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Items: 1 to 50 of 1080

1.

Discovery of a selective inhibitor of doublecortin like kinase 1.

Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS.

Nat Chem Biol. 2020 Apr 6. doi: 10.1038/s41589-020-0506-0. [Epub ahead of print]

PMID:
32251410
2.

Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics.

Santana-Codina N, Chandhoke AS, Yu Q, Małachowska B, Kuljanin M, Gikandi A, Stańczak M, Gableske S, Jedrychowski MP, Scott DA, Aguirre AJ, Fendler W, Gray NS, Mancias JD.

Cell Rep. 2020 Mar 31;30(13):4584-4599.e4. doi: 10.1016/j.celrep.2020.03.021.

3.

Age-Associated DNA Methylation Patterns Are Shared Between the Hippocampus and Peripheral Blood Cells.

Harris CJ, Davis BA, Zweig JA, Nevonen KA, Quinn JF, Carbone L, Gray NE.

Front Genet. 2020 Mar 6;11:111. doi: 10.3389/fgene.2020.00111. eCollection 2020.

4.

Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations.

Ogino A, Choi J, Lin M, Wilkens MK, Calles A, Xu M, Adeni AE, Chambers ES, Capelletti M, Butaney M, Gray NS, Gokhale PC, Palakurthi S, Kirschmeier P, Oxnard GR, Sholl LM, Jänne PA.

Mol Oncol. 2020 Mar 19. doi: 10.1002/1878-0261.12673. [Epub ahead of print]

5.

Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.

Manz TD, Sivakumaren SC, Yasgar A, Hall MD, Davis MI, Seo HS, Card JD, Ficarro SB, Shim H, Marto JA, Dhe-Paganon S, Sasaki AT, Boxer MB, Simeonov A, Cantley LC, Shen M, Zhang T, Ferguson FM, Gray NS.

ACS Med Chem Lett. 2019 Nov 3;11(3):346-352. doi: 10.1021/acsmedchemlett.9b00402. eCollection 2020 Mar 12.

PMID:
32184968
6.

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors.

Lochhead PA, Tucker JA, Tatum NJ, Wang J, Oxley D, Kidger AM, Johnson VP, Cassidy MA, Gray NS, Noble MEM, Cook SJ.

Nat Commun. 2020 Mar 13;11(1):1383. doi: 10.1038/s41467-020-15031-3.

7.

Correction: Evaluation of ERK as a therapeutic target in acute myelogenous leukemia.

Weisberg E, Meng C, Case A, Sattler M, Tiv HL, Gokhale PC, Buhrlage S, Wang J, Gray N, Stone R, Liu S, Bhagwat SV, Tiu RV, Adamia S, Griffin JD.

Leukemia. 2020 Mar 6. doi: 10.1038/s41375-020-0782-4. [Epub ahead of print]

PMID:
32144400
8.

Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.

Sivakumaren SC, Shim H, Zhang T, Ferguson FM, Lundquist MR, Browne CM, Seo HS, Paddock MN, Manz TD, Jiang B, Hao MF, Krishnan P, Wang DG, Yang TJ, Kwiatkowski NP, Ficarro SB, Cunningham JM, Marto JA, Dhe-Paganon S, Cantley LC, Gray NS.

Cell Chem Biol. 2020 Mar 3. pii: S2451-9456(20)30067-2. doi: 10.1016/j.chembiol.2020.02.003. [Epub ahead of print]

PMID:
32130941
9.

Light-induced control of protein destruction by opto-PROTAC.

Liu J, Chen H, Ma L, He Z, Wang D, Liu Y, Lin Q, Zhang T, Gray N, Kaniskan HÜ, Jin J, Wei W.

Sci Adv. 2020 Feb 21;6(8):eaay5154. doi: 10.1126/sciadv.aay5154. eCollection 2020 Feb.

10.

Relativistic photography with a wide aperture.

Gray N, O'Donnell R, MacSporran R, Oxburgh S, Courtial J.

