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Long-term effect of CFTR modulator therapy on airway nitric oxide.

Grasemann H, Klingel M, Avolio J, Prentice C, Gonska T, Tullis E, Ratjen F.

Eur Respir J. 2019 Oct 10. pii: 1901113. doi: 10.1183/13993003.01113-2019. [Epub ahead of print] No abstract available.


Normal saline bolus use in pediatric emergency departments is associated with poorer pain control in children with sickle cell anemia and vaso-occlusive pain.

Carden MA, Brousseau DC, Ahmad FA, Bennett J, Bhatt S, Bogie A, Brown K, Casper TC, Chapman LL, Chumpitazi CE, Cohen D, Dampier C, Ellison AM, Grasemann H, Hickey RW, Hsu LL, Leibovich S, Powell E, Richards R, Sarnaik S, Weiner DL, Morris CR; Sickle Cell Disease Arginine Study Group and the Pediatric Emergency Care Applied Research Network (PECARN).

Am J Hematol. 2019 Jun;94(6):689-696. doi: 10.1002/ajh.25471. Epub 2019 Apr 29.


Progression of Cystic Fibrosis Lung Disease from Childhood to Adulthood: Neutrophils, Neutrophil Extracellular Trap (NET) Formation, and NET Degradation.

Khan MA, Ali ZS, Sweezey N, Grasemann H, Palaniyar N.

Genes (Basel). 2019 Feb 26;10(3). pii: E183. doi: 10.3390/genes10030183. Review.


Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction.

Xia E, Duan R, Shi F, Seigel KE, Grasemann H, Hu J.

Mol Ther Nucleic Acids. 2018 Dec 7;13:699-709. doi: 10.1016/j.omtn.2018.10.015. Epub 2018 Oct 30.


Activity of a novel antimicrobial peptide against Pseudomonas aeruginosa biofilms.

Beaudoin T, Stone TA, Glibowicka M, Adams C, Yau Y, Ahmadi S, Bear CE, Grasemann H, Waters V, Deber CM.

Sci Rep. 2018 Oct 3;8(1):14728. doi: 10.1038/s41598-018-33016-7.


A randomized clinical trial of age and genotype-guided tacrolimus dosing after pediatric solid organ transplantation.

Min S, Papaz T, Lafreniere-Roula M, Nalli N, Grasemann H, Schwartz SM, Kamath BM, Ng V, Parekh RS, Manlhiot C, Mital S.

Pediatr Transplant. 2018 Nov;22(7):e13285. doi: 10.1111/petr.13285. Epub 2018 Sep 3.


Changes in Lung Clearance Index in Preschool-aged Patients with Cystic Fibrosis Treated with Ivacaftor (GOAL): A Clinical Trial.

Ratjen F, Klingel M, Black P, Powers MR, Grasemann H, Solomon M, Sagel SD, Donaldson SH, Rowe SM, Rosenfeld M.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):526-528. doi: 10.1164/rccm.201802-0243LE. No abstract available.


Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis.

Khan MA, Philip LM, Cheung G, Vadakepeedika S, Grasemann H, Sweezey N, Palaniyar N.

Front Med (Lausanne). 2018 Feb 13;5:19. doi: 10.3389/fmed.2018.00019. eCollection 2018.


Transducing Airway Basal Cells with a Helper-Dependent Adenoviral Vector for Lung Gene Therapy.

Cao H, Ouyang H, Grasemann H, Bartlett C, Du K, Duan R, Shi F, Estrada M, Seigel KE, Coates AL, Yeger H, Bear CE, Gonska T, Moraes TJ, Hu J.

Hum Gene Ther. 2018 Jun;29(6):643-652. doi: 10.1089/hum.2017.201. Epub 2018 Mar 16.


Association of wheeze with lung function decline in children with sickle cell disease.

Bendiak GN, Mateos-Corral D, Sallam A, Atenafu EG, Kirby M, Odame I, Bikangaga P, Subbarao P, Grasemann H.

