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Granzyme B as a therapeutic target for wound healing.

Turner CT, Hiroyasu S, Granville DJ.

Expert Opin Ther Targets. 2019 Sep;23(9):745-754. doi: 10.1080/14728222.2019.1661380. Epub 2019 Sep 4.


Cleavage and Sub-Cellular Redistribution of Nuclear Pore Protein 98 by Coxsackievirus B3 Protease 2A Impairs Cardioprotection.

Hanson PJ, Hossain AR, Qiu Y, Zhang HM, Zhao G, Li C, Lin V, Sulaimon S, Vlok M, Fung G, Chen VH, Jan E, McManus BM, Granville DJ, Yang D.

Front Cell Infect Microbiol. 2019 Jul 24;9:265. doi: 10.3389/fcimb.2019.00265. eCollection 2019.


Proteases in Pemphigoid Diseases.

Hiroyasu S, Turner CT, Richardson KC, Granville DJ.

Front Immunol. 2019 Jun 26;10:1454. doi: 10.3389/fimmu.2019.01454. eCollection 2019. Review.


Soluble Wood Smoke Extract Promotes Barrier Dysfunction in Alveolar Epithelial Cells through a MAPK Signaling Pathway.

Zeglinski MR, Turner CT, Zeng R, Schwartz C, Santacruz S, Pawluk MA, Zhao H, Chan AWH, Carlsten C, Granville DJ.

Sci Rep. 2019 Jul 11;9(1):10027. doi: 10.1038/s41598-019-46400-8.


Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation.

Cait J, Hughes MR, Zeglinski MR, Chan AW, Osterhof S, Scott RW, Canals Hernaez D, Cait A, Vogl AW, Bernatchez P, Underhill TM, Granville DJ, Murphy TH, Roskelley CD, McNagny KM.

Proc Natl Acad Sci U S A. 2019 Feb 20. pii: 201814766. doi: 10.1073/pnas.1814766116. [Epub ahead of print]


Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo.

Haage A, Goodwin K, Whitewood A, Camp D, Bogutz A, Turner CT, Granville DJ, Lefebvre L, Plotnikov S, Goult BT, Tanentzapf G.

Cell Rep. 2018 Nov 27;25(9):2401-2416.e5. doi: 10.1016/j.celrep.2018.10.098.


Transcatheter Aortic Heart Valves: Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration.

Sellers SL, Turner CT, Sathananthan J, Cartlidge TRG, Sin F, Bouchareb R, Mooney J, Nørgaard BL, Bax JJ, Bernatchez PN, Dweck MR, Granville DJ, Newby DE, Lauck S, Webb JG, Payne GW, Pibarot P, Blanke P, Seidman MA, Leipsic JA.

JACC Cardiovasc Imaging. 2019 Jan;12(1):135-145. doi: 10.1016/j.jcmg.2018.06.028. Epub 2018 Nov 15.


Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling.

Turner CT, Zeglinski MR, Richardson KC, Zhao H, Shen Y, Papp A, Bird PI, Granville DJ.

J Invest Dermatol. 2019 Apr;139(4):930-939. doi: 10.1016/j.jid.2018.09.031. Epub 2018 Nov 3.


Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction.

Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, Franzke CW, Overall CM, Granville DJ.

Sci Rep. 2018 Jun 26;8(1):9690. doi: 10.1038/s41598-018-28070-0.


Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing.

Shen Y, Zeglinski MR, Turner CT, Raithatha SA, Wu Z, Russo V, Oram C, Hiroyasu S, Nabai L, Zhao H, Bozin T, Westendorf K, Kopko I, Huang R, Arns S, Tan J, Zeng H, Boey A, Liggins R, Jaquith J, Cameron DR, Papp A, Granville DJ.

Exp Mol Med. 2018 May 30;50(5):68. doi: 10.1038/s12276-018-0095-0.


Granzyme B in skin inflammation and disease.

Turner CT, Lim D, Granville DJ.

Matrix Biol. 2019 Jan;75-76:126-140. doi: 10.1016/j.matbio.2017.12.005. Epub 2017 Dec 14. Review.


Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture.

Shen Y, Russo V, Zeglinski MR, Sellers SL, Wu Z, Oram C, Santacruz S, Merkulova Y, Turner C, Tauh K, Zhao H, Bozin T, Bohunek L, Zeng H, Seidman MA, Bleackley RC, McManus BM, Ruoslahti E, Järvinen TAH, Granville DJ.

Sci Rep. 2017 Nov 20;7(1):15857. doi: 10.1038/s41598-017-16194-8.


The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances.

Arias M, Martínez-Lostao L, Santiago L, Ferrandez A, Granville DJ, Pardo J.

Trends Cancer. 2017 Jun;3(6):407-422. doi: 10.1016/j.trecan.2017.04.001. Epub 2017 Jun 9. Review.


Granzyme B inhibits keratinocyte migration by disrupting epidermal growth factor receptor (EGFR)-mediated signaling.

Merkulova Y, Shen Y, Parkinson LG, Raithatha SA, Zhao H, Westendorf K, Sharma M, Bleackley RC, Granville DJ.

