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Items: 39

1.

Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.

Etzerodt A, Tsalkitzi K, Maniecki M, Damsky W, Delfini M, Baudoin E, Moulin M, Bosenberg M, Graversen JH, Auphan-Anezin N, Moestrup SK, Lawrence T.

J Exp Med. 2019 Aug 2. pii: jem.20182124. doi: 10.1084/jem.20182124. [Epub ahead of print]

PMID:
31375534
2.

Using the hemoglobin-binding Staphylococcus aureus protein IsdH to enable plasma analysis of hemolyzed blood samples.

Sæderup KL, Revsholm J, Richardt PB, Christiansen SH, Hennig D, Moestrup SK, Graversen JH.

Clin Chem Lab Med. 2019 Jun 22. pii: /j/cclm.ahead-of-print/cclm-2019-0381/cclm-2019-0381.xml. doi: 10.1515/cclm-2019-0381. [Epub ahead of print]

PMID:
31228860
3.

Targeted lipid nanoparticle delivery of calcitriol to human monocyte-derived macrophages in vitro and in vivo: investigation of the anti-inflammatory effects of calcitriol.

Rafique A, Etzerodt A, Graversen JH, Moestrup SK, Dagnæs-Hansen F, Møller HJ.

Int J Nanomedicine. 2019 Apr 23;14:2829-2846. doi: 10.2147/IJN.S192113. eCollection 2019.

4.

STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes.

Andersen MN, Etzerodt A, Graversen JH, Holthof LC, Moestrup SK, Hokland M, Møller HJ.

Cancer Immunol Immunother. 2019 Mar;68(3):489-502. doi: 10.1007/s00262-019-02301-3. Epub 2019 Jan 14.

PMID:
30637473
5.

Novel Monoclonal Antibodies Against Native Human Collectin L1, Using the Heteromeric Complex CL-LK as Immunogen.

Aagaard JB, Bjerrum KB, Graversen JH, Henriksen ML, Hansen SWK.

Monoclon Antib Immunodiagn Immunother. 2018 Nov;37(5):207-211. doi: 10.1089/mab.2018.0024.

PMID:
30362927
6.

CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High and Co-Localized Expression in Secretory Epithelia and Mucosa.

Hansen SWK, Aagaard JB, Bjerrum KB, Hejbøl EK, Nielsen O, Schrøder HD, Skjoedt K, Sørensen AL, Graversen JH, Henriksen ML.

Front Immunol. 2018 Jul 31;9:1757. doi: 10.3389/fimmu.2018.01757. eCollection 2018.

7.

Immunomodulating peptides derived from different human endogenous retroviruses (HERVs) show dissimilar impact on pathogenesis of a multiple sclerosis animal disease model.

Bahrami S, Gryz EA, Graversen JH, Troldborg A, Stengaard Pedersen K, Laska MJ.

Clin Immunol. 2018 Jun;191:37-43. doi: 10.1016/j.clim.2018.03.007. Epub 2018 Mar 19.

PMID:
29567431
8.

Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes.

Svendsen P, Graversen JH, Etzerodt A, Hager H, Røge R, Grønbæk H, Christensen EI, Møller HJ, Vilstrup H, Moestrup SK.

Mol Ther Methods Clin Dev. 2016 Dec 24;4:50-61. doi: 10.1016/j.omtm.2016.11.004. eCollection 2017 Mar 17.

9.

The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen.

Sæderup KL, Stødkilde K, Graversen JH, Dickson CF, Etzerodt A, Hansen SW, Fago A, Gell D, Andersen CB, Moestrup SK.

J Biol Chem. 2016 Nov 11;291(46):23989-23998. Epub 2016 Sep 28.

10.

Haptoglobin.

Andersen CBF, Stødkilde K, Sæderup KL, Kuhlee A, Raunser S, Graversen JH, Moestrup SK.

Antioxid Redox Signal. 2017 May 10;26(14):814-831. doi: 10.1089/ars.2016.6793. Epub 2016 Nov 8. Review.

PMID:
27650279
11.

Anti-CD163-dexamethasone conjugate inhibits the acute phase response to lipopolysaccharide in rats.

Thomsen KL, Møller HJ, Graversen JH, Magnusson NE, Moestrup SK, Vilstrup H, Grønbæk H.

World J Hepatol. 2016 Jun 18;8(17):726-30. doi: 10.4254/wjh.v8.i17.726.