Eur Respir J. 2017 Nov 30;50(5). pii: 1602433. doi: 10.1183/13993003.02433-2016. Print 2017 Nov. No abstract available.


CFTR Modulator Therapy for Cystic Fibrosis.

Grasemann H.

N Engl J Med. 2017 Nov 23;377(21):2085-2088. doi: 10.1056/NEJMe1712335. Epub 2017 Nov 3. No abstract available.


Quality of life outcomes following pediatric lung transplantation.

Lazor T, Grasemann H, Solomon M, Anthony SJ.

Pediatr Pulmonol. 2017 Nov;52(11):1495-1501. doi: 10.1002/ppul.23788. Epub 2017 Sep 14.


Changes in magnetic resonance imaging scores and ventilation inhomogeneity in children with cystic fibrosis pulmonary exacerbations.

Grasemann H, Ciet P, Amin R, McDonald N, Klingel M, Tiddens HAWM, Ratjen F, Grosse-Wortmann L.

Eur Respir J. 2017 Aug 24;50(2). pii: 1700244. doi: 10.1183/13993003.00244-2017. Print 2017 Aug. No abstract available.


JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis.

Khan MA, Farahvash A, Douda DN, Licht JC, Grasemann H, Sweezey N, Palaniyar N.

Sci Rep. 2017 Jun 13;7(1):3409. doi: 10.1038/s41598-017-03257-z.


Effect of Hydroxyurea Therapy on Pulmonary Function in Children with Sickle Cell Anemia.

McLaren A, Klingel M, Behera S, Odame I, Kirby-Allen M, Grasemann H.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):689-691. doi: 10.1164/rccm.201606-1119LE. No abstract available.


Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung.

Grasemann C, Herrmann R, Starschinova J, Gertsen M, Palmert MR, Grasemann H.

Nutr Diabetes. 2017 Feb 20;7(2):e244. doi: 10.1038/nutd.2016.56.


l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells.

Winnica D, Que LG, Baffi C, Grasemann H, Fiedler K, Yang Z, Etling E, Wasil K, Wenzel SE, Freeman B, Holguin F.

Clin Exp Allergy. 2017 Feb;47(2):190-199. doi: 10.1111/cea.12802. Epub 2016 Oct 4.


Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma.

McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST; CAMP Research Group.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1465-1474.


Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma.

McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Weiss ST, Strunk RC.

N Engl J Med. 2016 May 12;374(19):1842-1852. doi: 10.1056/NEJMoa1513737.


Changes in airway inflammation during pulmonary exacerbations in patients with cystic fibrosis and primary ciliary dyskinesia.

Ratjen F, Waters V, Klingel M, McDonald N, Dell S, Leahy TR, Yau Y, Grasemann H.

Eur Respir J. 2016 Mar;47(3):829-36. doi: 10.1183/13993003.01390-2015. Epub 2015 Nov 19.


Metabolic origins of childhood asthma.

Grasemann H.

Mol Cell Pediatr. 2015 Dec;2(1):6. doi: 10.1186/s40348-015-0017-3. Epub 2015 Apr 1.


New Developments in Cystic Fibrosis Airway Inflammation.

Palaniyar N, Mall MA, Taube C, Worgall S, Grasemann H.

Mediators Inflamm. 2015;2015:769425. doi: 10.1155/2015/769425. Epub 2015 Jun 29. No abstract available.


Effect of ivacaftor therapy on exhaled nitric oxide in patients with cystic fibrosis.

Grasemann H, Gonska T, Avolio J, Klingel M, Tullis E, Ratjen F.

J Cyst Fibros. 2015 Nov;14(6):727-32. doi: 10.1016/j.jcf.2015.07.001. Epub 2015 Jul 11.


Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth.

Ghorbani P, Santhakumar P, Hu Q, Djiadeu P, Wolever TM, Palaniyar N, Grasemann H.

