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Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice.

Matthews DG, Caruso M, Murchison CF, Zhu JY, Wright KM, Harris CJ, Gray NE, Quinn JF, Soumyanath A.

Antioxidants (Basel). 2019 Dec 8;8(12). pii: E630. doi: 10.3390/antiox8120630.


Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.

Chopra SS, Jenney A, Palmer A, Niepel M, Chung M, Mills C, Sivakumaren SC, Liu Q, Chen JY, Yapp C, Asara JM, Gray NS, Sorger PK.

Cell Syst. 2019 Dec 2. pii: S2405-4712(19)30387-4. doi: 10.1016/j.cels.2019.11.001. [Epub ahead of print]


Early Life Exposure to Air Pollution and Incidence of Childhood Asthma, Allergic Rhinitis and Eczema.

To T, Zhu J, Stieb D, Gray N, Fong I, Pinault L, Jerrett M, Robichaud A, Ménard R, van Donkelaar A, Martin RV, Hystad P, Brook JR, Dell S.

Eur Respir J. 2019 Dec 5. pii: 1900913. doi: 10.1183/13993003.00913-2019. [Epub ahead of print]


Sex differences in health services and medication use among older adults with asthma.

To T, Gray N, Ryckman K, Zhu J, Fong I, Gershon A.

ERJ Open Res. 2019 Dec 2;5(4). pii: 00242-2019. doi: 10.1183/23120541.00242-2019. eCollection 2019 Oct.


Combining thermal hydrolysis and methylation-gas chromatography/mass spectrometry with X-ray photoelectron spectroscopy to characterise complex organic assemblages in geological material.

Purvis G, Sano N, van der Land C, Barlow A, Lopez-Capel E, Cumpson P, Hood J, Sheriff J, Gray N.

MethodsX. 2019 Nov 2;6:2646-2655. doi: 10.1016/j.mex.2019.10.034. eCollection 2019.


Analysis of Toxic Metals in Liquid from Electronic Cigarettes.

Gray N, Halstead M, Gonzalez-Jimenez N, Valentin-Blasini L, Watson C, Pappas RS.

Int J Environ Res Public Health. 2019 Nov 13;16(22). pii: E4450. doi: 10.3390/ijerph16224450.


Nail changes in acro-osteolysis: A case report and review of the literature.

Gray NA, Scott C, Ngwanya RM, Pillay K, Isaacs T.

JAAD Case Rep. 2019 Nov 13;5(12):1033-1036. doi: 10.1016/j.jdcr.2019.09.016. eCollection 2019 Dec. No abstract available.


Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.

De Clercq DJH, Heppner DE, To C, Jang J, Park E, Yun CH, Mushajiang M, Shin BH, Gero TW, Scott DA, Jänne PA, Eck MJ, Gray NS.

ACS Med Chem Lett. 2019 Oct 22;10(11):1549-1553. doi: 10.1021/acsmedchemlett.9b00381. eCollection 2019 Nov 14.


Development and Characterization of a Wee1 Kinase Degrader.

Li Z, Pinch BJ, Olson CM, Donovan KA, Nowak RP, Mills CE, Scott DA, Doctor ZM, Eleuteri NA, Chung M, Sorger PK, Fischer ES, Gray NS.

Cell Chem Biol. 2019 Nov 13. pii: S2451-9456(19)30358-7. doi: 10.1016/j.chembiol.2019.10.013. [Epub ahead of print]


Twisted in Pain: The Multidisciplinary Treatment Approach to Functional Dystonia.

Khachane Y, Kozlowska K, Savage B, McClure G, Butler G, Gray N, Worth A, Mihailovich S, Perez DL, Helgeland H, Chrousos GP.

Harv Rev Psychiatry. 2019 Nov/Dec;27(6):359-381. doi: 10.1097/HRP.0000000000000237. No abstract available.


Web Exclusive. Annals Graphic Medicine - Cicely Saunders: The Woman Who Changed How We Die.

Gray NA.