J Opt Soc Am A Opt Image Sci Vis. 2020 Jan 1;37(1):123-134. doi: 10.1364/JOSAA.37.000123.

PMID:
32118889
11.

Pharmacist and Data-Driven Quality Improvement in Primary Care (P-DQIP): a qualitative study of anticipated implementation factors informed by the Theoretical Domains Framework.

Tang J, Toma M, Gray NM, Delvaux J, Guthrie B, Grant A, Duncan EM, Dreischulte T.

BMJ Open. 2020 Feb 28;10(2):e033574. doi: 10.1136/bmjopen-2019-033574.

12.

Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS.

J Biol Chem. 2020 Feb 28;295(9):2886. doi: 10.1074/jbc.AAC120.012837. Epub 2020 Feb 28. No abstract available.

13.

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging.

Xiao H, Jedrychowski MP, Schweppe DK, Huttlin EL, Yu Q, Heppner DE, Li J, Long J, Mills EL, Szpyt J, He Z, Du G, Garrity R, Reddy A, Vaites LP, Paulo JA, Zhang T, Gray NS, Gygi SP, Chouchani ET.

Cell. 2020 Mar 5;180(5):968-983.e24. doi: 10.1016/j.cell.2020.02.012. Epub 2020 Feb 27.

PMID:
32109415
14.

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.

Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM.

J Clin Invest. 2020 Feb 27. pii: 133753. doi: 10.1172/JCI133753. [Epub ahead of print]

15.

Sugar intake among German adolescents: trends from 1990-2016 based on biomarker excretion in 24-h urine samples.

Perrar I, Gray N, Kuhnle GG, Remer T, Buyken AE, Alexy U.

Br J Nutr. 2020 Feb 27:1-23. doi: 10.1017/S0007114520000665. [Epub ahead of print]

PMID:
32102699
16.

Improving the methane productivity of anaerobic digestion using aqueous extracts from municipal solid waste incinerator ash.

Shamurad B, Gray N, Petropoulos E, Tabraiz S, Sallis P.

J Environ Manage. 2020 Apr 15;260:110160. doi: 10.1016/j.jenvman.2020.110160. Epub 2020 Jan 23.

PMID:
32090847
17.

Self-Esteem, Narcissism, and Aggression: Different Types of Self-Esteem Predict Different Types of Aggression.

Amad S, Gray NS, Snowden RJ.

J Interpers Violence. 2020 Feb 17:886260520905540. doi: 10.1177/0886260520905540. [Epub ahead of print]

PMID:
32065011
18.

Inhibition of the deubiquitinase USP10 induces degradation of SYK.

Yang J, Meng C, Weisberg E, Case A, Lamberto I, Magin RS, Adamia S, Wang J, Gray N, Liu S, Stone R, Sattler M, Buhrlage S, Griffin JD.

Br J Cancer. 2020 Feb 4. doi: 10.1038/s41416-020-0731-z. [Epub ahead of print]

PMID:
32015510
19.

In depth metagenomic analysis in contrasting oil wells reveals syntrophic bacterial and archaeal associations for oil biodegradation in petroleum reservoirs.

Sierra-Garcia IN, Belgini DRB, Torres-Ballesteros A, Paez-Espino D, Capilla R, Santos Neto EV, Gray N, de Oliveira VM.

Sci Total Environ. 2020 May 1;715:136646. doi: 10.1016/j.scitotenv.2020.136646. Epub 2020 Jan 15.

PMID:
32014760
20.

SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas.

Munshi M, Liu X, Chen JG, Xu L, Tsakmaklis N, Demos MG, Kofides A, Guerrera ML, Jimenez C, Chan GG, Hunter ZR, Palomba ML, Argyropoulos KV, Meid K, Keezer A, Gustine J, Dubeau T, Castillo JJ, Patterson CJ, Wang J, Buhrlage SJ, Gray NS, Treon SP, Yang G.

Blood Cancer J. 2020 Jan 31;10(1):12. doi: 10.1038/s41408-020-0277-6.

21.

