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Items: 29

1.

Outcomes of controlled human malaria infection after BCG vaccination.

Walk J, de Bree LCJ, Graumans W, Stoter R, van Gemert GJ, van de Vegte-Bolmer M, Teelen K, Hermsen CC, Arts RJW, Behet MC, Keramati F, Moorlag SJCFM, Yang ASP, van Crevel R, Aaby P, de Mast Q, van der Ven AJAM, Stabell Benn C, Netea MG, Sauerwein RW.

Nat Commun. 2019 Feb 20;10(1):874. doi: 10.1038/s41467-019-08659-3.

2.

Plasmodium falciparum Gametocyte Enrichment in Peripheral Blood Samples by Magnetic Fractionation: Gametocyte Yields and Possibilities to Reuse Columns.

Graumans W, Andolina C, Awandu SS, Grignard L, Lanke K, Bousema T.

Am J Trop Med Hyg. 2019 Mar;100(3):572-577. doi: 10.4269/ajtmh.18-0773.

3.

Controlled Human Malaria Infection with Graded Numbers of Plasmodium falciparum NF135.C10- or NF166.C8-Infected Mosquitoes.

Langenberg MCC, Wammes LJ, McCall MBB, Bijker EM, van Gemert GJ, Graumans W, van de Vegte-Bolmer MG, Teelen K, Hermsen CC, Koelewijn R, van Hellemond JJ, van Genderen PJJ, Sauerwein RW.

Am J Trop Med Hyg. 2018 Sep;99(3):709-712. doi: 10.4269/ajtmh.18-0194. Epub 2018 Jul 12.

4.

Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density.

Bradley J, Stone W, Da DF, Morlais I, Dicko A, Cohuet A, Guelbeogo WM, Mahamar A, Nsango S, Soumaré HM, Diawara H, Lanke K, Graumans W, Siebelink-Stoter R, van de Vegte-Bolmer M, Chen I, Tiono A, Gonçalves BP, Gosling R, Sauerwein RW, Drakeley C, Churcher TS, Bousema T.

Elife. 2018 May 31;7. pii: e34463. doi: 10.7554/eLife.34463.

5.

The Complement System Contributes to Functional Antibody-Mediated Responses Induced by Immunization with Plasmodium falciparum Malaria Sporozoites.

Behet MC, Kurtovic L, van Gemert GJ, Haukes CM, Siebelink-Stoter R, Graumans W, van de Vegte-Bolmer MG, Scholzen A, Langereis JD, Diavatopoulos DA, Beeson JG, Sauerwein RW.

Infect Immun. 2018 Jun 21;86(7). pii: e00920-17. doi: 10.1128/IAI.00920-17. Print 2018 Jul.

6.

Mosquito Infectivity and Parasitemia after Controlled Human Malaria Infection.

Walk J, van Gemert GJ, Graumans W, Sauerwein RW, Bijker EM.

Am J Trop Med Hyg. 2018 Jun;98(6):1705-1708. doi: 10.4269/ajtmh.17-0952. Epub 2018 Apr 26.

7.

Publisher Correction: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity.

Stone WJR, Campo JJ, Ouédraogo AL, Meerstein-Kessel L, Morlais I, Da D, Cohuet A, Nsango S, Sutherland CJ, van de Vegte-Bolmer M, Siebelink-Stoter R, van Gemert GJ, Graumans W, Lanke K, Shandling AD, Pablo JV, Teng AA, Jones S, de Jong RM, Fabra-García A, Bradley J, Roeffen W, Lasonder E, Gremo G, Schwarzer E, Janse CJ, Singh SK, Theisen M, Felgner P, Marti M, Drakeley C, Sauerwein R, Bousema T, Jore MM.

Nat Commun. 2018 Apr 11;9(1):1498. doi: 10.1038/s41467-018-03769-w.

8.

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model.

Reuling IJ, van de Schans LA, Coffeng LE, Lanke K, Meerstein-Kessel L, Graumans W, van Gemert GJ, Teelen K, Siebelink-Stoter R, van de Vegte-Bolmer M, de Mast Q, van der Ven AJ, Ivinson K, Hermsen CC, de Vlas S, Bradley J, Collins KA, Ockenhouse CF, McCarthy J, Sauerwein RW, Bousema T.

Elife. 2018 Feb 27;7. pii: e31549. doi: 10.7554/eLife.31549.

9.

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity.

Stone WJR, Campo JJ, Ouédraogo AL, Meerstein-Kessel L, Morlais I, Da D, Cohuet A, Nsango S, Sutherland CJ, van de Vegte-Bolmer M, Siebelink-Stoter R, van Gemert GJ, Graumans W, Lanke K, Shandling AD, Pablo JV, Teng AA, Jones S, de Jong RM, Fabra-García A, Bradley J, Roeffen W, Lasonder E, Gremo G, Schwarzer E, Janse CJ, Singh SK, Theisen M, Felgner P, Marti M, Drakeley C, Sauerwein R, Bousema T, Jore MM.