12.

Anti-inflammatory liposomes have no impact on liver regeneration in rats.

Jepsen BN, Andersen KJ, Knudsen AR, Nyengaard JR, Hamilton-Dutoit S, Svendsen P, Etzerodt A, Møller HJ, Moestrup SK, Graversen JH, Mortensen FV.

Ann Med Surg (Lond). 2015 Nov 2;4(4):452-61. doi: 10.1016/j.amsu.2015.10.018. eCollection 2015 Dec.

13.

Anti-CD163-dexamethasone protects against apoptosis after ischemia/reperfusion injuries in the rat liver.

Møller LN, Knudsen AR, Andersen KJ, Nyengaard JR, Hamilton-Dutoit S, Okholm Møller EM, Svendsen P, Møller HJ, Moestrup SK, Graversen JH, Mortensen FV.

Ann Med Surg (Lond). 2015 Sep 3;4(4):331-7. doi: 10.1016/j.amsu.2015.09.001. eCollection 2015 Dec.

14.

Drug Trafficking into Macrophages via the Endocytotic Receptor CD163.

Graversen JH, Moestrup SK.

Membranes (Basel). 2015 Jun 23;5(2):228-52. doi: 10.3390/membranes5020228. Review.

15.

Targeting dexamethasone to macrophages in a porcine endotoxemic model.

Granfeldt A, Hvas CL, Graversen JH, Christensen PA, Petersen MD, Anton G, Svendsen P, Sølling C, Etzerodt A, Tønnesen E, Moestrup SK, Møller HJ.

Crit Care Med. 2013 Nov;41(11):e309-18. doi: 10.1097/CCM.0b013e31828a45ef.

PMID:
23928834
16.

Targeting the hemoglobin scavenger receptor CD163 in macrophages highly increases the anti-inflammatory potency of dexamethasone.

Graversen JH, Svendsen P, Dagnæs-Hansen F, Dal J, Anton G, Etzerodt A, Petersen MD, Christensen PA, Møller HJ, Moestrup SK.

Mol Ther. 2012 Aug;20(8):1550-8. doi: 10.1038/mt.2012.103. Epub 2012 May 29.

17.

Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163.

Etzerodt A, Maniecki MB, Graversen JH, Møller HJ, Torchilin VP, Moestrup SK.

J Control Release. 2012 May 30;160(1):72-80. doi: 10.1016/j.jconrel.2012.01.034. Epub 2012 Jan 27.

PMID:
22306335
18.

Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression.

Maniecki MB, Etzerodt A, Moestrup SK, Møller HJ, Graversen JH.

Immunobiology. 2011 Aug;216(8):882-90. doi: 10.1016/j.imbio.2011.02.001. Epub 2011 Feb 22.

PMID:
21458881
19.

A pivotal role of the human kidney in catabolism of HDL protein components apolipoprotein A-I and A-IV but not of A-II.

Graversen JH, Castro G, Kandoussi A, Nielsen H, Christensen EI, Norden A, Moestrup SK.

Lipids. 2008 May;43(5):467-70. doi: 10.1007/s11745-008-3169-2. Epub 2008 Mar 19.

PMID:
18350327
20.

Trimerization of apolipoprotein A-I retards plasma clearance and preserves antiatherosclerotic properties.

Graversen JH, Laurberg JM, Andersen MH, Falk E, Nieland J, Christensen J, Etzerodt M, Thøgersen HC, Moestrup SK.

J Cardiovasc Pharmacol. 2008 Feb;51(2):170-7. doi: 10.1097/FJC.0b013e31815ed0b9.

PMID:
18287885
21.

A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex.

Nielsen MJ, Petersen SV, Jacobsen C, Thirup S, Enghild JJ, Graversen JH, Moestrup SK.

J Biol Chem. 2007 Jan 12;282(2):1072-9. Epub 2006 Nov 13.

22.

Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region.

Madsen M, Møller HJ, Nielsen MJ, Jacobsen C, Graversen JH, van den Berg T, Moestrup SK.

J Biol Chem. 2004 Dec 3;279(49):51561-7. Epub 2004 Sep 24.

23.

Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity.

Mogues T, Etzerodt M, Hall C, Engelich G, Graversen JH, Hartshorn KL.

J Biomed Biotechnol. 2004;2004(2):73-78.

24.

