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Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice.

Boehm DT, Hall JM, Wong TY, DiVenere AM, Sen-Kilic E, Bevere JR, Bradford SD, Blackwood CB, Elkins CM, DeRoos KA, Gray MC, Cooper CG, Varney ME, Maynard JA, Hewlett EL, Barbier M, Damron FH.

Infect Immun. 2018 Sep 21;86(10). pii: e00857-17. doi: 10.1128/IAI.00857-17. Print 2018 Oct.


Endocervical and Neutrophil Lipoxygenases Coordinate Neutrophil Transepithelial Migration to Neisseria gonorrhoeae.

Stevens JS, Gray MC, Morisseau C, Criss AK.

J Infect Dis. 2018 Oct 5;218(10):1663-1674. doi: 10.1093/infdis/jiy347.


Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin.

Gonyar LA, Gray MC, Christianson GJ, Mehrad B, Hewlett EL.

Infect Immun. 2017 May 23;85(6). pii: e00198-17. doi: 10.1128/IAI.00198-17. Print 2017 Jun.


Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.

Eby JC, Gray MC, Warfel JM, Merkel TJ, Hewlett EL.

Clin Vaccine Immunol. 2017 Jan 5;24(1). pii: e00370-16. doi: 10.1128/CVI.00370-16. Print 2017 Jan.


The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies.

Wang X, Gray MC, Hewlett EL, Maynard JA.

J Biol Chem. 2015 Sep 18;290(38):23025. doi: 10.1074/jbc.A114.585281. No abstract available.


A glycosyl hydrolase family 16 gene is responsible for the endogenous production of β-1,3-glucanases within decapod crustaceans.

Linton SM, Cameron MS, Gray MC, Donald JA, Saborowski R, von Bergen M, Tomm JM, Allardyce BJ.

Gene. 2015 Sep 15;569(2):203-17. doi: 10.1016/j.gene.2015.05.056. Epub 2015 May 27.


High temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types.

D'Auria KM, Bloom MJ, Reyes Y, Gray MC, van Opstal EJ, Papin JA, Hewlett EL.

BMC Microbiol. 2015 Feb 4;15:7. doi: 10.1186/s12866-015-0361-4.


Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin.

Eby JC, Gray MC, Hewlett EL.

Infect Immun. 2014 Dec;82(12):5256-69. doi: 10.1128/IAI.02487-14. Epub 2014 Oct 6.


The role of innominate artery ligation in the management of massive haemorrhage from trachea-innominate artery fistula.

Gray MC, Gowrie Mohan S, Suxena A, Selvakumar S.

Anaesth Intensive Care. 2014 Mar;42(2):266-7. No abstract available.


Gender and age interact to affect early outcome after intracerebral hemorrhage.

Umeano O, Phillips-Bute B, Hailey CE, Sun W, Gray MC, Roulhac-Wilson B, McDonagh DL, Kranz PG, Laskowitz DT, James ML.

PLoS One. 2013 Nov 27;8(11):e81664. doi: 10.1371/journal.pone.0081664. eCollection 2013.


Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.

Murray PS, Kirkwood CM, Gray MC, Fish KN, Ikonomovic MD, Hamilton RL, Kofler JK, Klunk WE, Lopez OL, Sweet RA.

J Alzheimers Dis. 2014;39(4):759-73. doi: 10.3233/JAD-131166.


Predictors of extraventricular drain-associated bacterial ventriculitis.

Williamson RA, Phillips-Bute BG, McDonagh DL, Gray MC, Zomorodi AR, Olson DM, Britz GW, Laskowitz DT, James ML.

J Crit Care. 2014 Feb;29(1):77-82. doi: 10.1016/j.jcrc.2013.08.012. Epub 2013 Oct 11.


In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B.

D'Auria KM, Kolling GL, Donato GM, Warren CA, Gray MC, Hewlett EL, Papin JA.

Infect Immun. 2013 Oct;81(10):3814-24. doi: 10.1128/IAI.00869-13. Epub 2013 Jul 29.


Survey of anesthesiologists practicing in American neurointensive care units as neurointensivists.

James ML, Dority J, Gray MC, Bellows ST, McDonagh DL, Brambrink AM.

J Neurosurg Anesthesiol. 2014 Jan;26(1):11-6. doi: 10.1097/ANA.0b013e31829e705e.


Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection.

Eby JC, Gray MC, Warfel JM, Paddock CD, Jones TF, Day SR, Bowden J, Poulter MD, Donato GM, Merkel TJ, Hewlett EL.

Infect Immun. 2013 May;81(5):1390-8. doi: 10.1128/IAI.00110-13. Epub 2013 Feb 19.


Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation.

Henderson MW, Inatsuka CS, Sheets AJ, Williams CL, Benaron DJ, Donato GM, Gray MC, Hewlett EL, Cotter PA.

Infect Immun. 2012 Jun;80(6):2061-75. doi: 10.1128/IAI.00148-12. Epub 2012 Apr 2.


β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis.

Murray PS, Kirkwood CM, Gray MC, Ikonomovic MD, Paljug WR, Abrahamson EE, Henteleff RA, Hamilton RL, Kofler JK, Klunk WE, Lopez OL, Penzes P, Sweet RA.

Neurobiol Aging. 2012 Dec;33(12):2807-16. doi: 10.1016/j.neurobiolaging.2012.02.015. Epub 2012 Mar 17.


Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles.

Donato GM, Goldsmith CS, Paddock CD, Eby JC, Gray MC, Hewlett EL.

FEBS Lett. 2012 Feb 17;586(4):459-65. doi: 10.1016/j.febslet.2012.01.032. Epub 2012 Jan 28.


Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control.

D'Auria KM, Donato GM, Gray MC, Kolling GL, Warren CA, Cave LM, Solga MD, Lannigan JA, Papin JA, Hewlett EL.

