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Items: 4


The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.

Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR Jr, Sacchettini JC, Heussler V, Sinnis P, Fidock DA.

Cell Host Microbe. 2008 Dec 11;4(6):567-78. doi: 10.1016/j.chom.2008.11.001.


Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.

Gratraud P, Huws E, Falkard B, Adjalley S, Fidock DA, Berry L, Jacobs WR Jr, Baird MS, Vial H, Kremer L.

PLoS One. 2009 Sep 3;4(9):e6889. doi: 10.1371/journal.pone.0006889.


Antimycobacterial Activity and Mechanism of Action of NAS-91.

Gratraud P, Surolia N, Besra GS, Surolia A, Kremer L.

Antimicrob Agents Chemother. 2008 Mar;52(3):1162-6. Epub 2007 Dec 17.


EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.

Dover LG, Alahari A, Gratraud P, Gomes JM, Bhowruth V, Reynolds RC, Besra GS, Kremer L.

Antimicrob Agents Chemother. 2007 Mar;51(3):1055-63. Epub 2007 Jan 12.

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