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Items: 21


Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway.

Stewart JIP, Fava VM, Kerkaert JD, Subramanian AS, Gravelat FN, Lehoux M, Howell PL, Cramer RA, Sheppard DC.

mBio. 2020 Feb 4;11(1). pii: e03202-19. doi: 10.1128/mBio.03202-19.


PtaB, a lim-domain binding protein in Aspergillus fumigatus regulates biofilm formation and conidiation through distinct pathways.

Zhang S, Chen Y, Ma Z, Chen Q, Ostapska H, Gravelat FN, Lu L, Sheppard DC.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12799. Epub 2017 Nov 17. Erratum in: Cell Microbiol. 2018 Mar;20(3):.


Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity.

Snarr BD, Baker P, Bamford NC, Sato Y, Liu H, Lehoux M, Gravelat FN, Ostapska H, Baistrocchi SR, Cerone RP, Filler EE, Parsek MR, Filler SG, Howell PL, Sheppard DC.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7124-7129. doi: 10.1073/pnas.1702798114. Epub 2017 Jun 20.


Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation.

Lee MJ, Geller AM, Bamford NC, Liu H, Gravelat FN, Snarr BD, Le Mauff F, Chabot J, Ralph B, Ostapska H, Lehoux M, Cerone RP, Baptista SD, Vinogradov E, Stajich JE, Filler SG, Howell PL, Sheppard DC.

mBio. 2016 Apr 5;7(2):e00252-16. doi: 10.1128/mBio.00252-16.


The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps.

Lee MJ, Liu H, Barker BM, Snarr BD, Gravelat FN, Al Abdallah Q, Gavino C, Baistrocchi SR, Ostapska H, Xiao T, Ralph B, Solis NV, Lehoux M, Baptista SD, Thammahong A, Cerone RP, Kaminskyj SG, Guiot MC, Latgé JP, Fontaine T, Vinh DC, Filler SG, Sheppard DC.

PLoS Pathog. 2015 Oct 22;11(10):e1005187. doi: 10.1371/journal.ppat.1005187. eCollection 2015 Oct.


Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus.

Bamford NC, Snarr BD, Gravelat FN, Little DJ, Lee MJ, Zacharias CA, Chabot JC, Geller AM, Baptista SD, Baker P, Robinson H, Howell PL, Sheppard DC.

J Biol Chem. 2015 Nov 13;290(46):27438-50. doi: 10.1074/jbc.M115.679050. Epub 2015 Sep 4.


Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides.

Lee MJ, Gravelat FN, Cerone RP, Baptista SD, Campoli PV, Choe SI, Kravtsov I, Vinogradov E, Creuzenet C, Liu H, Berghuis AM, Latgé JP, Filler SG, Fontaine T, Sheppard DC.

J Biol Chem. 2014 Jan 17;289(3):1243-56. doi: 10.1074/jbc.M113.522516. Epub 2013 Nov 20.


Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system.

Gravelat FN, Beauvais A, Liu H, Lee MJ, Snarr BD, Chen D, Xu W, Kravtsov I, Hoareau CM, Vanier G, Urb M, Campoli P, Al Abdallah Q, Lehoux M, Chabot JC, Ouimet MC, Baptista SD, Fritz JH, Nierman WC, Latgé JP, Mitchell AP, Filler SG, Fontaine T, Sheppard DC.

PLoS Pathog. 2013;9(8):e1003575. doi: 10.1371/journal.ppat.1003575. Epub 2013 Aug 22.


Accumulation of ergot alkaloids during conidiophore development in Aspergillus fumigatus.

Mulinti P, Allen NA, Coyle CM, Gravelat FN, Sheppard DC, Panaccione DG.

Curr Microbiol. 2014 Jan;68(1):1-5. doi: 10.1007/s00284-013-0434-2. Epub 2013 Aug 8.


A conserved C-terminal domain of the Aspergillus fumigatus developmental regulator MedA is required for nuclear localization, adhesion and virulence.

