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Items: 1 to 50 of 1009

1.

Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies.

Weisberg E, Meng C, Case AE, Sattler M, Tiv HL, Gokhale PC, Buhrlage SJ, Liu X, Yang J, Wang J, Gray N, Stone RM, Adamia S, Dubreuil P, Letard S, Griffin JD.

Br J Haematol. 2019 Jul 15. doi: 10.1111/bjh.16092. [Epub ahead of print]

PMID:
31309543
2.

Effect of extended hours dialysis on markers of chronic kidney disease-mineral and bone disorder in the ACTIVE Dialysis study.

Zhan Z, Smyth B, Toussaint ND, Gray NA, Zuo L, de Zoysa JR, Chan CT, Jin C, Scaria A, Hawley CM, Perkovic V, Jardine MJ, Zhang L.

BMC Nephrol. 2019 Jul 12;20(1):258. doi: 10.1186/s12882-019-1438-3.

3.

Socioeconomic status and dialysis quality of care.

Krishnasamy R, Jegatheesan D, Lawton P, Gray NA.

Nephrology (Carlton). 2019 Jul 1. doi: 10.1111/nep.13629. [Epub ahead of print]

PMID:
31264328
4.

Current practice in dialysis central venous catheter management: multi-disciplinary renal team perspectives.

Craswell A, Massey D, Wallis M, Sriram D, Gray NA, Kotwal S; REDUCCTION Investigators (full list in Acknowlegdments).

Nephrology (Carlton). 2019 Jul 1. doi: 10.1111/nep.13626. [Epub ahead of print]

PMID:
31260594
5.

Motivating Change: a grounded theory of how to achieve large-scale, sustained change, co-created with improvement organisations across the UK.

Breckenridge JP, Gray N, Toma M, Ashmore S, Glassborow R, Stark C, Renfrew MJ.

BMJ Open Qual. 2019 Jun 14;8(2):e000553. doi: 10.1136/bmjoq-2018-000553. eCollection 2019.

6.

Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000-17: a spatial and temporal modelling study.

Weiss DJ, Lucas TCD, Nguyen M, Nandi AK, Bisanzio D, Battle KE, Cameron E, Twohig KA, Pfeffer DA, Rozier JA, Gibson HS, Rao PC, Casey D, Bertozzi-Villa A, Collins EL, Dalrymple U, Gray N, Harris JR, Howes RE, Kang SY, Keddie SH, May D, Rumisha S, Thorn MP, Barber R, Fullman N, Huynh CK, Kulikoff X, Kutz MJ, Lopez AD, Mokdad AH, Naghavi M, Nguyen G, Shackelford KA, Vos T, Wang H, Smith DL, Lim SS, Murray CJL, Bhatt S, Hay SI, Gething PW.

Lancet. 2019 Jun 19. pii: S0140-6736(19)31097-9. doi: 10.1016/S0140-6736(19)31097-9. [Epub ahead of print]

7.

The Triarchic Model of Psychopathy and Antisocial Behavior: Results From an Offender Population With Personality Disorder.

Gray NS, Blumenthal S, Shuker R, Wood H, Fonagy P, Snowden RJ.

J Interpers Violence. 2019 Jun 13:886260519853404. doi: 10.1177/0886260519853404. [Epub ahead of print]

PMID:
31189393
8.

Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.

Ferguson FM, Doctor ZM, Ficarro SB, Marto JA, Kim ND, Sim T, Gray NS.

Bioorg Med Chem Lett. 2019 Aug 1;29(15):1985-1993. doi: 10.1016/j.bmcl.2019.05.024. Epub 2019 May 23.

PMID:
31175010
9.

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.

Morotti M, Bridges E, Valli A, Choudhry H, Sheldon H, Wigfield S, Gray N, Zois CE, Grimm F, Jones D, Teoh EJ, Cheng WC, Lord S, Anastasiou D, Haider S, McIntyre A, Goberdhan DCI, Buffa F, Harris AL.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12452-12461. doi: 10.1073/pnas.1818521116. Epub 2019 May 31.

