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Items: 41

1.

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

Rozen EJ, Roewenstrunk J, Barallobre MJ, Di Vona C, Jung C, Figueiredo AF, Luna J, Fillat C, Arbonés ML, Graupera M, Valverde MA, de la Luna S.

Cell Rep. 2018 May 8;23(6):1867-1878. doi: 10.1016/j.celrep.2018.04.008.

2.

ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation.

Alsina-Sanchís E, García-Ibáñez Y, Figueiredo AM, Riera-Domingo C, Figueras A, Matias-Guiu X, Casanovas O, Botella LM, Pujana MA, Riera-Mestre A, Graupera M, Viñals F.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1216-1229. doi: 10.1161/ATVBAHA.118.310760. Epub 2018 Feb 15.

PMID:
29449337
3.

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B.

Nat Commun. 2017 Nov 24;8(1):1773. doi: 10.1038/s41467-017-02002-4.

4.

A Role for CXCR4 in Peritoneal and Hematogenous Ovarian Cancer Dissemination.

Figueras A, Alsina-Sanchís E, Lahiguera Á, Abreu M, Muinelo-Romay L, Moreno-Bueno G, Casanovas O, Graupera M, Matias-Guiu X, Vidal A, Villanueva A, Viñals F.

Mol Cancer Ther. 2018 Feb;17(2):532-543. doi: 10.1158/1535-7163.MCT-17-0643. Epub 2017 Nov 16.

PMID:
29146630
5.

Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A.

Nat Cell Biol. 2017 Jun 29;19(7):873. doi: 10.1038/ncb3558.

PMID:
28659639
6.

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-Sebastian A, Serra H, Cuadras D, Blanco I, Lozano J, Canals F, Sieuwerts AM, de Weerd V, Look MP, Puertas S, García N, Perkins AS, Bonifaci N, Skowron M, Gómez-Baldó L, Hernández V, Martínez-Aranda A, Martínez-Iniesta M, Serrat X, Cerón J, Brunet J, Barretina MP, Gil M, Falo C, Fernández A, Morilla I, Pernas S, Plà MJ, Andreu X, Seguí MA, Ballester R, Castellà E, Nellist M, Morales S, Valls J, Velasco A, Matias-Guiu X, Figueras A, Sánchez-Mut JV, Sánchez-Céspedes M, Cordero A, Gómez-Miragaya J, Palomero L, Gómez A, Gajewski TF, Cohen EEW, Jesiotr M, Bodnar L, Quintela-Fandino M, López-Bigas N, Valdés-Mas R, Puente XS, Viñals F, Casanovas O, Graupera M, Hernández-Losa J, Ramón Y Cajal S, García-Alonso L, Saez-Rodriguez J, Esteller M, Sierra A, Martín-Martín N, Matheu A, Carracedo A, González-Suárez E, Nanjundan M, Cortés J, Lázaro C, Odero MD, Martens JWM, Moreno-Bueno G, Barcellos-Hoff MH, Villanueva A, Gomis RR, Pujana MA.

Oncogene. 2017 May 11;36(19):2737-2749. doi: 10.1038/onc.2016.427. Epub 2016 Dec 19.

7.

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.

Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A.

Nat Commun. 2016 Nov 29;7:13650. doi: 10.1038/ncomms13650.

8.

Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action.

Duran I, Lambea J, Maroto P, González-Larriba JL, Flores L, Granados-Principal S, Graupera M, Sáez B, Vivancos A, Casanovas O.

Target Oncol. 2017 Feb;12(1):19-35. doi: 10.1007/s11523-016-0463-4. Review.

PMID:
27844272
9.

Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors.

Soler A, Figueiredo AM, Castel P, Martin L, Monelli E, Angulo-Urarte A, Milà-Guasch M, Viñals F, Baselga J, Casanovas O, Graupera M.

Clin Cancer Res. 2016 Dec 1;22(23):5805-5817. Epub 2016 May 25.

10.

Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy.

Okkenhaug K, Graupera M, Vanhaesebroeck B.

Cancer Discov. 2016 Oct;6(10):1090-1105. Epub 2016 Sep 21. Review.

11.

The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.

Alsina-Sanchis E, Figueras A, Lahiguera Á, Vidal A, Casanovas O, Graupera M, Villanueva A, Viñals F.

Int J Cancer. 2016 Oct 15;139(8):1894-903. doi: 10.1002/ijc.30233. Epub 2016 Jun 25.

12.

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A.