Biol Chem. 2016 Sep 1;397(9):883-95. doi: 10.1515/hsz-2016-0129.


Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1.

Sharma M, Merkulova Y, Raithatha S, Parkinson LG, Shen Y, Cooper D, Granville DJ.

FEBS J. 2016 May;283(9):1734-47. doi: 10.1111/febs.13699. Epub 2016 Mar 22.


Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis.

Shen Y, Cheng F, Sharma M, Merkulova Y, Raithatha SA, Parkinson LG, Zhao H, Westendorf K, Bohunek L, Bozin T, Hsu I, Ang LS, Williams SJ, Bleackley RC, Eriksson JE, Seidman MA, McManus BM, Granville DJ.

Am J Pathol. 2016 Jan;186(1):87-100. doi: 10.1016/j.ajpath.2015.09.010. Epub 2015 Nov 25.


Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes.

Hanson PJ, Ye X, Qiu Y, Zhang HM, Hemida MG, Wang F, Lim T, Gu A, Cho B, Kim H, Fung G, Granville DJ, Yang D.

Cell Death Differ. 2016 May;23(5):828-40. doi: 10.1038/cdd.2015.145. Epub 2015 Nov 20.


Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis.

Sharma A, Sellers S, Stefanovic N, Leung C, Tan SM, Huet O, Granville DJ, Cooper ME, de Haan JB, Bernatchez P.

Diabetes. 2015 Nov;64(11):3937-50. doi: 10.2337/db15-0472. Epub 2015 Jun 26.


Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.

Parkinson LG, Toro A, Zhao H, Brown K, Tebbutt SJ, Granville DJ.

Aging Cell. 2015 Feb;14(1):67-77. doi: 10.1111/acel.12298. Epub 2014 Dec 11.


Lipids, adiposity and tendinopathy: is there a mechanistic link? Critical review.

Scott A, Zwerver J, Grewal N, de Sa A, Alktebi T, Granville DJ, Hart DA.

Br J Sports Med. 2015 Aug;49(15):984-8. doi: 10.1136/bjsports-2014-093989. Epub 2014 Dec 8.


Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing.

Hsu I, Parkinson LG, Shen Y, Toro A, Brown T, Zhao H, Bleackley RC, Granville DJ.

Cell Death Dis. 2014 Oct 9;5:e1458. doi: 10.1038/cddis.2014.423.


Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.

Hendel A, Hsu I, Granville DJ.

Lab Invest. 2014 Jul;94(7):716-25. doi: 10.1038/labinvest.2014.62. Epub 2014 May 5.


A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.

Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM.

Nat Med. 2014 May;20(5):493-502. doi: 10.1038/nm.3508. Epub 2014 Apr 28.


Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice.

Hiebert PR, Boivin WA, Zhao H, McManus BM, Granville DJ.

PLoS One. 2013 Oct 24;8(10):e78939. doi: 10.1371/journal.pone.0078939. eCollection 2013.


Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice.

Hiebert PR, Wu D, Granville DJ.

Cell Death Differ. 2013 Oct;20(10):1404-14. doi: 10.1038/cdd.2013.96. Epub 2013 Aug 2.


Development of autoimmune hair loss disease alopecia areata is associated with cardiac dysfunction in C3H/HeJ mice.

Wang E, Chong K, Yu M, Akhoundsadegh N, Granville DJ, Shapiro J, McElwee KJ.

PLoS One. 2013 Apr 26;8(4):e62935. doi: 10.1371/journal.pone.0062935. Print 2013.


Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.

Hirota JA, Hiebert PR, Gold M, Wu D, Graydon C, Smith JA, Ask K, McNagny K, Granville DJ, Knight DA.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):453-62. doi: 10.1165/rcmb.2012-0512OC.


A possible role for CD8+ and non-CD8+ cell granzyme B in early small airway wall remodelling in centrilobular emphysema.

Kim WD, Chi HS, Choe KH, Oh YM, Lee SD, Kim KR, Yoo KH, Ngan DA, Elliott WM, Granville DJ, Sin DD, Hogg JC.

Respirology. 2013 May;18(4):688-96. doi: 10.1111/resp.12069.


Granzyme B cleavage of fibronectin disrupts endothelial cell adhesion, migration and capillary tube formation.

Hendel A, Granville DJ.

Matrix Biol. 2013 Jan;32(1):14-22. doi: 10.1016/j.matbio.2012.11.013. Epub 2012 Dec 7.


Granzyme B in injury, inflammation, and repair.

Hiebert PR, Granville DJ.

Trends Mol Med. 2012 Dec;18(12):732-41. doi: 10.1016/j.molmed.2012.09.009. Epub 2012 Oct 22. Review.


Inflammaging and proteases in abdominal aortic aneurysm.

Hendel A, Ang LS, Granville DJ.

Curr Vasc Pharmacol. 2015;13(1):95-110. Review.


Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.

Boivin WA, Shackleford M, Vanden Hoek A, Zhao H, Hackett TL, Knight DA, Granville DJ.

