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Items: 1 to 50 of 135

1.

Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.

Gayden T, Sepulveda FE, Khuong-Quang DA, Pratt J, Valera ET, Garrigue A, Kelso S, Sicheri F, Mikael LG, Hamel N, Bajic A, Dali R, Deshmukh S, Dervovic D, Schramek D, Guerin F, Taipale M, Nikbakht H, Majewski J, Moshous D, Charlebois J, Abish S, Bole-Feysot C, Nitschke P, Bader-Meunier B, Mitchell D, Thieblemont C, Battistella M, Gravel S, Nguyen VH, Conyers R, Diana JS, McCormack C, Prince HM, Besnard M, Blanche S, Ekert PG, Fraitag S, Foulkes WD, Fischer A, Neven B, Michonneau D, de Saint Basile G, Jabado N.

Nat Genet. 2018 Nov 14. doi: 10.1038/s41588-018-0304-8. [Epub ahead of print]

PMID:
30429576
2.

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.

Gayden T, Sepulveda FE, Khuong-Quang DA, Pratt J, Valera ET, Garrigue A, Kelso S, Sicheri F, Mikael LG, Hamel N, Bajic A, Dali R, Deshmukh S, Dervovic D, Schramek D, Guerin F, Taipale M, Nikbakht H, Majewski J, Moshous D, Charlebois J, Abish S, Bole-Feysot C, Nitschke P, Bader-Meunier B, Mitchell D, Thieblemont C, Battistella M, Gravel S, Nguyen VH, Conyers R, Diana JS, McCormack C, Prince HM, Besnard M, Blanche S, Ekert PG, Fraitag S, Foulkes WD, Fischer A, Neven B, Michonneau D, de Saint Basile G, Jabado N.

Nat Genet. 2018 Oct 29. doi: 10.1038/s41588-018-0251-4. [Epub ahead of print] Erratum in: Nat Genet. 2018 Nov 14;:.

PMID:
30374066
3.

Genomic inference using diffusion models and the allele frequency spectrum.

Ragsdale AP, Moreau C, Gravel S.

Curr Opin Genet Dev. 2018 Oct 23;53:140-147. doi: 10.1016/j.gde.2018.10.001. [Epub ahead of print] Review.

PMID:
30366252
4.

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I.

Cell Metab. 2018 Sep 17. pii: S1550-4131(18)30566-7. doi: 10.1016/j.cmet.2018.09.001. [Epub ahead of print]

PMID:
30244971
5.

A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response.

Shamalnasab M, Gravel SP, St-Pierre J, Breton L, Jäger S, Aguilaniu H.

Aging Cell. 2018 Sep 7:e12830. doi: 10.1111/acel.12830. [Epub ahead of print]

6.

Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs.

Thivierge C, Tseng HW, Mayya VK, Lussier C, Gravel SP, Duchaine TF.

Nucleic Acids Res. 2018 Nov 2;46(19):10340-10352. doi: 10.1093/nar/gky666.

7.

LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.

Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM, Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S, Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J, Jones RG.

Science. 2018 Jul 27;361(6400):406-411. doi: 10.1126/science.aan3975.

PMID:
30049881
8.

Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE).

Chourey S, Ye Q, Reddy CN, Wang R, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00154. [Epub ahead of print]

PMID:
29972644
9.

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

Im YK, Najyb O, Gravel SP, McGuirk S, Ahn R, Avizonis DZ, Chénard V, Sabourin V, Hudson J, Pawson T, Topisirovic I, Pollak M, St-Pierre J, Ursini-Siegel J.

Cancer Res. 2018 Sep 1;78(17):4826-4838. doi: 10.1158/0008-5472.CAN-17-3696. Epub 2018 Jun 21.

PMID:
29930100
10.

Intratumor Heterogeneity and Circulating Tumor Cell Clusters.

Ahmed Z, Gravel S.

Mol Biol Evol. 2017 Jun 12. doi: 10.1093/molbev/msy115. [Epub ahead of print]

PMID:
29897504
11.

