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Rheumatoid arthritis morning stiffness is associated with synovial fibrin and neutrophils.

Orange DE, Blachere NE, DiCarlo EF, Mirza S, Pannellini T, Jiang CS, Frank MO, Parveen S, Figgie MP, Gravallese EM, Bykerk VP, Orbai AM, Mackie SL, Goodman SM.

Arthritis Rheumatol. 2019 Oct 15. doi: 10.1002/art.41141. [Epub ahead of print]


The Role of IFNγ-Producing Th1 Cells in a Type I IFN-Independent Murine Model of Autoinflammation Resulting from DNase II-Deficiency.

Pawaria S, Nündel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A.

Arthritis Rheumatol. 2019 Aug 28. doi: 10.1002/art.41090. [Epub ahead of print]


An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study.

Henchie TF, Gravallese EM, Bredbenner TL, Troy KL.

Comput Methods Biomech Biomed Engin. 2019 Aug;22(10):942-952. doi: 10.1080/10255842.2019.1607315. Epub 2019 May 8.


Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM 2nd; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S.

Nat Immunol. 2019 Jul;20(7):928-942. doi: 10.1038/s41590-019-0378-1. Epub 2019 May 6.


Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission.

Orange DE, Agius P, DiCarlo EF, Mirza SZ, Pannellini T, Szymonifka J, Jiang CS, Figgie MP, Frank MO, Robinson WH, Donlin LT, Rozo C, Gravallese EM, Bykerk VP, Goodman SM.

Arthritis Rheumatol. 2019 Jul;71(7):1034-1041. doi: 10.1002/art.40878. Epub 2019 Jun 5.


Breathing New Life into Interstitial Lung Disease in Rheumatoid Arthritis.

Gregersen PK, Gravallese EM.

N Engl J Med. 2018 Dec 6;379(23):2265-2266. doi: 10.1056/NEJMe1811767. Epub 2018 Oct 20. No abstract available.


Effects of the IL-23-IL-17 pathway on bone in spondyloarthritis.

Gravallese EM, Schett G.

Nat Rev Rheumatol. 2018 Nov;14(11):631-640. doi: 10.1038/s41584-018-0091-8. Review.


Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.


Author Correction: Towards an arthritis flare-responsive drug delivery system.

Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM.

Nat Commun. 2018 May 11;9(1):1954. doi: 10.1038/s41467-018-04346-x.


Towards an arthritis flare-responsive drug delivery system.

Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM.

Nat Commun. 2018 Apr 3;9(1):1275. doi: 10.1038/s41467-018-03691-1. Erratum in: Nat Commun. 2018 May 11;9(1):1954.


The Science Behind Biosimilars: Entering a New Era of Biologic Therapy.

Bridges SL Jr, White DW, Worthing AB, Gravallese EM, O'Dell JR, Nola K, Kay J, Cohen SB; American College of Rheumatology.

Arthritis Rheumatol. 2018 Mar;70(3):334-344. doi: 10.1002/art.40388. Epub 2018 Feb 7. No abstract available.


Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications.

Shim JH, Stavre Z, Gravallese EM.

Calcif Tissue Int. 2018 May;102(5):533-546. doi: 10.1007/s00223-017-0373-1. Epub 2017 Dec 4. Review.



Gravallese EM, Kay J, Duryea J, Solomon DH.

Arthritis Rheumatol. 2018 Mar;70(3):476. doi: 10.1002/art.40387. Epub 2018 Feb 6. No abstract available.


Bone Wasn't Built in a Day: Destruction and Formation of Bone in the Rheumatic Diseases.

Gravallese EM.

Trans Am Clin Climatol Assoc. 2017;128:24-43. Review.


Effects of Teriparatide on Joint Erosions in Rheumatoid Arthritis: A Randomized Controlled Trial.

Solomon DH, Kay J, Duryea J, Lu B, Bolster MB, Yood RA, Han R, Ball S, Coleman C, Lo E, Wohlfahrt A, Sury M, Yin M, Yu Z, Zak A, Gravallese EM.

Arthritis Rheumatol. 2017 Sep;69(9):1741-1750. doi: 10.1002/art.40156. Epub 2017 Jul 14.


Differential Effects of Inflammation on Bone and Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis.

Stavre Z, Upchurch K, Kay J, Gravallese EM.

Curr Rheumatol Rep. 2016 Dec;18(12):72. doi: 10.1007/s11926-016-0620-x. Review.


