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Inhibition of Interleukin 1β Signaling by Anakinra Ameliorates Proinflammatory Cytokine Responses in Zika Virus-Infected Human Blood-Brain Barrier Endothelial Cells.

Hueston L, Grau GE, Mahalingam S.

J Infect Dis. 2019 Sep 26;220(9):1539-1540. doi: 10.1093/infdis/jiz276. No abstract available.


Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.

Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA, Rosenthal PJ, Grau GER, Hunt NH, Payne RJ.

J Med Chem. 2019 Jun 13;62(11):5562-5578. doi: 10.1021/acs.jmedchem.9b00504. Epub 2019 May 22.


The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity.

Sierro F, Grau GER.

Front Immunol. 2019 Apr 17;10:830. doi: 10.3389/fimmu.2019.00830. eCollection 2019. Review.


Bronchial epithelial cell extracellular vesicles ameliorate epithelial-mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization.

He S, Chen D, Hu M, Zhang L, Liu C, Traini D, Grau GE, Zeng Z, Lu J, Zhou G, Xie L, Sun S.

Nanomedicine. 2019 Jun;18:259-271. doi: 10.1016/j.nano.2019.03.010. Epub 2019 Apr 11.


Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.

Li JJ, Hosseini-Beheshti E, Grau GE, Zreiqat H, Little CB.

Nanomaterials (Basel). 2019 Feb 14;9(2). pii: E261. doi: 10.3390/nano9020261. Review.


Experimental severe malaria is resolved by targeting newly-identified monocyte subsets using immune-modifying particles combined with artesunate.

Niewold P, Cohen A, van Vreden C, Getts DR, Grau GE, King NJC.

Commun Biol. 2018 Dec 13;1:227. doi: 10.1038/s42003-018-0216-2. eCollection 2018.


Interplay of extracellular vesicles and other players in cerebral malaria pathogenesis.

Debs S, Cohen A, Hosseini-Beheshti E, Chimini G, Hunt NH, Grau GER.

Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):325-331. doi: 10.1016/j.bbagen.2018.10.012. Epub 2018 Oct 17. Review.


Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-β signalling pathways.

Martin-Alonso A, Cohen A, Quispe-Ricalde MA, Foronda P, Benito A, Berzosa P, Valladares B, Grau GE.

Sci Rep. 2018 Jul 26;8(1):11277. doi: 10.1038/s41598-018-29721-y.


The Early Innate Immune Response to, and Phagocyte-Dependent Entry of, Cryptococcus neoformans Map to the Perivascular Space of Cortical Post-Capillary Venules in Neurocryptococcosis.

Kaufman-Francis K, Djordjevic JT, Juillard PG, Lev S, Desmarini D, Grau GER, Sorrell TC.

Am J Pathol. 2018 Jul;188(7):1653-1665. doi: 10.1016/j.ajpath.2018.03.015. Epub 2018 Jun 19.


Extracellular vesicles and microvascular pathology: Decoding the active dialogue.

Hosseini-Beheshti E, Grau GER.

Microcirculation. 2019 Feb;26(2):e12485. doi: 10.1111/micc.12485. Epub 2018 Jul 23. Review.


Stable thrombus formation on irradiated microvascular endothelial cells under pulsatile flow: Pre-testing annexin V-thrombin conjugate for treatment of brain arteriovenous malformations.

Subramanian S, Ugoya SO, Zhao Z, McRobb LS, Grau GE, Combes V, Inglis DW, Gauden AJ, Lee VS, Moutrie V, Santos ED, Stoodley MA.

Thromb Res. 2018 Jul;167:104-112. doi: 10.1016/j.thromres.2018.05.016. Epub 2018 May 17.


Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria.

Cohen A, Zinger A, Tiberti N, Grau GER, Combes V.

Malar J. 2018 May 11;17(1):192. doi: 10.1186/s12936-018-2330-5.


Extracellular vesicles as mediators of immunopathology in infectious diseases.

Hosseini-Beheshti E, Grau GER.

