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Items: 15

1.

Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121).

Schoeberl B, Kudla A, Masson K, Kalra A, Curley M, Finn G, Pace E, Harms B, Kim J, Kearns J, Fulgham A, Burenkova O, Grantcharova V, Yarar D, Paragas V, Fitzgerald J, Wainszelbaum M, West K, Mathews S, Nering R, Adiwijaya B, Garcia G, Kubasek B, Moyo V, Czibere A, Nielsen UB, MacBeath G.

NPJ Syst Biol Appl. 2017 Jan 5;3:16034. doi: 10.1038/npjsba.2016.34. eCollection 2017. Review.

2.

A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions.

Chang BH, Gujral TS, Karp ES, BuKhalid R, Grantcharova VP, MacBeath G.

Chem Biol. 2011 Sep 23;18(9):1143-52. doi: 10.1016/j.chembiol.2011.06.013.

3.

Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.

Schoeberl B, Pace EA, Fitzgerald JB, Harms BD, Xu L, Nie L, Linggi B, Kalra A, Paragas V, Bukhalid R, Grantcharova V, Kohli N, West KA, Leszczyniecka M, Feldhaus MJ, Kudla AJ, Nielsen UB.

Sci Signal. 2009 Jun 30;2(77):ra31. doi: 10.1126/scisignal.2000352.

4.

PDZ domain binding selectivity is optimized across the mouse proteome.

Stiffler MA, Chen JR, Grantcharova VP, Lei Y, Fuchs D, Allen JE, Zaslavskaia LA, MacBeath G.

Science. 2007 Jul 20;317(5836):364-9. Erratum in: Science. 2007 Oct 19;318(5849):393.

5.

Effects of HER2 overexpression on cell signaling networks governing proliferation and migration.

Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova V, Lauffenburger DA, White FM.

Mol Syst Biol. 2006;2:54. Epub 2006 Oct 3.

6.

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G.

J Am Chem Soc. 2006 May 3;128(17):5913-22.

7.

Mechanisms of protein folding.

Grantcharova V, Alm EJ, Baker D, Horwich AL.

Curr Opin Struct Biol. 2001 Feb;11(1):70-82. Review.

PMID:
11179895
8.

Circularization changes the folding transition state of the src SH3 domain.

Grantcharova VP, Baker D.

J Mol Biol. 2001 Feb 23;306(3):555-63.

PMID:
11178913
9.

Long-range order in the src SH3 folding transition state.

Grantcharova VP, Riddle DS, Baker D.

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7084-9.

10.

Experiment and theory highlight role of native state topology in SH3 folding.

Riddle DS, Grantcharova VP, Santiago JV, Alm E, Ruczinski I, Baker D.

Nat Struct Biol. 1999 Nov;6(11):1016-24.

PMID:
10542092
11.

Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain.

Grantcharova VP, Riddle DS, Santiago JV, Baker D.

Nat Struct Biol. 1998 Aug;5(8):714-20.

PMID:
9699636
12.

Simplified proteins: minimalist solutions to the 'protein folding problem'.

Plaxco KW, Riddle DS, Grantcharova V, Baker D.

Curr Opin Struct Biol. 1998 Feb;8(1):80-5. Review.

PMID:
9519299
13.

Folding dynamics of the src SH3 domain.

Grantcharova VP, Baker D.

Biochemistry. 1997 Dec 16;36(50):15685-92.

PMID:
9398297
14.

Functional rapidly folding proteins from simplified amino acid sequences.

Riddle DS, Santiago JV, Bray-Hall ST, Doshi N, Grantcharova VP, Yi Q, Baker D.

Nat Struct Biol. 1997 Oct;4(10):805-9.

PMID:
9334745
15.

Modifying the helical structure of DNA by design: recruitment of an architecture-specific protein to an enforced DNA bend.

Wolfe SA, Ferentz AE, Grantcharova V, Churchill ME, Verdine GL.

Chem Biol. 1995 Apr;2(4):213-21.

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