Nat Commun. 2018 Feb 8;9(1):558. doi: 10.1038/s41467-017-02646-2. Erratum in: Nat Commun. 2018 Apr 11;9(1):1498.

10.

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites.

Meerstein-Kessel L, van der Lee R, Stone W, Lanke K, Baker DA, Alano P, Silvestrini F, Janse CJ, Khan SM, van de Vegte-Bolmer M, Graumans W, Siebelink-Stoter R, Kooij TWA, Marti M, Drakeley C, Campo JJ, van Dam TJP, Sauerwein R, Bousema T, Huynen MA.

Sci Rep. 2018 Jan 11;8(1):410. doi: 10.1038/s41598-017-18840-7.

11.

The Relative Contribution of Symptomatic and Asymptomatic Plasmodium vivax and Plasmodium falciparum Infections to the Infectious Reservoir in a Low-Endemic Setting in Ethiopia.

Tadesse FG, Slater HC, Chali W, Teelen K, Lanke K, Belachew M, Menberu T, Shumie G, Shitaye G, Okell LC, Graumans W, van Gemert GJ, Kedir S, Tesfaye A, Belachew F, Abebe W, Mamo H, Sauerwein R, Balcha T, Aseffa A, Yewhalaw D, Gadisa E, Drakeley C, Bousema T.

Clin Infect Dis. 2018 Jun 1;66(12):1883-1891. doi: 10.1093/cid/cix1123.

12.

Comparative assessment of An. gambiae and An. stephensi mosquitoes to determine transmission-reducing activity of antibodies against P. falciparum sexual stage antigens.

Eldering M, Bompard A, Miura K, Stone W, Morlais I, Cohuet A, van Gemert GJ, Brock PM, Rijpma SR, van de Vegte-Bolmer M, Graumans W, Siebelink-Stoter R, Da DF, Long CA, Morin MJ, Sauerwein RW, Churcher TS, Bousema T.

Parasit Vectors. 2017 Oct 17;10(1):489. doi: 10.1186/s13071-017-2414-z.

13.

A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance.

Stone W, Sawa P, Lanke K, Rijpma S, Oriango R, Nyaurah M, Osodo P, Osoti V, Mahamar A, Diawara H, Woestenenk R, Graumans W, van de Vegte-Bolmer M, Bradley J, Chen I, Brown J, Siciliano G, Alano P, Gosling R, Dicko A, Drakeley C, Bousema T.

J Infect Dis. 2017 Aug 15;216(4):457-467. doi: 10.1093/infdis/jix237.

14.

Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial.

Walk J, Reuling IJ, Behet MC, Meerstein-Kessel L, Graumans W, van Gemert GJ, Siebelink-Stoter R, van de Vegte-Bolmer M, Janssen T, Teelen K, de Wilt JHW, de Mast Q, van der Ven AJ, Diez Benavente E, Campino S, Clark TG, Huynen MA, Hermsen CC, Bijker EM, Scholzen A, Sauerwein RW.

BMC Med. 2017 Sep 13;15(1):168. doi: 10.1186/s12916-017-0923-4.

15.

Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR.

Graumans W, Tadesse FG, Andolina C, van Gemert GJ, Teelen K, Lanke K, Gadisa E, Yewhalaw D, van de Vegte-Bolmer M, Siebelink-Stoter R, Reuling I, Sauerwein R, Bousema T.

Malar J. 2017 Sep 6;16(1):356. doi: 10.1186/s12936-017-2011-9.

16.

Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays.

Reuling IJ, Stone WJR, van de Vegte-Bolmer M, van Gemert GJ, Siebelink-Stoter R, Graumans W, Lanke K, Bousema T, Sauerwein RW.

Malar J. 2017 Aug 5;16(1):315. doi: 10.1186/s12936-017-1959-9.

17.

Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers.

McCall MBB, Wammes LJ, Langenberg MCC, van Gemert GJ, Walk J, Hermsen CC, Graumans W, Koelewijn R, Franetich JF, Chishimba S, Gerdsen M, Lorthiois A, van de Vegte M, Mazier D, Bijker EM, van Hellemond JJ, van Genderen PJJ, Sauerwein RW.

Sci Transl Med. 2017 Jun 21;9(395). pii: eaag2490. doi: 10.1126/scitranslmed.aag2490.

PMID:
28637923
18.

Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development.

Rijpma SR, van der Velden M, Annoura T, Matz JM, Kenthirapalan S, Kooij TW, Matuschewski K, van Gemert GJ, van de Vegte-Bolmer M, Siebelink-Stoter R, Graumans W, Ramesar J, Klop O, Russel FG, Sauerwein RW, Janse CJ, Franke-Fayard BM, Koenderink JB.

Mol Microbiol. 2016 Jul;101(1):78-91. doi: 10.1111/mmi.13373. Epub 2016 May 23.

19.

Variation in susceptibility of African Plasmodium falciparum malaria parasites to TEP1 mediated killing in Anopheles gambiae mosquitoes.

Eldering M, Morlais I, van Gemert GJ, van de Vegte-Bolmer M, Graumans W, Siebelink-Stoter R, Vos M, Abate L, Roeffen W, Bousema T, Levashina EA, Sauerwein RW.

