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Items: 1 to 50 of 75

1.

The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy.

Fu Z, Indrisiunaite G, Kaledhonkar S, Shah B, Sun M, Chen B, Grassucci RA, Ehrenberg M, Frank J.

Nat Commun. 2019 Jun 12;10(1):2579. doi: 10.1038/s41467-019-10608-z.

PMID:
31189921
2.

Structure and activity of lipid bilayer within a membrane-protein transporter.

Qiu W, Fu Z, Xu GG, Grassucci RA, Zhang Y, Frank J, Hendrickson WA, Guo Y.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12985-12990. doi: 10.1073/pnas.1812526115. Epub 2018 Dec 3.

3.

Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography.

Siegmund SE, Grassucci R, Carter SD, Barca E, Farino ZJ, Juanola-Falgarona M, Zhang P, Tanji K, Hirano M, Schon EA, Frank J, Freyberg Z.

iScience. 2018 Aug 31;6:83-91. doi: 10.1016/j.isci.2018.07.014. Epub 2018 Jul 20.

4.

Opening of the human epithelial calcium channel TRPV6.

McGoldrick LL, Singh AK, Saotome K, Yelshanskaya MV, Twomey EC, Grassucci RA, Sobolevsky AI.

Nature. 2018 Jan 11;553(7687):233-237. doi: 10.1038/nature25182. Epub 2017 Dec 20.

5.

Channel opening and gating mechanism in AMPA-subtype glutamate receptors.

Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI.

Nature. 2017 Sep 7;549(7670):60-65. doi: 10.1038/nature23479. Epub 2017 Jul 24.

6.

Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.

Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI.

Neuron. 2017 May 3;94(3):569-580.e5. doi: 10.1016/j.neuron.2017.04.025.

7.

A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM.

Feng X, Fu Z, Kaledhonkar S, Jia Y, Shah B, Jin A, Liu Z, Sun M, Chen B, Grassucci RA, Ren Y, Jiang H, Frank J, Lin Q.

Structure. 2017 Apr 4;25(4):663-670.e3. doi: 10.1016/j.str.2017.02.005. Epub 2017 Mar 9.

8.

Key Intermediates in Ribosome Recycling Visualized by Time-Resolved Cryoelectron Microscopy.

Fu Z, Kaledhonkar S, Borg A, Sun M, Chen B, Grassucci RA, Ehrenberg M, Frank J.

Structure. 2016 Dec 6;24(12):2092-2101. doi: 10.1016/j.str.2016.09.014. Epub 2016 Nov 3.

9.

Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.

Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Ramesh M, Espina N, Sun M, Tutuncuoglu B, Madison-Antenucci S, Woolford JL Jr, Tong L, Frank J.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12174-12179. Epub 2016 Oct 10.

10.

Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM.

Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Sun M, Espina N, Madison-Antenucci S, Tong L, Frank J.

Protein Sci. 2017 Jan;26(1):82-92. doi: 10.1002/pro.3068. Epub 2016 Oct 26. Review.

11.

Structural Basis for Gating and Activation of RyR1.

des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J.

Cell. 2016 Sep 22;167(1):145-157.e17. doi: 10.1016/j.cell.2016.08.075.

12.

Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.

Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI.

Science. 2016 Jul 1;353(6294):83-6. doi: 10.1126/science.aaf8411.

13.

CTF Challenge: Result summary.

Marabini R, Carragher B, Chen S, Chen J, Cheng A, Downing KH, Frank J, Grassucci RA, Bernard Heymann J, Jiang W, Jonic S, Liao HY, Ludtke SJ, Patwari S, Piotrowski AL, Quintana A, Sorzano CO, Stahlberg H, Vargas J, Voss NR, Chiu W, Carazo JM.

J Struct Biol. 2015 Jun;190(3):348-59. doi: 10.1016/j.jsb.2015.04.003. Epub 2015 Apr 23.

14.

Structure of a mammalian ryanodine receptor.

Zalk R, Clarke OB, des Georges A, Grassucci RA, Reiken S, Mancia F, Hendrickson WA, Frank J, Marks AR.

Nature. 2015 Jan 1;517(7532):44-9. doi: 10.1038/nature13950. Epub 2014 Dec 1.

15.

Structure of the mammalian ribosomal pre-termination complex associated with eRF1.eRF3.GDPNP.

des Georges A, Hashem Y, Unbehaun A, Grassucci RA, Taylor D, Hellen CU, Pestova TV, Frank J.