Ann Intern Med. 2019 Nov 12. doi: 10.7326/G18-0035. [Epub ahead of print] No abstract available.


Salt-Inducible Kinase inhibition suppresses acute myeloid leukemia progression in vivo.

Tarumoto Y, Lin S, Wang J, Milazzo JP, Xu Y, Lu B, Yang Z, Wei Y, Polyanskaya S, Wunderlich M, Gray NS, Stegmaier K, Vakoc CR.

Blood. 2019 Nov 1. pii: blood.2019001576. doi: 10.1182/blood.2019001576. [Epub ahead of print]


Maternal health after Ebola: unmet needs and barriers to healthcare in rural Sierra Leone.

Elston JWT, Danis K, Gray N, West K, Lokuge K, Black B, Stringer B, Jimmisa AS, Biankoe A, Sanko MO, Kazungu DS, Sang S, Loof A, Stephan C, Caleo G.

Health Policy Plan. 2019 Nov 7. pii: czz102. doi: 10.1093/heapol/czz102. [Epub ahead of print]


Sexual Attraction to Both Genders in Ambiphilic Men: Evidence from Implicit Cognitions.

Snowden RJ, Fitton E, McKinnon A, Gray NS.

Arch Sex Behav. 2019 Nov 5. doi: 10.1007/s10508-019-01552-6. [Epub ahead of print]


Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.

Faust TB, Yoon H, Nowak RP, Donovan KA, Li Z, Cai Q, Eleuteri NA, Zhang T, Gray NS, Fischer ES.

Nat Chem Biol. 2019 Nov 4. doi: 10.1038/s41589-019-0378-3. [Epub ahead of print]


Correction to Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein.

Lian W, Jang J, Potisopon S, Li PC, Rahmeh A, Wang J, Kwiatkowski NP, Gray NS, Yang PL.

ACS Infect Dis. 2019 Dec 13;5(12):2176. doi: 10.1021/acsinfecdis.9b00401. Epub 2019 Nov 1. No abstract available.


Varying Association of Extended Hours Dialysis with Quality of Life.

Smyth B, van den Broek-Best O, Hong D, Howard K, Rogers K, Zuo L, Gray NA, de Zoysa JR, Chan CT, Lin H, Zhang L, Xu J, Cass A, Gallagher M, Perkovic V, Jardine M.

Clin J Am Soc Nephrol. 2019 Dec 6;14(12):1751-1762. doi: 10.2215/CJN.06800619. Epub 2019 Oct 31.


4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.

Jeong SY, Hogarth P, Placzek A, Gregory AM, Fox R, Zhen D, Hamada J, van der Zwaag M, Lambrechts R, Jin H, Nilsen A, Cobb J, Pham T, Gray N, Ralle M, Duffy M, Schwanemann L, Rai P, Freed A, Wakeman K, Woltjer RL, Sibon OC, Hayflick SJ.

EMBO Mol Med. 2019 Dec;11(12):e10489. doi: 10.15252/emmm.201910489. Epub 2019 Oct 29.


Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation.

Zhang T, Hatcher JM, Teng M, Gray NS, Kostic M.

Cell Chem Biol. 2019 Nov 21;26(11):1486-1500. doi: 10.1016/j.chembiol.2019.09.012. Epub 2019 Oct 17. Review.


A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.

Menzl I, Zhang T, Berger-Becvar A, Grausenburger R, Heller G, Prchal-Murphy M, Edlinger L, Knab VM, Uras IZ, Grundschober E, Bauer K, Roth M, Skucha A, Liu Y, Hatcher JM, Liang Y, Kwiatkowski NP, Fux D, Hoelbl-Kovacic A, Kubicek S, Melo JV, Valent P, Weichhart T, Grebien F, Zuber J, Gray NS, Sexl V.

Nat Commun. 2019 Oct 18;10(1):4741. doi: 10.1038/s41467-019-12656-x.


Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold.