Synovium-Derived MicroRNAs Regulate Bone Pathways in Rheumatoid Arthritis.

Maeda Y, Farina NH, Matzelle MM, Fanning PJ, Lian JB, Gravallese EM.

J Bone Miner Res. 2017 Mar;32(3):461-472. doi: 10.1002/jbmr.3005. Epub 2016 Oct 28.


STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.

Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM.

Arthritis Rheumatol. 2017 Feb;69(2):460-471. doi: 10.1002/art.39863.


RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis.

O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF.

Arthritis Rheumatol. 2016 Dec;68(12):2889-2900. doi: 10.1002/art.39837.


Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?

Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A.

J Leukoc Biol. 2017 Jan;101(1):121-126. doi: 10.1189/jlb.3MR0316-115R. Epub 2016 Aug 16. Review.


Control of the innate immune response by the mevalonate pathway.

Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D.

Nat Immunol. 2016 Aug;17(8):922-9. doi: 10.1038/ni.3487. Epub 2016 Jun 6.


IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis.

Shaw AT, Maeda Y, Gravallese EM.

Arthritis Res Ther. 2016 May 10;18(1):104. doi: 10.1186/s13075-016-0998-x.


Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation.

Matzelle MM, Shaw AT, Baum R, Maeda Y, Li J, Karmakar S, Manning CA, Walsh NC, Rosen V, Gravallese EM.

Scand J Rheumatol. 2016 Oct;45(5):379-83. doi: 10.3109/03009742.2015.1126347. Epub 2016 Mar 16.


Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.

Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A.

J Immunol. 2016 Feb 1;196(3):1348-54. doi: 10.4049/jimmunol.1502130. Epub 2016 Jan 4.


Mediators of inflammation and bone remodeling in rheumatic disease.

Shaw AT, Gravallese EM.

Semin Cell Dev Biol. 2016 Jan;49:2-10. doi: 10.1016/j.semcdb.2015.10.013. Epub 2015 Oct 19. Review.


Brief Report: Development and Validation of a Semiautomated Method to Measure Erosion Volume in Inflammatory Arthritis by Computed Tomography Scanning.

Duryea J, Russell R, Gravallese EM, Kay J, Han R, Lu B, Solomon DH.

Arthritis Rheumatol. 2016 Feb;68(2):332-6. doi: 10.1002/art.39459.


An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.

Pawaria S, Moody KL, Busto P, Nündel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S70-3. Epub 2015 Oct 12. Review.


Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts.

Baum R, Gravallese EM.

Clin Rev Allergy Immunol. 2016 Aug;51(1):1-15. doi: 10.1007/s12016-015-8515-6. Review.


Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model.

Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G 3rd, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR.

Arthritis Rheumatol. 2015 Dec;67(12):3146-57. doi: 10.1002/art.39321.


Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.

Baum R, Sharma S, Carpenter S, Li QZ, Busto P, Fitzgerald KA, Marshak-Rothstein A, Gravallese EM.

J Immunol. 2015 Feb 1;194(3):873-7. doi: 10.4049/jimmunol.1402573. Epub 2014 Dec 29.


Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and experimental arthritis.

Kim SJ, Chen Z, Chamberlain ND, Essani AB, Volin MV, Amin MA, Volkov S, Gravallese EM, Arami S, Swedler W, Lane NE, Mehta A, Sweiss N, Shahrara S.

J Immunol. 2014 Oct 15;193(8):3902-13. doi: 10.4049/jimmunol.1302998. Epub 2014 Sep 8.


Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation.

Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J.

Ann Rheum Dis. 2015 Nov;74(11):2062-9. doi: 10.1136/annrheumdis-2013-204900. Epub 2014 Jun 9.


Clinical disease activity and acute phase reactant levels are discordant among patients with active rheumatoid arthritis: acute phase reactant levels contribute separately to predicting outcome at one year.

Kay J, Morgacheva O, Messing SP, Kremer JM, Greenberg JD, Reed GW, Gravallese EM, Furst DE.

Arthritis Res Ther. 2014 Feb 3;16(1):R40. doi: 10.1186/ar4469.


Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant.

Dusad A, Duryee MJ, Shaw AT, Klassen LW, Anderson DR, Wang D, Ren K, Gravallese EM, O'Dell JR, Mikuls TR, Thiele GM.

Immunol Res. 2014 Jan;58(1):51-60. doi: 10.1007/s12026-013-8479-7.


Impact of inflammation on the osteoblast in rheumatic diseases.