Nucleic Acids Res. 2014 Mar;42(5):3409-18. doi: 10.1093/nar/gkt1279. Epub 2013 Dec 11.

16.

Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit.

Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Pestova TV, Hellen CU, Frank J.

Nature. 2013 Nov 28;503(7477):539-43. doi: 10.1038/nature12658. Epub 2013 Nov 3.

17.

Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29.

Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Hellen CU, Pestova TV, Frank J.

Cell. 2013 May 23;153(5):1108-19. doi: 10.1016/j.cell.2013.04.036.

18.

High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome.

Hashem Y, des Georges A, Fu J, Buss SN, Jossinet F, Jobe A, Zhang Q, Liao HY, Grassucci RA, Bajaj C, Westhof E, Madison-Antenucci S, Frank J.

Nature. 2013 Feb 21;494(7437):385-9. doi: 10.1038/nature11872. Epub 2013 Feb 10.

19.

Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome.

Sharma G, Pallesen J, Das S, Grassucci R, Langlois R, Hampton CM, Kelly DF, des Georges A, Frank J.

J Struct Biol. 2013 Feb;181(2):190-4. doi: 10.1016/j.jsb.2012.11.006. Epub 2012 Dec 8.

20.

Cryo-EM structure of the mammalian eukaryotic release factor eRF1-eRF3-associated termination complex.

Taylor D, Unbehaun A, Li W, Das S, Lei J, Liao HY, Grassucci RA, Pestova TV, Frank J.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18413-8. doi: 10.1073/pnas.1216730109. Epub 2012 Oct 22.

21.

The group II intron ribonucleoprotein precursor is a large, loosely packed structure.

Huang T, Shaikh TR, Gupta K, Contreras-Martin LM, Grassucci RA, Van Duyne GD, Frank J, Belfort M.

Nucleic Acids Res. 2011 Apr;39(7):2845-54. doi: 10.1093/nar/gkq1202. Epub 2010 Dec 3.

22.

Time-dependent insulin oligomer reaction pathway prior to fibril formation: cooling and seeding.

Sorci M, Grassucci RA, Hahn I, Frank J, Belfort G.

Proteins. 2009 Oct;77(1):62-73. doi: 10.1002/prot.22417.

23.

Determination of signal-to-noise ratios and spectral SNRs in cryo-EM low-dose imaging of molecules.

Baxter WT, Grassucci RA, Gao H, Frank J.

J Struct Biol. 2009 May;166(2):126-32. doi: 10.1016/j.jsb.2009.02.012. Epub 2009 Mar 6.

24.

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis.

Villa E, Sengupta J, Trabuco LG, LeBarron J, Baxter WT, Shaikh TR, Grassucci RA, Nissen P, Ehrenberg M, Schulten K, Frank J.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1063-8. doi: 10.1073/pnas.0811370106. Epub 2009 Jan 2.

25.

Exploration of parameters in cryo-EM leading to an improved density map of the E. coli ribosome.

LeBarron J, Grassucci RA, Shaikh TR, Baxter WT, Sengupta J, Frank J.

J Struct Biol. 2008 Oct;164(1):24-32. doi: 10.1016/j.jsb.2008.05.007. Epub 2008 Jun 18.

26.

Visualization of macromolecular complexes using cryo-electron microscopy with FEI Tecnai transmission electron microscopes.

Grassucci RA, Taylor D, Frank J.

Nat Protoc. 2008;3(2):330-9. doi: 10.1038/nprot.2007.474.

27.

Preparation of macromolecular complexes for cryo-electron microscopy.

Grassucci RA, Taylor DJ, Frank J.

Nat Protoc. 2007;2(12):3239-46.

28.
29.

Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications.

Agrawal RK, Sharma MR, Kiel MC, Hirokawa G, Booth TM, Spahn CM, Grassucci RA, Kaji A, Frank J.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8900-5. Epub 2004 Jun 3.

30.

Structure of the signal recognition particle interacting with the elongation-arrested ribosome.

Halic M, Becker T, Pool MR, Spahn CM, Grassucci RA, Frank J, Beckmann R.

Nature. 2004 Feb 26;427(6977):808-14.

PMID:
14985753
31.

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.

Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jørgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J.

EMBO J. 2004 Mar 10;23(5):1008-19. Epub 2004 Feb 19.