Remillard D, Buckley DL, Seo HS, Ferguson FM, Dhe-Paganon S, Bradner JE, Gray NS.

ACS Med Chem Lett. 2019 Sep 13;10(10):1443-1449. doi: 10.1021/acsmedchemlett.9b00243. eCollection 2019 Oct 10.


Analysis of Toxic Metals in Electronic Cigarette Aerosols Using a Novel Trap Design.

Halstead M, Gray N, Gonzalez-Jimenez N, Fresquez M, Valentin-Blasini L, Watson C, Pappas RS.

J Anal Toxicol. 2019 Oct 4. pii: bkz078. doi: 10.1093/jat/bkz078. [Epub ahead of print]


Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.

Gooding S, Olechnowicz SWZ, Morris EV, Armitage AE, Arezes J, Frost J, Repapi E, Edwards JR, Ashley N, Waugh C, Gray N, Martinez-Hackert E, Lim PJ, Pasricha SR, Knowles H, Mead AJ, Ramasamy K, Drakesmith H, Edwards CM.

Nat Commun. 2019 Oct 4;10(1):4533. doi: 10.1038/s41467-019-12296-1.


Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bachman JA, Goodale A, Lee Y, Bagul M, Liao R, Navarro A, Yuan TL, Ng RWS, Raghavan S, Gray NS, Tsherniak A, Vazquez F, Root DE, Firestone AJ, Settleman J, Hahn WC, Aguirre AJ.

Cell Rep. 2019 Oct 1;29(1):118-134.e8. doi: 10.1016/j.celrep.2019.08.090.


Beyond N and P: The impact of Ni on crude oil biodegradation.

Mejeha OK, Head IM, Sherry A, McCann CM, Leary P, Jones DM, Gray ND.

Chemosphere. 2019 Dec;237:124545. doi: 10.1016/j.chemosphere.2019.124545. Epub 2019 Aug 8.


NCDs and the WHO Essential Medicines Lists: children need universal health coverage too.

Gray NJ, Chanoine JP, Farmer MY, Jarvis JD, Armstrong K, Barr RD, Faunce TA, Lashley PM, Ndikumwenayo F, Hauerslev M, Karekezi CW, Klein JD; NCD Child Task Force on Essential Medicines and Equipment.

Lancet Child Adolesc Health. 2019 Nov;3(11):756-757. doi: 10.1016/S2352-4642(19)30294-9. Epub 2019 Sep 16. No abstract available.


Evaluation of (-)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake.

Ottaviani JI, Fong R, Kimball J, Ensunsa JL, Gray N, Vogiatzoglou A, Britten A, Lucarelli D, Luben R, Grace PB, Mawson DH, Tym A, Wierzbicki A, Smith AD, Wareham NJ, Forouhi NG, Khaw KT, Schroeter H, Kuhnle GGC.

Sci Rep. 2019 Sep 11;9(1):13108. doi: 10.1038/s41598-019-49702-z.


Evaluation of ERK as a therapeutic target in acute myelogenous leukemia.

Weisberg E, Meng C, Case A, Sattler M, Tiv HL, Gokhale PC, Buhrlage S, Wang J, Gray N, Stone R, Liu S, Bhagwat SV, Tiu RV, Adamia S, Griffin JD.

Leukemia. 2019 Aug 27. doi: 10.1038/s41375-019-0552-3. [Epub ahead of print] No abstract available.


Inulin-fortification of a processed meat product attenuates formation of nitroso compounds in the gut of healthy rats.

Thøgersen R, Gray N, Kuhnle G, Van Hecke T, De Smet S, Young JF, Sundekilde UK, Hansen AK, Bertram HC.

Food Chem. 2020 Jan 1;302:125339. doi: 10.1016/j.foodchem.2019.125339. Epub 2019 Aug 8.


Inclusion of Real-Time Hand Hygiene Observation and Feedback in a Multimodal Hand Hygiene Improvement Strategy in Low-Resource Settings.

