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Items: 1 to 50 of 72

1.

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.

Jeong MY, Lin YH, Wennersten SA, Demos-Davies KM, Cavasin MA, Mahaffey JH, Monzani V, Saripalli C, Mascagni P, Reece TB, Ambardekar AV, Granzier HL, Dinarello CA, McKinsey TA.

Sci Transl Med. 2018 Feb 7;10(427). pii: eaao0144. doi: 10.1126/scitranslmed.aao0144.

2.

Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy.

Evans JM, Cox ML, Huska J, Li F, Gaitero L, Guo LT, Casal ML, Granzier HL, Shelton GD, Clark LA.

Mamm Genome. 2016 Oct;27(9-10):495-502. doi: 10.1007/s00335-016-9644-9. Epub 2016 May 23.

3.

Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats.

Kovács Á, Fülöp GÁ, Kovács A, Csípő T, Bódi B, Priksz D, Juhász B, Beke L, Hendrik Z, Méhes G, Granzier HL, Édes I, Fagyas M, Papp Z, Barta J, Tóth A.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1671-82. doi: 10.1152/ajpheart.00842.2015. Epub 2016 Apr 8.

4.

Role of Titin Missense Variants in Dilated Cardiomyopathy.

Begay RL, Graw S, Sinagra G, Merlo M, Slavov D, Gowan K, Jones KL, Barbati G, Spezzacatene A, Brun F, Di Lenarda A, Smith JE, Granzier HL, Mestroni L, Taylor M; Familial Cardiomyopathy Registry.

J Am Heart Assoc. 2015 Nov 13;4(11). pii: e002645. doi: 10.1161/JAHA.115.002645.

5.

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.

Pappas CT, Mayfield RM, Henderson C, Jamilpour N, Cover C, Hernandez Z, Hutchinson KR, Chu M, Nam KH, Valdez JM, Wong PK, Granzier HL, Gregorio CC.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13573-8. doi: 10.1073/pnas.1508273112. Epub 2015 Oct 20.

6.

Myosin light chain phosphorylation to the rescue.

Granzier HL, de Tombe PP.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9148-9. doi: 10.1073/pnas.1511455112. Epub 2015 Jul 8. No abstract available.

7.

Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy.

Li F, Buck D, De Winter J, Kolb J, Meng H, Birch C, Slater R, Escobar YN, Smith JE 3rd, Yang L, Konhilas J, Lawlor MW, Ottenheijm C, Granzier HL.

Hum Mol Genet. 2015 Sep 15;24(18):5219-33. doi: 10.1093/hmg/ddv243. Epub 2015 Jun 29.

8.

Reply to Tskhovrebova et al.: Titin's IA junction does not control thick filament length.

Granzier HL.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1173. doi: 10.1073/pnas.1500871112. Epub 2015 Feb 18. No abstract available.

9.

Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin.

Zile MR, Baicu CF, Ikonomidis JS, Stroud RE, Nietert PJ, Bradshaw AD, Slater R, Palmer BM, Van Buren P, Meyer M, Redfield MM, Bull DA, Granzier HL, LeWinter MM.

Circulation. 2015 Apr 7;131(14):1247-59. doi: 10.1161/CIRCULATIONAHA.114.013215. Epub 2015 Jan 30.

10.

Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.

Granzier HL, Hutchinson KR, Tonino P, Methawasin M, Li FW, Slater RE, Bull MM, Saripalli C, Pappas CT, Gregorio CC, Smith JE 3rd.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14589-94. doi: 10.1073/pnas.1411493111. Epub 2014 Sep 22.

11.

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension.

Rain S, Bos Dda S, Handoko ML, Westerhof N, Stienen G, Ottenheijm C, Goebel M, Dorfmüller P, Guignabert C, Humbert M, Bogaard HJ, Remedios CD, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS.

J Am Heart Assoc. 2014 Jun 3;3(3):e000716. doi: 10.1161/JAHA.113.000716.

12.

Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice.

Hidalgo C, Saripalli C, Granzier HL.

Arch Biochem Biophys. 2014 Jun 15;552-553:100-7. doi: 10.1016/j.abb.2014.02.010. Epub 2014 Mar 3.

PMID:
24603287
13.

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.

Buck D, Smith JE 3rd, Chung CS, Ono Y, Sorimachi H, Labeit S, Granzier HL.

J Gen Physiol. 2014 Feb;143(2):215-30. doi: 10.1085/jgp.201311129.

14.

Cardiac titin and heart disease.

LeWinter MM, Granzier HL.

J Cardiovasc Pharmacol. 2014 Mar;63(3):207-12. doi: 10.1097/FJC.0000000000000007. Review.

15.

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension.

Rain S, Handoko ML, Trip P, Gan CT, Westerhof N, Stienen GJ, Paulus WJ, Ottenheijm CA, Marcus JT, Dorfmüller P, Guignabert C, Humbert M, Macdonald P, Dos Remedios C, Postmus PE, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS.