Eur Respir J. 2015 Oct;46(4):1033-45. doi: 10.1183/09031936.00143614. Epub 2015 May 28.


Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.

Scott JA, North ML, Rafii M, Huang H, Pencharz P, Grasemann H.

J Appl Physiol (1985). 2015 May 15;118(10):1229-33. doi: 10.1152/japplphysiol.00865.2014. Epub 2015 Apr 2.


The role of the endothelin-1 pathway as a biomarker for donor lung assessment in clinical ex vivo lung perfusion.

Machuca TN, Cypel M, Zhao Y, Grasemann H, Tavasoli F, Yeung JC, Bonato R, Chen M, Zamel R, Chun YM, Guan Z, de Perrot M, Waddell TK, Liu M, Keshavjee S.

J Heart Lung Transplant. 2015 Jun;34(6):849-57. doi: 10.1016/j.healun.2015.01.003. Epub 2015 Jan 16.


A lipid mediator hepoxilin A3 is a natural inducer of neutrophil extracellular traps in human neutrophils.

Douda DN, Grasemann H, Pace-Asciak C, Palaniyar N.

Mediators Inflamm. 2015;2015:520871. doi: 10.1155/2015/520871. Epub 2015 Feb 16.


SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx.

Douda DN, Khan MA, Grasemann H, Palaniyar N.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2817-22. doi: 10.1073/pnas.1414055112. Epub 2015 Feb 17.


Factors associated with response to treatment of pulmonary exacerbations in cystic fibrosis patients.

Waters VJ, Stanojevic S, Sonneveld N, Klingel M, Grasemann H, Yau YC, Tullis E, Wilcox P, Freitag A, Chilvers M, Ratjen FA.

J Cyst Fibros. 2015 Nov;14(6):755-62. doi: 10.1016/j.jcf.2015.01.007. Epub 2015 Feb 14.


Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs.

Grasemann H, Dhaliwal R, Ivanovska J, Kantores C, McNamara PJ, Scott JA, Belik J, Jankov RP.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15;308(6):L503-10. doi: 10.1152/ajplung.00328.2014. Epub 2015 Jan 16.


Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients.

Yau YC, Ratjen F, Tullis E, Wilcox P, Freitag A, Chilvers M, Grasemann H, Zlosnik J, Speert D, Corey M, Stanojevic S, Matukas L, Leahy TR, Shih S, Waters V.

J Cyst Fibros. 2015 Mar;14(2):262-6. doi: 10.1016/j.jcf.2014.09.013. Epub 2014 Oct 30.


Arginine metabolism in asthma.

Scott JA, Grasemann H.

Immunol Allergy Clin North Am. 2014 Nov;34(4):767-75. doi: 10.1016/j.iac.2014.07.007. Epub 2014 Aug 19. Review.


Multitracer stable isotope quantification of arginase and nitric oxide synthase activity in a mouse model of pseudomonas lung infection.

Grasemann H, Jaecklin T, Mehl A, Huang H, Rafii M, Pencharz P, Ratjen F.

Mediators Inflamm. 2014;2014:323526. doi: 10.1155/2014/323526. Epub 2014 Aug 11.


Lung arginase expression and activity is increased in cystic fibrosis mouse models.

Jaecklin T, Duerr J, Huang H, Rafii M, Bear CE, Ratjen F, Pencharz P, Kavanagh BP, Mall MA, Grasemann H.

J Appl Physiol (1985). 2014 Aug 1;117(3):284-8. doi: 10.1152/japplphysiol.00167.2014. Epub 2014 Jun 12.


Asymmetric dimethylarginine in chronic obstructive pulmonary disease (ADMA in COPD).

Scott JA, Duongh M, Young AW, Subbarao P, Gauvreau GM, Grasemann H.

Int J Mol Sci. 2014 Apr 10;15(4):6062-71. doi: 10.3390/ijms15046062.


Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia.

Mehl A, Ghorbani P, Douda D, Huang H, Palaniyar N, Ratjen F, Grasemann H.