Sci Rep. 2016 Feb 10;6:20440. doi: 10.1038/srep20440.

20.

Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers Under Chloroquine Prophylaxis: A Randomized Controlled Trial.

Bastiaens GJH, van Meer MPA, Scholzen A, Obiero JM, Vatanshenassan M, van Grinsven T, Sim BKL, Billingsley PF, James ER, Gunasekera A, Bijker EM, van Gemert GJ, van de Vegte-Bolmer M, Graumans W, Hermsen CC, de Mast Q, van der Ven AJAM, Hoffman SL, Sauerwein RW.

Am J Trop Med Hyg. 2016 Mar;94(3):663-673. doi: 10.4269/ajtmh.15-0621. Epub 2015 Dec 28.

21.

Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites.

Schats R, Bijker EM, van Gemert GJ, Graumans W, van de Vegte-Bolmer M, van Lieshout L, Haks MC, Hermsen CC, Scholzen A, Visser LG, Sauerwein RW.

PLoS One. 2015 May 1;10(5):e0124243. doi: 10.1371/journal.pone.0124243. eCollection 2015.

22.

Novel pantothenate derivatives for anti-malarial chemotherapy.

Pett HE, Jansen PA, Hermkens PH, Botman PN, Beuckens-Schortinghuis CA, Blaauw RH, Graumans W, van de Vegte-Bolmer M, Koolen KM, Rutjes FP, Dechering KJ, Sauerwein RW, Schalkwijk J.

Malar J. 2015 Apr 18;14:169. doi: 10.1186/s12936-015-0673-8.

23.

Sporozoite immunization of human volunteers under mefloquine prophylaxis is safe, immunogenic and protective: a double-blind randomized controlled clinical trial.

Bijker EM, Schats R, Obiero JM, Behet MC, van Gemert GJ, van de Vegte-Bolmer M, Graumans W, van Lieshout L, Bastiaens GJ, Teelen K, Hermsen CC, Scholzen A, Visser LG, Sauerwein RW.

PLoS One. 2014 Nov 14;9(11):e112910. doi: 10.1371/journal.pone.0112910. eCollection 2014.

24.

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.

Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, van de Vegte-Bolmer M, van Gemert GJ, Wirjanata G, Sebayang B, Marfurt J, Russell B, Suwanarusk R, Price RN, Nosten F, Tungtaeng A, Gettayacamin M, Sattabongkot J, Taylor J, Walker JR, Tully D, Patra KP, Flannery EL, Vinetz JM, Renia L, Sauerwein RW, Winzeler EA, Glynne RJ, Diagana TT.

Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7. doi: 10.1128/AAC.02727-13. Epub 2014 Jun 9.

25.

A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase.

Stone WJ, Churcher TS, Graumans W, van Gemert GJ, Vos MW, Lanke KH, van de Vegte-Bolmer MG, Siebelink-Stoter R, Dechering KJ, Vaughan AM, Camargo N, Kappe SH, Sauerwein RW, Bousema T.

J Infect Dis. 2014 Nov 1;210(9):1456-63. doi: 10.1093/infdis/jiu271. Epub 2014 May 14.

PMID:
24829466
26.

The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays.

Stone WJ, Eldering M, van Gemert GJ, Lanke KH, Grignard L, van de Vegte-Bolmer MG, Siebelink-Stoter R, Graumans W, Roeffen WF, Drakeley CJ, Sauerwein RW, Bousema T.

Sci Rep. 2013 Dec 4;3:3418. doi: 10.1038/srep03418.

27.

Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.

Bijker EM, Bastiaens GJ, Teirlinck AC, van Gemert GJ, Graumans W, van de Vegte-Bolmer M, Siebelink-Stoter R, Arens T, Teelen K, Nahrendorf W, Remarque EJ, Roeffen W, Jansens A, Zimmerman D, Vos M, van Schaijk BC, Wiersma J, van der Ven AJ, de Mast Q, van Lieshout L, Verweij JJ, Hermsen CC, Scholzen A, Sauerwein RW.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7862-7. doi: 10.1073/pnas.1220360110. Epub 2013 Apr 18.

28.

NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections.

Teirlinck AC, Roestenberg M, van de Vegte-Bolmer M, Scholzen A, Heinrichs MJ, Siebelink-Stoter R, Graumans W, van Gemert GJ, Teelen K, Vos MW, Nganou-Makamdop K, Borrmann S, Rozier YP, Erkens MA, Luty AJ, Hermsen CC, Sim BK, van Lieshout L, Hoffman SL, Visser LG, Sauerwein RW.

J Infect Dis. 2013 Feb 15;207(4):656-60. doi: 10.1093/infdis/jis725. Epub 2012 Nov 27.

29.

The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector.

van Pelt-Koops JC, Pett HE, Graumans W, van der Vegte-Bolmer M, van Gemert GJ, Rottmann M, Yeung BK, Diagana TT, Sauerwein RW.

Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8. doi: 10.1128/AAC.06377-11. Epub 2012 Apr 16.

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