Structure of the plasminogen kringle 4 binding calcium-free form of the C-type lectin-like domain of tetranectin.

Nielbo S, Thomsen JK, Graversen JH, Jensen PH, Etzerodt M, Poulsen FM, Thøgersen HC.

Biochemistry. 2004 Jul 13;43(27):8636-43.

PMID:
15236571
25.

Generation of a haptoglobin-hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163.

Horn IR, Nielsen MJ, Madsen M, Jacobsen C, Graversen JH, Moestrup SK.

Eur J Haematol. 2003 Oct;71(4):289-93. Erratum in: Eur J Haematol. 2004 Jan;72(1):77.

PMID:
12950239
26.

Specificity determinants in the interaction of apolipoprotein(a) kringles with tetranectin and LDL.

Caterer NR, Graversen JH, Jacobsen C, Moestrup SK, Sigurskjold BW, Etzerodt M, Thøgersen HC.

Biol Chem. 2002 Nov;383(11):1743-50.

PMID:
12530539
27.

Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes.

Madsen M, Graversen JH, Moestrup SK.

Redox Rep. 2001;6(6):386-8. Review.

PMID:
11865982
28.

CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma.

Graversen JH, Madsen M, Moestrup SK.

Int J Biochem Cell Biol. 2002 Apr;34(4):309-14. Review.

PMID:
11854028
29.

Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma.

Møller HJ, Peterslund NA, Graversen JH, Moestrup SK.

Blood. 2002 Jan 1;99(1):378-80.

30.

Identification of the haemoglobin scavenger receptor.

Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK.

Nature. 2001 Jan 11;409(6817):198-201.

PMID:
11196644
31.

Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity ontp the trtranectin lectin scaffold.

Graversen JH, Jacobsen C, Sigurskjold BW, Lorentsen RH, Moestrup SK, Thogersen HC, Etzerodt M.

J Biol Chem. 2000 Dec 1;275(48):37390-6.

32.

Tetranectin-binding site on plasminogen kringle 4 involves the lysine-binding pocket and at least one additional amino acid residue.

Graversen JH, Sigurskjold BW, Thøgersen HC, Etzerodt M.

Biochemistry. 2000 Jun 27;39(25):7414-9.

PMID:
10858289
33.

Crystallization and molecular-replacement solution of a truncated form of human recombinant tetranectin.

Nielsen BB, Kastrup JS, Rasmussen H, Graversen JH, Etzerodt M, Thøgersen HC, Larsen IK.

Acta Crystallogr D Biol Crystallogr. 2000 May;56(Pt 5):637-9.

PMID:
10771434
34.

The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain.

Lorentsen RH, Graversen JH, Caterer NR, Thogersen HC, Etzerodt M.

Biochem J. 2000 Apr 1;347 Pt 1:83-7.

35.

The plasminogen binding site of the C-type lectin tetranectin is located in the carbohydrate recognition domain, and binding is sensitive to both calcium and lysine.

Graversen JH, Lorentsen RH, Jacobsen C, Moestrup SK, Sigurskjold BW, Thogersen HC, Etzerodt M.

J Biol Chem. 1998 Oct 30;273(44):29241-6.

36.

Structure of the C-type lectin carbohydrate recognition domain of human tetranectin.

Kastrup JS, Nielsen BB, Rasmussen H, Holtet TL, Graversen JH, Etzerodt M, Thøgersen HC, Larsen IK.

Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):757-66.

PMID:
9757090
37.

Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil.

Nielsen BB, Kastrup JS, Rasmussen H, Holtet TL, Graversen JH, Etzerodt M, Thøgersen HC, Larsen IK.

FEBS Lett. 1997 Jul 28;412(2):388-96.

38.

Tetranectin, a trimeric plasminogen-binding C-type lectin.

Holtet TL, Graversen JH, Clemmensen I, Thøgersen HC, Etzerodt M.

Protein Sci. 1997 Jul;6(7):1511-5.

39.

Human plasminogen binding protein tetranectin: crystallization and preliminary X-ray analysis of the C-type lectin CRD and the full-length protein.

Kastrup JS, Rasmussen H, Nielsen BB, Larsen IK, Holtet TL, Graversen JH, Etzerodt M, Thøgersen HC.

Acta Crystallogr D Biol Crystallogr. 1997 Jan 1;53(Pt 1):108-11.

PMID:
15299977

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