10.

Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.

Cragle CE, MacNicol MC, Byrum SD, Hardy LL, Mackintosh SG, Richardson WA, Gray NK, Childs GV, Tackett AJ, MacNicol AM.

J Biol Chem. 2019 Jul 12;294(28):10969-10986. doi: 10.1074/jbc.RA119.007220. Epub 2019 May 31.

PMID:
31152063
11.

Arteriovenous access practices in Australian and New Zealand dialysis units.

Smyth B, Kotwal S, Gallagher M, Gray NA, Polkinghorne KR.

J Vasc Access. 2019 May 30:1129729819851061. doi: 10.1177/1129729819851061. [Epub ahead of print]

PMID:
31144566
12.

Quinoline and thiazolopyridine allosteric inhibitors of MALT1.

Scott DA, Hatcher JM, Liu H, Fu M, Du G, Fontán L, Us I, Casalena G, Qiao Q, Wu H, Melnick A, Gray NS.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1694-1698. doi: 10.1016/j.bmcl.2019.05.040. Epub 2019 May 20.

PMID:
31129051
13.

Co-digestion of organic and mineral wastes for enhanced biogas production: Reactor performance and evolution of microbial community and function.

Shamurad B, Gray N, Petropoulos E, Tabraiz S, Acharya K, Quintela-Baluja M, Sallis P.

Waste Manag. 2019 Mar 15;87:313-325. doi: 10.1016/j.wasman.2019.02.021. Epub 2019 Feb 13.

PMID:
31109531
14.

'Working to stay healthy', health-seeking behaviour in Bangladesh's urban slums: a qualitative study.

van der Heijden J, Gray N, Stringer B, Rahman A, Akhter S, Kalon S, Dada M, Biswas A.

BMC Public Health. 2019 May 17;19(1):600. doi: 10.1186/s12889-019-6750-0.

15.

What It Takes to Improve a First-Generation Inhibitor to a Second- or Third-Generation Small Molecule.

Rodon Ahnert J, Gray N, Mok T, Gainor J.

Am Soc Clin Oncol Educ Book. 2019 Jan;39:196-205. doi: 10.1200/EDBK_242209. Epub 2019 May 17.

PMID:
31099659
16.

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.

To C, Jang J, Chen T, Park E, Mushajiang M, De Clercq DJH, Xu M, Wang S, Cameron MD, Heppner DE, Shin BH, Gero TW, Yang A, Dahlberg SE, Wong KK, Eck MJ, Gray NS, Jänne PA.

Cancer Discov. 2019 Jul;9(7):926-943. doi: 10.1158/2159-8290.CD-18-0903. Epub 2019 May 15.

PMID:
31092401
17.

BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models.

Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J, Tao J.

Cancer Cell. 2019 May 13;35(5):752-766.e9. doi: 10.1016/j.ccell.2019.04.005.

PMID:
31085176
18.

Data of metal and microbial analyses from anaerobic co-digestion of organic and mineral wastes.

Shamurad B, Gray N, Petropoulos E, Tabraiz S, Acharya K, Quintela-Baluja M, Sallis P.

Data Brief. 2019 Apr 19;24:103934. doi: 10.1016/j.dib.2019.103934. eCollection 2019 Jun.

19.

Centella asiatica triterpenes for diabetic neuropathy: a randomized, double-blind, placebo-controlled, pilot clinical study.

Lou JS, Dimitrova DM, Murchison C, Arnold GC, Belding H, Seifer N, Le N, Andrea SB, Gray NE, Wright KM, Caruso M, Soumyanath A.

Esper Dermatol. 2018 Jun;20(2 Suppl 1):12-22. doi: 10.23736/S1128-9155.18.00455-7.

20.

JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells.

Du L, Anderson A, Nguyen K, Ojeda SS, Ortiz-Rivera I, Nguyen TN, Zhang T, Kaoud TS, Gray NS, Dalby KN, Tsai KY.

