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Items: 1 to 50 of 60

1.

Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function.

Deutschmeyer V, Breuer J, Walesch SK, Sokol AM, Graumann J, Bartkuhn M, Boettger T, Rossbach O, Richter AM.

Clin Epigenetics. 2019 Dec 4;11(1):182. doi: 10.1186/s13148-019-0774-2.

2.

A PhotoClick cholesterol-based quantitative proteomics screen for cytoplasmic sterol binding proteins in Saccharomyces cerevisiae.

Chauhan N, Sere YY, Sokol AM, Graumann J, Menon AK.

Yeast. 2019 Nov 22. doi: 10.1002/yea.3448. [Epub ahead of print]

PMID:
31758572
3.

Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma.

Graumann J, Finkernagel F, Reinartz S, Stief T, Brödje D, Renz H, Jansen JM, Wagner U, Worzfeld T, Pogge von Strandmann E, Müller R.

Front Oncol. 2019 Nov 1;9:1150. doi: 10.3389/fonc.2019.01150. eCollection 2019.

4.

Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.

Finkernagel F, Reinartz S, Schuldner M, Malz A, Jansen JM, Wagner U, Worzfeld T, Graumann J, von Strandmann EP, Müller R.

Theranostics. 2019 Aug 22;9(22):6601-6617. doi: 10.7150/thno.37549. eCollection 2019.

5.

Cardiolipin depletion-induced changes in the Trypanosoma brucei proteome.

Schädeli D, Serricchio M, Ben Hamidane H, Loffreda A, Hemphill A, Beneke T, Gluenz E, Graumann J, Bütikofer P.

FASEB J. 2019 Dec;33(12):13161-13175. doi: 10.1096/fj.201901184RR. Epub 2019 Sep 19.

PMID:
31536395
6.

Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis.

Fukuda R, Gunawan F, Ramadass R, Beisaw A, Konzer A, Mullapudi ST, Gentile A, Maischein HM, Graumann J, Stainier DYR.

Dev Cell. 2019 Oct 7;51(1):62-77.e5. doi: 10.1016/j.devcel.2019.08.006. Epub 2019 Sep 5.

PMID:
31495694
7.

Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis.

Kesireddy VS, Chillappagari S, Ahuja S, Knudsen L, Henneke I, Graumann J, Meiners S, Ochs M, Ruppert C, Korfei M, Seeger W, Mahavadi P.

FASEB J. 2019 Nov;33(11):12392-12408. doi: 10.1096/fj.201900854R. Epub 2019 Aug 20.

PMID:
31431059
8.

A Systems-level Characterization of the Differentiation of Human Embryonic Stem Cells into Mesenchymal Stem Cells.

Billing AM, Dib SS, Bhagwat AM, da Silva IT, Drummond RD, Hayat S, Al-Mismar R, Ben-Hamidane H, Goswami N, Engholm-Keller K, Larsen MR, Suhre K, Rafii A, Graumann J.

Mol Cell Proteomics. 2019 Oct;18(10):1950-1966. doi: 10.1074/mcp.RA119.001356. Epub 2019 Jul 22.

PMID:
31332097
9.

Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome.

Suhre K, Trbojević-Akmačić I, Ugrina I, Mook-Kanamori DO, Spector T, Graumann J, Lauc G, Falchi M.

Metabolites. 2019 Jun 26;9(7). pii: E122. doi: 10.3390/metabo9070122.

10.

Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.

Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S.

J Clin Invest. 2019 Jun 17;129(7):2775-2791. doi: 10.1172/JCI123825. eCollection 2019 Jun 17.

11.

Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure.

Adams V, Bowen TS, Werner S, Barthel P, Amberger C, Konzer A, Graumann J, Sehr P, Lewis J, Provaznik J, Benes V, Büttner P, Gasch A, Mangner N, Witt CC, Labeit D, Linke A, Labeit S.

J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):1102-1115. doi: 10.1002/jcsm.12448. Epub 2019 May 29.

12.

MARMoSET - Extracting Publication-ready Mass Spectrometry Metadata from RAW Files.

Kiweler M, Looso M, Graumann J.

Mol Cell Proteomics. 2019 Aug;18(8):1700-1702. doi: 10.1074/mcp.TIR119.001505. Epub 2019 May 16.

13.

Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis.

Yu F, Hubrack SZ, Chakraborty S, Sun L, Alcantara-Adap E, Kulkarni R, Billing AM, Graumann J, Taylor CW, Machaca K.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10392-10401. doi: 10.1073/pnas.1821399116. Epub 2019 May 7.

