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Items: 46

1.

BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers.

Lavitrano M, Ianzano L, Bonomo S, Cialdella A, Cerrito MG, Pisano F, Missaglia C, Giovannoni R, Romano G, McLean CM, Voest EE, D'Amato F, Noli B, Ferri GL, Agostini M, Pucciarelli S, Helin K, Leone BE, Canzonieri V, Grassilli E.

J Pathol. 2020 Feb;250(2):134-147. doi: 10.1002/path.5347. Epub 2019 Dec 2.

PMID:
31518438
2.

Role of Bruton's Tyrosine Kinase in Stage III Colorectal Cancer.

Basile D, Gerratana L, Buonadonna A, Garattini SK, Perin T, Grassilli E, Miolo G, Cerrito MG, Belluco C, Bertola G, De Paoli A, Cannizzaro R, Lavitrano M, Puglisi F, Canzonieri V.

Cancers (Basel). 2019 Jun 24;11(6). pii: E880. doi: 10.3390/cancers11060880.

3.

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma.

Giordano F, Vaira V, Cortinovis D, Bonomo S, Goedmakers J, Brena F, Cialdella A, Ianzano L, Forno I, Cerrito MG, Giovannoni R, Ferri GL, Tasciotti E, Vicent S, Damarco F, Bosari S, Lavitrano M, Grassilli E.

J Exp Clin Cancer Res. 2019 Jun 14;38(1):260. doi: 10.1186/s13046-019-1199-7.

4.

Specific Expression of a New Bruton Tyrosine Kinase Isoform (p65BTK) in the Glioblastoma Gemistocytic Histotype.

Sala L, Cirillo G, Riva G, Romano G, Giussani C, Cialdella A, Todisco A, Virtuoso A, Cerrito MG, Bentivegna A, Grassilli E, Ardizzoia A, Bonoldi E, Giovannoni R, Papa M, Lavitrano M.

Front Mol Neurosci. 2019 Jan 24;12:2. doi: 10.3389/fnmol.2019.00002. eCollection 2019.

5.

Metronomic combination of Vinorelbine and 5Fluorouracil is able to inhibit triple-negative breast cancer cells. Results from the proof-of-concept VICTOR-0 study.

Cerrito MG, De Giorgi M, Pelizzoni D, Bonomo SM, Digiacomo N, Scagliotti A, Bugarin C, Gaipa G, Grassilli E, Lavitrano M, Giovannoni R, Bidoli P, Cazzaniga ME.

Oncotarget. 2018 Jun 8;9(44):27448-27459. doi: 10.18632/oncotarget.25422. eCollection 2018 Jun 8.

6.

Simultaneous overexpression of human E5NT and ENTPD1 protects porcine endothelial cells against H2O2-induced oxidative stress and cytotoxicity in vitro.

Chisci E, De Giorgi M, Zanfrini E, Testasecca A, Brambilla E, Cinti A, Farina L, Kutryb-Zajac B, Bugarin C, Villa C, Grassilli E, Combi R, Gaipa G, Cerrito MG, Rivolta I, Smolenski RT, Lavitrano M, Giovannoni R.

Free Radic Biol Med. 2017 Jul;108:320-333. doi: 10.1016/j.freeradbiomed.2017.03.038. Epub 2017 Apr 5.

7.

Unexpected frequency of genomic alterations in histologically normal colonic tissue from colon cancer patients.

Conconi D, Redaelli S, Bovo G, Leone BE, Filippi E, Ambrosiani L, Cerrito MG, Grassilli E, Giovannoni R, Dalprà L, Lavitrano M.

Tumour Biol. 2016 Oct;37(10):13831-13842. Epub 2016 Aug 2.

8.

The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells.

Romano G, Santi L, Bianco MR, Giuffrè MR, Pettinato M, Bugarin C, Garanzini C, Savarese L, Leoni S, Cerrito MG, Leone BE, Gaipa G, Grassilli E, Papa M, Lavitrano M, Giovannoni R.

Oncotarget. 2016 Apr 19;7(16):22077-91. doi: 10.18632/oncotarget.7895.

9.

A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.