Baum R, Gravallese EM.

Curr Osteoporos Rep. 2014 Mar;12(1):9-16. doi: 10.1007/s11914-013-0183-y. Review.


Role of vascular channels as a novel mechanism for subchondral bone damage at cruciate ligament entheses in osteoarthritis and inflammatory arthritis.

Binks DA, Gravallese EM, Bergin D, Hodgson RJ, Tan AL, Matzelle MM, McGonagle D, Radjenovic A.

Ann Rheum Dis. 2015 Jan;74(1):196-203. doi: 10.1136/annrheumdis-2013-203972. Epub 2013 Oct 4.


Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL.

Walsh NC, Alexander KA, Manning CA, Karmakar S, Wang JF, Weyand CM, Pettit AR, Gravallese EM.

Genes Immun. 2013 Jul-Aug;14(5):336-45. doi: 10.1038/gene.2013.29. Epub 2013 May 23. Erratum in: Genes Immun. 2013 Sep;14(6):407. Karmakar, S K [corrected to Karmakar, S].


Rheumatoid arthritis: erosion defined: back to basics.

Kay J, Gravallese EM.

Nat Rev Rheumatol. 2013 Jun;9(6):323-4. doi: 10.1038/nrrheum.2013.60. Epub 2013 Apr 23. No abstract available.


Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway.

Matzelle MM, Gallant MA, Condon KW, Walsh NC, Manning CA, Stein GS, Lian JB, Burr DB, Gravallese EM.

Arthritis Rheum. 2012 May;64(5):1540-50. doi: 10.1002/art.33504.


Assessment of control of rheumatoid arthritis disease activity.

Salomon-Escoto KI, Gravallese EM, Kay J.

Best Pract Res Clin Rheumatol. 2011 Aug;25(4):497-507. doi: 10.1016/j.berh.2011.10.007. Review.


Rheumatoid arthritis: Repair of erosion in RA--shifting the balance to formation.

Gravallese EM, Walsh NC.

Nat Rev Rheumatol. 2011 Sep 20;7(11):626-8. doi: 10.1038/nrrheum.2011.133. No abstract available.


Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention.

Karmakar S, Kay J, Gravallese EM.

Rheum Dis Clin North Am. 2010 May;36(2):385-404. doi: 10.1016/j.rdc.2010.03.003. Review.


Bone remodeling in rheumatic disease: a question of balance.

Walsh NC, Gravallese EM.

Immunol Rev. 2010 Jan;233(1):301-12. doi: 10.1111/j.0105-2896.2009.00857.x. Review.


Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA.

Desai SP, Gravallese EM, Shadick NA, Glass R, Cui J, Frits M, Chibnik LB, Maher N, Weinblatt ME, Solomon DH.

Rheumatology (Oxford). 2010 Mar;49(3):513-9. doi: 10.1093/rheumatology/kep385. Epub 2009 Dec 21.


Entheses and bones in spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN).

Colbert RA, Deodhar AA, Fox D, Gravallese EM, Khan MA, McGonagle D, Reveille JD, Schett G, Weisman M, Clegg DO; SPARTAN Group.

J Rheumatol. 2009 Jul;36(7):1527-31. doi: 10.3899/jrheum.090122.


The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis.

Solomon DH, Finkelstein JS, Shadick N, LeBoff MS, Winalski CS, Stedman M, Glass R, Brookhart MA, Weinblatt ME, Gravallese EM.

Arthritis Rheum. 2009 Jun;60(6):1624-31. doi: 10.1002/art.24551.


Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis.

Walsh NC, Reinwald S, Manning CA, Condon KW, Iwata K, Burr DB, Gravallese EM.

J Bone Miner Res. 2009 Sep;24(9):1572-85. doi: 10.1359/jbmr.090320.


The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis.

Shen Z, Crotti TN, McHugh KP, Matsuzaki K, Gravallese EM, Bierbaum BE, Goldring SR.

Arthritis Res Ther. 2006;8(3):R70. Epub 2006 Apr 13.


RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis.

Pettit AR, Walsh NC, Manning C, Goldring SR, Gravallese EM.

Rheumatology (Oxford). 2006 Sep;45(9):1068-76. Epub 2006 Feb 20.


Rheumatic diseases: the effects of inflammation on bone.

Walsh NC, Crotti TN, Goldring SR, Gravallese EM.

Immunol Rev. 2005 Dec;208:228-51. Review.


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