14.

Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.

Sokol AM, Uszczynska-Ratajczak B, Collins MM, Bazala M, Topf U, Lundegaard PR, Sugunan S, Guenther S, Kuenne C, Graumann J, Chan SSL, Stainier DYR, Chacinska A.

PLoS Genet. 2019 Jan 31;15(1):e1007972. doi: 10.1371/journal.pgen.1007972. eCollection 2019 Jan.

15.

Characterization of mast cell-derived rRNA-containing microvesicles and their inflammatory impact on endothelial cells.

Elsemüller AK, Tomalla V, Gärtner U, Troidl K, Jeratsch S, Graumann J, Baal N, Hackstein H, Lasch M, Deindl E, Preissner KT, Fischer S.

FASEB J. 2019 Apr;33(4):5457-5467. doi: 10.1096/fj.201801853RR. Epub 2019 Jan 31.

PMID:
30702929
16.

Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes.

Halama A, Kahal H, Bhagwat AM, Zierer J, Sathyapalan T, Graumann J, Suhre K, Atkin SL.

Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111/dom.13602. [Epub ahead of print]

PMID:
30525282
17.

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists.

Mullapudi ST, Helker CS, Boezio GL, Maischein HM, Sokol AM, Guenther S, Matsuda H, Kubicek S, Graumann J, Yang YHC, Stainier DY.

Elife. 2018 Dec 6;7. pii: e42209. doi: 10.7554/eLife.42209.

18.

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.

Sokol AM, Uszczynska-Ratajczak B, Collins MM, Bazala M, Topf U, Lundegaard PR, Sugunan S, Guenther S, Kuenne C, Graumann J, Chan SSL, Stainier DYR, Chacinska A.

PLoS Genet. 2018 Nov 20;14(11):e1007743. doi: 10.1371/journal.pgen.1007743. eCollection 2018 Nov. Erratum in: PLoS Genet. 2019 Jan 31;15(1):e1007972.

19.

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR.

Nat Commun. 2018 Nov 2;9(1):4600. doi: 10.1038/s41467-018-06833-7.

20.

Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.

Reinartz S, Lieber S, Pesek J, Brandt DT, Asafova A, Finkernagel F, Watzer B, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Konzer A, Graumann J, Grosse R, Worzfeld T, Müller-Brüsselbach S, Müller R.

Mol Oncol. 2019 Feb;13(2):185-201. doi: 10.1002/1878-0261.12396. Epub 2018 Nov 15.

21.

The CCT chaperonin is a novel regulator of Ca2+ signaling through modulation of Orai1 trafficking.

Hodeify R, Nandakumar M, Own M, Courjaret RJ, Graumann J, Hubrack SZ, Machaca K.

Sci Adv. 2018 Sep 26;4(9):eaau1935. doi: 10.1126/sciadv.aau1935. eCollection 2018 Sep.

22.

Author Correction: Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

Yao C, Chen G, Song C, Keefe J, Mendelson M, Huan T, Sun BB, Laser A, Maranville JC, Wu H, Ho JE, Courchesne P, Lyass A, Larson MG, Gieger C, Graumann J, Johnson AD, Danesh J, Runz H, Hwang SJ, Liu C, Butterworth AS, Suhre K, Levy D.

Nat Commun. 2018 Sep 18;9(1):3853. doi: 10.1038/s41467-018-06231-z.

23.

Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

Yao C, Chen G, Song C, Keefe J, Mendelson M, Huan T, Sun BB, Laser A, Maranville JC, Wu H, Ho JE, Courchesne P, Lyass A, Larson MG, Gieger C, Graumann J, Johnson AD, Danesh J, Runz H, Hwang SJ, Liu C, Butterworth AS, Suhre K, Levy D.

Nat Commun. 2018 Aug 15;9(1):3268. doi: 10.1038/s41467-018-05512-x. Erratum in: Nat Commun. 2018 Sep 18;9(1):3853.

24.

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization.

Singh I, Contreras A, Cordero J, Rubio K, Dobersch S, Günther S, Jeratsch S, Mehta A, Krüger M, Graumann J, Seeger W, Dobreva G, Braun T, Barreto G.

Nat Genet. 2018 Jul;50(7):990-1001. doi: 10.1038/s41588-018-0139-3. Epub 2018 Jun 4.

PMID:
29867223
25.

The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling.

Nader N, Dib M, Courjaret R, Hodeify R, Machaca R, Graumann J, Machaca K.

J Cell Sci. 2018 May 23;131(10). pii: jcs212522. doi: 10.1242/jcs.212522.