Triarchic or septarchic?-Uncovering the Triarchic Psychopathy Measure's (TriPM) structure.

Roy S, Vize C, Uzieblo K, van Dongen JDM, Miller J, Lynam D, Brazil I, Yoon D, Mokros A, Gray NS, Snowden R, Neumann CS.

Personal Disord. 2020 Jan 23. doi: 10.1037/per0000392. [Epub ahead of print]

PMID:
31971417
22.

Effects of the multi-kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia.

Weisberg E, Meng C, Case AE, Tiv HL, Gokhale PC, Buhrlage SJ, Yang J, Liu X, Wang J, Gray N, Adamia S, Sattler M, Stone R, Griffin JD.

J Cell Mol Med. 2020 Mar;24(5):2968-2980. doi: 10.1111/jcmm.14927. Epub 2020 Jan 22.

23.

NRF2 as a Therapeutic Target in Neurodegenerative Diseases.

Brandes MS, Gray NE.

ASN Neuro. 2020 Jan-Dec;12:1759091419899782. doi: 10.1177/1759091419899782. No abstract available.

24.

The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations.

Weisberg E, Meng C, Case AE, Tiv HL, Gokhale PC, Toure AA, Buhrlage S, Liu X, Wang J, Gray N, Stone R, Adamia S, Winer E, Sattler M, Griffin JD.

J Cell Mol Med. 2020 Feb;24(3):2145-2156. doi: 10.1111/jcmm.14820. Epub 2020 Jan 14.

25.

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.

Kurppa KJ, Liu Y, To C, Zhang T, Fan M, Vajdi A, Knelson EH, Xie Y, Lim K, Cejas P, Portell A, Lizotte PH, Ficarro SB, Li S, Chen T, Haikala HM, Wang H, Bahcall M, Gao Y, Shalhout S, Boettcher S, Shin BH, Thai T, Wilkens MK, Tillgren ML, Mushajiang M, Xu M, Choi J, Bertram AA, Ebert BL, Beroukhim R, Bandopadhayay P, Awad MM, Gokhale PC, Kirschmeier PT, Marto JA, Camargo FD, Haq R, Paweletz CP, Wong KK, Barbie DA, Long HW, Gray NS, Jänne PA.

Cancer Cell. 2020 Jan 13;37(1):104-122.e12. doi: 10.1016/j.ccell.2019.12.006.

PMID:
31935369
26.

Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.

Du G, Rao S, Gurbani D, Henning NJ, Jiang J, Che J, Yang A, Ficarro SB, Marto JA, Aguirre AJ, Sorger PK, Westover KD, Zhang T, Gray NS.

J Med Chem. 2020 Feb 27;63(4):1624-1641. doi: 10.1021/acs.jmedchem.9b01502. Epub 2020 Jan 30.

PMID:
31935084
27.

Benzopyrimidodiazepinone inhibitors of TNK2.

Groendyke BJ, Powell CE, Feru F, Gero TW, Li Z, Szabo H, Pang K, Feutrill J, Chen B, Li B, Gray NS, Scott DA.

Bioorg Med Chem Lett. 2020 Feb 15;30(4):126948. doi: 10.1016/j.bmcl.2020.126948. Epub 2020 Jan 7.

PMID:
31928839
28.

A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation.

de Wispelaere M, Carocci M, Burri DJ, Neidermyer WJ Jr, Olson CM, Roggenbach I, Liang Y, Wang J, Whelan SPJ, Gray NS, Yang PL.

J Biol Chem. 2020 Feb 7;295(6):1694-1703. doi: 10.1074/jbc.RA119.011132. Epub 2019 Dec 30.

29.

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells.

Kim JW, Berrios C, Kim M, Schade AE, Adelmant G, Yeerna H, Damato E, Iniguez AB, Florens L, Washburn MP, Stegmaier K, Gray NS, Tamayo P, Gjoerup O, Marto JA, DeCaprio J, Hahn WC.

Elife. 2020 Jan 8;9. pii: e53003. doi: 10.7554/eLife.53003.