32.

A cryo-electron microscopic study of ribosome-bound termination factor RF2.

Rawat UB, Zavialov AV, Sengupta J, Valle M, Grassucci RA, Linde J, Vestergaard B, Ehrenberg M, Frank J.

Nature. 2003 Jan 2;421(6918):87-90.

PMID:
12511960
33.

An assay for local quality in cryo-electron micrographs of single particles.

Gao H, Spahn CM, Grassucci RA, Frank J.

Ultramicroscopy. 2002 Nov;93(2):169-78.

PMID:
12425594
34.

Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process.

Valle M, Sengupta J, Swami NK, Grassucci RA, Burkhardt N, Nierhaus KH, Agrawal RK, Frank J.

EMBO J. 2002 Jul 1;21(13):3557-67.

35.

The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

Gabashvili IS, Gregory ST, Valle M, Grassucci R, Worbs M, Wahl MC, Dahlberg AE, Frank J.

Mol Cell. 2001 Jul;8(1):181-8.

36.

Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance.

Spahn CM, Blaha G, Agrawal RK, Penczek P, Grassucci RA, Trieber CA, Connell SR, Taylor DE, Nierhaus KH, Frank J.

Mol Cell. 2001 May;7(5):1037-45.

37.

Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit.

Spahn CM, Kieft JS, Grassucci RA, Penczek PA, Zhou K, Doudna JA, Frank J.

Science. 2001 Mar 9;291(5510):1959-62.

38.

Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle.

Agrawal RK, Spahn CM, Penczek P, Grassucci RA, Nierhaus KH, Frank J.

J Cell Biol. 2000 Aug 7;150(3):447-60.

39.

Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution.

Gomez-Lorenzo MG, Spahn CM, Agrawal RK, Grassucci RA, Penczek P, Chakraburtty K, Ballesta JP, Lavandera JL, Garcia-Bustos JF, Frank J.

EMBO J. 2000 Jun 1;19(11):2710-8.

40.

Three-dimensional cryoelectron microscopy of ribosomes.

Frank J, Penczek P, Agrawal RK, Grassucci RA, Heagle AB.

Methods Enzymol. 2000;317:276-91. Review. No abstract available.

PMID:
10829286
41.

Solution structure of the E. coli 70S ribosome at 11.5 A resolution.

Gabashvili IS, Agrawal RK, Spahn CM, Grassucci RA, Svergun DI, Frank J, Penczek P.

Cell. 2000 Mar 3;100(5):537-49.

43.

Haloarcula marismortui 50S subunit-complementarity of electron microscopy and X-Ray crystallographic information.

Penczek P, Ban N, Grassucci RA, Agrawal RK, Frank J.

J Struct Biol. 1999 Dec 1;128(1):44-50.

PMID:
10600557
44.

Major rearrangements in the 70S ribosomal 3D structure caused by a conformational switch in 16S ribosomal RNA.

Gabashvili IS, Agrawal RK, Grassucci R, Squires CL, Dahlberg AE, Frank J.

EMBO J. 1999 Nov 15;18(22):6501-7.

45.

EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome.

Agrawal RK, Heagle AB, Penczek P, Grassucci RA, Frank J.

Nat Struct Biol. 1999 Jul;6(7):643-7.

PMID:
10404220
46.

Location of translational initiation factor IF3 on the small ribosomal subunit.

McCutcheon JP, Agrawal RK, Philips SM, Grassucci RA, Gerchman SE, Clemons WM Jr, Ramakrishnan V, Frank J.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4301-6.

47.

Effect of buffer conditions on the position of tRNA on the 70 S ribosome as visualized by cryoelectron microscopy.

Agrawal RK, Penczek P, Grassucci RA, Burkhardt N, Nierhaus KH, Frank J.

J Biol Chem. 1999 Mar 26;274(13):8723-9.

48.
49.

Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor.

Sharma MR, Penczek P, Grassucci R, Xin HB, Fleischer S, Wagenknecht T.

J Biol Chem. 1998 Jul 17;273(29):18429-34.

50.

A 9 A resolution X-ray crystallographic map of the large ribosomal subunit.

Ban N, Freeborn B, Nissen P, Penczek P, Grassucci RA, Sweet R, Frank J, Moore PB, Steitz TA.

Cell. 1998 Jun 26;93(7):1105-15.

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