Grassilli E, Pisano F, Cialdella A, Bonomo S, Missaglia C, Cerrito MG, Masiero L, Ianzano L, Giordano F, Cicirelli V, Narloch R, D'Amato F, Noli B, Ferri GL, Leone BE, Stanta G, Bonin S, Helin K, Giovannoni R, Lavitrano M.

Oncogene. 2016 Aug 18;35(33):4368-78. doi: 10.1038/onc.2015.504. Epub 2016 Jan 25.

10.

GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis.

Grassilli E, Ianzano L, Bonomo S, Missaglia C, Cerrito MG, Giovannoni R, Masiero L, Lavitrano M.

PLoS One. 2014 Jul 1;9(7):e100947. doi: 10.1371/journal.pone.0100947. eCollection 2014.

11.

Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy.

Grassilli E, Narloch R, Federzoni E, Ianzano L, Pisano F, Giovannoni R, Romano G, Masiero L, Leone BE, Bonin S, Donada M, Stanta G, Helin K, Lavitrano M.

Clin Cancer Res. 2013 Jul 15;19(14):3820-31. doi: 10.1158/1078-0432.CCR-12-3289. Epub 2013 May 31.

12.

Exposure to 900 MHz radiofrequency radiation induces caspase 3 activation in proliferating human lymphocytes.

Palumbo R, Brescia F, Capasso D, Sannino A, Sarti M, Capri M, Grassilli E, Scarfì MR.

Radiat Res. 2008 Sep;170(3):327-34. doi: 10.1667/RR1098.1.

PMID:
18763855
13.

Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways.

Grassilli E, Ballabeni A, Maellaro E, Del Bello B, Helin K.

J Biol Chem. 2004 May 14;279(20):21318-26. Epub 2004 Feb 27.

14.

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

Müller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini E, Vigo E, Oliner JD, Helin K.

Genes Dev. 2001 Feb 1;15(3):267-85.

15.

BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CbetaII-dependent pathway.

Perrotti D, Iervolino A, Cesi V, Cirinná M, Lombardini S, Grassilli E, Bonatti S, Claudio PP, Calabretta B.

Mol Cell Biol. 2000 Aug;20(16):6159-69.

16.

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis.

Peruzzi F, Prisco M, Dews M, Salomoni P, Grassilli E, Romano G, Calabretta B, Baserga R.

Mol Cell Biol. 1999 Oct;19(10):7203-15.

17.

Resistance to apoptosis in CTLL-2 cells overexpressing B-Myb is associated with B-Myb-dependent bcl-2 induction.

Grassilli E, Salomoni P, Perrotti D, Franceschi C, Calabretta B.

Cancer Res. 1999 May 15;59(10):2451-6.

18.

Inhibition of proteasome function prevents thymocyte apoptosis: involvement of ornithine decarboxylase.

Grassilli E, Benatti F, Dansi P, Giammarioli AM, Malorni W, Franceschi C, Desiderio MA.

Biochem Biophys Res Commun. 1998 Sep 18;250(2):293-7.

PMID:
9753623
19.

TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.

Perrotti D, Bonatti S, Trotta R, Martinez R, Skorski T, Salomoni P, Grassilli E, Lozzo RV, Cooper DR, Calabretta B.

EMBO J. 1998 Aug 3;17(15):4442-55.

20.

Protection against apoptosis by monoamine oxidase A inhibitors.

Malorni W, Giammarioli AM, Matarrese P, Pietrangeli P, Agostinelli E, Ciaccio A, Grassilli E, Mondovi B.

FEBS Lett. 1998 Apr 10;426(1):155-9.

21.

Growth properties and growth factor responsiveness in skin fibroblasts from centenarians.

Tesco G, Vergelli M, Grassilli E, Salomoni P, Bellesia E, Sikora E, Radziszewska E, Barbieri D, Latorraca S, Fagiolo U, Santacaterina S, Amaducci L, Tiozzo R, Franceschi C, Sorbi S.

Biochem Biophys Res Commun. 1998 Mar 27;244(3):912-6.

PMID:
9535767
22.

Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (TRK): a role for BCL-2.

Pincelli C, Haake AR, Benassi L, Grassilli E, Magnoni C, Ottani D, Polakowska R, Franceschi C, Giannetti A.