Lenglet A, van Deursen B, Viana R, Abubakar N, Hoare S, Murtala A, Okanlawon M, Osatogbe J, Emeh V, Gray N, Keller S, Masters P, Roolvink D, Davies J, Hickox K, Fotso A, Bil K, Ikenna Nwankwo C, Ahmad B, Caluwaerts A, Lessard I, Dimeglio S, Malou N, Kanapathipillai R, McRae M, Wong S, Hopman J.

JAMA Netw Open. 2019 Aug 2;2(8):e199118. doi: 10.1001/jamanetworkopen.2019.9118.


BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells.

Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, Yuan GC, Young RA, George RE.

Nature. 2019 Aug;572(7771):676-680. doi: 10.1038/s41586-019-1472-0. Epub 2019 Aug 7.


The Kinetics of Amyloid Fibrillar Aggregation of Uperin 3.5 Is Directed by the Peptide's Secondary Structure.

John T, Dealey TJA, Gray NP, Patil NA, Hossain MA, Abel B, Carver JA, Hong Y, Martin LL.

Biochemistry. 2019 Sep 3;58(35):3656-3668. doi: 10.1021/acs.biochem.9b00536. Epub 2019 Aug 21.


Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.

de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL.

Nat Commun. 2019 Aug 1;10(1):3468. doi: 10.1038/s41467-019-11429-w.


Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice.

Tang X, Drotar J, Li K, Clairmont CD, Brumm AS, Sullins AJ, Wu H, Liu XS, Wang J, Gray NS, Sur M, Jaenisch R.

Sci Transl Med. 2019 Jul 31;11(503). pii: eaau0164. doi: 10.1126/scitranslmed.aau0164.


Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies.

Weisberg E, Meng C, Case AE, Sattler M, Tiv HL, Gokhale PC, Buhrlage SJ, Liu X, Yang J, Wang J, Gray N, Stone RM, Adamia S, Dubreuil P, Letard S, Griffin JD.

Br J Haematol. 2019 Nov;187(4):488-501. doi: 10.1111/bjh.16092. Epub 2019 Jul 15.


Effect of extended hours dialysis on markers of chronic kidney disease-mineral and bone disorder in the ACTIVE Dialysis study.

Zhan Z, Smyth B, Toussaint ND, Gray NA, Zuo L, de Zoysa JR, Chan CT, Jin C, Scaria A, Hawley CM, Perkovic V, Jardine MJ, Zhang L.

BMC Nephrol. 2019 Jul 12;20(1):258. doi: 10.1186/s12882-019-1438-3.


Socioeconomic status and dialysis quality of care.

Krishnasamy R, Jegatheesan D, Lawton P, Gray NA.

Nephrology (Carlton). 2019 Jul 1. doi: 10.1111/nep.13629. [Epub ahead of print]


Current practice in dialysis central venous catheter management: Multi-disciplinary renal team perspectives.

Craswell A, Massey D, Wallis M, Sriram D, Gray NA, Kotwal S; REDUCCTION Investigators.

Nephrology (Carlton). 2019 Jul 1. doi: 10.1111/nep.13626. [Epub ahead of print]


Motivating Change: a grounded theory of how to achieve large-scale, sustained change, co-created with improvement organisations across the UK.

Breckenridge JP, Gray N, Toma M, Ashmore S, Glassborow R, Stark C, Renfrew MJ.

BMJ Open Qual. 2019 Jun 14;8(2):e000553. doi: 10.1136/bmjoq-2018-000553. eCollection 2019.


Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000-17: a spatial and temporal modelling study.

Weiss DJ, Lucas TCD, Nguyen M, Nandi AK, Bisanzio D, Battle KE, Cameron E, Twohig KA, Pfeffer DA, Rozier JA, Gibson HS, Rao PC, Casey D, Bertozzi-Villa A, Collins EL, Dalrymple U, Gray N, Harris JR, Howes RE, Kang SY, Keddie SH, May D, Rumisha S, Thorn MP, Barber R, Fullman N, Huynh CK, Kulikoff X, Kutz MJ, Lopez AD, Mokdad AH, Naghavi M, Nguyen G, Shackelford KA, Vos T, Wang H, Smith DL, Lim SS, Murray CJL, Bhatt S, Hay SI, Gething PW.