Immunol Cell Biol. 2018 Mar 25. doi: 10.1111/imcb.12044. [Epub ahead of print]


Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.

Rahbari M, Rahlfs S, Przyborski JM, Schuh AK, Hunt NH, Fidock DA, Grau GE, Becker K.

Sci Rep. 2017 Sep 5;7(1):10449. doi: 10.1038/s41598-017-10093-8.


Dysregulation of pulmonary endothelial protein C receptor and thrombomodulin in severe falciparum malaria-associated ARDS relevant to hemozoin.

Maknitikul S, Luplertlop N, Grau GER, Ampawong S.

PLoS One. 2017 Jul 21;12(7):e0181674. doi: 10.1371/journal.pone.0181674. eCollection 2017.


Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling.

Claser C, De Souza JB, Thorburn SG, Grau GE, Riley EM, Rénia L, Hafalla JCR.

Infect Immun. 2017 May 23;85(6). pii: e00941-16. doi: 10.1128/IAI.00941-16. Print 2017 Jun.


Infrared spectroscopic characterization of monocytic microvesicles (microparticles) released upon lipopolysaccharide stimulation.

Lee J, Wen B, Carter EA, Combes V, Grau GER, Lay PA.

FASEB J. 2017 Jul;31(7):2817-2827. doi: 10.1096/fj.201601272R. Epub 2017 Mar 17.


Divergent roles of β- and γ-actin isoforms during spread of vaccinia virus.

Marzook NB, Latham SL, Lynn H, Mckenzie C, Chaponnier C, Grau GE, Newsome TP.

Cytoskeleton (Hoboken). 2017 Apr;74(4):170-183. doi: 10.1002/cm.21356. Epub 2017 Mar 17.



Combes V, Latham SL, Wen B, Allison AC, Grau GE.

Int J Innov Med Health Sci. 2016;7:1-11.


Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH.

Lev S, Kaufman-Francis K, Desmarini D, Juillard PG, Li C, Stifter SA, Feng CG, Sorrell TC, Grau GE, Bahn YS, Djordjevic JT.

mSphere. 2017 Jan 25;2(1). pii: e00381-16. doi: 10.1128/mSphere.00381-16. eCollection 2017 Jan-Feb.


Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response.

Gramaglia I, Velez J, Combes V, Grau GE, Wree M, van der Heyde HC.

Blood. 2017 Mar 23;129(12):1669-1679. doi: 10.1182/blood-2016-08-733519. Epub 2017 Jan 17.


Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content.

Tiberti N, Latham SL, Bush S, Cohen A, Opoka RO, John CC, Juillard A, Grau GE, Combes V.

Sci Rep. 2016 Dec 5;6:37871. doi: 10.1038/srep37871.


The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells.

Ghadiri M, Young PM, Jarolimek W, Grau GE, Oliver BG, Traini D.

J Drug Target. 2017 Apr;25(4):342-349. doi: 10.1080/1061186X.2016.1258703. Epub 2016 Nov 24.


Expression of VEGF 111 and other VEGF-A variants in the rat uterus is correlated with stage of pregnancy.

Whittington CM, Danastas K, Grau GE, Murphy CR, Thompson MB.

J Comp Physiol B. 2017 Feb;187(2):353-360. doi: 10.1007/s00360-016-1040-y. Epub 2016 Oct 8.


Severe malaria: what's new on the pathogenesis front?

Wassmer SC, Grau GE.

Int J Parasitol. 2017 Feb;47(2-3):145-152. doi: 10.1016/j.ijpara.2016.08.002. Epub 2016 Sep 23. Review.


Effect of polyunsaturated fatty acids (PUFAs) on airway epithelial cells' tight junction.

Ghadiri M, Mamlouk M, Spicer P, Jarolimek W, Grau GE, Young PM, Traini D.

Pulm Pharmacol Ther. 2016 Oct;40:30-8. doi: 10.1016/j.pupt.2016.07.004. Epub 2016 Jul 22. No abstract available.


Platelets as pathogenetic effectors and killer cells in cerebral malaria.