30.

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer.

Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG Jr, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK.

Cancer Cell. 2020 Jan 13;37(1):37-54.e9. doi: 10.1016/j.ccell.2019.11.003. Epub 2019 Dec 26.

PMID:
31883968
31.

Exploring Targeted Degradation Strategy for Oncogenic KRASG12C.

Zeng M, Xiong Y, Safaee N, Nowak RP, Donovan KA, Yuan CJ, Nabet B, Gero TW, Feru F, Li L, Gondi S, Ombelets LJ, Quan C, Jänne PA, Kostic M, Scott DA, Westover KD, Fischer ES, Gray NS.

Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6. doi: 10.1016/j.chembiol.2019.12.006. Epub 2019 Dec 26.

PMID:
31883964
32.

FACTORS INFLUENCING LOW SODIUM INTAKE IN PEOPLE WITH NON-DIALYSIS DEPENDENT CHRONIC KIDNEY DISEASE.

Wright HH, Kickbusch H, Swanepoel E, Gray N.

J Ren Care. 2019 Dec 22. doi: 10.1111/jorc.12311. [Epub ahead of print]

PMID:
31867867
33.

Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling.

You I, Erickson EC, Donovan KA, Eleuteri NA, Fischer ES, Gray NS, Toker A.

Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7. doi: 10.1016/j.chembiol.2019.11.014. Epub 2019 Dec 16.

PMID:
31859249
34.

Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.

Iacono D, Lee P, Edlow BL, Gray N, Fischl B, Kenney K, Lew HL, Lozanoff S, Liacouras P, Lichtenberger J, Dams-O'Connor K, Cifu D, Hinds SR, Perl DP.

J Neuropathol Exp Neurol. 2020 Feb 1;79(2):144-162. doi: 10.1093/jnen/nlz122.

35.

Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.

Chen YL, Gomes T, Hardman CS, Vieira Braga FA, Gutowska-Owsiak D, Salimi M, Gray N, Duncan DA, Reynolds G, Johnson D, Salio M, Cerundolo V, Barlow JL, McKenzie ANJ, Teichmann SA, Haniffa M, Ogg G.

J Exp Med. 2020 Mar 2;217(3). pii: e20190811. doi: 10.1084/jem.20190811.

PMID:
31845972
36.

Loss of NRF2 leads to impaired mitochondrial function, decreased synaptic density and exacerbated age-related cognitive deficits.

Zweig JA, Caruso M, Brandes MS, Gray NE.

Exp Gerontol. 2020 Mar;131:110767. doi: 10.1016/j.exger.2019.110767. Epub 2019 Dec 13.

PMID:
31843395
37.

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice.

Matthews DG, Caruso M, Murchison CF, Zhu JY, Wright KM, Harris CJ, Gray NE, Quinn JF, Soumyanath A.

Antioxidants (Basel). 2019 Dec 8;8(12). pii: E630. doi: 10.3390/antiox8120630.

38.

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.

Chopra SS, Jenney A, Palmer A, Niepel M, Chung M, Mills C, Sivakumaren SC, Liu Q, Chen JY, Yapp C, Asara JM, Gray NS, Sorger PK.

Cell Syst. 2020 Jan 22;10(1):66-81.e11. doi: 10.1016/j.cels.2019.11.001. Epub 2019 Dec 4.

39.

Early life exposure to air pollution and incidence of childhood asthma, allergic rhinitis and eczema.

To T, Zhu J, Stieb D, Gray N, Fong I, Pinault L, Jerrett M, Robichaud A, Ménard R, van Donkelaar A, Martin RV, Hystad P, Brook JR, Dell S.

Eur Respir J. 2020 Feb 20;55(2). pii: 1900913. doi: 10.1183/13993003.00913-2019. Print 2020 Feb.

40.

Sex differences in health services and medication use among older adults with asthma.

To T, Gray N, Ryckman K, Zhu J, Fong I, Gershon A.

