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Items: 1 to 50 of 91

1.

TREX-1-Related Disease Associated with the Presence of Cryofibrinogenemia.

Paradis C, Cadieux-Dion M, Meloche C, Gravel M, Paradis J, Des Roches A, Leclerc G, Cossette P, Begin P.

J Clin Immunol. 2019 Jan;39(1):118-125. doi: 10.1007/s10875-018-0584-x. Epub 2019 Jan 26.

PMID:
30685859
2.

Oxazolium Salts as Organocatalysts for the Umpolung of Aldehydes.

Garapati VKR, Gravel M.

Org Lett. 2018 Oct 19;20(20):6372-6375. doi: 10.1021/acs.orglett.8b02636. Epub 2018 Oct 1.

PMID:
30270631
3.

Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study.

May P, Girard S, Harrer M, Bobbili DR, Schubert J, Wolking S, Becker F, Lachance-Touchette P, Meloche C, Gravel M, Niturad CE, Knaus J, De Kovel C, Toliat M, Polvi A, Iacomino M, Guerrero-López R, Baulac S, Marini C, Thiele H, Altmüller J, Jabbari K, Ruppert AK, Jurkowski W, Lal D, Rusconi R, Cestèle S, Terragni B, Coombs ID, Reid CA, Striano P, Caglayan H, Siren A, Everett K, Møller RS, Hjalgrim H, Muhle H, Helbig I, Kunz WS, Weber YG, Weckhuysen S, Jonghe P, Sisodiya SM, Nabbout R, Franceschetti S, Coppola A, Vari MS, Kasteleijn-Nolst Trenité D, Baykan B, Ozbek U, Bebek N, Klein KM, Rosenow F, Nguyen DK, Dubeau F, Carmant L, Lortie A, Desbiens R, Clément JF, Cieuta-Walti C, Sills GJ, Auce P, Francis B, Johnson MR, Marson AG, Berghuis B, Sander JW, Avbersek A, McCormack M, Cavalleri GL, Delanty N, Depondt C, Krenn M, Zimprich F, Peter S, Nikanorova M, Kraaij R, van Rooij J, Balling R, Ikram MA, Uitterlinden AG, Avanzini G, Schorge S, Petrou S, Mantegazza M, Sander T, LeGuern E, Serratosa JM, Koeleman BPC, Palotie A, Lehesjoki AE, Nothnagel M, Nürnberg P, Maljevic S, Zara F, Cossette P, Krause R, Lerche H; Epicure Consortium; EuroEPINOMICS CoGIE Consortium; EpiPGX Consortium.

Lancet Neurol. 2018 Aug;17(8):699-708. doi: 10.1016/S1474-4422(18)30215-1. Epub 2018 Jul 17.

4.

DZ-2384 has a superior preclinical profile to taxanes for the treatment of triple-negative breast cancer and is synergistic with anti-CTLA-4 immunotherapy.

Bernier C, Soliman A, Gravel M, Dankner M, Savage P, Petrecca K, Park M, Siegel PM, Shore GC, Roulston A.

Anticancer Drugs. 2018 Sep;29(8):774-785. doi: 10.1097/CAD.0000000000000653.

5.

Global characterization of copy number variants in epilepsy patients from whole genome sequencing.

Monlong J, Girard SL, Meloche C, Cadieux-Dion M, Andrade DM, Lafreniere RG, Gravel M, Spiegelman D, Dionne-Laporte A, Boelman C, Hamdan FF, Michaud JL, Rouleau G, Minassian BA, Bourque G, Cossette P.

PLoS Genet. 2018 Apr 12;14(4):e1007285. doi: 10.1371/journal.pgen.1007285. eCollection 2018 Apr.

6.

Author Correction: Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo.

Liu H, Su D, Zhang J, Ge S, Li Y, Wang F, Gravel M, Roulston A, Song Q, Xu W, Liang JG, Shore G, Wang X, Liang P.

Sci Rep. 2018 Mar 22;8(1):5266. doi: 10.1038/s41598-018-23057-3.

7.

Assembly of Complex Macrocycles by Incrementally Amalgamating Unprotected Peptides with a Designed Four-Armed Insert.

Curtin BH, Manoni F, Park J, Sisto LJ, Lam YH, Gravel M, Roulston A, Harran PG.

J Org Chem. 2018 Mar 16;83(6):3090-3108. doi: 10.1021/acs.joc.7b02958. Epub 2018 Mar 7.

PMID:
29494773
8.

Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy.

Cole J, Guiot MC, Gravel M, Bernier C, Shore GC, Roulston A.