Nat Cell Biol. 2016 Jun;18(6):645-656. doi: 10.1038/ncb3357. Epub 2016 May 23. Erratum in: Nat Cell Biol. 2017 Jun 29;19(7):873.

13.

Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients.

Jiménez-Valerio G, Martínez-Lozano M, Bassani N, Vidal A, Ochoa-de-Olza M, Suárez C, García-Del-Muro X, Carles J, Viñals F, Graupera M, Indraccolo S, Casanovas O.

Cell Rep. 2016 May 10;15(6):1134-43. doi: 10.1016/j.celrep.2016.04.015. Epub 2016 Apr 28.

14.

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans.

Castillo SD, Tzouanacou E, Zaw-Thin M, Berenjeno IM, Parker VE, Chivite I, Milà-Guasch M, Pearce W, Solomon I, Angulo-Urarte A, Figueiredo AM, Dewhurst RE, Knox RG, Clark GR, Scudamore CL, Badar A, Kalber TL, Foster J, Stuckey DJ, David AL, Phillips WA, Lythgoe MF, Wilson V, Semple RK, Sebire NJ, Kinsler VA, Graupera M, Vanhaesebroeck B.

Sci Transl Med. 2016 Mar 30;8(332):332ra43. doi: 10.1126/scitranslmed.aad9982.

15.

Class I PI-3-Kinase Signaling Is Critical for Bone Formation Through Regulation of SMAD1 Activity in Osteoblasts.

Gámez B, Rodríguez-Carballo E, Graupera M, Rosa JL, Ventura F.

J Bone Miner Res. 2016 Aug;31(8):1617-30. doi: 10.1002/jbmr.2819. Epub 2016 Mar 15.

16.

Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease.

Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R.

Gastroenterology. 2016 Apr;150(4):982-97.e30. doi: 10.1053/j.gastro.2015.11.038. Epub 2015 Nov 26.

PMID:
26627607
17.

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M.

Nat Commun. 2015 Jul 31;6:7935. doi: 10.1038/ncomms8935.

18.

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.

Guillermet-Guibert J, Smith LB, Halet G, Whitehead MA, Pearce W, Rebourcet D, León K, Crépieux P, Nock G, Strömstedt M, Enerback M, Chelala C, Graupera M, Carroll J, Cosulich S, Saunders PT, Huhtaniemi I, Vanhaesebroeck B.

PLoS Genet. 2015 Jul 1;11(7):e1005304. doi: 10.1371/journal.pgen.1005304. eCollection 2015 Jul.

19.

PI3K at the crossroads of tumor angiogenesis signaling pathways.

Soler A, Angulo-Urarte A, Graupera M.

Mol Cell Oncol. 2015 Feb 26;2(2):e975624. doi: 10.4161/23723556.2014.975624. eCollection 2015 Apr-Jun. Review.

20.

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.

Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Laviña B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T.

Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00172-2. doi: 10.1016/j.celrep.2015.02.026. [Epub ahead of print]

21.

The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors.

Juliachs M, Muñoz C, Moutinho CA, Vidal A, Condom E, Esteller M, Graupera M, Casanovas O, Germà JR, Villanueva A, Viñals F.

Clin Cancer Res. 2014 Feb 1;20(3):658-67. doi: 10.1158/1078-0432.CCR-13-1131. Epub 2013 Nov 25.

22.

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.

Soler A, Serra H, Pearce W, Angulo A, Guillermet-Guibert J, Friedman LS, Viñals F, Gerhardt H, Casanovas O, Graupera M, Vanhaesebroeck B.

J Exp Med. 2013 Sep 23;210(10):1937-45. doi: 10.1084/jem.20121571. Epub 2013 Sep 16.

23.

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors.

Juliachs M, Vidal A, Del Muro XG, Piulats JM, Condom E, Casanovas O, Graupera M, Germà JR, Villanueva A, Viñals F.

BMC Cancer. 2013 Aug 10;13:382. doi: 10.1186/1471-2407-13-382.

24.

Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells.

Vives M, Ginestà MM, Gracova K, Graupera M, Casanovas O, Capellà G, Serrano T, Laquente B, Viñals F.

Int J Cancer. 2013 Nov 15;133(10):2464-72. doi: 10.1002/ijc.28259. Epub 2013 Jun 4.

25.

Regulation of angiogenesis by PI3K signaling networks.

Graupera M, Potente M.

Exp Cell Res. 2013 May 15;319(9):1348-55. doi: 10.1016/j.yexcr.2013.02.021. Epub 2013 Mar 13. Review.

