1038/mi.2012.12. Epub 2012 Feb 22.

47.

Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae.

Sarantis H, Gray-Owen SD.

Infect Immun. 2012 Jan;80(1):345-58. doi: 10.1128/IAI.05702-11. Epub 2011 Nov 7.

48.

Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replication.

Dobson-Belaire WN, Cochrane A, Ostrowski MA, Gray-Owen SD.

PLoS One. 2011 Apr 22;6(4):e18133. doi: 10.1371/journal.pone.0018133.

49.

Adherent-invasive Escherichia coli target the epithelial barrier.

Wine E, Ossa JC, Gray-Owen SD, Sherman PM.

Gut Microbes. 2010 Mar;1(2):80-84. Epub 2010 Jan 5.

50.

Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria.

Sadarangani M, Pollard AJ, Gray-Owen SD.

FEMS Microbiol Rev. 2011 May;35(3):498-514. doi: 10.1111/j.1574-6976.2010.00260.x. Epub 2011 Jan 17. Review.

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