26.

Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates.

Choi S, Bhagwat AM, Al Mismar R, Goswami N, Ben Hamidane H, Sun L, Graumann J.

Sci Rep. 2018 Apr 11;8(1):5858. doi: 10.1038/s41598-018-24256-8.

27.

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.

Zaghlool SB, Mook-Kanamori DO, Kader S, Stephan N, Halama A, Engelke R, Sarwath H, Al-Dous EK, Mohamoud YA, Roemisch-Margl W, Adamski J, Kastenmüller G, Friedrich N, Visconti A, Tsai PC, Spector T, Bell JT, Falchi M, Wahl A, Waldenberger M, Peters A, Gieger C, Pezer M, Lauc G, Graumann J, Malek JA, Suhre K.

Hum Mol Genet. 2018 Mar 15;27(6):1106-1121. doi: 10.1093/hmg/ddy006.

28.

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment.

Worzfeld T, Finkernagel F, Reinartz S, Konzer A, Adhikary T, Nist A, Stiewe T, Wagner U, Looso M, Graumann J, Müller R.

Mol Cell Proteomics. 2018 Feb;17(2):270-289. doi: 10.1074/mcp.RA117.000400. Epub 2017 Nov 15.

29.

Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E.

Guo M, Zhang T, Dong X, Xiang JZ, Lei M, Evans T, Graumann J, Chen S.

Cell Rep. 2017 May 23;19(8):1512-1521. doi: 10.1016/j.celrep.2017.04.070.

30.

Erratum: Connecting genetic risk to disease end points through the human blood plasma proteome.

Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J, Sarwath H, Thareja G, Wahl A, DeLisle RK, Gold L, Pezer M, Lauc G, El-Din Selim MA, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J.

Nat Commun. 2017 Apr 11;8:15345. doi: 10.1038/ncomms15345. No abstract available.

31.

flippant-An R package for the automated analysis of fluorescence-based scramblase assays.

Cotton RJ, Ploier B, Goren MA, Menon AK, Graumann J.

BMC Bioinformatics. 2017 Mar 3;18(1):146. doi: 10.1186/s12859-017-1542-y.

32.

Connecting genetic risk to disease end points through the human blood plasma proteome.

Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J, Sarwath H, Thareja G, Wahl A, DeLisle RK, Gold L, Pezer M, Lauc G, El-Din Selim MA, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J.

Nat Commun. 2017 Feb 27;8:14357. doi: 10.1038/ncomms14357.

33.

Complementarity of SOMAscan to LC-MS/MS and RNA-seq for quantitative profiling of human embryonic and mesenchymal stem cells.

Billing AM, Ben Hamidane H, Bhagwat AM, Cotton RJ, Dib SS, Kumar P, Hayat S, Goswami N, Suhre K, Rafii A, Graumann J.

J Proteomics. 2017 Jan 6;150:86-97. doi: 10.1016/j.jprot.2016.08.023. Epub 2016 Sep 6.

34.

The arc of Mass Spectrometry Exchange Formats is long, but it bends toward HDF5.

Askenazi M, Ben Hamidane H, Graumann J.

Mass Spectrom Rev. 2017 Sep;36(5):668-673. doi: 10.1002/mas.21522. Epub 2016 Oct 14. Review.

35.

Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.

Ploier B, Caro LN, Morizumi T, Pandey K, Pearring JN, Goren MA, Finnemann SC, Graumann J, Arshavsky VY, Dittman JS, Ernst OP, Menon AK.

Nat Commun. 2016 Oct 3;7:12832. doi: 10.1038/ncomms12832.

36.

An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.

Zeng H, Guo M, Zhou T, Tan L, Chong CN, Zhang T, Dong X, Xiang JZ, Yu AS, Yue L, Qi Q, Evans T, Graumann J, Chen S.

Cell Stem Cell. 2016 Sep 1;19(3):326-40. doi: 10.1016/j.stem.2016.07.002. Epub 2016 Aug 11.

37.

MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.

Graham B, Marcais A, Dharmalingam G, Carroll T, Kanellopoulou C, Graumann J, Nesterova TB, Bermange A, Brazauskas P, Xella B, Kriaucionis S, Higgs DR, Brockdorff N, Mann M, Fisher AG, Merkenschlager M.

Stem Cell Reports. 2016 May 10;6(5):635-642. doi: 10.1016/j.stemcr.2016.03.005. Epub 2016 Apr 14.

38.

readat: An R package for reading and working with SomaLogic ADAT files.