PMID:
23500680
26.

ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.

Juliachs M, Castillo-Ávila W, Vidal A, Piulats JM, Garcia Del Muro X, Condom E, Hernández-Losa J, Teixidó C, Pandiella A, Graupera M, Casanovas O, Germà JR, Villanueva A, Viñals F.

Int J Cancer. 2013 Jul;133(1):235-46. doi: 10.1002/ijc.28009. Epub 2013 Feb 12.

27.

Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function.

Fernández-Martín L, Marcos-Ramiro B, Bigarella CL, Graupera M, Cain RJ, Reglero-Real N, Jiménez A, Cernuda-Morollón E, Correas I, Cox S, Ridley AJ, Millán J.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):e90-102. doi: 10.1161/ATVBAHA.112.252080. Epub 2012 Jun 21.

28.

Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis.

Stenzel D, Lundkvist A, Sauvaget D, Busse M, Graupera M, van der Flier A, Wijelath ES, Murray J, Sobel M, Costell M, Takahashi S, Fässler R, Yamaguchi Y, Gutmann DH, Hynes RO, Gerhardt H.

Development. 2011 Oct;138(20):4451-63. doi: 10.1242/dev.071381. Epub 2011 Aug 31.

29.

The emerging mechanisms of isoform-specific PI3K signalling.

Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B.

Nat Rev Mol Cell Biol. 2010 May;11(5):329-41. doi: 10.1038/nrm2882. Epub 2010 Apr 9. Review.

PMID:
20379207
30.

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B.

Nature. 2008 May 29;453(7195):662-6. doi: 10.1038/nature06892. Epub 2008 Apr 30.

PMID:
18449193
31.

Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis.

Rodríguez-Vilarrupla A, Graupera M, Matei V, Bataller R, Abraldes JG, Bosch J, García-Pagán JC.

Liver Int. 2008 Apr;28(4):566-73. doi: 10.1111/j.1478-3231.2008.01668.x.

PMID:
18339082
32.

Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats.

Abraldes JG, Rodríguez-Vilarrupla A, Graupera M, Zafra C, García-Calderó H, García-Pagán JC, Bosch J.

J Hepatol. 2007 Jun;46(6):1040-6. Epub 2007 Feb 15.

PMID:
17335931
33.

Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule.

March S, Graupera M, Rosa Sarrias M, Lozano F, Pizcueta P, Bosch J, Engel P.

Am J Pathol. 2007 Jan;170(1):176-87.

34.

Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry.

Cutillas PR, Khwaja A, Graupera M, Pearce W, Gharbi S, Waterfield M, Vanhaesebroeck B.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8959-64. Epub 2006 Jun 2.

35.

Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers.

Graupera M, March S, Engel P, Rodés J, Bosch J, García-Pagán JC.

Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G763-70. Epub 2004 Nov 18.

36.

Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers.

Graupera M, García-Pagán JC, Parés M, Abraldes JG, Roselló J, Bosch J, Rodés J.

J Hepatol. 2003 Oct;39(4):515-21.

PMID:
12971960
37.

Left ventricular hypertrophy in rats with biliary cirrhosis.

Inserte J, Perelló A, Agulló L, Ruiz-Meana M, Schlüter KD, Escalona N, Graupera M, Bosch J, Garcia-Dorado D.

Hepatology. 2003 Sep;38(3):589-98.

PMID:
12939585
38.

Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers.

Graupera M, García-Pagán JC, Abraldes JG, Peralta C, Bragulat M, Corominola H, Bosch J, Rodés J.

Hepatology. 2003 Jan;37(1):172-81.

PMID:
12500202
39.

Acute propranolol administration effectively decreases portal pressure in patients with TIPS dysfunction. Transjugular intrahepatic portosystemic shunt.

Bellis L, Moitinho E, Abraldes JG, Graupera M, García-Pagán JC, Rodés J, Bosch J.

Gut. 2003 Jan;52(1):130-3.

40.

5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes.

Graupera M, García-Pagán JC, Titos E, Claria J, Massaguer A, Bosch J, Rodés J.

Gastroenterology. 2002 Feb;122(2):387-93.

PMID:
11832453
41.

The Cuban National Cancer Registry: 1986-1990.

Martín AA, Galán YH, Rodríguez AJ, Graupera M, Lorenzo-Luaces P, Fernández LM, Camacho R, Lezcano M.

Eur J Epidemiol. 1998 Apr;14(3):287-97.

PMID:
9663522

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