Wassmer SC, Grau GE.

Expert Rev Hematol. 2016 Jun;9(6):515-7. doi: 10.1080/17474086.2016.1179571. Epub 2016 May 3. No abstract available.


Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients.

Zinger A, Latham SL, Combes V, Byrne S, Barnett MH, Hawke S, Grau GE.

Mult Scler. 2016 Dec;22(14):1883-1887. Epub 2016 Mar 1.


The kynurenine pathway and parasitic infections that affect CNS function.

Hunt NH, Too LK, Khaw LT, Guo J, Hee L, Mitchell AJ, Grau GE, Ball HJ.

Neuropharmacology. 2017 Jan;112(Pt B):389-398. doi: 10.1016/j.neuropharm.2016.02.029. Epub 2016 Feb 26. Review.


Author Correction for Hochman et al., Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection.

Hochman SE, Madaline TF, Wassmer SC, Mbale E, Choi N, Seydel KB, Whitten RO, Varughese J, Grau GE, Kamiza S, Molyneux ME, Taylor TE, Lee S, Milner DA Jr, Kim K.

MBio. 2016 Feb 2;7(1):e02068-15. doi: 10.1128/mBio.02068-15. No abstract available.


Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites.

Hackett MJ, Aitken JB, El-Assaad F, McQuillan JA, Carter EA, Ball HJ, Tobin MJ, Paterson D, de Jonge MD, Siegele R, Cohen DD, Vogt S, Grau GE, Hunt NH, Lay PA.

Sci Adv. 2015 Dec 18;1(11):e1500911. doi: 10.1126/sciadv.1500911. eCollection 2015 Dec.


Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells.

Kam A, Li KM, Razmovski-Naumovski V, Nammi S, Chan K, Grau GE, Li GQ.

J Pharm Pharm Sci. 2015;18(4):424-33.


Sexual characteristics of high-temperature sterilized male Mozambique tilapia, Oreochromis mossambicus.

Nakamura M, Nozu R, Ijiri S, Kobayashi T, Hirai T, Yamaguchi Y, Seale A, Lerner DT, Grau GE.

Zoological Lett. 2015 Jul 22;1:21. doi: 10.1186/s40851-015-0021-4. eCollection 2015.


Immuno-analysis of microparticles: probing at the limits of detection.

Latham SL, Tiberti N, Gokoolparsadh N, Holdaway K, Couraud PO, Grau GE, Combes V.

Sci Rep. 2015 Nov 10;5:16314. doi: 10.1038/srep16314.


A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria.

O'Regan N, Gegenbauer K, O'Sullivan JM, Maleki S, Brophy TM, Dalton N, Chion A, Fallon PG, Grau GE, Budde U, Smith OP, Craig AG, Preston RJ, O'Donnell JS.

Blood. 2016 Mar 3;127(9):1192-201. doi: 10.1182/blood-2015-07-654921. Epub 2015 Oct 28.


An updated h-index measures both the primary and total scientific output of a researcher.

Bucur O, Almasan A, Zubarev R, Friedman M, Nicolson GL, Sumazin P, Leabu M, Nikolajczyk BS, Avram D, Kunej T, Calin GA, Godwin AK, Adami HO, Zaphiropoulos PG, Richardson DR, Schmitt-Ulms G, Westerblad H, Keniry M, Grau GE, Carbonetto S, Stan RV, Popa-Wagner A, Takhar K, Baron BW, Galardy PJ, Yang F, Data D, Fadare O, Yeo KJ, Gabreanu GR, Andrei S, Soare GR, Nelson MA, Liehn EA.

Discoveries (Craiova). 2015 Jul-Sep;3(3). pii: e50. Epub 2015 Sep 30.


VEGF: inflammatory paradoxes.

Grau GE, Thompson MB, Murphy CR.

Pathog Glob Health. 2015 Sep;109(6):253-4. doi: 10.1179/2047772415Z.000000000271. No abstract available.


A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury.

Ampawong S, Chaisri U, Viriyavejakul P, Prapansilp P, Grau GE, Turner GD, Pongponratn E.