BMC Syst Biol. 2012 Jan 6;6:2. doi: 10.1186/1752-0509-6-2.


Improving influenza virus detection.

Gray MC, Su WY, Hal SJ.

Expert Opin Med Diagn. 2012 Jan;6(1):75-87. doi: 10.1517/17530059.2012.642860. Epub 2011 Dec 16.


Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis.

Eby JC, Gray MC, Mangan AR, Donato GM, Hewlett EL.

Infect Immun. 2012 Feb;80(2):850-9. doi: 10.1128/IAI.05979-11. Epub 2011 Dec 5.


In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation.

Coffee RL Jr, Williamson AJ, Adkins CM, Gray MC, Page TL, Broadie K.

Hum Mol Genet. 2012 Feb 15;21(4):900-15. doi: 10.1093/hmg/ddr527. Epub 2011 Nov 11.


Psychological distress (depression and anxiety) in people with head and neck cancers.

Neilson KA, Pollard AC, Boonzaier AM, Corry J, Castle DJ, Mead KR, Gray MC, Smith DI, Trauer T, Couper JW.

Med J Aust. 2010 Sep 6;193(5 Suppl):S48-51.


Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis.

Gray MC, Hewlett EL.

Cell Microbiol. 2011 Jan;13(1):123-34. doi: 10.1111/j.1462-5822.2010.01525.x. Epub 2010 Oct 14.


Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution.

Lee SJ, Gray MC, Zu K, Hewlett EL.

Arch Biochem Biophys. 2005 Jun 1;438(1):80-7. Epub 2005 Apr 19.


Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis.

Gray MC, Donato GM, Jones FR, Kim T, Hewlett EL.

Mol Microbiol. 2004 Sep;53(6):1709-19.


Sugar monomer and oligomer solubility: data and predictions for application to biomass hydrolysis.

Gray MC, Converse AO, Wyman CE.

Appl Biochem Biotechnol. 2003 Spring;105 -108:179-93.


Structural consequences of divalent metal binding by the adenylyl cyclase toxin of Bordetella pertussis.

Rhodes CR, Gray MC, Watson JM, Muratore TL, Kim SB, Hewlett EL, Grisham CM.

Arch Biochem Biophys. 2001 Nov 15;395(2):169-76.


Translocation-specific conformation of adenylate cyclase toxin from Bordetella pertussis inhibits toxin-mediated hemolysis.

Gray MC, Lee SJ, Gray LS, Zaretzky FR, Otero AS, Szabo G, Hewlett EL.

J Bacteriol. 2001 Oct;183(20):5904-10.


Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions.

Hewlett EL, Kim KJ, Lee SJ, Gray MC.

Int J Med Microbiol. 2000 Oct;290(4-5):333-5.


Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils.

Weingart CL, Mobberley-Schuman PS, Hewlett EL, Gray MC, Weiss AA.

Infect Immun. 2000 Dec;68(12):7152-5.


Characterization of binding of adenylate cyclase toxin to target cells by flow cytometry.

Gray MC, Ross W, Kim K, Hewlett EL.

Infect Immun. 1999 Sep;67(9):4393-9.


Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin.

Lee SJ, Gray MC, Guo L, Sebo P, Hewlett EL.

Infect Immun. 1999 May;67(5):2090-5.


Medical complications of anorexia nervosa.

Mehler PS, Gray MC, Schulte M.

J Womens Health. 1997 Oct;6(5):533-41. Review.


Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli.

Hackett M, Walker CB, Guo L, Gray MC, Van Cuyk S, Ullmann A, Shabanowitz J, Hunt DF, Hewlett EL, Sebo P.

J Biol Chem. 1995 Sep 1;270(35):20250-3.


Membrane depolarization prevents cell invasion by Bordetella pertussis adenylate cyclase toxin.

Otero AS, Yi XB, Gray MC, Szabo G, Hewlett EL.

J Biol Chem. 1995 Apr 28;270(17):9695-7.


Microenzymatic fluorescence assay for serum cholesterol.

Gray MC, Plant AL, Nicholson JM, May WE.

Anal Biochem. 1995 Jan 1;224(1):286-92.


Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC.

Hewlett EL, Gray MC, Ehrmann IE, Maloney NJ, Otero AS, Gray L, Allietta M, Szabo G, Weiss AA, Barry EM.

J Biol Chem. 1993 Apr 15;268(11):7842-8.


Enzymatic activity of adenylate cyclase toxin from Bordetella pertussis is not required for hemolysis.

Ehrmann IE, Weiss AA, Goodwin MS, Gray MC, Barry E, Hewlett EL.

FEBS Lett. 1992 Jun 8;304(1):51-6. Erratum in: FEBS Lett 1993 Mar 29;320(1):86.


Adenylate cyclase toxin from Bordetella pertussis. Conformational change associated with toxin activity.

Hewlett EL, Gray L, Allietta M, Ehrmann I, Gordon VM, Gray MC.

J Biol Chem. 1991 Sep 15;266(26):17503-8.


Hemolytic activity of adenylate cyclase toxin from Bordetella pertussis.

Ehrmann IE, Gray MC, Gordon VM, Gray LS, Hewlett EL.

FEBS Lett. 1991 Jan 14;278(1):79-83.


Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation.

Barry EM, Weiss AA, Ehrmann IE, Gray MC, Hewlett EL, Goodwin MS.

J Bacteriol. 1991 Jan;173(2):720-6.


Adenylate cyclase toxin from Bordetella pertussis. Identification and purification of the holotoxin molecule.

Hewlett EL, Gordon VM, McCaffery JD, Sutherland WM, Gray MC.

J Biol Chem. 1989 Nov 15;264(32):19379-84.

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