Al Abdallah Q, Choe SI, Campoli P, Baptista S, Gravelat FN, Lee MJ, Sheppard DC.

PLoS One. 2012;7(11):e49959. doi: 10.1371/journal.pone.0049959. Epub 2012 Nov 21.


Role of Aspergillus niger acrA in arsenic resistance and its use as the basis for an arsenic biosensor.

Choe SI, Gravelat FN, Al Abdallah Q, Lee MJ, Gibbs BF, Sheppard DC.

Appl Environ Microbiol. 2012 Jun;78(11):3855-63. doi: 10.1128/AEM.07771-11. Epub 2012 Mar 30.


Targeted gene deletion in Aspergillus fumigatus using the hygromycin-resistance split-marker approach.

Gravelat FN, Askew DS, Sheppard DC.

Methods Mol Biol. 2012;845:119-30. doi: 10.1007/978-1-61779-539-8_8.


Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis.

Liu H, Gravelat FN, Chiang LY, Chen D, Vanier G, Ejzykowicz DE, Ibrahim AS, Nierman WC, Sheppard DC, Filler SG.

Mol Microbiol. 2010 Nov;78(4):1038-54. doi: 10.1111/j.1365-2958.2010.07389.x. Epub 2010 Sep 27.


Role of Aspergillus fumigatus DvrA in host cell interactions and virulence.

Ejzykowicz DE, Solis NV, Gravelat FN, Chabot J, Li X, Sheppard DC, Filler SG.

Eukaryot Cell. 2010 Oct;9(10):1432-40. doi: 10.1128/EC.00055-10. Epub 2010 Jul 30.


Role of trehalose biosynthesis in Aspergillus fumigatus development, stress response, and virulence.

Al-Bader N, Vanier G, Liu H, Gravelat FN, Urb M, Hoareau CM, Campoli P, Chabot J, Filler SG, Sheppard DC.

Infect Immun. 2010 Jul;78(7):3007-18. doi: 10.1128/IAI.00813-09. Epub 2010 May 3.


Aspergillus fumigatus MedA governs adherence, host cell interactions and virulence.

Gravelat FN, Ejzykowicz DE, Chiang LY, Chabot JC, Urb M, Macdonald KD, al-Bader N, Filler SG, Sheppard DC.

Cell Microbiol. 2010 Apr 1;12(4):473-88. doi: 10.1111/j.1462-5822.2009.01408.x. Epub 2009 Nov 4.


Aspergillus fumigatus induces immunoglobulin E-independent mast cell degranulation.

Urb M, Pouliot P, Gravelat FN, Olivier M, Sheppard DC.

J Infect Dis. 2009 Aug 1;200(3):464-72. doi: 10.1086/600070.


The Aspergillus fumigatus transcription factor Ace2 governs pigment production, conidiation and virulence.

Ejzykowicz DE, Cunha MM, Rozental S, Solis NV, Gravelat FN, Sheppard DC, Filler SG.

Mol Microbiol. 2009 Apr;72(1):155-69. doi: 10.1111/j.1365-2958.2009.06631.x. Epub 2009 Feb 11.


Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus.

Twumasi-Boateng K, Yu Y, Chen D, Gravelat FN, Nierman WC, Sheppard DC.

Eukaryot Cell. 2009 Jan;8(1):104-15. doi: 10.1128/EC.00265-08. Epub 2008 Nov 21.


In vivo analysis of Aspergillus fumigatus developmental gene expression determined by real-time reverse transcription-PCR.

Gravelat FN, Doedt T, Chiang LY, Liu H, Filler SG, Patterson TF, Sheppard DC.

Infect Immun. 2008 Aug;76(8):3632-9. doi: 10.1128/IAI.01483-07. Epub 2008 May 19.


Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary disease.

Chiang LY, Sheppard DC, Gravelat FN, Patterson TF, Filler SG.

Infect Immun. 2008 Aug;76(8):3429-38. doi: 10.1128/IAI.01510-07. Epub 2008 May 19.

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