Corrigendum to "In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys" [Biochem. Pharmacol. 138 (2017) 107-118].

Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Biochem Pharmacol. 2018 Aug;154:174. doi: 10.1016/j.bcp.2018.04.025. Epub 2018 May 10. No abstract available.

PMID:
29754018
12.

Exposure to polybrominated diphenyl ethers (PBDEs) in American and Canadian workers: Biomonitoring data from two national surveys.

Gravel S, Lavoué J, Labrèche F.

Sci Total Environ. 2018 Aug 1;631-632:1465-1471. doi: 10.1016/j.scitotenv.2018.03.025. Epub 2018 Mar 28.

PMID:
29727970
13.

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis.

Gravel SP.

Front Oncol. 2018 Mar 23;8:75. doi: 10.3389/fonc.2018.00075. eCollection 2018. Review.

14.

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP.

Cancer Res. 2018 May 1;78(9):2191-2204. doi: 10.1158/0008-5472.CAN-17-2215. Epub 2018 Feb 12.

PMID:
29440170
15.

Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study.

Gravel S, Chiasson JL, Dallaire S, Turgeon J, Michaud V.

BMJ Open. 2018 Feb 8;8(2):e020922. doi: 10.1136/bmjopen-2017-020922.

16.

Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys.

Reddy CN, Alhamza H, Chourey S, Ye Q, Gore V, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Eur J Pharm Sci. 2018 Mar 30;115:88-99. doi: 10.1016/j.ejps.2018.01.021. Epub 2018 Jan 12.

PMID:
29339225
17.

On the decidability of population size histories from finite allele frequency spectra.

Baharian S, Gravel S.

Theor Popul Biol. 2018 Mar;120:42-51. doi: 10.1016/j.tpb.2017.12.008. Epub 2018 Jan 3.

PMID:
29305873
18.

Has the question of e-waste opened a Pandora's box? An overview of unpredictable issues and challenges.

Bakhiyi B, Gravel S, Ceballos D, Flynn MA, Zayed J.

Environ Int. 2018 Jan;110:173-192. doi: 10.1016/j.envint.2017.10.021. Epub 2017 Nov 6. Review.

PMID:
29122313
19.

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species.

Rabinovitch RC, Samborska B, Faubert B, Ma EH, Gravel SP, Andrzejewski S, Raissi TC, Pause A, St-Pierre J, Jones RG.

Cell Rep. 2017 Oct 3;21(1):1-9. doi: 10.1016/j.celrep.2017.09.026.

20.
21.

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists.

Ye Q, Chourey S, Wang R, Chintam NR, Gravel S, Powell WS, Rokach J.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4770-4776. doi: 10.1016/j.bmcl.2017.08.034. Epub 2017 Aug 19.

PMID:
28943042
22.

Glutaric Aciduria Type 3: Three Unrelated Canadian Cases, with Different Routes of Ascertainment.

Waters PJ, Kitzler TM, Feigenbaum A, Geraghty MT, Al-Dirbashi O, Bherer P, Auray-Blais C, Gravel S, McIntosh N, Siriwardena K, Trakadis Y, Brunel-Guitton C, Al-Hertani W.

JIMD Rep. 2018;39:89-96. doi: 10.1007/8904_2017_49. Epub 2017 Aug 2.

23.

PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms.

Uetani N, Hardy S, Gravel SP, Kiessling S, Pietrobon A, Wong NN, Chénard V, Cermakian N, St-Pierre J, Tremblay ML.

JCI Insight. 2017 Jul 6;2(13). pii: 91722. doi: 10.1172/jci.insight.91722. [Epub ahead of print]

24.

Inferring the Joint Demographic History of Multiple Populations: Beyond the Diffusion Approximation.

Jouganous J, Long W, Ragsdale AP, Gravel S.

Genetics. 2017 Jul;206(3):1549-1567. doi: 10.1534/genetics.117.200493. Epub 2017 May 11.

25.

In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.

Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Biochem Pharmacol. 2017 Aug 15;138:107-118. doi: 10.1016/j.bcp.2017.04.031. Epub 2017 May 3. Erratum in: Biochem Pharmacol. 2018 May 10;154:174.

26.

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.

Martin AR, Gignoux CR, Walters RK, Wojcik GL, Neale BM, Gravel S, Daly MJ, Bustamante CD, Kenny EE.

Am J Hum Genet. 2017 Apr 6;100(4):635-649. doi: 10.1016/j.ajhg.2017.03.004. Epub 2017 Mar 30.

27.

Highly sensitive LC-MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human.

Grangeon A, Gravel S, Gaudette F, Turgeon J, Michaud V.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:144-158. doi: 10.1016/j.jchromb.2016.12.006. Epub 2016 Dec 6.

PMID:
27978469
28.

Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.

Cossette C, Chourey S, Ye Q, Nagendra Reddy C, Gore V, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

J Med Chem. 2016 Nov 23;59(22):10127-10146. Epub 2016 Nov 7.

PMID:
27766872
29.

Methylmalonyl-coA epimerase deficiency: A new case, with an acute metabolic presentation and an intronic splicing mutation in the MCEE gene.

Waters PJ, Thuriot F, Clarke JT, Gravel S, Watkins D, Rosenblatt DS, Lévesque S.

Mol Genet Metab Rep. 2016 Sep 24;9:19-24. eCollection 2016 Dec.

30.

Metabolomics Analyses of Cancer Cells in Controlled Microenvironments.

Gravel SP, Avizonis D, St-Pierre J.

Methods Mol Biol. 2016;1458:273-90. doi: 10.1007/978-1-4939-3801-8_20.

PMID:
27581029
31.

Stronger and More Vulnerable: A Balanced View of the Impacts of the NICU Experience on Parents.

Janvier A, Lantos J, Aschner J, Barrington K, Batton B, Batton D, Berg SF, Carter B, Campbell D, Cohn F, Lyerly AD, Ellsbury D, Fanaroff A, Fanaroff J, Fanaroff K, Gravel S, Haward M, Kutzsche S, Marlow N, Montello M, Maitre N, Morris JT, Paulsen OG, Prentice T, Spitzer AR.

Pediatrics. 2016 Sep;138(3). pii: e20160655. doi: 10.1542/peds.2016-0655. Epub 2016 Aug 3.

32.

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.

Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V.

Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156.

33.

The Great Migration and African-American Genomic Diversity.

Baharian S, Barakatt M, Gignoux CR, Shringarpure S, Errington J, Blot WJ, Bustamante CD, Kenny EE, Williams SM, Aldrich MC, Gravel S.

PLoS Genet. 2016 May 27;12(5):e1006059. doi: 10.1371/journal.pgen.1006059. eCollection 2016 May.

34.

When Is Selection Effective?

Gravel S.

Genetics. 2016 May;203(1):451-62. doi: 10.1534/genetics.115.184630. Epub 2016 Mar 23.

35.

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.

Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I.

Genome Res. 2016 May;26(5):636-48. doi: 10.1101/gr.197566.115. Epub 2016 Mar 16.

36.

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.

Audet-Walsh É, Papadopoli DJ, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J.

Cell Rep. 2016 Feb 2;14(4):920-931. doi: 10.1016/j.celrep.2015.12.086. Epub 2016 Jan 21.

37.

Genomic Insights into the Ancestry and Demographic History of South America.

Homburger JR, Moreno-Estrada A, Gignoux CR, Nelson D, Sanchez E, Ortiz-Tello P, Pons-Estel BA, Acevedo-Vasquez E, Miranda P, Langefeld CD, Gravel S, Alarcón-Riquelme ME, Bustamante CD.

PLoS Genet. 2015 Dec 4;11(12):e1005602. doi: 10.1371/journal.pgen.1005602. eCollection 2015 Dec.

38.

Computationally Efficient Composite Likelihood Statistics for Demographic Inference.