J Invest Dermatol. 1997 Dec;109(6):757-64.

23.

c-fos/c-jun expression and AP-1 activation in skin fibroblasts from centenarians.

Grassilli E, Bellesia E, Salomoni P, Croce MA, Sikora E, Radziszewska E, Tesco G, Vergelli M, Latorraca S, Barbieri D, Fagiolo U, Santacaterina S, Amaducci L, Tiozzo R, Sorbi S, Franceschi C.

Biochem Biophys Res Commun. 1996 Sep 13;226(2):517-23.

PMID:
8806666
24.

Interference between DNA binding activities of AP-1 and GR transcription factors in rat thymocytes undergoing dexamethasone-induced apoptosis.

Sikora E, Rossini GP, Grassilli E, Bellesia E, Salomoni P, Franceschi C.

Acta Biochim Pol. 1996;43(4):721-31.

25.

Successful immunosenescence and the remodelling of immune responses with ageing.

Franceschi C, Monti D, Barbieri D, Salvioli S, Grassilli E, Capri M, Troiano L, Guido M, Bonafè M, Tropea F, Salomoni P, Benatti F, Bellesia E, Macchioni S, Anderlini R, Sansoni P, Mariotti S, Wratten ML, Tetta C, Cossarizza A.

Nephrol Dial Transplant. 1996;11 Suppl 9:18-25. Review.

PMID:
9050030
26.

Is polyamine decrease a common feature of apoptosis? Evidence from gamma rays- and heat shock-induced cell death.

Grassilli E, Desiderio MA, Bellesia E, Salomoni P, Benatti F, Franceschi C.

Biochem Biophys Res Commun. 1995 Nov 13;216(2):708-14.

PMID:
7488168
27.

Meeting Report: Apoptosis: is it a digestive problem?

Grassilli E.

Cell Death Differ. 1995 Jul;2(3):221-5. No abstract available.

PMID:
17180045
28.

Involvement of ornithine decarboxylase and polyamines in glucocorticoid-induced apoptosis of rat thymocytes.

Desiderio MA, Grassilli E, Bellesia E, Salomoni P, Franceschi C.

Cell Growth Differ. 1995 May;6(5):505-13.

29.

Immunosenescence in humans: deterioration or remodelling?

Franceschi C, Monti D, Barbieri D, Grassilli E, Troiano L, Salvioli S, Negro P, Capri M, Guido M, Azzi R, et al.

Int Rev Immunol. 1995;12(1):57-74. Review. No abstract available.

PMID:
7595015
30.

Mitochondrial modifications during rat thymocyte apoptosis: a study at the single cell level.

Cossarizza A, Kalashnikova G, Grassilli E, Chiappelli F, Salvioli S, Capri M, Barbieri D, Troiano L, Monti D, Franceschi C.

Exp Cell Res. 1994 Sep;214(1):323-30.

PMID:
8082735
31.

Apoptosis and spermatogenesis: evidence from an in vivo model of testosterone withdrawal in the adult rat.

Troiano L, Fustini MF, Lovato E, Frasoldati A, Malorni W, Capri M, Grassilli E, Marrama P, Franceschi C.

Biochem Biophys Res Commun. 1994 Aug 15;202(3):1315-21.

PMID:
8060308
32.

D-ribose and deoxy-D-ribose induce apoptosis in human quiescent peripheral blood mononuclear cells.

Barbieri D, Grassilli E, Monti D, Salvioli S, Franceschini MG, Franchini A, Bellesia E, Salomoni P, Negro P, Capri M, et al.

Biochem Biophys Res Commun. 1994 Jun 30;201(3):1109-16.

PMID:
8024552
33.

Transcription factors DNA-binding activity in rat thymocytes undergoing apoptosis after heat-shock or dexamethasone treatment.

Sikora E, Grassilli E, Radziszewska E, Bellesia E, Barbieri D, Franceschi C.

Biochem Biophys Res Commun. 1993 Dec 15;197(2):709-15.

PMID:
8267607
34.
35.

Senescence, immortalization, and apoptosis. An intriguing relationship.

Monti D, Grassilli E, Troiano L, Cossarizza A, Salvioli S, Barbieri D, Agnesini C, Bettuzzi S, Ingletti MC, Corti A, et al.