Circulation. 2013 Oct 29;128(18):2016-25, 1-10. doi: 10.1161/CIRCULATIONAHA.113.001873. Epub 2013 Sep 20.

16.

Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.

Chung CS, Hutchinson KR, Methawasin M, Saripalli C, Smith JE 3rd, Hidalgo CG, Luo X, Labeit S, Guo C, Granzier HL.

Circulation. 2013 Jul 2;128(1):19-28. doi: 10.1161/CIRCULATIONAHA.112.001268. Epub 2013 May 24.

17.

Titin is a major human disease gene.

LeWinter MM, Granzier HL.

Circulation. 2013 Feb 26;127(8):938-44. doi: 10.1161/CIRCULATIONAHA.112.139717. Review. No abstract available.

18.

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.

Lee EJ, Nedrud J, Schemmel P, Gotthardt M, Irving TC, Granzier HL.

Arch Biochem Biophys. 2013 Jul 1;535(1):76-83. doi: 10.1016/j.abb.2012.12.004. Epub 2012 Dec 14.

19.

The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

Hidalgo CG, Chung CS, Saripalli C, Methawasin M, Hutchinson KR, Tsaprailis G, Labeit S, Mattiazzi A, Granzier HL.

J Mol Cell Cardiol. 2013 Jan;54:90-7. doi: 10.1016/j.yjmcc.2012.11.012. Epub 2012 Dec 5.

20.

Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations.

Anderson BR, Granzier HL.

Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):204-17. doi: 10.1016/j.pbiomolbio.2012.08.003. Epub 2012 Aug 11. Review.

21.

Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction.

Reil JC, Hohl M, Reil GH, Granzier HL, Kratz MT, Kazakov A, Fries P, Müller A, Lenski M, Custodis F, Gräber S, Fröhlig G, Steendijk P, Neuberger HR, Böhm M.

Eur Heart J. 2013 Sep;34(36):2839-49. doi: 10.1093/eurheartj/ehs218. Epub 2012 Jul 24.

22.

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.

Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F.

J Biol Chem. 2012 Aug 24;287(35):29273-84. doi: 10.1074/jbc.M112.372839. Epub 2012 Jul 9.

23.

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.

Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J.

J Clin Invest. 2012 Apr;122(4):1209-21. doi: 10.1172/JCI61134. Epub 2012 Mar 19.

24.

Titin and diaphragm dysfunction in mechanically ventilated rats.

van Hees HW, Schellekens WJ, Andrade Acuña GL, Linkels M, Hafmans T, Ottenheijm CA, Granzier HL, Scheffer GJ, van der Hoeven JG, Dekhuijzen PN, Heunks LM.

Intensive Care Med. 2012 Apr;38(4):702-9. doi: 10.1007/s00134-012-2504-5. Epub 2012 Feb 11.

25.

Titin-actin interaction: PEVK-actin-based viscosity in a large animal.

Chung CS, Bogomolovas J, Gasch A, Hidalgo CG, Labeit S, Granzier HL.

J Biomed Biotechnol. 2011;2011:310791. doi: 10.1155/2011/310791. Epub 2011 Nov 15.

26.

Transforming growth factor beta signaling in adult cardiovascular diseases and repair.

Doetschman T, Barnett JV, Runyan RB, Camenisch TD, Heimark RL, Granzier HL, Conway SJ, Azhar M.

Cell Tissue Res. 2012 Jan;347(1):203-23. doi: 10.1007/s00441-011-1241-3. Epub 2011 Sep 28. Review.

27.

Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.

Chung CS, Methawasin M, Nelson OL, Radke MH, Hidalgo CG, Gotthardt M, Granzier HL.

J Mol Cell Cardiol. 2011 Sep;51(3):428-34. doi: 10.1016/j.yjmcc.2011.06.006. Epub 2011 Jun 16.

28.

The cytoskeleton and the cellular transduction of mechanical strain in the heart: a special issue.

de Tombe PP, Granzier HL.

Pflugers Arch. 2011 Jul;462(1):1-2. doi: 10.1007/s00424-011-0976-8. Epub 2011 May 19. No abstract available.

PMID:
21594569
29.

Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle.

Chung CS, Granzier HL.

J Mol Cell Cardiol. 2011 Apr;50(4):731-9. doi: 10.1016/j.yjmcc.2011.01.005. Epub 2011 Jan 19.

30.

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice.

Lee EJ, Peng J, Radke M, Gotthardt M, Granzier HL.

J Mol Cell Cardiol. 2010 Sep;49(3):449-58. doi: 10.1016/j.yjmcc.2010.05.006. Epub 2010 May 23.

31.

Activation and stretch-induced passive force enhancement--are you pulling my chain? Focus on "Regulation of muscle force in the absence of actin-myosin-based cross-bridge interaction".

Granzier HL.