ACS Chem Biol. 2019 Jul 19;14(7):1426-1435. doi: 10.1021/acschembio.9b00083. Epub 2019 May 17.

PMID:
31063355
21.

Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis.

Waslo C, Bourdette D, Gray N, Wright K, Spain R.

Curr Treat Options Neurol. 2019 May 6;21(6):26. doi: 10.1007/s11940-019-0566-1. Review.

PMID:
31056714
22.

An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice.

Chen TC, Lee RA, Tsai SL, Kanamaluru D, Gray NE, Yiv N, Cheang RT, Tan JH, Lee JY, Fitch MD, Hellerstein MK, Wang JC.

J Biol Chem. 2019 Jun 7;294(23):9213-9224. doi: 10.1074/jbc.RA118.006259. Epub 2019 May 3.

PMID:
31053639
23.

Enrichment and Characterisation of a Mixed-Source Ethanologenic Community Degrading the Organic Fraction of Municipal Solid Waste Under Minimal Environmental Control.

Carrillo-Barragan P, Bowler B, Dolfing J, Sallis P, Gray ND.

Front Microbiol. 2019 Apr 9;10:722. doi: 10.3389/fmicb.2019.00722. eCollection 2019.

24.

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.

Krajewska M, Dries R, Grassetti AV, Dust S, Gao Y, Huang H, Sharma B, Day DS, Kwiatkowski N, Pomaville M, Dodd O, Chipumuro E, Zhang T, Greenleaf AL, Yuan GC, Gray NS, Young RA, Geyer M, Gerber SA, George RE.

Nat Commun. 2019 Apr 15;10(1):1757. doi: 10.1038/s41467-019-09703-y.

25.

Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, Tan L, Schröder M, Gondi S, Ficarro SB, Sim T, Kim ND, Berberich MJ, Knapp S, Marto JA, Westover KD, Sorger PK, Gray NS.

Cell Chem Biol. 2019 Jun 20;26(6):818-829.e9. doi: 10.1016/j.chembiol.2019.02.021. Epub 2019 Apr 11.

PMID:
30982749
26.

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.

Di Genua C, Norfo R, Rodriguez-Meira A, Wen WX, Drissen R, Booth CAG, Povinelli B, Repapi E, Gray N, Carrelha J, Kettyle LM, Jamieson L, Neo WH, Thongjuea S, Nerlov C, Mead AJ.

Haematologica. 2019 Apr 11. pii: haematol.2018.205351. doi: 10.3324/haematol.2018.205351. [Epub ahead of print]

27.

Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries.

Moret N, Clark NA, Hafner M, Wang Y, Lounkine E, Medvedovic M, Wang J, Gray N, Jenkins J, Sorger PK.

Cell Chem Biol. 2019 May 16;26(5):765-777.e3. doi: 10.1016/j.chembiol.2019.02.018. Epub 2019 Apr 4.

28.

Peptide-based covalent inhibitors of MALT1 paracaspase.

Hatcher JM, Du G, Fontán L, Us I, Qiao Q, Chennamadhavuni S, Shao J, Wu H, Melnick A, Gray NS, Scott DA.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1336-1339. doi: 10.1016/j.bmcl.2019.03.046. Epub 2019 Mar 29.

PMID:
30954428
29.

Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.

Ferguson FM, Doctor ZM, Ficarro SB, Browne CM, Marto JA, Johnson JL, Yaron TM, Cantley LC, Kim ND, Sim T, Berberich MJ, Kalocsay M, Sorger PK, Gray NS.

Cell Chem Biol. 2019 Jun 20;26(6):804-817.e12. doi: 10.1016/j.chembiol.2019.02.015. Epub 2019 Mar 28.

PMID:
30930164
30.

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.

Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ.

Elife. 2019 Mar 25;8. pii: e45457. doi: 10.7554/eLife.45457.

31.

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.