Oncotarget. 2017 Sep 12;8(44):77846-77859. doi: 10.18632/oncotarget.20840. eCollection 2017 Sep 29.

9.

Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo.

Liu H, Su D, Zhang J, Ge S, Li Y, Wang F, Gravel M, Roulston A, Song Q, Xu W, Liang JG, Shore G, Wang X, Liang P.

Sci Rep. 2017 Aug 21;7(1):8953. doi: 10.1038/s41598-017-09518-1. Erratum in: Sci Rep. 2018 Mar 22;8(1):5266.

10.

Substrate-Controlled Diastereoselectivity Reversal in NHC-Catalyzed Cross-Benzoin Reactions Using N-Boc-N-Bn-Protected α-Amino Aldehydes.

Haghshenas P, Quail JW, Gravel M.

J Org Chem. 2016 Dec 16;81(24):12075-12083. Epub 2016 Dec 2.

PMID:
27978724
11.

Studies Directed toward the Synthesis of Aspidophytine: Construction of Its Perhydroquinoline Core.

Türkmen YE, Gravel M, Rawal VH.

J Org Chem. 2016 Nov 4;81(21):10454-10462. Epub 2016 Aug 29.

PMID:
27525506
12.

Chemo- and Diastereoselective N-Heterocyclic Carbene-Catalyzed Cross-Benzoin Reactions Using N-Boc-α-amino Aldehydes.

Haghshenas P, Gravel M.

Org Lett. 2016 Sep 16;18(18):4518-21. doi: 10.1021/acs.orglett.6b02123. Epub 2016 Aug 30.

PMID:
27574804
13.

IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1.

Gravel M, Béland LC, Soucy G, Abdelhamid E, Rahimian R, Gravel C, Kriz J.

J Neurosci. 2016 Jan 20;36(3):1031-48. doi: 10.1523/JNEUROSCI.0854-15.2016.

14.

X-linked focal epilepsy with reflex bathing seizures: Characterization of a distinct epileptic syndrome.

Nguyen DK, Rouleau I, Sénéchal G, Ansaldo AI, Gravel M, Benfenati F, Cossette P.

Epilepsia. 2015 Jul;56(7):1098-108. doi: 10.1111/epi.13042. Epub 2015 Jun 19.

15.

The planar cell polarity protein Vangl2 is required for retinal axon guidance.

Leung V, Iliescu A, Jolicoeur C, Gravel M, Apuzzo S, Torban E, Cayouette M, Gros P.

Dev Neurobiol. 2016 Feb;76(2):150-65. doi: 10.1002/dneu.22305. Epub 2015 Jun 2.

16.

Origin of chemoselectivity in N-heterocyclic carbene catalyzed cross-benzoin reactions: DFT and experimental insights.

Langdon SM, Legault CY, Gravel M.

J Org Chem. 2015 Apr 3;80(7):3597-610. doi: 10.1021/acs.joc.5b00301. Epub 2015 Mar 18.

PMID:
25734574
17.

Retrospective analysis of phone queries to an epilepsy clinic hotline.

Laforme A, Jubinville S, Gravel M, Cossette P, Nguyen DK.

Can J Neurosci Nurs. 2014;36(3):41-5.

PMID:
25638916
18.

Bis(amino)cyclopropenylidene (BAC) catalyzed aza-benzoin reaction.

Wilde MM, Gravel M.

Org Lett. 2014 Oct 17;16(20):5308-11. doi: 10.1021/ol5024807. Epub 2014 Oct 2.

PMID:
25272948
19.

Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption.

Chan M, Gravel M, Bramoullé A, Bridon G, Avizonis D, Shore GC, Roulston A.

Cancer Res. 2014 Nov 1;74(21):5948-54. doi: 10.1158/0008-5472.CAN-14-0809. Epub 2014 Aug 21.

20.

Independent mutations at Arg181 and Arg274 of Vangl proteins that are associated with neural tube defects in humans decrease protein stability and impair membrane targeting.

Iliescu A, Gravel M, Horth C, Gros P.

Biochemistry. 2014 Aug 19;53(32):5356-64. doi: 10.1021/bi500400g. Epub 2014 Aug 6.

PMID:
25068569
21.

Donation after circulatory determination of death: the university of michigan experience with extracorporeal support.

Rojas-Peña A, Sall LE, Gravel MT, Cooley EG, Pelletier SJ, Bartlett RH, Punch JD.

Transplantation. 2014 Aug 15;98(3):328-34. doi: 10.1097/TP.0000000000000070.

PMID:
24825520
22.

Chemoselective N-heterocyclic carbene-catalyzed cross-benzoin reactions: importance of the fused ring in triazolium salts.