Lancet. 2019 Jul 27;394(10195):322-331. doi: 10.1016/S0140-6736(19)31097-9. Epub 2019 Jun 19.


The Triarchic Model of Psychopathy and Antisocial Behavior: Results From an Offender Population With Personality Disorder.

Gray NS, Blumenthal S, Shuker R, Wood H, Fonagy P, Snowden RJ.

J Interpers Violence. 2019 Jun 13:886260519853404. doi: 10.1177/0886260519853404. [Epub ahead of print]


Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.

Ferguson FM, Doctor ZM, Ficarro SB, Marto JA, Kim ND, Sim T, Gray NS.

Bioorg Med Chem Lett. 2019 Aug 1;29(15):1985-1993. doi: 10.1016/j.bmcl.2019.05.024. Epub 2019 May 23.


Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.

Morotti M, Bridges E, Valli A, Choudhry H, Sheldon H, Wigfield S, Gray N, Zois CE, Grimm F, Jones D, Teoh EJ, Cheng WC, Lord S, Anastasiou D, Haider S, McIntyre A, Goberdhan DCI, Buffa F, Harris AL.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12452-12461. doi: 10.1073/pnas.1818521116. Epub 2019 May 31.


Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.

Cragle CE, MacNicol MC, Byrum SD, Hardy LL, Mackintosh SG, Richardson WA, Gray NK, Childs GV, Tackett AJ, MacNicol AM.

J Biol Chem. 2019 Jul 12;294(28):10969-10986. doi: 10.1074/jbc.RA119.007220. Epub 2019 May 31.


Arteriovenous access practices in Australian and New Zealand dialysis units.

Smyth B, Kotwal S, Gallagher M, Gray NA, Polkinghorne KR.

J Vasc Access. 2019 Nov;20(6):740-745. doi: 10.1177/1129729819851061. Epub 2019 May 30.


Quinoline and thiazolopyridine allosteric inhibitors of MALT1.

Scott DA, Hatcher JM, Liu H, Fu M, Du G, Fontán L, Us I, Casalena G, Qiao Q, Wu H, Melnick A, Gray NS.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1694-1698. doi: 10.1016/j.bmcl.2019.05.040. Epub 2019 May 20.


Co-digestion of organic and mineral wastes for enhanced biogas production: Reactor performance and evolution of microbial community and function.

Shamurad B, Gray N, Petropoulos E, Tabraiz S, Acharya K, Quintela-Baluja M, Sallis P.

Waste Manag. 2019 Mar 15;87:313-325. doi: 10.1016/j.wasman.2019.02.021. Epub 2019 Feb 13.


'Working to stay healthy', health-seeking behaviour in Bangladesh's urban slums: a qualitative study.

van der Heijden J, Gray N, Stringer B, Rahman A, Akhter S, Kalon S, Dada M, Biswas A.

BMC Public Health. 2019 May 17;19(1):600. doi: 10.1186/s12889-019-6750-0.


What It Takes to Improve a First-Generation Inhibitor to a Second- or Third-Generation Small Molecule.

Rodon Ahnert J, Gray N, Mok T, Gainor J.

Am Soc Clin Oncol Educ Book. 2019 Jan;39:196-205. doi: 10.1200/EDBK_242209. Epub 2019 May 17. Review.


Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.

To C, Jang J, Chen T, Park E, Mushajiang M, De Clercq DJH, Xu M, Wang S, Cameron MD, Heppner DE, Shin BH, Gero TW, Yang A, Dahlberg SE, Wong KK, Eck MJ, Gray NS, Jänne PA.

Cancer Discov. 2019 Jul;9(7):926-943. doi: 10.1158/2159-8290.CD-18-0903. Epub 2019 May 15.


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