Ann N Y Acad Sci. 1992 Dec 26;673:70-82. Review. No abstract available.

PMID:
1485736
36.

SGP-2, apoptosis, and aging.

Grassilli E, Bettuzzi S, Troiano L, Ingletti MC, Monti D, Corti A, Franceschi C.

Ann N Y Acad Sci. 1992 Nov 21;663:471-4. No abstract available.

PMID:
1482089
37.

Cell proliferation and cell death in immunosenescence.

Monti D, Troiano L, Grassilli E, Agnesini C, Tropea F, Barbieri D, Capri M, Cristofalo EA, Salvioli S, Ronchetti I, et al.

Ann N Y Acad Sci. 1992 Nov 21;663:250-61. No abstract available.

PMID:
1482057
38.

Studies of the relationship between cell proliferation and cell death. II. Early gene expression during concanavalin A-induced proliferation or dexamethasone-induced apoptosis of rat thymocytes.

Grassilli E, Carcereri de Prati A, Monti D, Troiano L, Menegazzi M, Barbieri D, Franceschi C, Suzuki H.

Biochem Biophys Res Commun. 1992 Nov 16;188(3):1261-6.

PMID:
1445359
39.

Inhibition of apoptosis by zinc: a reappraisal.

Barbieri D, Troiano L, Grassilli E, Agnesini C, Cristofalo EA, Monti D, Capri M, Cossarizza A, Franceschi C.

Biochem Biophys Res Commun. 1992 Sep 30;187(3):1256-61.

PMID:
1417802
40.

Apoptosis--programmed cell death: a role in the aging process?

Monti D, Troiano L, Tropea F, Grassilli E, Cossarizza A, Barozzi D, Pelloni MC, Tamassia MG, Bellomo G, Franceschi C.

Am J Clin Nutr. 1992 Jun;55(6 Suppl):1208S-1214S. doi: 10.1093/ajcn/55.6.1208S. Review.

PMID:
1590258
41.

Caloric restriction modulates aging rate and sensitivity to oxygen free radical damage in rats.

Monti D, Tamassia MG, Barozzi D, Pelloni MC, Cossarizza A, Nuzzo C, Grassilli E, Troiano L, Tropea F, Leoni L, et al.

Aging (Milano). 1991 Dec;3(4):410-2. No abstract available.

PMID:
1841622
42.

Studies on the relationship between cell proliferation and cell death: opposite patterns of SGP-2 and ornithine decarboxylase mRNA accumulation in PHA-stimulated human lymphocytes.

Grassilli E, Bettuzzi S, Monti D, Ingletti MC, Franceschi C, Corti A.

Biochem Biophys Res Commun. 1991 Oct 15;180(1):59-63.

PMID:
1718280
43.

In vivo accumulation of sulfated glycoprotein 2 mRNA in rat thymocytes upon dexamethasone-induced cell death.

Bettuzzi S, Troiano L, Davalli P, Tropea F, Ingletti MC, Grassilli E, Monti D, Corti A, Franceschi C.

Biochem Biophys Res Commun. 1991 Mar 29;175(3):810-5.

PMID:
2025255
44.

DNA and cell death.

Monti D, Troiano L, Tropea F, Grassilli E, Cossarizza A, Barozzi D, Bettuzzi S, Corti A, Franceschi C.

Cytotechnology. 1991 Feb;5(Suppl 1):74-7. doi: 10.1007/BF00736814.

PMID:
22358960
45.

Philadelphia-positive chronic myelogenous leukemia with typical bcr/abl molecular features and atypical, prolonged survival.

Selleri L, Emilia G, Temperani P, Grassilli E, Zucchini P, Tagliafico E, Bonati A, Venezia L, Ferrari S, Torelli U, et al.

Leukemia. 1989 Jul;3(7):538-42.

PMID:
2733455
46.

[Polymerase chain reaction for the diagnostic identification of HIV infection].

Selleri L, Grassilli E, Tagliafico E, Corradi M, Luppi M, Ceccherelli G, Borghi V.

Medicina (Firenze). 1989 Jan-Mar;9(1):41-3. Italian.

PMID:
2739527

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