Olson CM, Liang Y, Leggett A, Park WD, Li L, Mills CE, Elsarrag SZ, Ficarro SB, Zhang T, Düster R, Geyer M, Sim T, Marto JA, Sorger PK, Westover KD, Lin CY, Kwiatkowski N, Gray NS.

Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10. doi: 10.1016/j.chembiol.2019.02.012. Epub 2019 Mar 21.

PMID:
30905681
32.

A balanced approach to identifying, prioritising and evaluating all potential consequences of quality improvement: modified Delphi study.

Toma M, Dreischulte T, Gray NM, Guthrie B.

BMJ Open. 2019 Mar 23;9(3):e023890. doi: 10.1136/bmjopen-2018-023890.

33.

A Community Hospital NICU Developmental Care Partner Program: Feasibility and Association With Decreased Nurse Burnout Without Increased Infant Infection Rates.

Clubbs BH, Barnette AR, Gray N, Weiner L, Bond A, Harden J, Pineda R.

Adv Neonatal Care. 2019 Mar 19. doi: 10.1097/ANC.0000000000000600. [Epub ahead of print]

PMID:
30893098
34.

A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers.

Rao S, Du G, Hafner M, Subramanian K, Sorger PK, Gray NS.

J Biol Chem. 2019 May 24;294(21):8664-8673. doi: 10.1074/jbc.RA118.006805. Epub 2019 Mar 11.

35.

Targeting chronic myeloid leukemia stem cells with ERK5 pathway inhibitors.

4° JOINT MEETING OF PATHOLOGY AND LABORATORY MEDICINE SIPMET–SIPMEL - SECOND JOINT MEETING IN COLLABORATION WITH ASIP–AMP–UEMS–WASPALM - 4° SIPMEL NATIONAL CONGRESS - 34° SIPMET NATIONAL CONGRESS - 4° CONGRESS OF PATHOLOGY AND LABORATORY MEDICINE, Tusa I, Cheloni G, Poteti M, Gozzini A, Deng X, Gray NS, Li S, Dello Sbarba P, Rovida E.

J Biol Regul Homeost Agents. 2018 Jul-Aug;32(4 Suppl. 1):36. No abstract available.

PMID:
30810012
36.

Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6.

Jiang B, Wang ES, Donovan KA, Liang Y, Fischer ES, Zhang T, Gray NS.

Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. doi: 10.1002/anie.201901336. Epub 2019 Mar 29.

PMID:
30802347
37.

Zinc and atopic dermatitis: a systematic review and meta-analysis.

Gray NA, Dhana A, Stein DJ, Khumalo NP.

J Eur Acad Dermatol Venereol. 2019 Jun;33(6):1042-1050. doi: 10.1111/jdv.15524. Epub 2019 Mar 15. Review.

PMID:
30801794
38.

Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation.

Hsieh HHS, Agarwal S, Cholok DJ, Loder SJ, Kaneko K, Huber A, Chung MT, Ranganathan K, Habbouche J, Li J, Butts J, Reimer J, Kaura A, Drake J, Breuler C, Priest CR, Nguyen J, Brownley C, Peterson J, Ozgurel SU, Niknafs YS, Li S, Inagaki M, Scott G, Krebsbach PH, Longaker MT, Westover K, Gray N, Ninomiya-Tsuji J, Mishina Y, Levi B.

Stem Cells. 2019 Jun;37(6):766-778. doi: 10.1002/stem.2991. Epub 2019 Mar 14.

PMID:
30786091
39.

Identification of small molecule inhibitors targeting the Zika virus envelope protein.

Pitts J, Hsia CY, Lian W, Wang J, Pfeil MP, Kwiatkowski N, Li Z, Jang J, Gray NS, Yang PL.

Antiviral Res. 2019 Apr;164:147-153. doi: 10.1016/j.antiviral.2019.02.008. Epub 2019 Feb 13.

PMID:
30771406
40.

Quality of life in caregivers compared with dialysis recipients: The Co-ACTIVE sub-study of the ACTIVE dialysis trial.