Malar J. 2015 Oct 5;14:389. doi: 10.1186/s12936-015-0922-x.


Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection.

Hochman SE, Madaline TF, Wassmer SC, Mbale E, Choi N, Seydel KB, Whitten RO, Varughese J, Grau GE, Kamiza S, Molyneux ME, Taylor TE, Lee S, Milner DA Jr, Kim K.

MBio. 2015 Sep 22;6(5):e01390-15. doi: 10.1128/mBio.01390-15. Erratum in: MBio. 2016;7(1):e02068-15.


Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265.

Sorrell TC, Juillard PG, Djordjevic JT, Kaufman-Francis K, Dietmann A, Milonig A, Combes V, Grau GE.

Microbes Infect. 2016 Jan;18(1):57-67. doi: 10.1016/j.micinf.2015.08.017. Epub 2015 Sep 11.


MicroRNAs and Malaria - A Dynamic Interaction Still Incompletely Understood.

Cohen A, Combes V, Grau GE.

J Neuroinfect Dis. 2015 Mar;6(1). pii: 165.


Unusual angiogenic factor plays a role in lizard pregnancy but is not unique to viviparity.

Whittington CM, Grau GE, Murphy CR, Thompson MB.

J Exp Zool B Mol Dev Evol. 2015 Mar;324(2):152-8. doi: 10.1002/jez.b.22615. Epub 2015 Mar 2.


VEGF111: new insights in tissue invasion.

Danastas K, Combes V, Lindsay LA, Grau GE, Thompson MB, Murphy CR.

Front Physiol. 2015 Jan 22;6:2. doi: 10.3389/fphys.2015.00002. eCollection 2015.


Endothelial microparticles interact with and support the proliferation of T cells.

Wheway J, Latham SL, Combes V, Grau GE.

J Immunol. 2014 Oct 1;193(7):3378-87. doi: 10.4049/jimmunol.1303431. Epub 2014 Sep 3.


Cerebral malaria: gamma-interferon redux.

Hunt NH, Ball HJ, Hansen AM, Khaw LT, Guo J, Bakmiwewa S, Mitchell AJ, Combes V, Grau GE.

Front Cell Infect Microbiol. 2014 Aug 15;4:113. doi: 10.3389/fcimb.2014.00113. eCollection 2014. Review.


Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors.

Khaw LT, Ball HJ, Mitchell AJ, Grau GE, Stocker R, Golenser J, Hunt NH.

Exp Parasitol. 2014 Oct;145:34-41. doi: 10.1016/j.exppara.2014.07.002. Epub 2014 Jul 18.


Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis.

Pai S, Qin J, Cavanagh L, Mitchell A, El-Assaad F, Jain R, Combes V, Hunt NH, Grau GE, Weninger W.

PLoS Pathog. 2014 Jul 17;10(7):e1004236. doi: 10.1371/journal.ppat.1004236. eCollection 2014 Jul.


Electron microscopic features of brain edema in rodent cerebral malaria in relation to glial fibrillary acidic protein expression.

Ampawong S, Chaisri U, Viriyavejakul P, Nontprasert A, Grau GE, Pongponratn E.

Int J Clin Exp Pathol. 2014 Apr 15;7(5):2056-67. eCollection 2014.


Production, fate and pathogenicity of plasma microparticles in murine cerebral malaria.

El-Assaad F, Wheway J, Hunt NH, Grau GE, Combes V.

PLoS Pathog. 2014 Mar 20;10(3):e1003839. doi: 10.1371/journal.ppat.1003839. eCollection 2014 Mar. Erratum in: PLoS Pathog. 2014 Apr;10(4):e1004119.


Endotoxin-induced monocytic microparticles have contrasting effects on endothelial inflammatory responses.

Wen B, Combes V, Bonhoure A, Weksler BB, Couraud PO, Grau GE.

PLoS One. 2014 Mar 19;9(3):e91597. doi: 10.1371/journal.pone.0091597. eCollection 2014.

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