PLoS One. 2014 Mar 3;9(3):e90232. doi: 10.1371/journal.pone.0090232. eCollection 2014.


Pulmonary venoocclusive disease in childhood.

Woerner C, Cutz E, Yoo SJ, Grasemann H, Humpl T.

Chest. 2014 Jul;146(1):167-174. doi: 10.1378/chest.13-0172.


Asymmetric dimethylarginine and asthma.

Scott JA, Gauvreau GM, Grasemann H.

Eur Respir J. 2014 Feb;43(2):647-8. doi: 10.1183/09031936.00080313. No abstract available.


Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis.

Douda DN, Yip L, Khan MA, Grasemann H, Palaniyar N.

Blood. 2014 Jan 23;123(4):597-600. doi: 10.1182/blood-2013-09-526707. No abstract available.


Early lung disease in cystic fibrosis.

Grasemann H, Ratjen F.

Lancet Respir Med. 2013 Apr;1(2):148-57. doi: 10.1016/S2213-2600(13)70026-2. Epub 2013 Mar 12. Review.


Aquagenic wrinkling of the palms in a patient with cystic fibrosis.

Grasemann H, Ratjen F, Solomon M.

N Engl J Med. 2013 Dec 12;369(24):2362-3. doi: 10.1056/NEJMc1308349. No abstract available.


Asymmetric dimethylarginine: a disease marker for asthma?

Scott JA, Grasemann H.

Chest. 2013 Aug;144(2):367-368. doi: 10.1378/chest.13-0480. No abstract available.


Energy expenditure and nutritional status in pediatric patients before and after lung transplantation.

Kalnins D, Pencharz PB, Grasemann H, Solomon M.

J Pediatr. 2013 Nov;163(5):1500-2. doi: 10.1016/j.jpeds.2013.05.063. Epub 2013 Jul 17.


Arginine metabolism in patients with cystic fibrosis.

Grasemann H, Pencharz PB.

J Pediatr. 2013 Aug;163(2):317-9. doi: 10.1016/j.jpeds.2013.02.042. Epub 2013 Mar 28. No abstract available.


Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.

North ML, Grasemann H, Khanna N, Inman MD, Gauvreau GM, Scott JA.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):694-702. doi: 10.1165/rcmb.2012-0323OC.


A child with autoimmune polyendocrinopathy candidiasis and ectodermal dysplasia treated with immunosuppression: a case report.

O'Gorman CS, Shulman R, Lara-Corrales I, Pope E, Marcon M, Grasemann H, Schneider R, Upton J, Sochett EB, Koltin D, Cohen E.

J Med Case Rep. 2013 Feb 14;7:44. doi: 10.1186/1752-1947-7-44.


A randomized controlled trial of inhaled L-arginine in patients with cystic fibrosis.

Grasemann H, Tullis E, Ratjen F.

J Cyst Fibros. 2013 Sep;12(5):468-74. doi: 10.1016/j.jcf.2012.12.008. Epub 2013 Jan 14.


L-ornithine derived polyamines in cystic fibrosis airways.

Grasemann H, Shehnaz D, Enomoto M, Leadley M, Belik J, Ratjen F.

PLoS One. 2012;7(10):e46618. doi: 10.1371/journal.pone.0046618. Epub 2012 Oct 5.


Cystic fibrosis: detecting changes in airway inflammation with FDG PET/CT.

Amin R, Charron M, Grinblat L, Shammas A, Grasemann H, Graniel K, Ciet P, Tiddens H, Ratjen F.

Radiology. 2012 Sep;264(3):868-75. doi: 10.1148/radiol.12111873. Epub 2012 Jul 24.


Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis.

Asner S, Waters V, Solomon M, Yau Y, Richardson SE, Grasemann H, Gharabaghi F, Tran D.

J Cyst Fibros. 2012 Sep;11(5):433-9. doi: 10.1016/j.jcf.2012.04.006. Epub 2012 May 10.

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