Gray NA, Zuo L, Hong D, Smyth B, Jun M, De Zoysa J, Vo K, Howard K, Wang J, Lu C, Liu Z, Cass A, Perkovic V, Jardine M.

Nephrology (Carlton). 2019 Feb 5. doi: 10.1111/nep.13530. [Epub ahead of print]

PMID:
30723975
41.

Pharmacist joint-working with general practices: evaluating the Sheffield Primary Care Pharmacy Programme. A mixed-methods study.

Marques I, Gray NJ, Tsoneva J, Magirr P, Blenkinsopp A.

BJGP Open. 2018 Oct 17;2(4):bjgpopen18X101611. doi: 10.3399/bjgpopen18X101611. eCollection 2018 Dec.

42.

Understanding drivers of antibiotic resistance genes in High Arctic soil ecosystems.

McCann CM, Christgen B, Roberts JA, Su JQ, Arnold KE, Gray ND, Zhu YG, Graham DW.

Environ Int. 2019 Apr;125:497-504. doi: 10.1016/j.envint.2019.01.034. Epub 2019 Jan 28.

43.

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).

Wang L, Ferrao R, Li Q, Hatcher JM, Choi HG, Buhrlage SJ, Gray NS, Wu H.

J Biol Chem. 2019 Mar 22;294(12):4511-4519. doi: 10.1074/jbc.RA118.005428. Epub 2019 Jan 24.

PMID:
30679311
44.

Small-molecule targeting of brachyury transcription factor addiction in chordoma.

Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, Zhang T, Gray NS, Clarke PA, Blagg J, Workman P, Sommer J, Hornicek F, Root DE, Hahn WC, Bradner JE, Wong KK, Clemons PA, Lin CY, Kotz JD, Schreiber SL.

Nat Med. 2019 Feb;25(2):292-300. doi: 10.1038/s41591-018-0312-3. Epub 2019 Jan 21.

PMID:
30664779
45.

A validated UPLC-MS/MS assay for the quantification of amino acids and biogenic amines in rat urine.

Gray N, Plumb RS, Wilson ID, Nicholson JK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Feb 1;1106-1107:50-57. doi: 10.1016/j.jchromb.2018.12.028. Epub 2018 Dec 29.

PMID:
30640163
46.

Development of RapidHIT® ID using NGMSElect™ Express chemistry for the processing of reference samples within the UK criminal justice system.

Shackleton D, Gray N, Ives L, Malsom S, Vanhinsbergh D.

Forensic Sci Int. 2019 Feb;295:179-188. doi: 10.1016/j.forsciint.2018.12.015. Epub 2018 Dec 21.

PMID:
30634140
47.

Psychopathy and impulsivity: The relationship of psychopathy to different aspects of UPPS-P impulsivity.

Gray NS, Weidacker K, Snowden RJ.

Psychiatry Res. 2019 Feb;272:474-482. doi: 10.1016/j.psychres.2018.12.155. Epub 2018 Dec 29.

PMID:
30611967
48.

Small Molecules Targeting the Flavivirus E Protein with Broad-Spectrum Activity and Antiviral Efficacy in Vivo.

Li PC, Jang J, Hsia CY, Groomes PV, Lian W, de Wispelaere M, Pitts JD, Wang J, Kwiatkowski N, Gray NS, Yang PL.

ACS Infect Dis. 2019 Mar 8;5(3):460-472. doi: 10.1021/acsinfecdis.8b00322. Epub 2019 Jan 14.

PMID:
30608640
49.

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.

Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE.

Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. doi: 10.1016/j.chembiol.2018.11.006. Epub 2018 Dec 27.

PMID:
30595531
50.

SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.

Chagraoui H, Kristiansen MS, Ruiz JP, Serra-Barros A, Richter J, Hall-Ponselé E, Gray N, Waithe D, Clark K, Hublitz P, Repapi E, Otto G, Sopp P, Taylor S, Thongjuea S, Vyas P, Porcher C.

Nat Commun. 2018 Dec 18;9(1):5375. doi: 10.1038/s41467-018-07787-6.

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