PLoS One. 2012;7(3):e33163. doi: 10.1371/journal.pone.0033163. Epub 2012 Mar 30. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/b1e4ff60-ba18-4f92-b856-0f2dd27e9a65.


The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.

McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, Pawelec G.

Vaccine. 2012 Mar 9;30(12):2060-7. doi: 10.1016/j.vaccine.2012.01.015. Epub 2012 Jan 27. Review.


Inflammation in myocardial diseases.

Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM.

Circ Res. 2012 Jan 6;110(1):126-44. doi: 10.1161/CIRCRESAHA.111.243170. Review.


Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm.

Ang LS, Boivin WA, Williams SJ, Zhao H, Abraham T, Carmine-Simmen K, McManus BM, Bleackley RC, Granville DJ.

Cell Death Dis. 2011 Sep 8;2:e209. doi: 10.1038/cddis.2011.88. Erratum in: Cell Death Dis. 2011;2:e215.


Granzyme K activates protease-activated receptor-1.

Cooper DM, Pechkovsky DV, Hackett TL, Knight DA, Granville DJ.

PLoS One. 2011;6(6):e21484. doi: 10.1371/journal.pone.0021484. Epub 2011 Jun 30.


Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice.

Hiebert PR, Boivin WA, Abraham T, Pazooki S, Zhao H, Granville DJ.

Exp Gerontol. 2011 Jun;46(6):489-99. doi: 10.1016/j.exger.2011.02.004. Epub 2011 Feb 18.


Proteinase inhibitor 9 is reduced in human atherosclerotic lesion development.

Hendel A, Cooper D, Abraham T, Zhao H, Allard MF, Granville DJ.

Cardiovasc Pathol. 2012 Jan-Feb;21(1):28-38. doi: 10.1016/j.carpath.2010.12.002. Epub 2011 Feb 5.


Granzymes in disease: bench to bedside.

Granville DJ.

Cell Death Differ. 2010 Apr;17(4):565-6. doi: 10.1038/cdd.2009.218. No abstract available.


Granzymes in age-related cardiovascular and pulmonary diseases.

Hendel A, Hiebert PR, Boivin WA, Williams SJ, Granville DJ.

Cell Death Differ. 2010 Apr;17(4):596-606. doi: 10.1038/cdd.2010.5. Epub 2010 Feb 5. Review.


Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm.

Chamberlain CM, Ang LS, Boivin WA, Cooper DM, Williams SJ, Zhao H, Hendel A, Folkesson M, Swedenborg J, Allard MF, McManus BM, Granville DJ.

Am J Pathol. 2010 Feb;176(2):1038-49. doi: 10.2353/ajpath.2010.090700. Epub 2009 Dec 24.


Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.

Boivin WA, Cooper DM, Hiebert PR, Granville DJ.

Lab Invest. 2009 Nov;89(11):1195-220. doi: 10.1038/labinvest.2009.91. Epub 2009 Sep 21. Review.


The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease.

Ngan DA, Vickerman SV, Granville DJ, Man SF, Sin DD.

Ther Adv Respir Dis. 2009 Jun;3(3):113-29. doi: 10.1177/1753465809341965. Epub 2009 Jul 28. Review.


The insect caspases.

Cooper DM, Granville DJ, Lowenberger C.

Apoptosis. 2009 Mar;14(3):247-56. doi: 10.1007/s10495-009-0322-1. Review.


Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice.

Ghosh S, Khazaei M, Moien-Afshari F, Ang LS, Granville DJ, Verchere CB, Dunn SR, McCue P, Mizisin A, Sharma K, Laher I.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F700-8. doi: 10.1152/ajprenal.90548.2008. Epub 2009 Jan 14.


Ramipril improves oxidative stress-related vascular endothelial dysfunction in db/db mice.

Liang W, Tan CY, Ang L, Sallam N, Granville DJ, Wright JM, Laher I.

J Physiol Sci. 2008 Dec;58(6):405-11. doi: 10.2170/physiolsci.RP012808.


Cytochrome p450 2C enzymes contribute to peritransplant ischemic injury and cardiac allograft vasculopathy.

Hunter AL, Kerjner A, Mueller KJ, McManus BM, Granville DJ.

Am J Transplant. 2008 Aug;8(8):1631-8. doi: 10.1111/j.1600-6143.2008.02296.x. Epub 2008 Jun 28.


Apolipoprotein E, an important player in longevity and age-related diseases.

Ang LS, Cruz RP, Hendel A, Granville DJ.

Exp Gerontol. 2008 Jul;43(7):615-22. doi: 10.1016/j.exger.2008.03.010. Epub 2008 Apr 4. Review.


Detection and quantification of apoptosis in the vasculature.

Boivin WA, Granville DJ.

Methods Mol Med. 2007;139:181-95.


Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice.

Elmi S, Sallam NA, Rahman MM, Teng X, Hunter AL, Moien-Afshari F, Khazaei M, Granville DJ, Laher I.

Vascul Pharmacol. 2008 Jan;48(1):1-8. Epub 2007 Sep 15.


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