ERJ Open Res. 2019 Dec 2;5(4). pii: 00242-2019. doi: 10.1183/23120541.00242-2019. eCollection 2019 Oct.

41.

Combining thermal hydrolysis and methylation-gas chromatography/mass spectrometry with X-ray photoelectron spectroscopy to characterise complex organic assemblages in geological material.

Purvis G, Sano N, van der Land C, Barlow A, Lopez-Capel E, Cumpson P, Hood J, Sheriff J, Gray N.

MethodsX. 2019 Nov 2;6:2646-2655. doi: 10.1016/j.mex.2019.10.034. eCollection 2019.

42.

Analysis of Toxic Metals in Liquid from Electronic Cigarettes.

Gray N, Halstead M, Gonzalez-Jimenez N, Valentin-Blasini L, Watson C, Pappas RS.

Int J Environ Res Public Health. 2019 Nov 13;16(22). pii: E4450. doi: 10.3390/ijerph16224450.

43.

Nail changes in acro-osteolysis: A case report and review of the literature.

Gray NA, Scott C, Ngwanya RM, Pillay K, Isaacs T.

JAAD Case Rep. 2019 Nov 13;5(12):1033-1036. doi: 10.1016/j.jdcr.2019.09.016. eCollection 2019 Dec. No abstract available.

44.

Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.

De Clercq DJH, Heppner DE, To C, Jang J, Park E, Yun CH, Mushajiang M, Shin BH, Gero TW, Scott DA, Jänne PA, Eck MJ, Gray NS.

ACS Med Chem Lett. 2019 Oct 22;10(11):1549-1553. doi: 10.1021/acsmedchemlett.9b00381. eCollection 2019 Nov 14.

PMID:
31749909
45.

Development and Characterization of a Wee1 Kinase Degrader.

Li Z, Pinch BJ, Olson CM, Donovan KA, Nowak RP, Mills CE, Scott DA, Doctor ZM, Eleuteri NA, Chung M, Sorger PK, Fischer ES, Gray NS.

Cell Chem Biol. 2020 Jan 16;27(1):57-65.e9. doi: 10.1016/j.chembiol.2019.10.013. Epub 2019 Nov 14.

PMID:
31735695
46.

Twisted in Pain: The Multidisciplinary Treatment Approach to Functional Dystonia.

Khachane Y, Kozlowska K, Savage B, McClure G, Butler G, Gray N, Worth A, Mihailovich S, Perez DL, Helgeland H, Chrousos GP.

Harv Rev Psychiatry. 2019 Nov/Dec;27(6):359-381. doi: 10.1097/HRP.0000000000000237. No abstract available.

47.

Web Exclusive. Annals Graphic Medicine - Cicely Saunders: The Woman Who Changed How We Die.

Gray NA.

Ann Intern Med. 2019 Nov 12. doi: 10.7326/G18-0035. [Epub ahead of print] No abstract available.

PMID:
31711092
48.

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.

Tarumoto Y, Lin S, Wang J, Milazzo JP, Xu Y, Lu B, Yang Z, Wei Y, Polyanskaya S, Wunderlich M, Gray NS, Stegmaier K, Vakoc CR.

Blood. 2020 Jan 2;135(1):56-70. doi: 10.1182/blood.2019001576.

49.

Maternal health after Ebola: unmet needs and barriers to healthcare in rural Sierra Leone.

Elston JWT, Danis K, Gray N, West K, Lokuge K, Black B, Stringer B, Jimmisa AS, Biankoe A, Sanko MO, Kazungu DS, Sang S, Loof A, Stephan C, Caleo G.

Health Policy Plan. 2020 Feb 1;35(1):78-90. doi: 10.1093/heapol/czz102.

PMID:
31697378
50.

Sexual Attraction to Both Genders in Ambiphilic Men: Evidence from Implicit Cognitions.

Snowden RJ, Fitton E, McKinnon A, Gray NS.

Arch Sex Behav. 2020 Feb;49(2):503-515. doi: 10.1007/s10508-019-01552-6. Epub 2019 Nov 5.

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