Am J Physiol Cell Physiol. 2010 Jul;299(1):C11-3. doi: 10.1152/ajpcell.00147.2010. Epub 2010 May 5. No abstract available.

32.

Exposure to low-dose trichloroethylene alters shear stress gene expression and function in the developing chick heart.

Makwana O, King NM, Ahles L, Selmin O, Granzier HL, Runyan RB.

Cardiovasc Toxicol. 2010 Jun;10(2):100-7. doi: 10.1007/s12012-010-9066-y.

33.

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness.

Hudson BD, Hidalgo CG, Gotthardt M, Granzier HL.

J Mol Cell Cardiol. 2010 May;48(5):972-8. doi: 10.1016/j.yjmcc.2009.12.006. Epub 2009 Dec 21.

34.

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M.

Circ Res. 2009 Sep 11;105(6):557-64. doi: 10.1161/CIRCRESAHA.109.200964. Epub 2009 Aug 13.

35.

Heart failure decreases passive tension generation of rat diaphragm fibers.

van Hees HW, Ottenheijm CA, Granzier HL, Dekhuijzen PN, Heunks LM.

Int J Cardiol. 2010 Jun 11;141(3):275-83. doi: 10.1016/j.ijcard.2008.12.042. Epub 2009 Jan 15.

PMID:
19150150
36.

Physiological functions of the giant elastic protein titin in mammalian striated muscle.

Fukuda N, Granzier HL, Ishiwata S, Kurihara S.

J Physiol Sci. 2008 Jun;58(3):151-9. doi: 10.2170/physiolsci.RV005408. Epub 2008 May 15. Review.

PMID:
18477421
37.

Dynamic left ventricular elastance: a model for integrating cardiac muscle contraction into ventricular pressure-volume relationships.

Campbell KB, Simpson AM, Campbell SG, Granzier HL, Slinker BK.

J Appl Physiol (1985). 2008 Apr;104(4):958-75. Epub 2007 Nov 29.

38.

New insights in the role of cardiac myosin binding protein C as a regulator of cardiac contractility.

Granzier HL, Campbell KB.

Circ Res. 2006 Oct 13;99(8):795-7. Review. No abstract available.

39.

The giant muscle protein titin is an adjustable molecular spring.

Granzier HL, Labeit S.

Exerc Sport Sci Rev. 2006 Apr;34(2):50-3.

PMID:
16672800
40.

Titin/connectin-based modulation of the Frank-Starling mechanism of the heart.

Fukuda N, Granzier HL.

J Muscle Res Cell Motil. 2005;26(6-8):319-23. Review.

PMID:
16453158
41.

Titin and diaphragm dysfunction in chronic obstructive pulmonary disease.

Ottenheijm CA, Heunks LM, Hafmans T, van der Ven PF, Benoist C, Zhou H, Labeit S, Granzier HL, Dekhuijzen PN.

Am J Respir Crit Care Med. 2006 Mar 1;173(5):527-34. Epub 2005 Dec 9.

42.

Titin and its associated proteins: the third myofilament system of the sarcomere.

Granzier HL, Labeit S.

Adv Protein Chem. 2005;71:89-119. Review. No abstract available.

PMID:
16230110
43.

Dynamic myocardial contractile parameters from left ventricular pressure-volume measurements.

Campbell KB, Wu Y, Simpson AM, Kirkpatrick RD, Shroff SG, Granzier HL, Slinker BK.

Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H114-30.

44.

Hierarchical extensibility in the PEVK domain of skeletal-muscle titin.

Nagy A, Grama L, Huber T, Bianco P, Trombitás K, Granzier HL, Kellermayer MS.

Biophys J. 2005 Jul;89(1):329-36. Epub 2005 Apr 22.

45.
46.

Titin isoform-dependent effect of calcium on passive myocardial tension.

Fujita H, Labeit D, Gerull B, Labeit S, Granzier HL.

Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2528-34.

47.

Cellular and molecular mechanisms of systolic and diastolic dysfunction in an avian model of dilated cardiomyopathy.

Wu Y, Tobias AH, Bell K, Barry W, Helmes M, Trombitas K, Tucker R, Campbell KB, Granzier HL.

J Mol Cell Cardiol. 2004 Jul;37(1):111-9.

PMID:
15242741
48.

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy.

Nagueh SF, Shah G, Wu Y, Torre-Amione G, King NM, Lahmers S, Witt CC, Becker K, Labeit S, Granzier HL.

Circulation. 2004 Jul 13;110(2):155-62. Epub 2004 Jul 6.

49.

The giant protein titin: a major player in myocardial mechanics, signaling, and disease.

Granzier HL, Labeit S.

Circ Res. 2004 Feb 20;94(3):284-95. Review.

50.

Variable titin-based stiffness adjustment in heart disease.

Granzier HL, Wu Y, Trombitas K, Witt C, Labeit S, Bell S, LeWinter M.

Circulation. 2003 Jul 29;108(4):e23. No abstract available.

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