Coffman AJ, Hsieh PH, Gravel S, Gutenkunst RN.

Mol Biol Evol. 2016 Feb;33(2):591-3. doi: 10.1093/molbev/msv255. Epub 2015 Nov 5.

39.

DNA damage checkpoint adaptation genes are required for division of cells harbouring eroded telomeres.

Mersaoui SY, Gravel S, Karpov V, Wellinger RJ.

Microb Cell. 2015 Sep 21;2(10):394-405. doi: 10.15698/mic2015.10.229.

40.

Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.

Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS.

Biochem Pharmacol. 2015 Aug 1;96(3):247-55. doi: 10.1016/j.bcp.2015.05.009. Epub 2015 May 29.

41.

Estimating the mutation load in human genomes.

Henn BM, Botigué LR, Bustamante CD, Clark AG, Gravel S.

Nat Rev Genet. 2015 Jun;16(6):333-43. doi: 10.1038/nrg3931. Epub 2015 May 12. Review.

42.

The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population.

Dagenais M, MacDonald D, Baron M, Hudson M, Tatibouet S, Steele R, Gravel S, Mohit S, El Sayegh T, Pope J, Fontaine A, Masseto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Aug;120(2):104-11. doi: 10.1016/j.oooo.2015.03.002. Epub 2015 Mar 25.

43.

The existence and abundance of ghost ancestors in biparental populations.

Gravel S, Steel M.

Theor Popul Biol. 2015 May;101:47-53. doi: 10.1016/j.tpb.2015.02.002. Epub 2015 Feb 19.

PMID:
25703300
44.

Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants.

Montpas N, Cabana J, St-Onge G, Gravel S, Morin G, Kuroyanagi T, Lavigne P, Fujii N, Oishi S, Heveker N.

Biochemistry. 2015 Feb 24;54(7):1505-15. doi: 10.1021/bi501526s. Epub 2015 Feb 11.

PMID:
25669416
45.

mTOR coordinates protein synthesis, mitochondrial activity and proliferation.

Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J, Topisirovic I.

Cell Cycle. 2015;14(4):473-80. doi: 10.4161/15384101.2014.991572. Review.

46.

Serine deprivation enhances antineoplastic activity of biguanides.

Gravel SP, Hulea L, Toban N, Birman E, Blouin MJ, Zakikhani M, Zhao Y, Topisirovic I, St-Pierre J, Pollak M.

Cancer Res. 2014 Dec 15;74(24):7521-33. doi: 10.1158/0008-5472.CAN-14-2643-T. Epub 2014 Nov 6.

47.

Relationship between disease characteristics and orofacial manifestations in systemic sclerosis: Canadian Systemic Sclerosis Oral Health Study III.

Baron M, Hudson M, Tatibouet S, Steele R, Lo E, Gravel S, Gyger G, El Sayegh T, Pope J, Fontaine A, Masetto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira G, Robinson D, Fritzler M, Gornitsky M.

Arthritis Care Res (Hoboken). 2015 May;67(5):681-90. doi: 10.1002/acr.22490.

48.

The Canadian systemic sclerosis oral health study II: the relationship between oral and global health-related quality of life in systemic sclerosis.

Baron M, Hudson M, Tatibouet S, Steele R, Lo E, Gravel S, Gyger G, El Sayegh T, Pope J, Fontaine A, Masetto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M.

Rheumatology (Oxford). 2015 Apr;54(4):692-6. doi: 10.1093/rheumatology/keu396. Epub 2014 Oct 6.

49.

Metformin directly acts on mitochondria to alter cellular bioenergetics.

Andrzejewski S, Gravel SP, Pollak M, St-Pierre J.

Cancer Metab. 2014 Aug 28;2:12. doi: 10.1186/2049-3002-2-12. eCollection 2014.

50.

Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.

Perry GH, Foll M, Grenier JC, Patin E, Nédélec Y, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3596-603. doi: 10.1073/pnas.1402875111. Epub 2014 Aug 18.

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