Langdon SM, Wilde MM, Thai K, Gravel M.

J Am Chem Soc. 2014 May 28;136(21):7539-42. doi: 10.1021/ja501772m. Epub 2014 May 16.

PMID:
24809936
23.

Expanding the clinical phenotype associated with ELOVL4 mutation: study of a large French-Canadian family with autosomal dominant spinocerebellar ataxia and erythrokeratodermia.

Cadieux-Dion M, Turcotte-Gauthier M, Noreau A, Martin C, Meloche C, Gravel M, Drouin CA, Rouleau GA, Nguyen DK, Cossette P.

JAMA Neurol. 2014 Apr;71(4):470-5. doi: 10.1001/jamaneurol.2013.6337.

PMID:
24566826
24.

Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis.

Patel P, Kriz J, Gravel M, Soucy G, Bareil C, Gravel C, Julien JP.

Mol Ther. 2014 Mar;22(3):498-510. doi: 10.1038/mt.2013.239. Epub 2013 Oct 17.

25.

A recurrent mutation in DEPDC5 predisposes to focal epilepsies in the French-Canadian population.

Martin C, Meloche C, Rioux MF, Nguyen DK, Carmant L, Andermann E, Gravel M, Cossette P.

Clin Genet. 2014 Dec;86(6):570-4. doi: 10.1111/cge.12311. Epub 2013 Nov 27.

PMID:
24283814
26.

Bis(amino)cyclopropenylidenes as organocatalysts for acyl anion and extended umpolung reactions.

Wilde MM, Gravel M.

Angew Chem Int Ed Engl. 2013 Nov 25;52(48):12651-4. doi: 10.1002/anie.201307167. Epub 2013 Oct 2. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2014 Jan 20;53(4):912.

PMID:
24123480
27.

Highly chemo- and enantioselective cross-benzoin reaction of aliphatic aldehydes and α-ketoesters.

Thai K, Langdon SM, Bilodeau F, Gravel M.

Org Lett. 2013 May 3;15(9):2214-7. doi: 10.1021/ol400769t. Epub 2013 Apr 23.

PMID:
23607338
28.

Oxidative stress associated with paternal care in smallmouth bass (Micropterus dolomieu).

Wilson SM, Gravel MA, Mackie TA, Willmore WG, Cooke SJ.

Comp Biochem Physiol A Mol Integr Physiol. 2012 Jul;162(3):212-8. doi: 10.1016/j.cbpa.2012.02.023. Epub 2012 Mar 3.

PMID:
22414434
29.

Scalable synthesis of highly reactive 1,3-diamino dienes from vinamidinium salts and their use in Diels-Alder reactions.

Zhou S, Sánchez-Larios E, Gravel M.

J Org Chem. 2012 Apr 6;77(7):3576-82. doi: 10.1021/jo202655h. Epub 2012 Mar 20.

PMID:
22397369
30.

Model system for live imaging of neuronal responses to injury and repair.

Gravel M, Weng YC, Kriz J.

Mol Imaging. 2011 Dec;10(6):434-45.

PMID:
22201534
31.

Highly enantioselective intermolecular Stetter reactions of β-aryl acceptors: α-ketoester moiety as handle for activation and synthetic manipulations.

Sánchez-Larios E, Thai K, Bilodeau F, Gravel M.

Org Lett. 2011 Sep 16;13(18):4942-5. doi: 10.1021/ol202040b. Epub 2011 Aug 16.

PMID:
21846082
32.

Transmembrane topology of mammalian planar cell polarity protein Vangl1.

Iliescu A, Gravel M, Horth C, Apuzzo S, Gros P.

Biochemistry. 2011 Mar 29;50(12):2274-82. doi: 10.1021/bi101767a. Epub 2011 Feb 25.

PMID:
21291170
33.

Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice.

Keller AF, Gravel M, Kriz J.

Exp Neurol. 2011 Mar;228(1):69-79. doi: 10.1016/j.expneurol.2010.12.010. Epub 2010 Dec 17.

PMID:
21168408
34.

Loss of membrane targeting of Vangl proteins causes neural tube defects.

Iliescu A, Gravel M, Horth C, Kibar Z, Gros P.

Biochemistry. 2011 Feb 8;50(5):795-804. doi: 10.1021/bi101286d. Epub 2011 Jan 13.

PMID:
21142127
35.

NHC-catalyzed spiro bis-indane formation via domino Stetter-aldol-Michael and Stetter-aldol-aldol reactions.

Sánchez-Larios E, Holmes JM, Daschner CL, Gravel M.