Cotton RJ, Graumann J.

BMC Bioinformatics. 2016 May 4;17(1):201. doi: 10.1186/s12859-016-1007-8.

39.

Comprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers.

Billing AM, Ben Hamidane H, Dib SS, Cotton RJ, Bhagwat AM, Kumar P, Hayat S, Yousri NA, Goswami N, Suhre K, Rafii A, Graumann J.

Sci Rep. 2016 Feb 9;6:21507. doi: 10.1038/srep21507.

40.

SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition.

Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing AM, Pasquier J, Bonkowski MS, Halabi N, Dalloul R, Sheriff MZ, Mesaeli N, ElRayess M, Sinclair DA, Graumann J, Mazloum NA.

J Biol Chem. 2016 Jan 29;291(5):2119-35. doi: 10.1074/jbc.M115.675645. Epub 2015 Dec 11.

41.

Quantitative proteomic approaches in mouse: stable isotope incorporation by metabolic (SILAC) or chemical labeling (reductive dimethylation) combined with high-resolution mass spectrometry.

Billing AM, Ben Hamidane H, Graumann J.

Curr Protoc Mouse Biol. 2015 Mar 2;5(1):1-20. doi: 10.1002/9780470942390.mo140156.

PMID:
25727197
42.

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells.

Marcais A, Blevins R, Graumann J, Feytout A, Dharmalingam G, Carroll T, Amado IF, Bruno L, Lee K, Walzer T, Mann M, Freitas AA, Boothby M, Fisher AG, Merkenschlager M.

J Exp Med. 2014 Oct 20;211(11):2281-95. doi: 10.1084/jem.20132059. Epub 2014 Oct 13.

43.

Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver.

Blanc V, Park E, Schaefer S, Miller M, Lin Y, Kennedy S, Billing AM, Ben Hamidane H, Graumann J, Mortazavi A, Nadeau JH, Davidson NO.

Genome Biol. 2014 Jun 19;15(6):R79. doi: 10.1186/gb-2014-15-6-r79.

44.

Adaptation of a commonly used, chemically defined medium for human embryonic stem cells to stable isotope labeling with amino acids in cell culture.

Liberski AR, Al-Noubi MN, Rahman ZH, Halabi NM, Dib SS, Al-Mismar R, Billing AM, Krishnankutty R, Ahmad FS, Raynaud CM, Rafii A, Engholm-Keller K, Graumann J.

J Proteome Res. 2013 Jul 5;12(7):3233-45. doi: 10.1021/pr400099j. Epub 2013 Jun 25.

45.

A SILAC-based approach identifies substrates of caspase-dependent cleavage upon TRAIL-induced apoptosis.

Stoehr G, Schaab C, Graumann J, Mann M.

Mol Cell Proteomics. 2013 May;12(5):1436-50. doi: 10.1074/mcp.M112.024679. Epub 2013 Jan 13.

46.

MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation.

O'Loghlen A, Muñoz-Cabello AM, Gaspar-Maia A, Wu HA, Banito A, Kunowska N, Racek T, Pemberton HN, Beolchi P, Lavial F, Masui O, Vermeulen M, Carroll T, Graumann J, Heard E, Dillon N, Azuara V, Snijders AP, Peters G, Bernstein E, Gil J.

Cell Stem Cell. 2012 Jan 6;10(1):33-46. doi: 10.1016/j.stem.2011.12.004.

47.

A framework for intelligent data acquisition and real-time database searching for shotgun proteomics.

Graumann J, Scheltema RA, Zhang Y, Cox J, Mann M.

Mol Cell Proteomics. 2012 Mar;11(3):M111.013185. doi: 10.1074/mcp.M111.013185. Epub 2011 Dec 13.

48.

Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming.

Singhal N, Graumann J, Wu G, Araúzo-Bravo MJ, Han DW, Greber B, Gentile L, Mann M, Schöler HR.

Cell. 2010 Jun 11;141(6):943-55. doi: 10.1016/j.cell.2010.04.037.

49.

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.

Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ.

Cell. 2008 Sep 5;134(5):804-16. doi: 10.1016/j.cell.2008.06.048.

50.

Stable isotope labeling by amino acids in cell culture (SILAC) and proteome quantitation of mouse embryonic stem cells to a depth of 5,111 proteins.

Graumann J, Hubner NC, Kim JB, Ko K, Moser M, Kumar C, Cox J, Schöler H, Mann M.

Mol Cell Proteomics. 2008 Apr;7(4):672-83. Epub 2007 Nov 28.

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