Org Lett. 2010 Dec 17;12(24):5772-5. doi: 10.1021/ol102685u. Epub 2010 Nov 22.

PMID:
21090705
36.

NHC-catalyzed intramolecular redox amidation for the synthesis of functionalized lactams.

Thai K, Wang L, Dudding T, Bilodeau F, Gravel M.

Org Lett. 2010 Dec 17;12(24):5708-11. doi: 10.1021/ol102536s. Epub 2010 Nov 16.

PMID:
21080709
37.

Comparative energetics and physiology of parental care in smallmouth bass Micropterus dolomieu across a latitudinal gradient.

Gravel MA, Couture P, Cooke SJ.

J Fish Biol. 2010 Jan;76(1):280-300. doi: 10.1111/j.1095-8649.2009.02482.x.

PMID:
20738708
38.

Screening of GABRB3 in French-Canadian families with idiopathic generalized epilepsy.

Lachance-Touchette P, Martin C, Poulin C, Gravel M, Carmant L, Cossette P.

Epilepsia. 2010 Sep;51(9):1894-7. doi: 10.1111/j.1528-1167.2010.02642.x.

39.

Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse.

Gravel M, Iliescu A, Horth C, Apuzzo S, Gros P.

Biochemistry. 2010 Apr 27;49(16):3445-55. doi: 10.1021/bi902180m.

PMID:
20329788
40.

Brood predation pressure during parental care does not influence parental enzyme activities related to swimming activity in a teleost fish.

Gravel MA, Couture P, Cooke SJ.

Comp Biochem Physiol A Mol Integr Physiol. 2010 Jan;155(1):100-6. doi: 10.1016/j.cbpa.2009.10.016. Epub 2009 Oct 23.

PMID:
19854286
41.

Diastereoselective synthesis of indanes via a domino Stetter-Michael reaction.

Sánchez-Larios E, Gravel M.

J Org Chem. 2009 Oct 2;74(19):7536-9. doi: 10.1021/jo901468h.

PMID:
19778082
42.

Practical synthesis and highly diastereoselective Diels-Alder reactions of 1-alkylthio-3-silyloxybutadienes.

Holmes JM, Albert AL, Gravel M.

J Org Chem. 2009 Aug 21;74(16):6406-9. doi: 10.1021/jo901347u.

PMID:
19627130
43.

NHC-catalyzed ring expansion of oxacycloalkane-2-carboxaldehydes: a versatile synthesis of lactones.

Wang L, Thai K, Gravel M.

Org Lett. 2009 Feb 19;11(4):891-3. doi: 10.1021/ol8029005.

PMID:
19199765
44.
45.

2',3'-Cyclic nucleotide 3'-phosphodiesterase: a novel RNA-binding protein that inhibits protein synthesis.

Gravel M, Robert F, Kottis V, Gallouzi IE, Pelletier J, Braun PE.

J Neurosci Res. 2009 Apr;87(5):1069-79. doi: 10.1002/jnr.21939.

PMID:
19021295
46.

Phenotypic concordance in 70 families with IGE-implications for genetic studies of epilepsy.

Kinirons P, Rabinowitz D, Gravel M, Long J, Winawer M, Sénéchal G, Ottman R, Cossette P.

Epilepsy Res. 2008 Nov;82(1):21-28. doi: 10.1016/j.eplepsyres.2008.06.011. Epub 2008 Aug 23.

47.

Physiological disturbance and recovery dynamics of bonefish (Albula vulpes), a tropical marine fish, in response to variable exercise and exposure to air.

Suski CD, Cooke SJ, Danylchuk AJ, O'Connor CM, Gravel MA, Redpath T, Hanson KC, Gingerich AJ, Murchie KJ, Danylchuk SE, Koppelman JB, Goldberg TL.

Comp Biochem Physiol A Mol Integr Physiol. 2007 Nov;148(3):664-73. Epub 2007 Aug 22.

PMID:
17884649
48.

Solution structure of the catalytic domain of RICH protein from goldfish.

Kozlov G, Denisov AY, Pomerantseva E, Gravel M, Braun PE, Gehring K.

FEBS J. 2007 Mar;274(6):1600-9.

49.

1H, 13C and 15N resonance assignments of the catalytic domain of the goldfish RICH protein.

Denisov AY, Kozlov G, Gravel M, Sprules T, Braun PE, Gehring K.

J Biomol NMR. 2006;36 Suppl 1:75. Epub 2006 Sep 20. No abstract available.

PMID:
17031527
50.

Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis.

Bissonauth V, Roy S, Gravel M, Guillemette S, Charron J.

Development. 2006 Sep;133(17):3429-40. Epub 2006 Aug 3.

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